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Protein

Serum amyloid A-1 protein

Gene

Saa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major acute phase protein.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: MGI
  2. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. cholesterol metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_272716. Formyl peptide receptors bind formyl peptides and many other ligands.
REACT_275137. TRAF6 mediated NF-kB activation.
REACT_282527. Scavenging by Class B Receptors.
REACT_283225. RIP-mediated NFkB activation via ZBP1.
REACT_305279. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_331048. G alpha (i) signalling events.
REACT_342554. Advanced glycosylation endproduct receptor signaling.
REACT_342573. Amyloids.
REACT_343658. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-1 protein
Gene namesi
Name:Saa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98221. Saa1.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. high-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 122103Serum amyloid A-1 proteinPRO_0000031588Add
BLAST

Proteomic databases

MaxQBiP05366.
PaxDbiP05366.
PRIDEiP05366.

Expressioni

Tissue specificityi

Detected in blood plasma (at protein level). Detected in liver.2 Publications

Inductioni

By bacterial lipopolysaccharide.1 Publication

Gene expression databases

BgeeiP05366.
CleanExiMM_SAA1.
ExpressionAtlasiP05366. baseline and differential.
GenevestigatoriP05366.

Interactioni

Subunit structurei

Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-127937.

Structurei

3D structure databases

ProteinModelPortaliP05366.
SMRiP05366. Positions 21-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4526Important for amyloid formationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26520.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP05366.
KOiK17310.
OMAiHEDTIAD.
OrthoDBiEOG7QVM4V.
PhylomeDBiP05366.
TreeFamiTF332544.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLTSLVFC SLLLGVCHGG FFSFVHEAFQ GAGDMWRAYT DMKEANWKNS
60 70 80 90 100
DKYFHARGNY DAAQRGPGGV WAAEKISDGR EAFQEFFGRG HEDTIADQEA
110 120
NRHGRSGKDP NYYRPPGLPD KY
Length:122
Mass (Da):13,770
Last modified:June 30, 1989 - v2
Checksum:i0AEF6D5F208EA4D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13521 Genomic DNA. Translation: AAA40084.1.
M11131 Genomic RNA. Translation: AAA40083.1.
CCDSiCCDS21284.1.
PIRiA23843.
RefSeqiNP_033143.1. NM_009117.3.
XP_006540789.1. XM_006540726.2.
UniGeneiMm.148800.

Genome annotation databases

EnsembliENSMUST00000128088; ENSMUSP00000119150; ENSMUSG00000074115.
GeneIDi20208.
KEGGimmu:20208.
UCSCiuc009gyz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13521 Genomic DNA. Translation: AAA40084.1.
M11131 Genomic RNA. Translation: AAA40083.1.
CCDSiCCDS21284.1.
PIRiA23843.
RefSeqiNP_033143.1. NM_009117.3.
XP_006540789.1. XM_006540726.2.
UniGeneiMm.148800.

3D structure databases

ProteinModelPortaliP05366.
SMRiP05366. Positions 21-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-127937.

Proteomic databases

MaxQBiP05366.
PaxDbiP05366.
PRIDEiP05366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128088; ENSMUSP00000119150; ENSMUSG00000074115.
GeneIDi20208.
KEGGimmu:20208.
UCSCiuc009gyz.1. mouse.

Organism-specific databases

CTDi6288.
MGIiMGI:98221. Saa1.

Phylogenomic databases

eggNOGiNOG26520.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP05366.
KOiK17310.
OMAiHEDTIAD.
OrthoDBiEOG7QVM4V.
PhylomeDBiP05366.
TreeFamiTF332544.

Enzyme and pathway databases

ReactomeiREACT_272716. Formyl peptide receptors bind formyl peptides and many other ligands.
REACT_275137. TRAF6 mediated NF-kB activation.
REACT_282527. Scavenging by Class B Receptors.
REACT_283225. RIP-mediated NFkB activation via ZBP1.
REACT_305279. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_331048. G alpha (i) signalling events.
REACT_342554. Advanced glycosylation endproduct receptor signaling.
REACT_342573. Amyloids.
REACT_343658. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi297797.
PROiP05366.
SOURCEiSearch...

Gene expression databases

BgeeiP05366.
CleanExiMM_SAA1.
ExpressionAtlasiP05366. baseline and differential.
GenevestigatoriP05366.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of the murine serum amyloid A gene family. Gene conversion."
    Lowell C.A., Potter D.A., Stearman R.S., Morrow J.F.
    J. Biol. Chem. 261:8442-8452(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete primary structures of two major murine serum amyloid A proteins deduced from cDNA sequences."
    Yamamoto K., Migita S.
    Proc. Natl. Acad. Sci. U.S.A. 82:2915-2919(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 9-122, TISSUE SPECIFICITY, INDUCTION BY LIPOPOLYSACCHARIDE.
  3. "Isolation and purification of two major serum amyloid A isotypes SAA1 and SAA2 from the acute phase plasma of mice."
    Kaplan B., Yakar S., Balta Y., Pras M., Martin B.
    J. Chromatogr. B 704:69-76(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-39, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiSAA1_MOUSE
AccessioniPrimary (citable) accession number: P05366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1988
Last sequence update: June 30, 1989
Last modified: March 31, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.