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P05316

- FUR4_YEAST

UniProt

P05316 - FUR4_YEAST

Protein

Uracil permease

Gene

FUR4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Transport of uracil.

    GO - Molecular functioni

    1. uracil:cation symporter activity Source: SGD

    GO - Biological processi

    1. transmembrane transport Source: SGD
    2. uracil transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29002-MONOMER.

    Protein family/group databases

    TCDBi2.A.39.3.2. the nucleobase:cation symporter-1 (ncs1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil permease
    Gene namesi
    Name:FUR4
    Ordered Locus Names:YBR021W
    ORF Names:YBR0303
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR021w.
    SGDiS000000225. FUR4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane raft Source: SGD
    3. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 633633Uracil permeasePRO_0000197925Add
    BLAST

    Post-translational modificationi

    Glycosylated (possible); but there is not yet direct biochemical evidence for it.

    Proteomic databases

    MaxQBiP05316.

    Expressioni

    Gene expression databases

    GenevestigatoriP05316.

    Interactioni

    Protein-protein interaction databases

    BioGridi32724. 13 interactions.
    DIPiDIP-4892N.
    IntActiP05316. 31 interactions.
    MINTiMINT-485049.
    STRINGi4932.YBR021W.

    Structurei

    3D structure databases

    ProteinModelPortaliP05316.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei400 – 42021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei442 – 46221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei521 – 54121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei559 – 57921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine-cytosine permease family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1953.
    GeneTreeiENSGT00530000065049.
    HOGENOMiHOG000202588.
    OMAiAIWFPVH.
    OrthoDBiEOG75B8F6.

    Family and domain databases

    InterProiIPR001248. Cyt_pur_permease.
    IPR012681. NCS1.
    [Graphical view]
    PfamiPF02133. Transp_cyt_pur. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00800. ncs1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P05316-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDNLSLHLS GSSKRLNSRQ LMESSNETFA PNNVDLEKEY KSSQSNITTE    50
    VYEASSFEEK VSSEKPQYSS FWKKIYYEYV VVDKSILGVS ILDSFMYNQD 100
    LKPVEKERRV WSWYNYCYFW LAECFNINTW QIAATGLQLG LNWWQCWITI 150
    WIGYGFVGAF VVLASRVGSA YHLSFPISSR ASFGIFFSLW PVINRVVMAI 200
    VWYSVQAYIA ATPVSLMLKS IFGKDLQDKI PDHFGSPNAT TYEFMCFFIF 250
    WAASLPFLLV PPHKIRHLFT VKAVLVPFAS FGFLIWAIRR AHGRIALGSL 300
    TDVQPHGSAF SWAFLRSLMG CMANFSTMVI NAPDFSRFSK NPNSALWSQL 350
    VCIPFLFSIT CLIGILVTAA GYEIYGINYW SPLDVLEKFL QTTYNKGTRA 400
    GVFLISFVFA VAQLGTNISA NSLSCGTDMS AIFPKFINIK RGSLFCAAMA 450
    LCICPWNLMA TSSKFTMALS AYAIFLSSIA GVVCSDYFVV RRGYIKLTHI 500
    YSHQKGSFYM YGNRFGINWR ALAAYLCGVA PCLPGFIAEV GAPAIKVSDG 550
    AMKLYYLSYW VGYGLSFSSY TALCYFFPVP GCPVNNIIKD KGWFQRWANV 600
    DDFEEEWKDT IERDDLVDDN ISVYEHEHEK TFI 633
    Length:633
    Mass (Da):71,736
    Last modified:October 1, 1994 - v2
    Checksum:i2FFCD9529412B2D6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti217 – 2171M → I in CAA29986. (PubMed:3276521)Curated
    Sequence conflicti229 – 2291K → R in CAA29986. (PubMed:3276521)Curated
    Sequence conflicti320 – 3201G → R in CAA29986. (PubMed:3276521)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76078 Genomic DNA. Translation: CAA53678.1.
    Z35890 Genomic DNA. Translation: CAA84963.1.
    X06830 Genomic DNA. Translation: CAA29986.1.
    BK006936 Genomic DNA. Translation: DAA07143.1.
    PIRiS45877.
    RefSeqiNP_009577.1. NM_001178369.1.

    Genome annotation databases

    EnsemblFungiiYBR021W; YBR021W; YBR021W.
    GeneIDi852309.
    KEGGisce:YBR021W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76078 Genomic DNA. Translation: CAA53678.1 .
    Z35890 Genomic DNA. Translation: CAA84963.1 .
    X06830 Genomic DNA. Translation: CAA29986.1 .
    BK006936 Genomic DNA. Translation: DAA07143.1 .
    PIRi S45877.
    RefSeqi NP_009577.1. NM_001178369.1.

    3D structure databases

    ProteinModelPortali P05316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32724. 13 interactions.
    DIPi DIP-4892N.
    IntActi P05316. 31 interactions.
    MINTi MINT-485049.
    STRINGi 4932.YBR021W.

    Protein family/group databases

    TCDBi 2.A.39.3.2. the nucleobase:cation symporter-1 (ncs1) family.

    Proteomic databases

    MaxQBi P05316.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR021W ; YBR021W ; YBR021W .
    GeneIDi 852309.
    KEGGi sce:YBR021W.

    Organism-specific databases

    CYGDi YBR021w.
    SGDi S000000225. FUR4.

    Phylogenomic databases

    eggNOGi COG1953.
    GeneTreei ENSGT00530000065049.
    HOGENOMi HOG000202588.
    OMAi AIWFPVH.
    OrthoDBi EOG75B8F6.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29002-MONOMER.

    Miscellaneous databases

    NextBioi 970987.

    Gene expression databases

    Genevestigatori P05316.

    Family and domain databases

    InterProi IPR001248. Cyt_pur_permease.
    IPR012681. NCS1.
    [Graphical view ]
    Pfami PF02133. Transp_cyt_pur. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00800. ncs1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the uracil transport protein of Saccharomyces cerevisiae."
      Jund R., Weber E., Chevallier M.-R.
      Eur. J. Biochem. 171:417-424(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 28383 / FL100 / VTT C-80102.
    2. "The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene."
      Smits P.H.M., de Haan M., Maat C., Grivell L.A.
      Yeast 10:S75-S80(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiFUR4_YEAST
    AccessioniPrimary (citable) accession number: P05316
    Secondary accession number(s): D6VQ23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3