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P05366 (SAA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serum amyloid A-1 protein
Gene names
Name:Saa1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length122 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Major acute phase protein. Ref.3

Subunit structure

Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin By similarity.

Subcellular location

Secreted Ref.3.

Tissue specificity

Detected in blood plasma (at protein level). Detected in liver. Ref.2 Ref.3

Induction

By bacterial lipopolysaccharide. Ref.2

Sequence similarities

Belongs to the SAA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.3
Chain20 – 122103Serum amyloid A-1 protein
PRO_0000031588

Regions

Region20 – 4526Important for amyloid formation By similarity

Sequences

Sequence LengthMass (Da)Tools
P05366 [UniParc].

Last modified July 1, 1989. Version 2.
Checksum: 0AEF6D5F208EA4D0

FASTA12213,770
        10         20         30         40         50         60 
MKLLTSLVFC SLLLGVCHGG FFSFVHEAFQ GAGDMWRAYT DMKEANWKNS DKYFHARGNY 

        70         80         90        100        110        120 
DAAQRGPGGV WAAEKISDGR EAFQEFFGRG HEDTIADQEA NRHGRSGKDP NYYRPPGLPD 


KY 

« Hide

References

[1]"Structure of the murine serum amyloid A gene family. Gene conversion."
Lowell C.A., Potter D.A., Stearman R.S., Morrow J.F.
J. Biol. Chem. 261:8442-8452(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete primary structures of two major murine serum amyloid A proteins deduced from cDNA sequences."
Yamamoto K., Migita S.
Proc. Natl. Acad. Sci. U.S.A. 82:2915-2919(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 9-122, TISSUE SPECIFICITY, INDUCTION BY LIPOPOLYSACCHARIDE.
[3]"Isolation and purification of two major serum amyloid A isotypes SAA1 and SAA2 from the acute phase plasma of mice."
Kaplan B., Yakar S., Balta Y., Pras M., Martin B.
J. Chromatogr. B 704:69-76(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-39, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M13521 Genomic DNA. Translation: AAA40084.1.
M11131 Genomic RNA. Translation: AAA40083.1.
CCDSCCDS21284.1.
PIRA23843.
RefSeqNP_033143.1. NM_009117.3.
XP_006540789.1. XM_006540726.1.
UniGeneMm.148800.

3D structure databases

ProteinModelPortalP05366.
SMRP05366. Positions 21-122.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-127937.

Proteomic databases

MaxQBP05366.
PaxDbP05366.
PRIDEP05366.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000128088; ENSMUSP00000119150; ENSMUSG00000074115.
GeneID20208.
KEGGmmu:20208.
UCSCuc009gyz.1. mouse.

Organism-specific databases

CTD6288.
MGIMGI:98221. Saa1.

Phylogenomic databases

eggNOGNOG26520.
HOGENOMHOG000126881.
HOVERGENHBG016327.
InParanoidP05366.
KOK17310.
OMAKWGRSGR.
OrthoDBEOG7QVM4V.
PhylomeDBP05366.
TreeFamTF332544.

Gene expression databases

ArrayExpressP05366.
BgeeP05366.
CleanExMM_SAA1.
GenevestigatorP05366.

Family and domain databases

InterProIPR000096. Serum_amyloid_A.
[Graphical view]
PfamPF00277. SAA. 1 hit.
[Graphical view]
PIRSFPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSPR00306. SERUMAMYLOID.
SMARTSM00197. SAA. 1 hit.
[Graphical view]
PROSITEPS00992. SAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297797.
PROP05366.
SOURCESearch...

Entry information

Entry nameSAA1_MOUSE
AccessionPrimary (citable) accession number: P05366
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot