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Protein

Uracil permease

Gene

FUR4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transport of uracil.

GO - Molecular functioni

  • uracil:cation symporter activity Source: SGD

GO - Biological processi

  • transmembrane transport Source: SGD
  • uracil transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-29002-MONOMER

Protein family/group databases

TCDBi2.A.39.3.2 the nucleobase:cation symporter-1 (ncs1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil permease
Gene namesi
Name:FUR4
Ordered Locus Names:YBR021W
ORF Names:YBR0303
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR021W
SGDiS000000225 FUR4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Transmembranei559 – 579HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979251 – 633Uracil permeaseAdd BLAST633

Post-translational modificationi

Glycosylated (possible); but there is not yet direct biochemical evidence for it.

Proteomic databases

MaxQBiP05316
PaxDbiP05316
PRIDEiP05316

PTM databases

iPTMnetiP05316

Interactioni

Protein-protein interaction databases

BioGridi32724, 18 interactors
DIPiDIP-4892N
IntActiP05316, 32 interactors
STRINGi4932.YBR021W

Structurei

3D structure databases

ProteinModelPortaliP05316
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000065049
HOGENOMiHOG000202588
InParanoidiP05316
OMAiVGLAMCP
OrthoDBiEOG092C1JZY

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR012681 NCS1
IPR001248 Pur-cyt_permease
IPR038271 Pur-cyt_permease_sf
PfamiView protein in Pfam
PF02133 Transp_cyt_pur, 1 hit
TIGRFAMsiTIGR00800 ncs1, 1 hit

Sequencei

Sequence statusi: Complete.

P05316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDNLSLHLS GSSKRLNSRQ LMESSNETFA PNNVDLEKEY KSSQSNITTE
60 70 80 90 100
VYEASSFEEK VSSEKPQYSS FWKKIYYEYV VVDKSILGVS ILDSFMYNQD
110 120 130 140 150
LKPVEKERRV WSWYNYCYFW LAECFNINTW QIAATGLQLG LNWWQCWITI
160 170 180 190 200
WIGYGFVGAF VVLASRVGSA YHLSFPISSR ASFGIFFSLW PVINRVVMAI
210 220 230 240 250
VWYSVQAYIA ATPVSLMLKS IFGKDLQDKI PDHFGSPNAT TYEFMCFFIF
260 270 280 290 300
WAASLPFLLV PPHKIRHLFT VKAVLVPFAS FGFLIWAIRR AHGRIALGSL
310 320 330 340 350
TDVQPHGSAF SWAFLRSLMG CMANFSTMVI NAPDFSRFSK NPNSALWSQL
360 370 380 390 400
VCIPFLFSIT CLIGILVTAA GYEIYGINYW SPLDVLEKFL QTTYNKGTRA
410 420 430 440 450
GVFLISFVFA VAQLGTNISA NSLSCGTDMS AIFPKFINIK RGSLFCAAMA
460 470 480 490 500
LCICPWNLMA TSSKFTMALS AYAIFLSSIA GVVCSDYFVV RRGYIKLTHI
510 520 530 540 550
YSHQKGSFYM YGNRFGINWR ALAAYLCGVA PCLPGFIAEV GAPAIKVSDG
560 570 580 590 600
AMKLYYLSYW VGYGLSFSSY TALCYFFPVP GCPVNNIIKD KGWFQRWANV
610 620 630
DDFEEEWKDT IERDDLVDDN ISVYEHEHEK TFI
Length:633
Mass (Da):71,736
Last modified:October 1, 1994 - v2
Checksum:i2FFCD9529412B2D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217M → I in CAA29986 (PubMed:3276521).Curated1
Sequence conflicti229K → R in CAA29986 (PubMed:3276521).Curated1
Sequence conflicti320G → R in CAA29986 (PubMed:3276521).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76078 Genomic DNA Translation: CAA53678.1
Z35890 Genomic DNA Translation: CAA84963.1
X06830 Genomic DNA Translation: CAA29986.1
BK006936 Genomic DNA Translation: DAA07143.1
PIRiS45877
RefSeqiNP_009577.1, NM_001178369.1

Genome annotation databases

EnsemblFungiiYBR021W; YBR021W; YBR021W
GeneIDi852309
KEGGisce:YBR021W

Similar proteinsi

Entry informationi

Entry nameiFUR4_YEAST
AccessioniPrimary (citable) accession number: P05316
Secondary accession number(s): D6VQ23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health