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P05328

- TRPG_ASPNG

UniProt

P05328 - TRPG_ASPNG

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Protein
Multifunctional tryptophan biosynthesis protein
Gene
trpC
Organism
Aspergillus niger
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.UniRule annotation

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041For GATase activity By similarity
Active sitei199 – 1991For GATase activity By similarity
Active sitei201 – 2011For GATase activity By similarity

GO - Molecular functioni

  1. anthranilate synthase activity Source: UniProtKB-EC
  2. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  3. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC
  4. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-KW
  2. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040.
UPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional tryptophan biosynthesis protein
Including the following 3 domains:
Anthranilate synthase component 2 (EC:4.1.3.27)
Short name:
AS
Alternative name(s):
Anthranilate synthase, glutamine amidotransferase component
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 770770Multifunctional tryptophan biosynthesis proteinUniRule annotation
PRO_0000056855Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP05328.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 225201Glutamine amidotransferase type-1
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni255 – 519265Indole-3-glycerol phosphate synthaseUniRule annotation
Add
BLAST
Regioni535 – 770236N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0134.

Family and domain databases

Gene3Di3.20.20.70. 3 hits.
3.40.50.880. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
PIRSFiPIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMiSSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05328-1 [UniParc]FASTAAdd to Basket

« Hide

MADSGLVDHS PHHPTKAAQL STASNVILID NYDSFTWNVY QYLVLEGATV    50
NVFRNDQITL EELIAKKPTQ LVISPGPGHP ETDAGISSAA IQYFSGKIPI 100
FGVCMGQQCI ITCFGGKVDV TGEILHGKTS PLKHDGKGAY EGLPGSLAVT 150
RYHSLAGTHA TIPDCLEVSS SVQLADDSNK DVIMGVRHKK LAVEGVQFHP 200
ESILTEYGRI MFRNFLKLTA GTWEGNGKHF GEQSSTTKAT VPSNPPPKTD 250
KKLSILERIY DHRRAAVAVQ KTIPSQRPAD LQAAYDLNLA PPQIPFPARL 300
RQSPYPLSLM AEIKRASPSK GMIAENACAP AQARQYAKAG ASVISVLTEP 350
EWFKGSIDDL RAVRQSLEGM TNRPAILRKE FVFDEYQILE ARLAGADTVL 400
LIVKMLSVEL LTRLYHYSRS LGMEPLVEVN TPEEMKIAVD LGAEVIGVNN 450
RDLTSFEVDL GTTSRLMDQV PSSTIVCALS GISGPKDVEA YKKEGVKAIL 500
VGEALMRAAD TATFIAELLG GSSQTVSSES RRSPLVKICG TRSEEAARAA 550
IEAGADLIGI IMVQGRTGCV PDDVALPISQ VVRSTPKPAS QALHTSQEPP 600
AATSVEYFDH SAKILRHPSR ALLVGVFQNQ PLDYILSQQQ KLGLDVVQLH 650
GSEPLEWAKL IPVPVIRKFG LDEPAIARRA YHSLPLLDSG VGGTGELLDQ 700
SRVQNVLDKD CGLRVILAGG LDPTNVAGIV QKLGESGRKV VGVDVSSGVE 750
SDGAQDLNKI RAFVQAVRGL 770
Length:770
Mass (Da):82,910
Last modified:November 1, 1988 - v1
Checksum:i36D8DE5B23097012
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07071 Genomic DNA. Translation: CAA30107.1.
M14403 Genomic DNA. Translation: AAA32710.1.
M14404 Genomic DNA. Translation: AAA32709.1.
PIRiS00643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07071 Genomic DNA. Translation: CAA30107.1 .
M14403 Genomic DNA. Translation: AAA32710.1 .
M14404 Genomic DNA. Translation: AAA32709.1 .
PIRi S00643.

3D structure databases

ProteinModelPortali P05328.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0134.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00040 .
UPA00035 ; UER00042 .
UPA00035 ; UER00043 .

Family and domain databases

Gene3Di 3.20.20.70. 3 hits.
3.40.50.880. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMi SSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Aspergillus niger trpC gene: structural relationship with analogous genes of other organisms."
    Kos T., Kuijvenhoven A., Hessing H.G.M., Pouwels P.H., van den Hondel C.A.M.J.J.
    Curr. Genet. 13:137-144(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 401.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69 AND 392-433.

Entry informationi

Entry nameiTRPG_ASPNG
AccessioniPrimary (citable) accession number: P05328
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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