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P05362

- ICAM1_HUMAN

UniProt

P05362 - ICAM1_HUMAN

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Protein

Intercellular adhesion molecule 1

Gene

ICAM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.4 Publications

GO - Molecular functioni

  1. integrin binding Source: BHF-UCL
  2. receptor activity Source: ProtInc
  3. transmembrane signaling receptor activity Source: ProtInc
  4. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. adhesion of symbiont to host Source: BHF-UCL
  2. cell adhesion Source: BHF-UCL
  3. cell adhesion mediated by integrin Source: Ensembl
  4. cell aging Source: Ensembl
  5. cellular response to alkaloid Source: Ensembl
  6. cellular response to glucose stimulus Source: Ensembl
  7. cellular response to hypoxia Source: Ensembl
  8. cellular response to interleukin-1 Source: Ensembl
  9. cellular response to lipopolysaccharide Source: Ensembl
  10. cellular response to nutrient levels Source: Ensembl
  11. cellular response to tumor necrosis factor Source: Ensembl
  12. cytokine-mediated signaling pathway Source: Reactome
  13. establishment of endothelial barrier Source: UniProt
  14. extracellular matrix organization Source: Reactome
  15. heterophilic cell-cell adhesion Source: BHF-UCL
  16. interferon-gamma-mediated signaling pathway Source: Reactome
  17. leukocyte cell-cell adhesion Source: BHF-UCL
  18. leukocyte migration Source: BHF-UCL
  19. membrane to membrane docking Source: BHF-UCL
  20. negative regulation of calcium ion transport Source: Ensembl
  21. negative regulation of endothelial cell apoptotic process Source: BHF-UCL
  22. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
  23. ovarian follicle development Source: Ensembl
  24. positive regulation of actin filament polymerization Source: Ensembl
  25. positive regulation of cellular extravasation Source: BHF-UCL
  26. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  27. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  28. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  29. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  30. positive regulation of Rho GTPase activity Source: Ensembl
  31. positive regulation of vasoconstriction Source: Ensembl
  32. receptor-mediated virion attachment to host cell Source: BHF-UCL
  33. regulation of cell adhesion Source: Ensembl
  34. regulation of cell shape Source: Ensembl
  35. regulation of immune response Source: Reactome
  36. regulation of leukocyte mediated cytotoxicity Source: BHF-UCL
  37. regulation of ruffle assembly Source: Ensembl
  38. response to amino acid Source: Ensembl
  39. response to amphetamine Source: Ensembl
  40. response to copper ion Source: Ensembl
  41. response to drug Source: Ensembl
  42. response to ethanol Source: Ensembl
  43. response to gonadotropin Source: Ensembl
  44. response to ionizing radiation Source: Ensembl
  45. response to organic cyclic compound Source: Ensembl
  46. response to sulfur dioxide Source: Ensembl
  47. T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: BHF-UCL
  48. T cell antigen processing and presentation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_13552. Integrin cell surface interactions.
REACT_25078. Interferon gamma signaling.
SABIO-RKP05362.

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 1
Short name:
ICAM-1
Alternative name(s):
Major group rhinovirus receptor
CD_antigen: CD54
Gene namesi
Name:ICAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:5344. ICAM1.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. external side of plasma membrane Source: Ensembl
  3. extracellular space Source: BHF-UCL
  4. extracellular vesicular exosome Source: UniProtKB
  5. focal adhesion Source: UniProtKB
  6. immunological synapse Source: Ensembl
  7. integral component of plasma membrane Source: ProtInc
  8. membrane Source: UniProtKB
  9. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

MIMi611162. phenotype.
Orphaneti1334. Chronic mucocutaneous candidosis.
PharmGKBiPA29592.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Add
BLAST
Chaini28 – 532505Intercellular adhesion molecule 1PRO_0000014783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 92
Disulfide bondi52 ↔ 96
Glycosylationi130 – 1301N-linked (GlcNAc...)1 Publication
Disulfide bondi135 ↔ 186
Glycosylationi145 – 1451N-linked (GlcNAc...) (complex)3 Publications
Glycosylationi183 – 1831N-linked (GlcNAc...)1 Publication
Glycosylationi202 – 2021N-linked (GlcNAc...)2 Publications
Disulfide bondi237 ↔ 290
Glycosylationi260 – 2601N-linked (GlcNAc...)1 Publication
Glycosylationi267 – 2671N-linked (GlcNAc...)4 Publications
Glycosylationi296 – 2961N-linked (GlcNAc...)1 Publication
Disulfide bondi332 ↔ 371
Glycosylationi385 – 3851N-linked (GlcNAc...)1 Publication
Disulfide bondi403 ↔ 419
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi431 ↔ 457
Modified residuei521 – 5211Phosphothreonine2 Publications
Modified residuei530 – 5301Phosphothreonine2 Publications

Post-translational modificationi

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP05362.
PaxDbiP05362.
PRIDEiP05362.

PTM databases

PhosphoSiteiP05362.

Miscellaneous databases

PMAP-CutDBP05362.

Expressioni

Gene expression databases

BgeeiP05362.
CleanExiHS_ICAM1.
ExpressionAtlasiP05362. baseline and differential.
GenevestigatoriP05362.

Organism-specific databases

HPAiCAB002142.
HPA002126.
HPA004877.

Interactioni

Subunit structurei

Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.7 PublicationsCurated

Protein-protein interaction databases

BioGridi109610. 141 interactions.
IntActiP05362. 7 interactions.
MINTiMINT-4053071.
STRINGi9606.ENSP00000264832.

Structurei

Secondary structure

1
532
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 3911
Beta strandi42 – 509
Beta strandi52 – 543
Beta strandi56 – 616
Beta strandi66 – 694
Beta strandi71 – 8414
Beta strandi91 – 955
Beta strandi97 – 993
Beta strandi100 – 1045
Beta strandi106 – 1116
Beta strandi114 – 1185
Beta strandi123 – 1253
Beta strandi129 – 13810
Helixi143 – 1453
Beta strandi146 – 1527
Beta strandi155 – 1617
Turni164 – 1663
Beta strandi167 – 1748
Helixi177 – 1793
Beta strandi183 – 1919
Helixi193 – 1953
Beta strandi199 – 2035
Beta strandi210 – 2123
Beta strandi220 – 2223
Beta strandi225 – 2284
Beta strandi231 – 24111
Helixi245 – 2473
Beta strandi249 – 2546
Beta strandi262 – 2654
Beta strandi267 – 27812
Helixi280 – 2823
Beta strandi284 – 29411
Beta strandi297 – 30812
Beta strandi314 – 3185
Beta strandi320 – 3234
Beta strandi327 – 3337
Beta strandi338 – 3447
Beta strandi346 – 3483
Beta strandi351 – 3544
Beta strandi357 – 3593
Helixi362 – 3643
Beta strandi367 – 37610
Beta strandi378 – 39720
Helixi400 – 4023
Beta strandi405 – 4106
Beta strandi422 – 4254
Beta strandi428 – 4336
Turni434 – 4363
Helixi449 – 4513
Beta strandi453 – 4619
Beta strandi464 – 47512

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D3Eelectron microscopy28.00I28-212[»]
1D3Ielectron microscopy26.00I28-212[»]
1D3LX-ray3.25A28-212[»]
1IAMX-ray2.10A28-212[»]
1IC1X-ray3.00A/B28-217[»]
1IJ4model-I44-109[»]
1MQ8X-ray3.30A/C28-318[»]
1P53X-ray3.06A/B212-477[»]
1Z7Zelectron microscopy8.00I28-477[»]
2OZ4X-ray2.70A213-477[»]
3TCXX-ray3.60A/C/E/G/I/K/M/O/Q/S/U/W/Y/a29-112[»]
ProteinModelPortaliP05362.
SMRiP05362. Positions 28-477.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05362.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 480453ExtracellularSequence AnalysisAdd
BLAST
Topological domaini504 – 53229CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei481 – 50323HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 10363Ig-like C2-type 1Add
BLAST
Domaini128 – 19366Ig-like C2-type 2Add
BLAST
Domaini230 – 29768Ig-like C2-type 3Add
BLAST
Domaini325 – 37854Ig-like C2-type 4Add
BLAST
Domaini412 – 46453Ig-like C2-type 5Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi152 – 1543Cell attachment site; atypicalSequence Analysis

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146347.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000059554.
HOVERGENiHBG052074.
InParanoidiP05362.
KOiK06490.
OMAiRDCPGNW.
OrthoDBiEOG7QG43X.
PhylomeDBiP05362.
TreeFamiTF333745.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05362-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPSKVILPR GGSVLVTCST
60 70 80 90 100
SCDQPKLLGI ETPLPKKELL LPGNNRKVYE LSNVQEDSQP MCYSNCPDGQ
110 120 130 140 150
STAKTFLTVY WTPERVELAP LPSWQPVGKN LTLRCQVEGG APRANLTVVL
160 170 180 190 200
LRGEKELKRE PAVGEPAEVT TTVLVRRDHH GANFSCRTEL DLRPQGLELF
210 220 230 240 250
ENTSAPYQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD GLFPVSEAQV
260 270 280 290 300
HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQRLTC AVILGNQSQE
310 320 330 340 350
TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPL
360 370 380 390 400
GPRAQLLLKA TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE
410 420 430 440 450
RDCPGNWTWP ENSQQTPMCQ AWGNPLPELK CLKDGTFPLP IGESVTVTRD
460 470 480 490 500
LEGTYLCRAR STQGEVTRKV TVNVLSPRYE IVIITVVAAA VIMGTAGLST
510 520 530
YLYNRQRKIK KYRLQQAQKG TPMKPNTQAT PP
Length:532
Mass (Da):57,825
Last modified:June 21, 2005 - v2
Checksum:i550089365A733AFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 102AL → PV in CAA40441. (PubMed:1983003)Curated
Sequence conflicti17 – 171L → F in AAQ14902. (PubMed:15572059)Curated
Sequence conflicti27 – 271A → V in AAQ14902. (PubMed:15572059)Curated

Polymorphismi

Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [MIMi:611162].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341S → C.
Corresponds to variant rs5491 [ dbSNP | Ensembl ].
VAR_049879
Natural varianti56 – 561K → M in Kilifi; at homozygosity it is associated with increased susceptibility to cerebral malaria. 3 Publications
Corresponds to variant rs5491 [ dbSNP | Ensembl ].
VAR_010204
Natural varianti155 – 1551K → N.
Corresponds to variant rs5492 [ dbSNP | Ensembl ].
VAR_014651
Natural varianti241 – 2411G → R.3 Publications
Corresponds to variant rs1799969 [ dbSNP | Ensembl ].
VAR_014186
Natural varianti315 – 3151V → M.
Corresponds to variant rs5495 [ dbSNP | Ensembl ].
VAR_014652
Natural varianti352 – 3521P → L.1 Publication
Corresponds to variant rs1801714 [ dbSNP | Ensembl ].
VAR_014653
Natural varianti397 – 3971R → Q.1 Publication
Corresponds to variant rs5497 [ dbSNP | Ensembl ].
VAR_014654
Natural varianti469 – 4691K → E.6 Publications
Corresponds to variant rs5498 [ dbSNP | Ensembl ].
VAR_014187
Natural varianti478 – 4781R → W.1 Publication
Corresponds to variant rs5030400 [ dbSNP | Ensembl ].
VAR_016267

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06990 mRNA. Translation: CAA30051.1.
J03132 mRNA. Translation: AAA52709.1.
M24283 mRNA. Translation: AAA52708.1.
X59286, X59287, X59288 Genomic DNA. Translation: CAA41977.1.
BT006854 mRNA. Translation: AAP35500.1.
AY225514 Genomic DNA. Translation: AAO30128.1.
AK312636 mRNA. Translation: BAG35520.1.
CH471106 Genomic DNA. Translation: EAW84086.1.
BC015969 mRNA. Translation: AAH15969.1.
X57151 Genomic DNA. Translation: CAA40441.1.
AF340039 mRNA. Translation: AAQ14902.1.
CCDSiCCDS12231.1.
PIRiA29849.
RefSeqiNP_000192.2. NM_000201.2.
UniGeneiHs.643447.

Genome annotation databases

EnsembliENST00000264832; ENSP00000264832; ENSG00000090339.
GeneIDi3383.
KEGGihsa:3383.
UCSCiuc002mnq.2. human.

Polymorphism databases

DMDMi68067956.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Intercellular adhesion molecule entry

SeattleSNPs
Virus Particle ExploreR db

Icosahedral capsid structure

Functional Glycomics Gateway - Glycan Binding

ICAM-1

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06990 mRNA. Translation: CAA30051.1 .
J03132 mRNA. Translation: AAA52709.1 .
M24283 mRNA. Translation: AAA52708.1 .
X59286 , X59287 , X59288 Genomic DNA. Translation: CAA41977.1 .
BT006854 mRNA. Translation: AAP35500.1 .
AY225514 Genomic DNA. Translation: AAO30128.1 .
AK312636 mRNA. Translation: BAG35520.1 .
CH471106 Genomic DNA. Translation: EAW84086.1 .
BC015969 mRNA. Translation: AAH15969.1 .
X57151 Genomic DNA. Translation: CAA40441.1 .
AF340039 mRNA. Translation: AAQ14902.1 .
CCDSi CCDS12231.1.
PIRi A29849.
RefSeqi NP_000192.2. NM_000201.2.
UniGenei Hs.643447.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1D3E electron microscopy 28.00 I 28-212 [» ]
1D3I electron microscopy 26.00 I 28-212 [» ]
1D3L X-ray 3.25 A 28-212 [» ]
1IAM X-ray 2.10 A 28-212 [» ]
1IC1 X-ray 3.00 A/B 28-217 [» ]
1IJ4 model - I 44-109 [» ]
1MQ8 X-ray 3.30 A/C 28-318 [» ]
1P53 X-ray 3.06 A/B 212-477 [» ]
1Z7Z electron microscopy 8.00 I 28-477 [» ]
2OZ4 X-ray 2.70 A 213-477 [» ]
3TCX X-ray 3.60 A/C/E/G/I/K/M/O/Q/S/U/W/Y/a 29-112 [» ]
ProteinModelPortali P05362.
SMRi P05362. Positions 28-477.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109610. 141 interactions.
IntActi P05362. 7 interactions.
MINTi MINT-4053071.
STRINGi 9606.ENSP00000264832.

Chemistry

BindingDBi P05362.
ChEMBLi CHEMBL2096661.
DrugBanki DB08818. Hyaluronan.
DB00108. Natalizumab.

PTM databases

PhosphoSitei P05362.

Polymorphism databases

DMDMi 68067956.

Proteomic databases

MaxQBi P05362.
PaxDbi P05362.
PRIDEi P05362.

Protocols and materials databases

DNASUi 3383.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264832 ; ENSP00000264832 ; ENSG00000090339 .
GeneIDi 3383.
KEGGi hsa:3383.
UCSCi uc002mnq.2. human.

Organism-specific databases

CTDi 3383.
GeneCardsi GC19P010381.
HGNCi HGNC:5344. ICAM1.
HPAi CAB002142.
HPA002126.
HPA004877.
MIMi 147840. gene.
611162. phenotype.
neXtProti NX_P05362.
Orphaneti 1334. Chronic mucocutaneous candidosis.
PharmGKBi PA29592.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146347.
GeneTreei ENSGT00530000063246.
HOGENOMi HOG000059554.
HOVERGENi HBG052074.
InParanoidi P05362.
KOi K06490.
OMAi RDCPGNW.
OrthoDBi EOG7QG43X.
PhylomeDBi P05362.
TreeFami TF333745.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_13552. Integrin cell surface interactions.
REACT_25078. Interferon gamma signaling.
SABIO-RK P05362.

Miscellaneous databases

ChiTaRSi ICAM1. human.
EvolutionaryTracei P05362.
GeneWikii ICAM-1.
GenomeRNAii 3383.
NextBioi 13376.
PMAP-CutDB P05362.
PROi P05362.
SOURCEi Search...

Gene expression databases

Bgeei P05362.
CleanExi HS_ICAM1.
ExpressionAtlasi P05362. baseline and differential.
Genevestigatori P05362.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
Pfami PF03921. ICAM_N. 1 hit.
[Graphical view ]
PRINTSi PR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM."
    Simmons D., Makgoba M.W., Seed B.
    Nature 331:624-627(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-469.
  2. "Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families."
    Staunton D.E., Marlin S.D., Stratowa C., Dustin M.L., Springer T.A.
    Cell 52:925-933(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-469.
  3. "cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1."
    Tomassini J.E., Graham D., Dewitt C.M., Lineberger D.W., Rodkey J.A., Colonno R.J.
    Proc. Natl. Acad. Sci. U.S.A. 86:4907-4911(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester."
    Voraberger G.F., Schaefer R., Stratowa C.
    J. Immunol. 147:2777-2786(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-469.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. SeattleSNPs variation discovery resource
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT KILIFI MET-56, VARIANTS ARG-241; LEU-352; GLN-397 AND TRP-478.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  10. "Structural characteristics of the 5' region of the human ICAM-1 gene."
    Stade B.G., Messer G., Riethmueller G., Johnson J.P.
    Immunobiology 182:79-87(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
  11. "The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs)."
    Walter N.A.R., Stebbing J., Messier W.
    J. Theor. Biol. 232:339-346(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-532, VARIANT GLU-469.
    Tissue: Blood.
  12. Cited for: PARTIAL PROTEIN SEQUENCE, FUNCTION AS A RHINOVIRUS RECEPTOR.
  13. "A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection."
    Marlin S.D., Staunton D.E., Springer T.A., Stratowa C., Sommergruber W., Merluzzi V.J.
    Nature 344:70-72(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A RHINOVIRUS RECEPTOR.
  14. Cited for: INTERACTION WITH MUC1, FUNCTION.
  15. Cited for: INTERACTION WITH COXSACKIEVIRUS A21 CAPSID PROTEINS.
  16. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-267.
    Tissue: Plasma.
  17. "MARCH-IX mediates ubiquitination and downregulation of ICAM-1."
    Hoer S., Smith L., Lehner P.J.
    FEBS Lett. 581:45-51(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.
  18. "RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration."
    van Buul J.D., Allingham M.J., Samson T., Meller J., Boulter E., Garcia-Mata R., Burridge K.
    J. Cell Biol. 178:1279-1293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARHGEF26, FUNCTION.
  19. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-521 AND THR-530, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  20. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-202; ASN-260 AND ASN-267.
    Tissue: Liver.
  21. Cited for: GLYCOSYLATION AT ASN-145.
  22. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145 AND ASN-267.
    Tissue: Leukemic T-cell.
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-521 AND THR-530, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. "A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1."
    Casasnovas J.M., Stehle T., Liu J.H., Wang J.H., Springer T.A.
    Proc. Natl. Acad. Sci. U.S.A. 95:4134-4139(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 28-217.
  26. "The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand."
    Bella J., Kolatkar P.R., Marlor C.W., Greve J.M., Rossmann M.G.
    Proc. Natl. Acad. Sci. U.S.A. 95:4140-4145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 28-212 IN COMPLEX WITH HUMAN RHINOVIRUS 14.
  27. "Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor."
    Kolatkar P.R., Bella J., Olson N.H., Bator C.M., Baker T.S., Rossmann M.G.
    EMBO J. 18:6249-6259(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 28-212.
  28. "Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation."
    Shimaoka M., Xiao T., Liu J.H., Yang Y., Dong Y., Jun C.D., McCormack A., Zhang R., Joachimiak A., Takagi J., Wang J.H., Springer T.A.
    Cell 112:99-111(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 28-318 IN COMPLEX WITH ITGAL VWFA DOMAIN, DISULFIDE BONDS, GLYCOSYLATION AT ASN-130; ASN-145; ASN-183 AND ASN-202.
  29. "Structural basis for dimerization of ICAM-1 on the cell surface."
    Yang Y., Jun C.D., Liu J.H., Zhang R., Joachimiak A., Springer T.A., Wang J.H.
    Mol. Cell 14:269-276(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.06 ANGSTROMS) OF 212-477, SUBUNIT, DISULFIDE BONDS, GLYCOSYLATION AT ASN-267; ASN-296 AND ASN-385.
  30. "The crystal structure of coxsackievirus A21 and its interaction with ICAM-1."
    Xiao C., Bator-Kelly C.M., Rieder E., Chipman P.R., Craig A., Kuhn R.J., Wimmer E., Rossmann M.G.
    Structure 13:1019-1033(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON CRYOMICROSCOPY (8.0 ANGSTROMS) OF 24-473 IN COMPLEX WITH COXSACKIEVIRUS A21, SUBUNIT.
  31. "Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster."
    Vora D.K., Rosenbloom C.L., Beaudet A.L., Cottingham R.W.
    Genomics 21:473-477(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ARG-241 AND GLU-469.
  32. "DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis."
    Wenzel K., Ernst M., Rohde K., Baumann G., Speer A.
    Hum. Genet. 97:15-20(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARG-241.
  33. "A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya."
    Fernandez-Reyes D., Craig A.G., Kyes S.A., Peshu N., Snow R.W., Berendt A.R., Marsh K., Newbold C.I.
    Hum. Mol. Genet. 6:1357-1360(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT KILIFI MET-56, ASSOCIATION WITH SUSCEPTIBILITY TO MALARIA.
  34. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
    Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
    Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT KILIFI MET-56, VARIANT GLU-469.

Entry informationi

Entry nameiICAM1_HUMAN
AccessioniPrimary (citable) accession number: P05362
Secondary accession number(s): B2R6M3, Q5NKV7, Q96B50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 188 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

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