Reviewed, UniProtKB/Swiss-Prot P05335 (ACOX4_CANMA)

Names and origin

Protein names

Recommended name:
    Acyl-coenzyme A oxidase 4
      Short name=Acyl-CoA oxidase 4
      Short name=AOX 4
    EC=1.3.3.6

Gene names

Name:

POX4

Organism

Candida maltosa (Yeast)

Taxonomic identifier

5479 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	709 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subcellular location	Peroxisome.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 709	708	Acyl-coenzyme A oxidase 4		PRO_0000204694

Sequences

	Sequence		Length	Mass (Da)
	P05335-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 7772A2E61D772D1A	FASTA	709	78,374
	10 20 30 40 50 60 MTFTKKNVSV SQGPDPRTSI QTERANSKFD PVTMNYFLEG SKERSELMKS LAQQIERDPI 70 80 90 100 110 120 LFTDGSYYDL TKDQQRELTV LKINRLSRYR EGDSVDTFNK RLSIMGVVDP QVATRIGVNL 130 140 150 160 170 180 GLFLSCISGN GTAEQFKYWA IDKGTHNIQG LYGCFGMTEL GHGSNVAGVE TTATFDKETD 190 200 210 220 230 240 EFVINTPHIG ATKWWIGGAA HSATHCSVYA RLVVDGKDYG VKTFVVPLRD SNHDLMPGVT 250 260 270 280 290 300 VGDIGAKMGR DGIDNGWIQF SNVRIPRFFM LQKFCKVSAE GEVVLPPLEQ LSYSALLGGR 310 320 330 340 350 360 VMMVLDSYRM LARVSTIALR YAIGRRQFKG DNVDQNDPNA LETQLIDYPL HQKRLFPYLA 370 380 390 400 410 420 AAYVVSTGAL KVEHTIQSTL ATLDAAVENN DTTAIFKSID DMKSLFIDSG SLKATTTWLA 430 440 450 460 470 480 AEAIDQCRQA CGGHGYSSYN GFAKAFNDWV VQCTWEGDNN VLSLSVGKPI IKQIIGIEDN 490 500 510 520 530 540 GKTVRGSTAF LNQVKDFTGS NASKVVLNNT SDLNDINKVI KSIEVAIIRL AHEAAISVRK 550 560 570 580 590 600 ESLDFAGAEL VQISKLKAHH YLLTEFVKRV GEFEHKELVP FLNTIGRLYS ATVVLDKFAG 610 620 630 640 650 660 VFLTFNVASP QAITDLASTQ IPKLCAEVRP NVVAYTDSFQ QSDMVINSAI GKYDGDVYEN 670 680 690 700 YFDLVKQLNP PKNTKAPYTA ALEGMLNRPS LEARERYEKS DETAAILSK

References

[1]	"Complete nucleotide sequence of the peroxisomal acyl CoA oxidase from the alkane-utilizing yeast Candida maltosa." Hill D.E., Boulay R., Rogers D. Nucleic Acids Res. 16:365-366(1988) [PubMed: 3340538] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 20184.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X06721 Genomic DNA. Translation: CAA29901.1.
PIR	OXCKPM. A29441.
3D structure databases
HSSP	HSSP built from PDB template 1IS2 based on UniProtKB P07872.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.3.3.6. 3846.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACOX4_CANMA

Accession

Primary (citable) accession number: P05335

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 66 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)