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P05366

- SAA1_MOUSE

UniProt

P05366 - SAA1_MOUSE

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Protein

Serum amyloid A-1 protein

Gene

Saa1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Major acute phase protein.1 Publication

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. cholesterol metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_196592. Scavenging by Class B Receptors.
REACT_198563. Amyloids.
REACT_198647. Advanced glycosylation endproduct receptor signaling.
REACT_202898. TRAF6 mediated NF-kB activation.
REACT_207651. G alpha (q) signalling events.
REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_222971. RIP-mediated NFkB activation via ZBP1.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-1 protein
Gene namesi
Name:Saa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:98221. Saa1.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. high-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 122103Serum amyloid A-1 proteinPRO_0000031588Add
BLAST

Proteomic databases

MaxQBiP05366.
PaxDbiP05366.
PRIDEiP05366.

Expressioni

Tissue specificityi

Detected in blood plasma (at protein level). Detected in liver.2 Publications

Inductioni

By bacterial lipopolysaccharide.1 Publication

Gene expression databases

BgeeiP05366.
CleanExiMM_SAA1.
ExpressionAtlasiP05366. baseline and differential.
GenevestigatoriP05366.

Interactioni

Subunit structurei

Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-127937.

Structurei

3D structure databases

ProteinModelPortaliP05366.
SMRiP05366. Positions 21-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4526Important for amyloid formationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26520.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP05366.
KOiK17310.
OMAiKWGRSGR.
OrthoDBiEOG7QVM4V.
PhylomeDBiP05366.
TreeFamiTF332544.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05366 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLTSLVFC SLLLGVCHGG FFSFVHEAFQ GAGDMWRAYT DMKEANWKNS
60 70 80 90 100
DKYFHARGNY DAAQRGPGGV WAAEKISDGR EAFQEFFGRG HEDTIADQEA
110 120
NRHGRSGKDP NYYRPPGLPD KY
Length:122
Mass (Da):13,770
Last modified:July 1, 1989 - v2
Checksum:i0AEF6D5F208EA4D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13521 Genomic DNA. Translation: AAA40084.1.
M11131 Genomic RNA. Translation: AAA40083.1.
CCDSiCCDS21284.1.
PIRiA23843.
RefSeqiNP_033143.1. NM_009117.3.
XP_006540789.1. XM_006540726.1.
UniGeneiMm.148800.

Genome annotation databases

EnsembliENSMUST00000128088; ENSMUSP00000119150; ENSMUSG00000074115.
GeneIDi20208.
KEGGimmu:20208.
UCSCiuc009gyz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13521 Genomic DNA. Translation: AAA40084.1 .
M11131 Genomic RNA. Translation: AAA40083.1 .
CCDSi CCDS21284.1.
PIRi A23843.
RefSeqi NP_033143.1. NM_009117.3.
XP_006540789.1. XM_006540726.1.
UniGenei Mm.148800.

3D structure databases

ProteinModelPortali P05366.
SMRi P05366. Positions 21-122.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-127937.

Proteomic databases

MaxQBi P05366.
PaxDbi P05366.
PRIDEi P05366.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000128088 ; ENSMUSP00000119150 ; ENSMUSG00000074115 .
GeneIDi 20208.
KEGGi mmu:20208.
UCSCi uc009gyz.1. mouse.

Organism-specific databases

CTDi 6288.
MGIi MGI:98221. Saa1.

Phylogenomic databases

eggNOGi NOG26520.
HOGENOMi HOG000126881.
HOVERGENi HBG016327.
InParanoidi P05366.
KOi K17310.
OMAi KWGRSGR.
OrthoDBi EOG7QVM4V.
PhylomeDBi P05366.
TreeFami TF332544.

Enzyme and pathway databases

Reactomei REACT_196592. Scavenging by Class B Receptors.
REACT_198563. Amyloids.
REACT_198647. Advanced glycosylation endproduct receptor signaling.
REACT_202898. TRAF6 mediated NF-kB activation.
REACT_207651. G alpha (q) signalling events.
REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_222971. RIP-mediated NFkB activation via ZBP1.

Miscellaneous databases

NextBioi 297797.
PROi P05366.
SOURCEi Search...

Gene expression databases

Bgeei P05366.
CleanExi MM_SAA1.
ExpressionAtlasi P05366. baseline and differential.
Genevestigatori P05366.

Family and domain databases

InterProi IPR000096. Serum_amyloid_A.
[Graphical view ]
Pfami PF00277. SAA. 1 hit.
[Graphical view ]
PIRSFi PIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSi PR00306. SERUMAMYLOID.
SMARTi SM00197. SAA. 1 hit.
[Graphical view ]
PROSITEi PS00992. SAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of the murine serum amyloid A gene family. Gene conversion."
    Lowell C.A., Potter D.A., Stearman R.S., Morrow J.F.
    J. Biol. Chem. 261:8442-8452(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete primary structures of two major murine serum amyloid A proteins deduced from cDNA sequences."
    Yamamoto K., Migita S.
    Proc. Natl. Acad. Sci. U.S.A. 82:2915-2919(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 9-122, TISSUE SPECIFICITY, INDUCTION BY LIPOPOLYSACCHARIDE.
  3. "Isolation and purification of two major serum amyloid A isotypes SAA1 and SAA2 from the acute phase plasma of mice."
    Kaplan B., Yakar S., Balta Y., Pras M., Martin B.
    J. Chromatogr. B 704:69-76(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-39, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiSAA1_MOUSE
AccessioniPrimary (citable) accession number: P05366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3