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Protein

Serum amyloid A-1 protein

Gene

Saa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major acute phase protein.1 Publication

GO - Molecular functioni

GO - Biological processi

  • acute-phase response Source: UniProtKB-KW
  • cholesterol metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-1 protein
Gene namesi
Name:Saa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98221. Saa1.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 122103Serum amyloid A-1 proteinPRO_0000031588Add
BLAST

Proteomic databases

PaxDbiP05366.
PRIDEiP05366.

Expressioni

Tissue specificityi

Detected in blood plasma (at protein level). Detected in liver.2 Publications

Inductioni

By bacterial lipopolysaccharide.1 Publication

Gene expression databases

BgeeiP05366.
CleanExiMM_SAA1.
ExpressionAtlasiP05366. baseline and differential.
GenevisibleiP05366. MM.

Interactioni

Subunit structurei

Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-127937.
STRINGi10090.ENSMUSP00000119150.

Structurei

3D structure databases

ProteinModelPortaliP05366.
SMRiP05366. Positions 21-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4526Important for amyloid formationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXU4. Eukaryota.
ENOG410YSBK. LUCA.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP05366.
KOiK17310.
OMAiEDTIADQ.
OrthoDBiEOG7QVM4V.
PhylomeDBiP05366.
TreeFamiTF332544.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLTSLVFC SLLLGVCHGG FFSFVHEAFQ GAGDMWRAYT DMKEANWKNS
60 70 80 90 100
DKYFHARGNY DAAQRGPGGV WAAEKISDGR EAFQEFFGRG HEDTIADQEA
110 120
NRHGRSGKDP NYYRPPGLPD KY
Length:122
Mass (Da):13,770
Last modified:July 1, 1989 - v2
Checksum:i0AEF6D5F208EA4D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13521 Genomic DNA. Translation: AAA40084.1.
M11131 Genomic RNA. Translation: AAA40083.1.
CCDSiCCDS21284.1.
PIRiA23843.
RefSeqiNP_033143.1. NM_009117.3.
XP_006540789.1. XM_006540726.2.
UniGeneiMm.148800.

Genome annotation databases

EnsembliENSMUST00000128088; ENSMUSP00000119150; ENSMUSG00000074115.
GeneIDi20208.
KEGGimmu:20208.
UCSCiuc009gyz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13521 Genomic DNA. Translation: AAA40084.1.
M11131 Genomic RNA. Translation: AAA40083.1.
CCDSiCCDS21284.1.
PIRiA23843.
RefSeqiNP_033143.1. NM_009117.3.
XP_006540789.1. XM_006540726.2.
UniGeneiMm.148800.

3D structure databases

ProteinModelPortaliP05366.
SMRiP05366. Positions 21-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-127937.
STRINGi10090.ENSMUSP00000119150.

Proteomic databases

PaxDbiP05366.
PRIDEiP05366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128088; ENSMUSP00000119150; ENSMUSG00000074115.
GeneIDi20208.
KEGGimmu:20208.
UCSCiuc009gyz.1. mouse.

Organism-specific databases

CTDi6288.
MGIiMGI:98221. Saa1.

Phylogenomic databases

eggNOGiENOG410IXU4. Eukaryota.
ENOG410YSBK. LUCA.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP05366.
KOiK17310.
OMAiEDTIADQ.
OrthoDBiEOG7QVM4V.
PhylomeDBiP05366.
TreeFamiTF332544.

Miscellaneous databases

NextBioi297797.
PROiP05366.
SOURCEiSearch...

Gene expression databases

BgeeiP05366.
CleanExiMM_SAA1.
ExpressionAtlasiP05366. baseline and differential.
GenevisibleiP05366. MM.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of the murine serum amyloid A gene family. Gene conversion."
    Lowell C.A., Potter D.A., Stearman R.S., Morrow J.F.
    J. Biol. Chem. 261:8442-8452(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete primary structures of two major murine serum amyloid A proteins deduced from cDNA sequences."
    Yamamoto K., Migita S.
    Proc. Natl. Acad. Sci. U.S.A. 82:2915-2919(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 9-122, TISSUE SPECIFICITY, INDUCTION BY LIPOPOLYSACCHARIDE.
  3. "Isolation and purification of two major serum amyloid A isotypes SAA1 and SAA2 from the acute phase plasma of mice."
    Kaplan B., Yakar S., Balta Y., Pras M., Martin B.
    J. Chromatogr. B 704:69-76(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-39, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiSAA1_MOUSE
AccessioniPrimary (citable) accession number: P05366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: May 11, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.