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P05305

- EDN1_HUMAN

UniProt

P05305 - EDN1_HUMAN

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Protein

Endothelin-1

Gene

EDN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KEL

GO - Molecular functioni

  1. cytokine activity Source: BHF-UCL
  2. endothelin A receptor binding Source: BHF-UCL
  3. endothelin B receptor binding Source: BHF-UCL
  4. hormone activity Source: BHF-UCL

GO - Biological processi

  1. artery smooth muscle contraction Source: BHF-UCL
  2. body fluid secretion Source: Ensembl
  3. calcium-mediated signaling Source: BHF-UCL
  4. cartilage development Source: Ensembl
  5. cell-cell signaling Source: BHF-UCL
  6. cell growth Source: Ensembl
  7. cell surface receptor signaling pathway Source: BHF-UCL
  8. cellular response to interleukin-1 Source: Ensembl
  9. cellular response to tumor necrosis factor Source: Ensembl
  10. dorsal/ventral pattern formation Source: Ensembl
  11. epithelial fluid transport Source: Ensembl
  12. glucose transport Source: Ensembl
  13. G-protein coupled receptor signaling pathway Source: BHF-UCL
  14. heart development Source: Ensembl
  15. histamine secretion Source: Ensembl
  16. inositol phosphate-mediated signaling Source: BHF-UCL
  17. in utero embryonic development Source: Ensembl
  18. leukocyte activation Source: BHF-UCL
  19. maternal process involved in parturition Source: Ensembl
  20. membrane depolarization Source: Ensembl
  21. middle ear morphogenesis Source: Ensembl
  22. multicellular organismal aging Source: Ensembl
  23. negative regulation of blood coagulation Source: BHF-UCL
  24. negative regulation of cAMP biosynthetic process Source: Ensembl
  25. negative regulation of cellular protein metabolic process Source: BHF-UCL
  26. negative regulation of hormone secretion Source: Ensembl
  27. negative regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
  28. negative regulation of smooth muscle cell apoptotic process Source: Ensembl
  29. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  30. neural crest cell development Source: Ensembl
  31. nitric oxide transport Source: BHF-UCL
  32. patterning of blood vessels Source: Ensembl
  33. peptide hormone secretion Source: BHF-UCL
  34. phosphatidylinositol 3-kinase signaling Source: BHF-UCL
  35. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
  36. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
  37. positive regulation of cell migration Source: BHF-UCL
  38. positive regulation of cell proliferation Source: BHF-UCL
  39. positive regulation of cell size Source: BHF-UCL
  40. positive regulation of chemokine-mediated signaling pathway Source: BHF-UCL
  41. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  42. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  43. positive regulation of endothelial cell migration Source: BHF-UCL
  44. positive regulation of heart rate Source: BHF-UCL
  45. positive regulation of hormone secretion Source: BHF-UCL
  46. positive regulation of JUN kinase activity Source: BHF-UCL
  47. positive regulation of MAP kinase activity Source: BHF-UCL
  48. positive regulation of mitosis Source: BHF-UCL
  49. positive regulation of neutrophil chemotaxis Source: Ensembl
  50. positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
  51. positive regulation of odontogenesis Source: Ensembl
  52. positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
  53. positive regulation of receptor biosynthetic process Source: BHF-UCL
  54. positive regulation of renal sodium excretion Source: Ensembl
  55. positive regulation of sarcomere organization Source: BHF-UCL
  56. positive regulation of smooth muscle cell proliferation Source: BHF-UCL
  57. positive regulation of smooth muscle contraction Source: Ensembl
  58. positive regulation of urine volume Source: Ensembl
  59. prostaglandin biosynthetic process Source: BHF-UCL
  60. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  61. protein kinase C deactivation Source: BHF-UCL
  62. regulation of pH Source: Ensembl
  63. regulation of sensory perception of pain Source: Ensembl
  64. regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
  65. regulation of vasoconstriction Source: InterPro
  66. respiratory gaseous exchange Source: Ensembl
  67. response to amino acid Source: Ensembl
  68. response to drug Source: Ensembl
  69. response to hypoxia Source: Ensembl
  70. response to lipopolysaccharide Source: Ensembl
  71. response to nicotine Source: Ensembl
  72. response to testosterone Source: Ensembl
  73. rhythmic excitation Source: Ensembl
  74. sensory perception of pain Source: Ensembl
  75. superoxide anion generation Source: Ensembl
  76. vasoconstriction Source: BHF-UCL
  77. vein smooth muscle contraction Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following 2 chains:
Gene namesi
Name:EDN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:3176. EDN1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. extracellular region Source: Reactome
  3. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Question mark ears, isolated (QME) [MIM:612798]: An auricular abnormality characterized by a cleft between the lobule and the lower part of the helix, sometimes accompanied by a prominent or deficient upper part of the helix, shallow skin dimple on the posterior surface of the ear, or transposition of the ear lobe/antitragus.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641V → D in QME. 1 Publication
VAR_071152
Auriculocondylar syndrome 3 (ARCND3) [MIM:615706]: A craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771P → H in ARCND3. 1 Publication
VAR_071153
Natural varianti91 – 911K → E in ARCND3. 1 Publication
VAR_071154

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi612798. phenotype.
615706. phenotype.
Orphaneti137888. Auriculocondylar syndrome.
PharmGKBiPA27614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Add
BLAST
Propeptidei18 – 5033PRO_0000008058Add
BLAST
Peptidei53 – 9038Big endothelin-1PRO_0000008059Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008060Add
BLAST
Propeptidei74 – 212139PRO_0000008061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 671 Publication
Disulfide bondi55 ↔ 631 Publication
Disulfide bondi109 ↔ 123By similarity
Disulfide bondi111 ↔ 119By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP05305.
PRIDEiP05305.

PTM databases

PhosphoSiteiP05305.

Miscellaneous databases

PMAP-CutDBP05305.

Expressioni

Tissue specificityi

Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.1 Publication

Gene expression databases

BgeeiP05305.
CleanExiHS_EDN1.
ExpressionAtlasiP05305. baseline and differential.
GenevestigatoriP05305.

Organism-specific databases

HPAiCAB032500.
CAB037291.
HPA031976.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EDNRAP251012EBI-715181,EBI-6624559
EDNRBP245302EBI-715181,EBI-6624656

Protein-protein interaction databases

BioGridi108228. 5 interactions.
IntActiP05305. 5 interactions.
MINTiMINT-1387120.
STRINGi9606.ENSP00000368683.

Structurei

Secondary structure

1
212
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi53 – 564Combined sources
Beta strandi57 – 593Combined sources
Helixi61 – 677Combined sources
Turni68 – 703Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EDNX-ray2.18A53-73[»]
1EDPNMR-A53-69[»]
1T7HX-ray1.13A/B51-68[»]
1V6RNMR-A53-73[»]
ProteinModelPortaliP05305.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05305.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 12315Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP05305.
KOiK16366.
OMAiMDYFPMI.
OrthoDBiEOG7PS1H7.
PhylomeDBiP05305.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05305-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT
110 120 130 140 150
KATDRENRCQ CASQKDKKCW NFCQAGKELR AEDIMEKDWN NHKKGKDCSK
160 170 180 190 200
LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE TMRNSVKSSF HDPKLKGKPS
210
RERYVTHNRA HW
Length:212
Mass (Da):24,425
Last modified:November 1, 1988 - v1
Checksum:iE2DA0EB86755BC3D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641V → D in QME. 1 Publication
VAR_071152
Natural varianti77 – 771P → H in ARCND3. 1 Publication
VAR_071153
Natural varianti91 – 911K → E in ARCND3. 1 Publication
VAR_071154
Natural varianti186 – 1861V → I.
Corresponds to variant rs6413478 [ dbSNP | Ensembl ].
VAR_048933
Natural varianti198 – 1981K → N Polymorphism associated with HDL cholesterol levels is some populations and in a sex-specific manner. 6 Publications
Corresponds to variant rs5370 [ dbSNP | Ensembl ].
VAR_014188

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00749 mRNA. Translation: CAA68718.1.
M25380
, M25377, M25378, M25379 Genomic DNA. Translation: AAA52407.1.
J05008 Genomic DNA. Translation: AAA52339.1.
S56805 mRNA. Translation: AAB25760.1.
AY434104 Genomic DNA. Translation: AAQ96600.1.
Z98050 Genomic DNA. Translation: CAB10846.1.
BC009720 mRNA. Translation: AAH09720.1.
M25549 Genomic DNA. Translation: AAA52338.1.
CCDSiCCDS4522.1.
PIRiA36517. ANHU1.
RefSeqiNP_001161791.1. NM_001168319.1.
NP_001946.3. NM_001955.4.
UniGeneiHs.511899.
Hs.713645.

Genome annotation databases

EnsembliENST00000379375; ENSP00000368683; ENSG00000078401.
GeneIDi1906.
KEGGihsa:1906.
UCSCiuc003nad.3. human.

Polymorphism databases

DMDMi119610.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
R&D Systems' cytokine source book: Endothelin-1
Wikipedia

Endothelin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00749 mRNA. Translation: CAA68718.1 .
M25380
, M25377 , M25378 , M25379 Genomic DNA. Translation: AAA52407.1 .
J05008 Genomic DNA. Translation: AAA52339.1 .
S56805 mRNA. Translation: AAB25760.1 .
AY434104 Genomic DNA. Translation: AAQ96600.1 .
Z98050 Genomic DNA. Translation: CAB10846.1 .
BC009720 mRNA. Translation: AAH09720.1 .
M25549 Genomic DNA. Translation: AAA52338.1 .
CCDSi CCDS4522.1.
PIRi A36517. ANHU1.
RefSeqi NP_001161791.1. NM_001168319.1.
NP_001946.3. NM_001955.4.
UniGenei Hs.511899.
Hs.713645.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EDN X-ray 2.18 A 53-73 [» ]
1EDP NMR - A 53-69 [» ]
1T7H X-ray 1.13 A/B 51-68 [» ]
1V6R NMR - A 53-73 [» ]
ProteinModelPortali P05305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108228. 5 interactions.
IntActi P05305. 5 interactions.
MINTi MINT-1387120.
STRINGi 9606.ENSP00000368683.

PTM databases

PhosphoSitei P05305.

Polymorphism databases

DMDMi 119610.

Proteomic databases

PaxDbi P05305.
PRIDEi P05305.

Protocols and materials databases

DNASUi 1906.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379375 ; ENSP00000368683 ; ENSG00000078401 .
GeneIDi 1906.
KEGGi hsa:1906.
UCSCi uc003nad.3. human.

Organism-specific databases

CTDi 1906.
GeneCardsi GC06P012290.
H-InvDB HIX0033211.
HGNCi HGNC:3176. EDN1.
HPAi CAB032500.
CAB037291.
HPA031976.
MIMi 131240. gene.
612798. phenotype.
615706. phenotype.
neXtProti NX_P05305.
Orphaneti 137888. Auriculocondylar syndrome.
PharmGKBi PA27614.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46593.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
InParanoidi P05305.
KOi K16366.
OMAi MDYFPMI.
OrthoDBi EOG7PS1H7.
PhylomeDBi P05305.
TreeFami TF333184.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTracei P05305.
GeneWikii Endothelin_1.
GenomeRNAii 1906.
NextBioi 7757.
PMAP-CutDB P05305.
PROi P05305.
SOURCEi Search...

Gene expression databases

Bgeei P05305.
CleanExi HS_EDN1.
ExpressionAtlasi P05305. baseline and differential.
Genevestigatori P05305.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin."
    Itoh Y., Yanagisawa M., Ohkubo S., Kimura C., Kosaka T., Inoue A., Ishida N., Mitsui Y., Onda H., Fujino M., Masaki T.
    FEBS Lett. 231:440-444(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression."
    Inoue A., Yanagisawa M., Takuwa Y., Mitsui Y., Kobayashi M., Masaki T.
    J. Biol. Chem. 264:14954-14959(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structural organization and chromosomal assignment of the gene encoding endothelin."
    Bloch K.D., Friedrich S.P., Lee M.E., Eddy R.L., Shows T.B., Quertermous T.
    J. Biol. Chem. 264:10851-10857(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Two preproendothelin 1 mRNAs transcribed by alternative promoters."
    Benatti L., Bonecchi L., Cozzi L., Sarmientos P.
    J. Clin. Invest. 91:1149-1156(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. NIEHS SNPs program
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-198.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-198.
    Tissue: Pancreas.
  8. "The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."
    Inoue A., Yanagisawa M., Kimura S., Kasuya Y., Miyauchi T., Goto K., Masaki T.
    Proc. Natl. Acad. Sci. U.S.A. 86:2863-2867(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-67.
  9. "Proteolytic processing of big endothelin-3 by the kell blood group protein."
    Lee S., Lin M., Mele A., Cao Y., Farmar J., Russo D., Redman C.
    Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, CLEAVAGE BY KELL, IDENTIFICATION BY MASS SPECTROMETRY.
  10. Cited for: PROTEOLYTIC PROCESSING.
  11. "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
    Bourgeois C., Robert B., Rebourcet R., Mondon F., Mignot T.-M., Duc-Goiran P., Ferre F.
    J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. "Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol."
    Pare G., Serre D., Brisson D., Anand S.S., Montpetit A., Tremblay G., Engert J.C., Hudson T.J., Gaudet D.
    Am. J. Hum. Genet. 80:673-682(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-198, CHARACTERIZATION OF VARIANT ASN-198.
  13. "Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease."
    Wiltshire S., Powell B.L., Jennens M., McCaskie P.A., Carter K.W., Palmer L.J., Thompson P.L., McQuillan B.M., Hung J., Beilby J.P.
    Hum. Genet. 123:307-313(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-198.
  14. "Crystallization and preliminary X-ray analysis of human endothelin."
    Wolff M., Day J., Greenwood A., Larson S., McPherson A.
    Acta Crystallogr. B 48:239-240(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF ET-1.
  15. Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF ET-1, DISULFIDE BONDS.
  16. "The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations."
    Reily M.D., Dunbar J.B. Jr.
    Biochem. Biophys. Res. Commun. 178:570-577(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF ET-1.
  17. "Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis."
    Andersen N.H., Chen C., Marschner T.M., Krystek S.R. Jr., Bassolino D.A.
    Biochemistry 31:1280-1295(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF ET-1.
  18. "Solution conformation of human big endothelin-1."
    Donlan M.L., Brown F.K., Jeffs P.W.
    J. Biomol. NMR 2:407-420(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 53-90.
  19. "A comparison of X-ray and NMR structures for human endothelin-1."
    Wallace B.A., Janes R.W., Bassolino D.A., Krystek S.R. Jr.
    Protein Sci. 4:75-83(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPARISON OF NMR STRUCTURE WITH X-RAY STRUCTURE.
  20. "Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling."
    Hewage C.M., Jiang L., Parkinson J.A., Ramage R., Sadler I.H.
    J. Pept. Res. 53:223-233(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF ET1 AGONIST.
  21. "The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people."
    Tiret L., Poirier O., Hallet V., McDonagh T.A., Morrison C., McMurray J.J., Dargie H.J., Arveiler D., Ruidavets J.B., Luc G., Evans A., Cambien F.
    Hypertension 33:1169-1174(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-198.
  22. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
    Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
    Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-198.
  23. Cited for: VARIANT QME ASP-64, VARIANTS ARCND3 HIS-77 AND GLU-91.

Entry informationi

Entry nameiEDN1_HUMAN
AccessioniPrimary (citable) accession number: P05305
Secondary accession number(s): Q96DA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: November 26, 2014
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3