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P05316

- FUR4_YEAST

UniProt

P05316 - FUR4_YEAST

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Protein

Uracil permease

Gene
FUR4, YBR021W, YBR0303
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Transport of uracil.

GO - Molecular functioni

  1. uracil:cation symporter activity Source: SGD

GO - Biological processi

  1. transmembrane transport Source: SGD
  2. uracil transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29002-MONOMER.

Protein family/group databases

TCDBi2.A.39.3.2. the nucleobase:cation symporter-1 (ncs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil permease
Gene namesi
Name:FUR4
Ordered Locus Names:YBR021W
ORF Names:YBR0303
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR021w.
SGDiS000000225. FUR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei143 – 16321Helical; Reviewed predictionAdd
BLAST
Transmembranei173 – 19321Helical; Reviewed predictionAdd
BLAST
Transmembranei197 – 21721Helical; Reviewed predictionAdd
BLAST
Transmembranei242 – 26221Helical; Reviewed predictionAdd
BLAST
Transmembranei268 – 28821Helical; Reviewed predictionAdd
BLAST
Transmembranei310 – 33021Helical; Reviewed predictionAdd
BLAST
Transmembranei350 – 37021Helical; Reviewed predictionAdd
BLAST
Transmembranei400 – 42021Helical; Reviewed predictionAdd
BLAST
Transmembranei442 – 46221Helical; Reviewed predictionAdd
BLAST
Transmembranei465 – 48521Helical; Reviewed predictionAdd
BLAST
Transmembranei521 – 54121Helical; Reviewed predictionAdd
BLAST
Transmembranei559 – 57921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane raft Source: SGD
  3. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Uracil permeasePRO_0000197925Add
BLAST

Post-translational modificationi

Glycosylated (possible); but there is not yet direct biochemical evidence for it.

Proteomic databases

MaxQBiP05316.

Expressioni

Gene expression databases

GenevestigatoriP05316.

Interactioni

Protein-protein interaction databases

BioGridi32724. 11 interactions.
DIPiDIP-4892N.
IntActiP05316. 31 interactions.
MINTiMINT-485049.
STRINGi4932.YBR021W.

Structurei

3D structure databases

ProteinModelPortaliP05316.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1953.
GeneTreeiENSGT00530000065049.
HOGENOMiHOG000202588.
OMAiAIWFPVH.
OrthoDBiEOG75B8F6.

Family and domain databases

InterProiIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

P05316-1 [UniParc]FASTAAdd to Basket

« Hide

MPDNLSLHLS GSSKRLNSRQ LMESSNETFA PNNVDLEKEY KSSQSNITTE    50
VYEASSFEEK VSSEKPQYSS FWKKIYYEYV VVDKSILGVS ILDSFMYNQD 100
LKPVEKERRV WSWYNYCYFW LAECFNINTW QIAATGLQLG LNWWQCWITI 150
WIGYGFVGAF VVLASRVGSA YHLSFPISSR ASFGIFFSLW PVINRVVMAI 200
VWYSVQAYIA ATPVSLMLKS IFGKDLQDKI PDHFGSPNAT TYEFMCFFIF 250
WAASLPFLLV PPHKIRHLFT VKAVLVPFAS FGFLIWAIRR AHGRIALGSL 300
TDVQPHGSAF SWAFLRSLMG CMANFSTMVI NAPDFSRFSK NPNSALWSQL 350
VCIPFLFSIT CLIGILVTAA GYEIYGINYW SPLDVLEKFL QTTYNKGTRA 400
GVFLISFVFA VAQLGTNISA NSLSCGTDMS AIFPKFINIK RGSLFCAAMA 450
LCICPWNLMA TSSKFTMALS AYAIFLSSIA GVVCSDYFVV RRGYIKLTHI 500
YSHQKGSFYM YGNRFGINWR ALAAYLCGVA PCLPGFIAEV GAPAIKVSDG 550
AMKLYYLSYW VGYGLSFSSY TALCYFFPVP GCPVNNIIKD KGWFQRWANV 600
DDFEEEWKDT IERDDLVDDN ISVYEHEHEK TFI 633
Length:633
Mass (Da):71,736
Last modified:October 1, 1994 - v2
Checksum:i2FFCD9529412B2D6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171M → I in CAA29986. 1 Publication
Sequence conflicti229 – 2291K → R in CAA29986. 1 Publication
Sequence conflicti320 – 3201G → R in CAA29986. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76078 Genomic DNA. Translation: CAA53678.1.
Z35890 Genomic DNA. Translation: CAA84963.1.
X06830 Genomic DNA. Translation: CAA29986.1.
BK006936 Genomic DNA. Translation: DAA07143.1.
PIRiS45877.
RefSeqiNP_009577.1. NM_001178369.1.

Genome annotation databases

EnsemblFungiiYBR021W; YBR021W; YBR021W.
GeneIDi852309.
KEGGisce:YBR021W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76078 Genomic DNA. Translation: CAA53678.1 .
Z35890 Genomic DNA. Translation: CAA84963.1 .
X06830 Genomic DNA. Translation: CAA29986.1 .
BK006936 Genomic DNA. Translation: DAA07143.1 .
PIRi S45877.
RefSeqi NP_009577.1. NM_001178369.1.

3D structure databases

ProteinModelPortali P05316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32724. 11 interactions.
DIPi DIP-4892N.
IntActi P05316. 31 interactions.
MINTi MINT-485049.
STRINGi 4932.YBR021W.

Protein family/group databases

TCDBi 2.A.39.3.2. the nucleobase:cation symporter-1 (ncs1) family.

Proteomic databases

MaxQBi P05316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR021W ; YBR021W ; YBR021W .
GeneIDi 852309.
KEGGi sce:YBR021W.

Organism-specific databases

CYGDi YBR021w.
SGDi S000000225. FUR4.

Phylogenomic databases

eggNOGi COG1953.
GeneTreei ENSGT00530000065049.
HOGENOMi HOG000202588.
OMAi AIWFPVH.
OrthoDBi EOG75B8F6.

Enzyme and pathway databases

BioCyci YEAST:G3O-29002-MONOMER.

Miscellaneous databases

NextBioi 970987.

Gene expression databases

Genevestigatori P05316.

Family and domain databases

InterProi IPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view ]
Pfami PF02133. Transp_cyt_pur. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00800. ncs1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the uracil transport protein of Saccharomyces cerevisiae."
    Jund R., Weber E., Chevallier M.-R.
    Eur. J. Biochem. 171:417-424(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 28383 / FL100 / VTT C-80102.
  2. "The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene."
    Smits P.H.M., de Haan M., Maat C., Grivell L.A.
    Yeast 10:S75-S80(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiFUR4_YEAST
AccessioniPrimary (citable) accession number: P05316
Secondary accession number(s): D6VQ23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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