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Protein

Endothelin-1

Gene

EDN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KEL

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • endothelin A receptor binding Source: BHF-UCL
  • endothelin B receptor binding Source: BHF-UCL
  • hormone activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following 2 chains:
Gene namesi
Name:EDN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:3176. EDN1.

Subcellular locationi

GO - Cellular componenti

  • basal part of cell Source: Ensembl
  • cytoplasm Source: BHF-UCL
  • cytosol Source: GOC
  • extracellular region Source: Reactome
  • extracellular space Source: BHF-UCL
  • rough endoplasmic reticulum lumen Source: Ensembl
  • Weibel-Palade body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Question mark ears, isolated (QME)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn auricular abnormality characterized by a cleft between the lobule and the lower part of the helix, sometimes accompanied by a prominent or deficient upper part of the helix, shallow skin dimple on the posterior surface of the ear, or transposition of the ear lobe/antitragus.

See also OMIM:612798
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641V → D in QME. 1 Publication
VAR_071152
Auriculocondylar syndrome 3 (ARCND3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.

See also OMIM:615706
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771P → H in ARCND3. 1 Publication
VAR_071153
Natural varianti91 – 911K → E in ARCND3. 1 Publication
VAR_071154

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi612798. phenotype.
615706. phenotype.
Orphaneti137888. Auriculocondylar syndrome.
PharmGKBiPA27614.

Polymorphism and mutation databases

BioMutaiEDN1.
DMDMi119610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Add
BLAST
Propeptidei18 – 5033PRO_0000008058Add
BLAST
Peptidei53 – 9038Big endothelin-1PRO_0000008059Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008060Add
BLAST
Propeptidei74 – 212139PRO_0000008061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 671 Publication
Disulfide bondi55 ↔ 631 Publication
Disulfide bondi109 ↔ 123By similarity
Disulfide bondi111 ↔ 119By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP05305.
PRIDEiP05305.

PTM databases

PhosphoSiteiP05305.

Miscellaneous databases

PMAP-CutDBP05305.

Expressioni

Tissue specificityi

Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.1 Publication

Gene expression databases

BgeeiP05305.
CleanExiHS_EDN1.
ExpressionAtlasiP05305. baseline and differential.
GenevisibleiP05305. HS.

Organism-specific databases

HPAiCAB032500.
CAB037291.
HPA031976.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EDNRAP251012EBI-715181,EBI-6624559
EDNRBP245302EBI-715181,EBI-6624656

Protein-protein interaction databases

BioGridi108228. 5 interactions.
IntActiP05305. 5 interactions.
MINTiMINT-1387120.
STRINGi9606.ENSP00000368683.

Structurei

Secondary structure

1
212
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi53 – 564Combined sources
Beta strandi57 – 593Combined sources
Helixi61 – 677Combined sources
Turni68 – 703Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EDNX-ray2.18A53-73[»]
1EDPNMR-A53-69[»]
1T7HX-ray1.13A/B51-68[»]
1V6RNMR-A53-73[»]
ProteinModelPortaliP05305.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05305.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 12315Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP05305.
KOiK16366.
OMAiCASQKDK.
OrthoDBiEOG7PS1H7.
PhylomeDBiP05305.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT
110 120 130 140 150
KATDRENRCQ CASQKDKKCW NFCQAGKELR AEDIMEKDWN NHKKGKDCSK
160 170 180 190 200
LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE TMRNSVKSSF HDPKLKGKPS
210
RERYVTHNRA HW
Length:212
Mass (Da):24,425
Last modified:November 1, 1988 - v1
Checksum:iE2DA0EB86755BC3D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641V → D in QME. 1 Publication
VAR_071152
Natural varianti77 – 771P → H in ARCND3. 1 Publication
VAR_071153
Natural varianti91 – 911K → E in ARCND3. 1 Publication
VAR_071154
Natural varianti186 – 1861V → I.
Corresponds to variant rs6413478 [ dbSNP | Ensembl ].
VAR_048933
Natural varianti198 – 1981K → N Polymorphism associated with HDL cholesterol levels is some populations and in a sex-specific manner. 6 Publications
Corresponds to variant rs5370 [ dbSNP | Ensembl ].
VAR_014188

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00749 mRNA. Translation: CAA68718.1.
M25380
, M25377, M25378, M25379 Genomic DNA. Translation: AAA52407.1.
J05008 Genomic DNA. Translation: AAA52339.1.
S56805 mRNA. Translation: AAB25760.1.
AY434104 Genomic DNA. Translation: AAQ96600.1.
Z98050 Genomic DNA. Translation: CAB10846.1.
BC009720 mRNA. Translation: AAH09720.1.
M25549 Genomic DNA. Translation: AAA52338.1.
CCDSiCCDS4522.1.
PIRiA36517. ANHU1.
RefSeqiNP_001161791.1. NM_001168319.1.
NP_001946.3. NM_001955.4.
XP_011512632.1. XM_011514330.1.
XP_011512633.1. XM_011514331.1.
UniGeneiHs.511899.
Hs.713645.

Genome annotation databases

EnsembliENST00000379375; ENSP00000368683; ENSG00000078401.
GeneIDi1906.
KEGGihsa:1906.
UCSCiuc003nad.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
R&D Systems' cytokine source book: Endothelin-1
Wikipedia

Endothelin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00749 mRNA. Translation: CAA68718.1.
M25380
, M25377, M25378, M25379 Genomic DNA. Translation: AAA52407.1.
J05008 Genomic DNA. Translation: AAA52339.1.
S56805 mRNA. Translation: AAB25760.1.
AY434104 Genomic DNA. Translation: AAQ96600.1.
Z98050 Genomic DNA. Translation: CAB10846.1.
BC009720 mRNA. Translation: AAH09720.1.
M25549 Genomic DNA. Translation: AAA52338.1.
CCDSiCCDS4522.1.
PIRiA36517. ANHU1.
RefSeqiNP_001161791.1. NM_001168319.1.
NP_001946.3. NM_001955.4.
XP_011512632.1. XM_011514330.1.
XP_011512633.1. XM_011514331.1.
UniGeneiHs.511899.
Hs.713645.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EDNX-ray2.18A53-73[»]
1EDPNMR-A53-69[»]
1T7HX-ray1.13A/B51-68[»]
1V6RNMR-A53-73[»]
ProteinModelPortaliP05305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108228. 5 interactions.
IntActiP05305. 5 interactions.
MINTiMINT-1387120.
STRINGi9606.ENSP00000368683.

PTM databases

PhosphoSiteiP05305.

Polymorphism and mutation databases

BioMutaiEDN1.
DMDMi119610.

Proteomic databases

PaxDbiP05305.
PRIDEiP05305.

Protocols and materials databases

DNASUi1906.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379375; ENSP00000368683; ENSG00000078401.
GeneIDi1906.
KEGGihsa:1906.
UCSCiuc003nad.3. human.

Organism-specific databases

CTDi1906.
GeneCardsiGC06P012290.
H-InvDBHIX0033211.
HGNCiHGNC:3176. EDN1.
HPAiCAB032500.
CAB037291.
HPA031976.
MIMi131240. gene.
612798. phenotype.
615706. phenotype.
neXtProtiNX_P05305.
Orphaneti137888. Auriculocondylar syndrome.
PharmGKBiPA27614.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP05305.
KOiK16366.
OMAiCASQKDK.
OrthoDBiEOG7PS1H7.
PhylomeDBiP05305.
TreeFamiTF333184.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTraceiP05305.
GeneWikiiEndothelin_1.
GenomeRNAii1906.
NextBioi7757.
PMAP-CutDBP05305.
PROiP05305.
SOURCEiSearch...

Gene expression databases

BgeeiP05305.
CleanExiHS_EDN1.
ExpressionAtlasiP05305. baseline and differential.
GenevisibleiP05305. HS.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin."
    Itoh Y., Yanagisawa M., Ohkubo S., Kimura C., Kosaka T., Inoue A., Ishida N., Mitsui Y., Onda H., Fujino M., Masaki T.
    FEBS Lett. 231:440-444(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression."
    Inoue A., Yanagisawa M., Takuwa Y., Mitsui Y., Kobayashi M., Masaki T.
    J. Biol. Chem. 264:14954-14959(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structural organization and chromosomal assignment of the gene encoding endothelin."
    Bloch K.D., Friedrich S.P., Lee M.E., Eddy R.L., Shows T.B., Quertermous T.
    J. Biol. Chem. 264:10851-10857(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Two preproendothelin 1 mRNAs transcribed by alternative promoters."
    Benatti L., Bonecchi L., Cozzi L., Sarmientos P.
    J. Clin. Invest. 91:1149-1156(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. NIEHS SNPs program
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-198.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-198.
    Tissue: Pancreas.
  8. "The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."
    Inoue A., Yanagisawa M., Kimura S., Kasuya Y., Miyauchi T., Goto K., Masaki T.
    Proc. Natl. Acad. Sci. U.S.A. 86:2863-2867(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-67.
  9. "Proteolytic processing of big endothelin-3 by the kell blood group protein."
    Lee S., Lin M., Mele A., Cao Y., Farmar J., Russo D., Redman C.
    Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, CLEAVAGE BY KELL, IDENTIFICATION BY MASS SPECTROMETRY.
  10. Cited for: PROTEOLYTIC PROCESSING.
  11. "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
    Bourgeois C., Robert B., Rebourcet R., Mondon F., Mignot T.-M., Duc-Goiran P., Ferre F.
    J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. "Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol."
    Pare G., Serre D., Brisson D., Anand S.S., Montpetit A., Tremblay G., Engert J.C., Hudson T.J., Gaudet D.
    Am. J. Hum. Genet. 80:673-682(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-198, CHARACTERIZATION OF VARIANT ASN-198.
  13. "Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease."
    Wiltshire S., Powell B.L., Jennens M., McCaskie P.A., Carter K.W., Palmer L.J., Thompson P.L., McQuillan B.M., Hung J., Beilby J.P.
    Hum. Genet. 123:307-313(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-198.
  14. "Crystallization and preliminary X-ray analysis of human endothelin."
    Wolff M., Day J., Greenwood A., Larson S., McPherson A.
    Acta Crystallogr. B 48:239-240(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF ET-1.
  15. Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF ET-1, DISULFIDE BONDS.
  16. "The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations."
    Reily M.D., Dunbar J.B. Jr.
    Biochem. Biophys. Res. Commun. 178:570-577(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF ET-1.
  17. "Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis."
    Andersen N.H., Chen C., Marschner T.M., Krystek S.R. Jr., Bassolino D.A.
    Biochemistry 31:1280-1295(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF ET-1.
  18. "Solution conformation of human big endothelin-1."
    Donlan M.L., Brown F.K., Jeffs P.W.
    J. Biomol. NMR 2:407-420(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 53-90.
  19. "A comparison of X-ray and NMR structures for human endothelin-1."
    Wallace B.A., Janes R.W., Bassolino D.A., Krystek S.R. Jr.
    Protein Sci. 4:75-83(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPARISON OF NMR STRUCTURE WITH X-RAY STRUCTURE.
  20. "Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling."
    Hewage C.M., Jiang L., Parkinson J.A., Ramage R., Sadler I.H.
    J. Pept. Res. 53:223-233(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF ET1 AGONIST.
  21. "The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people."
    Tiret L., Poirier O., Hallet V., McDonagh T.A., Morrison C., McMurray J.J., Dargie H.J., Arveiler D., Ruidavets J.B., Luc G., Evans A., Cambien F.
    Hypertension 33:1169-1174(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-198.
  22. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
    Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
    Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-198.
  23. Cited for: VARIANT QME ASP-64, VARIANTS ARCND3 HIS-77 AND GLU-91.

Entry informationi

Entry nameiEDN1_HUMAN
AccessioniPrimary (citable) accession number: P05305
Secondary accession number(s): Q96DA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: July 22, 2015
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.