P05324 (HIS4_METVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
EC=5.3.1.16

Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:

hisA

Organism

Methanococcus vannielii

Taxonomic identifier

2187 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP-Rule MF_01014
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the HisA/HisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP-Rule MF_01014		PRO_0000142098
Sites
	Active site	8	1	Proton acceptor By similarity
	Active site	130	1	Proton donor By similarity
Experimental info
	Sequence conflict	26	1	H → Q in CAA30300. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P05324 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: 5082D2AF54D9E756	FASTA	238	25,712
	10 20 30 40 50 60 MLIIPAVDMK NKKCVQLIQG NPDKKHVELD NPPEIAKKWV EQGAEMLHLV NLDGAINGKR 70 80 90 100 110 120 VNDEFIEETI KNSGVPVQIG GGIRSVSDAL YFIEKGAEKV ILGTVAIQNP KIVREISSIV 130 140 150 160 170 180 GKEKVTVALD AKDGKVLIKG WTEKTDYSPV QIGKILENMG AGSILFTNVD SEGLLEGINV 190 200 210 220 230 LPTKELVDNL NIPIIASGGV TTVEDLLKFK EIGVYAVVVG SALYKDMINL KDAILASK

References

[1]	"Structure and sequence divergence of two archaebacterial genes." Cue D., Beckler G.S., Reeve J.N., Konisky J. Proc. Natl. Acad. Sci. U.S.A. 82:4207-4211(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"An archaebacterial RNA polymerase binding site and transcription initiation of the hisA gene in Methanococcus vannielii." Brown J.W., Thomm M., Beckler G.S., Frey G., Stetter K.O., Reeve J.N. Nucleic Acids Res. 16:135-150(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-52.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11219 Genomic DNA. Translation: AAA72490.1. X07391 Genomic DNA. Translation: CAA30300.1.
PIR	S00580. T48888.
3D structure databases
ProteinModelPortal	P05324.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00031; UER00009.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_01014. HisA.
InterPro	IPR013785. Aldolase_TIM. IPR006062. His_biosynth. IPR006063. HisA. IPR023016. Isoase_HisA. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR00007. TIGR00007. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS4_METVA

Accession

Primary (citable) accession number: P05324

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program