Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P05328

- TRPG_ASPNG

UniProt

P05328 - TRPG_ASPNG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Multifunctional tryptophan biosynthesis protein

Gene

trpC

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041For GATase activityBy similarity
Active sitei199 – 1991For GATase activityBy similarity
Active sitei201 – 2011For GATase activityBy similarity

GO - Molecular functioni

  1. anthranilate synthase activity Source: UniProtKB-EC
  2. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  3. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC
  4. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-KW
  2. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040.
UPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional tryptophan biosynthesis protein
Including the following 3 domains:
Anthranilate synthase component 2 (EC:4.1.3.27)
Short name:
AS
Alternative name(s):
Anthranilate synthase, glutamine amidotransferase component
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 770770Multifunctional tryptophan biosynthesis proteinPRO_0000056855Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP05328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 225201Glutamine amidotransferase type-1Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni255 – 519265Indole-3-glycerol phosphate synthaseAdd
BLAST
Regioni535 – 770236N-(5'-phosphoribosyl)anthranilate isomeraseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0134.

Family and domain databases

Gene3Di3.20.20.70. 3 hits.
3.40.50.880. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
PIRSFiPIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMiSSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05328-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADSGLVDHS PHHPTKAAQL STASNVILID NYDSFTWNVY QYLVLEGATV
60 70 80 90 100
NVFRNDQITL EELIAKKPTQ LVISPGPGHP ETDAGISSAA IQYFSGKIPI
110 120 130 140 150
FGVCMGQQCI ITCFGGKVDV TGEILHGKTS PLKHDGKGAY EGLPGSLAVT
160 170 180 190 200
RYHSLAGTHA TIPDCLEVSS SVQLADDSNK DVIMGVRHKK LAVEGVQFHP
210 220 230 240 250
ESILTEYGRI MFRNFLKLTA GTWEGNGKHF GEQSSTTKAT VPSNPPPKTD
260 270 280 290 300
KKLSILERIY DHRRAAVAVQ KTIPSQRPAD LQAAYDLNLA PPQIPFPARL
310 320 330 340 350
RQSPYPLSLM AEIKRASPSK GMIAENACAP AQARQYAKAG ASVISVLTEP
360 370 380 390 400
EWFKGSIDDL RAVRQSLEGM TNRPAILRKE FVFDEYQILE ARLAGADTVL
410 420 430 440 450
LIVKMLSVEL LTRLYHYSRS LGMEPLVEVN TPEEMKIAVD LGAEVIGVNN
460 470 480 490 500
RDLTSFEVDL GTTSRLMDQV PSSTIVCALS GISGPKDVEA YKKEGVKAIL
510 520 530 540 550
VGEALMRAAD TATFIAELLG GSSQTVSSES RRSPLVKICG TRSEEAARAA
560 570 580 590 600
IEAGADLIGI IMVQGRTGCV PDDVALPISQ VVRSTPKPAS QALHTSQEPP
610 620 630 640 650
AATSVEYFDH SAKILRHPSR ALLVGVFQNQ PLDYILSQQQ KLGLDVVQLH
660 670 680 690 700
GSEPLEWAKL IPVPVIRKFG LDEPAIARRA YHSLPLLDSG VGGTGELLDQ
710 720 730 740 750
SRVQNVLDKD CGLRVILAGG LDPTNVAGIV QKLGESGRKV VGVDVSSGVE
760 770
SDGAQDLNKI RAFVQAVRGL
Length:770
Mass (Da):82,910
Last modified:November 1, 1988 - v1
Checksum:i36D8DE5B23097012
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07071 Genomic DNA. Translation: CAA30107.1.
M14403 Genomic DNA. Translation: AAA32710.1.
M14404 Genomic DNA. Translation: AAA32709.1.
PIRiS00643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07071 Genomic DNA. Translation: CAA30107.1 .
M14403 Genomic DNA. Translation: AAA32710.1 .
M14404 Genomic DNA. Translation: AAA32709.1 .
PIRi S00643.

3D structure databases

ProteinModelPortali P05328.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0134.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00040 .
UPA00035 ; UER00042 .
UPA00035 ; UER00043 .

Family and domain databases

Gene3Di 3.20.20.70. 3 hits.
3.40.50.880. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMi SSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Aspergillus niger trpC gene: structural relationship with analogous genes of other organisms."
    Kos T., Kuijvenhoven A., Hessing H.G.M., Pouwels P.H., van den Hondel C.A.M.J.J.
    Curr. Genet. 13:137-144(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 401.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69 AND 392-433.

Entry informationi

Entry nameiTRPG_ASPNG
AccessioniPrimary (citable) accession number: P05328
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: October 1, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3