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P05316

- FUR4_YEAST

UniProt

P05316 - FUR4_YEAST

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Protein

Uracil permease

Gene

FUR4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Transport of uracil.

GO - Molecular functioni

  1. uracil:cation symporter activity Source: SGD

GO - Biological processi

  1. transmembrane transport Source: SGD
  2. uracil transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29002-MONOMER.

Protein family/group databases

TCDBi2.A.39.3.2. the nucleobase:cation symporter-1 (ncs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil permease
Gene namesi
Name:FUR4
Ordered Locus Names:YBR021W
ORF Names:YBR0303
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR021w.
SGDiS000000225. FUR4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane raft Source: SGD
  3. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Uracil permeasePRO_0000197925Add
BLAST

Post-translational modificationi

Glycosylated (possible); but there is not yet direct biochemical evidence for it.

Proteomic databases

MaxQBiP05316.

Expressioni

Gene expression databases

GenevestigatoriP05316.

Interactioni

Protein-protein interaction databases

BioGridi32724. 13 interactions.
DIPiDIP-4892N.
IntActiP05316. 31 interactions.
MINTiMINT-485049.
STRINGi4932.YBR021W.

Structurei

3D structure databases

ProteinModelPortaliP05316.
SMRiP05316. Positions 96-519.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST
Transmembranei400 – 42021HelicalSequence AnalysisAdd
BLAST
Transmembranei442 – 46221HelicalSequence AnalysisAdd
BLAST
Transmembranei465 – 48521HelicalSequence AnalysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence AnalysisAdd
BLAST
Transmembranei559 – 57921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the purine-cytosine permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1953.
GeneTreeiENSGT00530000065049.
HOGENOMiHOG000202588.
InParanoidiP05316.
OMAiAIWFPVH.
OrthoDBiEOG75B8F6.

Family and domain databases

InterProiIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

P05316-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDNLSLHLS GSSKRLNSRQ LMESSNETFA PNNVDLEKEY KSSQSNITTE
60 70 80 90 100
VYEASSFEEK VSSEKPQYSS FWKKIYYEYV VVDKSILGVS ILDSFMYNQD
110 120 130 140 150
LKPVEKERRV WSWYNYCYFW LAECFNINTW QIAATGLQLG LNWWQCWITI
160 170 180 190 200
WIGYGFVGAF VVLASRVGSA YHLSFPISSR ASFGIFFSLW PVINRVVMAI
210 220 230 240 250
VWYSVQAYIA ATPVSLMLKS IFGKDLQDKI PDHFGSPNAT TYEFMCFFIF
260 270 280 290 300
WAASLPFLLV PPHKIRHLFT VKAVLVPFAS FGFLIWAIRR AHGRIALGSL
310 320 330 340 350
TDVQPHGSAF SWAFLRSLMG CMANFSTMVI NAPDFSRFSK NPNSALWSQL
360 370 380 390 400
VCIPFLFSIT CLIGILVTAA GYEIYGINYW SPLDVLEKFL QTTYNKGTRA
410 420 430 440 450
GVFLISFVFA VAQLGTNISA NSLSCGTDMS AIFPKFINIK RGSLFCAAMA
460 470 480 490 500
LCICPWNLMA TSSKFTMALS AYAIFLSSIA GVVCSDYFVV RRGYIKLTHI
510 520 530 540 550
YSHQKGSFYM YGNRFGINWR ALAAYLCGVA PCLPGFIAEV GAPAIKVSDG
560 570 580 590 600
AMKLYYLSYW VGYGLSFSSY TALCYFFPVP GCPVNNIIKD KGWFQRWANV
610 620 630
DDFEEEWKDT IERDDLVDDN ISVYEHEHEK TFI
Length:633
Mass (Da):71,736
Last modified:October 1, 1994 - v2
Checksum:i2FFCD9529412B2D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171M → I in CAA29986. (PubMed:3276521)Curated
Sequence conflicti229 – 2291K → R in CAA29986. (PubMed:3276521)Curated
Sequence conflicti320 – 3201G → R in CAA29986. (PubMed:3276521)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76078 Genomic DNA. Translation: CAA53678.1.
Z35890 Genomic DNA. Translation: CAA84963.1.
X06830 Genomic DNA. Translation: CAA29986.1.
BK006936 Genomic DNA. Translation: DAA07143.1.
PIRiS45877.
RefSeqiNP_009577.1. NM_001178369.1.

Genome annotation databases

EnsemblFungiiYBR021W; YBR021W; YBR021W.
GeneIDi852309.
KEGGisce:YBR021W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76078 Genomic DNA. Translation: CAA53678.1 .
Z35890 Genomic DNA. Translation: CAA84963.1 .
X06830 Genomic DNA. Translation: CAA29986.1 .
BK006936 Genomic DNA. Translation: DAA07143.1 .
PIRi S45877.
RefSeqi NP_009577.1. NM_001178369.1.

3D structure databases

ProteinModelPortali P05316.
SMRi P05316. Positions 96-519.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32724. 13 interactions.
DIPi DIP-4892N.
IntActi P05316. 31 interactions.
MINTi MINT-485049.
STRINGi 4932.YBR021W.

Protein family/group databases

TCDBi 2.A.39.3.2. the nucleobase:cation symporter-1 (ncs1) family.

Proteomic databases

MaxQBi P05316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR021W ; YBR021W ; YBR021W .
GeneIDi 852309.
KEGGi sce:YBR021W.

Organism-specific databases

CYGDi YBR021w.
SGDi S000000225. FUR4.

Phylogenomic databases

eggNOGi COG1953.
GeneTreei ENSGT00530000065049.
HOGENOMi HOG000202588.
InParanoidi P05316.
OMAi AIWFPVH.
OrthoDBi EOG75B8F6.

Enzyme and pathway databases

BioCyci YEAST:G3O-29002-MONOMER.

Miscellaneous databases

NextBioi 970987.

Gene expression databases

Genevestigatori P05316.

Family and domain databases

InterProi IPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view ]
Pfami PF02133. Transp_cyt_pur. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00800. ncs1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the uracil transport protein of Saccharomyces cerevisiae."
    Jund R., Weber E., Chevallier M.-R.
    Eur. J. Biochem. 171:417-424(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  2. "The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene."
    Smits P.H.M., de Haan M., Maat C., Grivell L.A.
    Yeast 10:S75-S80(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiFUR4_YEAST
AccessioniPrimary (citable) accession number: P05316
Secondary accession number(s): D6VQ23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3