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Protein

Uracil permease

Gene

FUR4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Transport of uracil.

GO - Molecular functioni

  • uracil:cation symporter activity Source: SGD

GO - Biological processi

  • transmembrane transport Source: SGD
  • uracil transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29002-MONOMER.

Protein family/group databases

TCDBi2.A.39.3.2. the nucleobase:cation symporter-1 (ncs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil permease
Gene namesi
Name:FUR4
Ordered Locus Names:YBR021W
ORF Names:YBR0303
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR021W.
SGDiS000000225. FUR4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Transmembranei559 – 579HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979251 – 633Uracil permeaseAdd BLAST633

Post-translational modificationi

Glycosylated (possible); but there is not yet direct biochemical evidence for it.

Proteomic databases

MaxQBiP05316.
PRIDEiP05316.

PTM databases

iPTMnetiP05316.

Interactioni

Protein-protein interaction databases

BioGridi32724. 15 interactors.
DIPiDIP-4892N.
IntActiP05316. 31 interactors.
MINTiMINT-485049.

Structurei

3D structure databases

ProteinModelPortaliP05316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000065049.
HOGENOMiHOG000202588.
InParanoidiP05316.
OMAiFTAKAYF.
OrthoDBiEOG092C1JZY.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

P05316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDNLSLHLS GSSKRLNSRQ LMESSNETFA PNNVDLEKEY KSSQSNITTE
60 70 80 90 100
VYEASSFEEK VSSEKPQYSS FWKKIYYEYV VVDKSILGVS ILDSFMYNQD
110 120 130 140 150
LKPVEKERRV WSWYNYCYFW LAECFNINTW QIAATGLQLG LNWWQCWITI
160 170 180 190 200
WIGYGFVGAF VVLASRVGSA YHLSFPISSR ASFGIFFSLW PVINRVVMAI
210 220 230 240 250
VWYSVQAYIA ATPVSLMLKS IFGKDLQDKI PDHFGSPNAT TYEFMCFFIF
260 270 280 290 300
WAASLPFLLV PPHKIRHLFT VKAVLVPFAS FGFLIWAIRR AHGRIALGSL
310 320 330 340 350
TDVQPHGSAF SWAFLRSLMG CMANFSTMVI NAPDFSRFSK NPNSALWSQL
360 370 380 390 400
VCIPFLFSIT CLIGILVTAA GYEIYGINYW SPLDVLEKFL QTTYNKGTRA
410 420 430 440 450
GVFLISFVFA VAQLGTNISA NSLSCGTDMS AIFPKFINIK RGSLFCAAMA
460 470 480 490 500
LCICPWNLMA TSSKFTMALS AYAIFLSSIA GVVCSDYFVV RRGYIKLTHI
510 520 530 540 550
YSHQKGSFYM YGNRFGINWR ALAAYLCGVA PCLPGFIAEV GAPAIKVSDG
560 570 580 590 600
AMKLYYLSYW VGYGLSFSSY TALCYFFPVP GCPVNNIIKD KGWFQRWANV
610 620 630
DDFEEEWKDT IERDDLVDDN ISVYEHEHEK TFI
Length:633
Mass (Da):71,736
Last modified:October 1, 1994 - v2
Checksum:i2FFCD9529412B2D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217M → I in CAA29986 (PubMed:3276521).Curated1
Sequence conflicti229K → R in CAA29986 (PubMed:3276521).Curated1
Sequence conflicti320G → R in CAA29986 (PubMed:3276521).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76078 Genomic DNA. Translation: CAA53678.1.
Z35890 Genomic DNA. Translation: CAA84963.1.
X06830 Genomic DNA. Translation: CAA29986.1.
BK006936 Genomic DNA. Translation: DAA07143.1.
PIRiS45877.
RefSeqiNP_009577.1. NM_001178369.1.

Genome annotation databases

EnsemblFungiiYBR021W; YBR021W; YBR021W.
GeneIDi852309.
KEGGisce:YBR021W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76078 Genomic DNA. Translation: CAA53678.1.
Z35890 Genomic DNA. Translation: CAA84963.1.
X06830 Genomic DNA. Translation: CAA29986.1.
BK006936 Genomic DNA. Translation: DAA07143.1.
PIRiS45877.
RefSeqiNP_009577.1. NM_001178369.1.

3D structure databases

ProteinModelPortaliP05316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32724. 15 interactors.
DIPiDIP-4892N.
IntActiP05316. 31 interactors.
MINTiMINT-485049.

Protein family/group databases

TCDBi2.A.39.3.2. the nucleobase:cation symporter-1 (ncs1) family.

PTM databases

iPTMnetiP05316.

Proteomic databases

MaxQBiP05316.
PRIDEiP05316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR021W; YBR021W; YBR021W.
GeneIDi852309.
KEGGisce:YBR021W.

Organism-specific databases

EuPathDBiFungiDB:YBR021W.
SGDiS000000225. FUR4.

Phylogenomic databases

GeneTreeiENSGT00530000065049.
HOGENOMiHOG000202588.
InParanoidiP05316.
OMAiFTAKAYF.
OrthoDBiEOG092C1JZY.

Enzyme and pathway databases

BioCyciYEAST:G3O-29002-MONOMER.

Miscellaneous databases

PROiP05316.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUR4_YEAST
AccessioniPrimary (citable) accession number: P05316
Secondary accession number(s): D6VQ23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.