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P05316 (FUR4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uracil permease
Gene names
Name:FUR4
Ordered Locus Names:YBR021W
ORF Names:YBR0303
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length633 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transport of uracil.

Subcellular location

Membrane; Multi-pass membrane protein.

Post-translational modification

Glycosylated (possible); but there is not yet direct biochemical evidence for it.

Sequence similarities

Belongs to the purine-cytosine permease family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 633633Uracil permease
PRO_0000197925

Regions

Transmembrane143 – 16321Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane242 – 26221Helical; Potential
Transmembrane268 – 28821Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane350 – 37021Helical; Potential
Transmembrane400 – 42021Helical; Potential
Transmembrane442 – 46221Helical; Potential
Transmembrane465 – 48521Helical; Potential
Transmembrane521 – 54121Helical; Potential
Transmembrane559 – 57921Helical; Potential

Experimental info

Sequence conflict2171M → I in CAA29986. Ref.1
Sequence conflict2291K → R in CAA29986. Ref.1
Sequence conflict3201G → R in CAA29986. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P05316 [UniParc].

Last modified October 1, 1994. Version 2.
Checksum: 2FFCD9529412B2D6

FASTA63371,736
        10         20         30         40         50         60 
MPDNLSLHLS GSSKRLNSRQ LMESSNETFA PNNVDLEKEY KSSQSNITTE VYEASSFEEK 

        70         80         90        100        110        120 
VSSEKPQYSS FWKKIYYEYV VVDKSILGVS ILDSFMYNQD LKPVEKERRV WSWYNYCYFW 

       130        140        150        160        170        180 
LAECFNINTW QIAATGLQLG LNWWQCWITI WIGYGFVGAF VVLASRVGSA YHLSFPISSR 

       190        200        210        220        230        240 
ASFGIFFSLW PVINRVVMAI VWYSVQAYIA ATPVSLMLKS IFGKDLQDKI PDHFGSPNAT 

       250        260        270        280        290        300 
TYEFMCFFIF WAASLPFLLV PPHKIRHLFT VKAVLVPFAS FGFLIWAIRR AHGRIALGSL 

       310        320        330        340        350        360 
TDVQPHGSAF SWAFLRSLMG CMANFSTMVI NAPDFSRFSK NPNSALWSQL VCIPFLFSIT 

       370        380        390        400        410        420 
CLIGILVTAA GYEIYGINYW SPLDVLEKFL QTTYNKGTRA GVFLISFVFA VAQLGTNISA 

       430        440        450        460        470        480 
NSLSCGTDMS AIFPKFINIK RGSLFCAAMA LCICPWNLMA TSSKFTMALS AYAIFLSSIA 

       490        500        510        520        530        540 
GVVCSDYFVV RRGYIKLTHI YSHQKGSFYM YGNRFGINWR ALAAYLCGVA PCLPGFIAEV 

       550        560        570        580        590        600 
GAPAIKVSDG AMKLYYLSYW VGYGLSFSSY TALCYFFPVP GCPVNNIIKD KGWFQRWANV 

       610        620        630 
DDFEEEWKDT IERDDLVDDN ISVYEHEHEK TFI 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure of the uracil transport protein of Saccharomyces cerevisiae."
Jund R., Weber E., Chevallier M.-R.
Eur. J. Biochem. 171:417-424(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 28383 / FL100 / VTT C-80102.
[2]"The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene."
Smits P.H.M., de Haan M., Maat C., Grivell L.A.
Yeast 10:S75-S80(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X76078 Genomic DNA. Translation: CAA53678.1.
Z35890 Genomic DNA. Translation: CAA84963.1.
X06830 Genomic DNA. Translation: CAA29986.1.
BK006936 Genomic DNA. Translation: DAA07143.1.
PIRS45877.
RefSeqNP_009577.1. NM_001178369.1.

3D structure databases

ProteinModelPortalP05316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32724. 11 interactions.
DIPDIP-4892N.
IntActP05316. 31 interactions.
MINTMINT-485049.
STRING4932.YBR021W.

Protein family/group databases

TCDB2.A.39.3.2. the nucleobase:cation symporter-1 (ncs1) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR021W; YBR021W; YBR021W.
GeneID852309.
KEGGsce:YBR021W.

Organism-specific databases

CYGDYBR021w.
SGDS000000225. FUR4.

Phylogenomic databases

eggNOGCOG1953.
GeneTreeENSGT00530000065049.
HOGENOMHOG000202588.
OMASSKFTMA.
OrthoDBEOG75B8F6.

Enzyme and pathway databases

BioCycYEAST:G3O-29002-MONOMER.

Gene expression databases

GenevestigatorP05316.

Family and domain databases

InterProIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view]
PfamPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsTIGR00800. ncs1. 1 hit.
ProtoNetSearch...

Other

NextBio970987.

Entry information

Entry nameFUR4_YEAST
AccessionPrimary (citable) accession number: P05316
Secondary accession number(s): D6VQ23
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families