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P05366

- SAA1_MOUSE

UniProt

P05366 - SAA1_MOUSE

Protein

Serum amyloid A-1 protein

Gene

Saa1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Major acute phase protein.1 Publication

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. protein binding Source: MGI

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. cholesterol metabolic process Source: MGI

    Keywords - Biological processi

    Acute phase

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196592. Scavenging by Class B Receptors.
    REACT_198563. Amyloids.
    REACT_198647. Advanced glycosylation endproduct receptor signaling.
    REACT_202898. TRAF6 mediated NF-kB activation.
    REACT_207651. G alpha (q) signalling events.
    REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_222971. RIP-mediated NFkB activation via ZBP1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serum amyloid A-1 protein
    Gene namesi
    Name:Saa1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:98221. Saa1.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: MGI
    2. high-density lipoprotein particle Source: UniProtKB-KW

    Keywords - Cellular componenti

    HDL, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 122103Serum amyloid A-1 proteinPRO_0000031588Add
    BLAST

    Proteomic databases

    MaxQBiP05366.
    PaxDbiP05366.
    PRIDEiP05366.

    Expressioni

    Tissue specificityi

    Detected in blood plasma (at protein level). Detected in liver.2 Publications

    Inductioni

    By bacterial lipopolysaccharide.1 Publication

    Gene expression databases

    ArrayExpressiP05366.
    BgeeiP05366.
    CleanExiMM_SAA1.
    GenevestigatoriP05366.

    Interactioni

    Subunit structurei

    Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin By similarity.By similarity

    Protein-protein interaction databases

    MINTiMINT-127937.

    Structurei

    3D structure databases

    ProteinModelPortaliP05366.
    SMRiP05366. Positions 21-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 4526Important for amyloid formationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SAA family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG26520.
    HOGENOMiHOG000126881.
    HOVERGENiHBG016327.
    InParanoidiP05366.
    KOiK17310.
    OMAiKWGRSGR.
    OrthoDBiEOG7QVM4V.
    PhylomeDBiP05366.
    TreeFamiTF332544.

    Family and domain databases

    InterProiIPR000096. Serum_amyloid_A.
    [Graphical view]
    PfamiPF00277. SAA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
    PRINTSiPR00306. SERUMAMYLOID.
    SMARTiSM00197. SAA. 1 hit.
    [Graphical view]
    PROSITEiPS00992. SAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05366-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLTSLVFC SLLLGVCHGG FFSFVHEAFQ GAGDMWRAYT DMKEANWKNS    50
    DKYFHARGNY DAAQRGPGGV WAAEKISDGR EAFQEFFGRG HEDTIADQEA 100
    NRHGRSGKDP NYYRPPGLPD KY 122
    Length:122
    Mass (Da):13,770
    Last modified:July 1, 1989 - v2
    Checksum:i0AEF6D5F208EA4D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13521 Genomic DNA. Translation: AAA40084.1.
    M11131 Genomic RNA. Translation: AAA40083.1.
    CCDSiCCDS21284.1.
    PIRiA23843.
    RefSeqiNP_033143.1. NM_009117.3.
    XP_006540789.1. XM_006540726.1.
    UniGeneiMm.148800.

    Genome annotation databases

    EnsembliENSMUST00000128088; ENSMUSP00000119150; ENSMUSG00000074115.
    GeneIDi20208.
    KEGGimmu:20208.
    UCSCiuc009gyz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13521 Genomic DNA. Translation: AAA40084.1 .
    M11131 Genomic RNA. Translation: AAA40083.1 .
    CCDSi CCDS21284.1.
    PIRi A23843.
    RefSeqi NP_033143.1. NM_009117.3.
    XP_006540789.1. XM_006540726.1.
    UniGenei Mm.148800.

    3D structure databases

    ProteinModelPortali P05366.
    SMRi P05366. Positions 21-122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-127937.

    Proteomic databases

    MaxQBi P05366.
    PaxDbi P05366.
    PRIDEi P05366.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000128088 ; ENSMUSP00000119150 ; ENSMUSG00000074115 .
    GeneIDi 20208.
    KEGGi mmu:20208.
    UCSCi uc009gyz.1. mouse.

    Organism-specific databases

    CTDi 6288.
    MGIi MGI:98221. Saa1.

    Phylogenomic databases

    eggNOGi NOG26520.
    HOGENOMi HOG000126881.
    HOVERGENi HBG016327.
    InParanoidi P05366.
    KOi K17310.
    OMAi KWGRSGR.
    OrthoDBi EOG7QVM4V.
    PhylomeDBi P05366.
    TreeFami TF332544.

    Enzyme and pathway databases

    Reactomei REACT_196592. Scavenging by Class B Receptors.
    REACT_198563. Amyloids.
    REACT_198647. Advanced glycosylation endproduct receptor signaling.
    REACT_202898. TRAF6 mediated NF-kB activation.
    REACT_207651. G alpha (q) signalling events.
    REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_222971. RIP-mediated NFkB activation via ZBP1.

    Miscellaneous databases

    NextBioi 297797.
    PROi P05366.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P05366.
    Bgeei P05366.
    CleanExi MM_SAA1.
    Genevestigatori P05366.

    Family and domain databases

    InterProi IPR000096. Serum_amyloid_A.
    [Graphical view ]
    Pfami PF00277. SAA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002472. Serum_amyloid_A. 1 hit.
    PRINTSi PR00306. SERUMAMYLOID.
    SMARTi SM00197. SAA. 1 hit.
    [Graphical view ]
    PROSITEi PS00992. SAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the murine serum amyloid A gene family. Gene conversion."
      Lowell C.A., Potter D.A., Stearman R.S., Morrow J.F.
      J. Biol. Chem. 261:8442-8452(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete primary structures of two major murine serum amyloid A proteins deduced from cDNA sequences."
      Yamamoto K., Migita S.
      Proc. Natl. Acad. Sci. U.S.A. 82:2915-2919(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 9-122, TISSUE SPECIFICITY, INDUCTION BY LIPOPOLYSACCHARIDE.
    3. "Isolation and purification of two major serum amyloid A isotypes SAA1 and SAA2 from the acute phase plasma of mice."
      Kaplan B., Yakar S., Balta Y., Pras M., Martin B.
      J. Chromatogr. B 704:69-76(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-39, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.

    Entry informationi

    Entry nameiSAA1_MOUSE
    AccessioniPrimary (citable) accession number: P05366
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3