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Protein

Substance-K receptor

Gene

TACR2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-380095. Tachykinin receptors bind tachykinins.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-K receptor
Short name:
SKR
Alternative name(s):
NK-2 receptor
Short name:
NK-2R
Neurokinin A receptor
Tachykinin receptor 2
Gene namesi
Name:TACR2
Synonyms:TAC2R
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5624Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini57 – 6913CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 10717ExtracellularSequence analysisAdd
BLAST
Transmembranei108 – 12922Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini130 – 14920CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 19626ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21822Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 25133CytoplasmicSequence analysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini273 – 29018ExtracellularSequence analysisAdd
BLAST
Transmembranei291 – 31020Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini311 – 38474CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Substance-K receptorPRO_0000069890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
Lipidationi324 – 3241S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP05363.
PRIDEiP05363.

Expressioni

Gene expression databases

ExpressionAtlasiP05363. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028870.

Chemistry

BindingDBiP05363.

Structurei

3D structure databases

ProteinModelPortaliP05363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP05363.
KOiK04223.
OMAiLCMAAFN.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGACVVMTDI NISSGLDSNA TGITAFSMPG WQLALWTAAY LALVLVAVMG
60 70 80 90 100
NATVIWIILA HQRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY
110 120 130 140 150
FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPGTRA
160 170 180 190 200
VIAGIWLVAL ALAFPQCFYS TITTDEGATK CVVAWPEDSG GKMLLLYHLI
210 220 230 240 250
VIALIYFLPL VVMFVAYSVI GLTLWRRSVP GHQAHGANLR HLQAKKKFVK
260 270 280 290 300
TMVLVVVTFA ICWLPYHLYF ILGTFQEDIY CHKFIQQVYL ALFWLAMSST
310 320 330 340 350
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TEEDKMELTY TPSLSTRVNR
360 370 380
CHTKEIFFMS GDVAPSEAVN GQAESPQAGV STEP
Length:384
Mass (Da):43,069
Last modified:November 1, 1988 - v1
Checksum:i1EC676BBD7FF1672
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06295 mRNA. Translation: CAA29621.1.
PIRiS00516.
RefSeqiNP_776894.1. NM_174469.2.
UniGeneiBt.323.

Genome annotation databases

EnsembliENSBTAT00000028870; ENSBTAP00000028870; ENSBTAG00000021664.
GeneIDi282088.
KEGGibta:282088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06295 mRNA. Translation: CAA29621.1.
PIRiS00516.
RefSeqiNP_776894.1. NM_174469.2.
UniGeneiBt.323.

3D structure databases

ProteinModelPortaliP05363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028870.

Chemistry

BindingDBiP05363.
ChEMBLiCHEMBL4815.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP05363.
PRIDEiP05363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028870; ENSBTAP00000028870; ENSBTAG00000021664.
GeneIDi282088.
KEGGibta:282088.

Organism-specific databases

CTDi6865.

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP05363.
KOiK04223.
OMAiLCMAAFN.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-BTA-380095. Tachykinin receptors bind tachykinins.
R-BTA-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi20805931.

Gene expression databases

ExpressionAtlasiP05363. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning of bovine substance-K receptor through oocyte expression system."
    Masu Y., Nakayama K., Tamaki H., Harada Y., Kuno M., Nakanishi S.
    Nature 329:836-838(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNK2R_BOVIN
AccessioniPrimary (citable) accession number: P05363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.