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P05305 (EDN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 162. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-1
Alternative name(s):
Preproendothelin-1
Short name=PPET1

Cleaved into the following 2 chains:

  1. Endothelin-1
    Short name=ET-1
  2. Big endothelin-1
Gene names
Name:EDN1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Endothelins are endothelium-derived vasoconstrictor peptides.

Subcellular location

Secreted.

Tissue specificity

Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. Ref.11

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionVasoactive
Vasoconstrictor
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 17078114. Source: BHF-UCL

artery smooth muscle contraction

Inferred from direct assay PubMed 8982507. Source: BHF-UCL

body fluid secretion

Inferred from electronic annotation. Source: Ensembl

calcium-mediated signaling

Inferred from direct assay PubMed 10770212PubMed 1917960. Source: BHF-UCL

cartilage development

Inferred from electronic annotation. Source: Ensembl

cell growth

Inferred from electronic annotation. Source: Ensembl

cell surface receptor signaling pathway

Inferred from direct assay PubMed 1713452. Source: BHF-UCL

cell-cell signaling

Inferred from direct assay PubMed 12379507. Source: BHF-UCL

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

dorsal/ventral pattern formation

Inferred from electronic annotation. Source: Ensembl

epithelial fluid transport

Inferred from electronic annotation. Source: Ensembl

glucose transport

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from electronic annotation. Source: Ensembl

histamine secretion

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

inositol phosphate-mediated signaling

Inferred from direct assay PubMed 1917960. Source: BHF-UCL

leukocyte activation

Traceable author statement PubMed 16820593. Source: BHF-UCL

maternal process involved in parturition

Inferred from electronic annotation. Source: Ensembl

membrane depolarization

Inferred from electronic annotation. Source: Ensembl

middle ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

multicellular organismal aging

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood coagulation

Traceable author statement PubMed 16820593. Source: BHF-UCL

negative regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cellular protein metabolic process

Inferred from direct assay PubMed 19767294. Source: BHF-UCL

negative regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of nitric-oxide synthase biosynthetic process

Inferred from direct assay PubMed 16820593. Source: BHF-UCL

negative regulation of smooth muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19767294. Source: BHF-UCL

neural crest cell development

Inferred from electronic annotation. Source: Ensembl

nitric oxide transport

Inferred from direct assay PubMed 16820593. Source: BHF-UCL

patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

peptide hormone secretion

Inferred from direct assay PubMed 10770212. Source: BHF-UCL

phosphatidylinositol 3-kinase signaling

Inferred from direct assay PubMed 17078114. Source: BHF-UCL

phospholipase D-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of JUN kinase activity

Inferred from direct assay PubMed 12847114. Source: BHF-UCL

positive regulation of MAP kinase activity

Inferred from direct assay PubMed 10770212PubMed 12847114. Source: BHF-UCL

positive regulation of cardiac muscle hypertrophy

Inferred from direct assay PubMed 12847114. Source: BHF-UCL

positive regulation of cell migration

Inferred from direct assay PubMed 9696419. Source: BHF-UCL

positive regulation of cell proliferation

Inferred from direct assay PubMed 17078114PubMed 1917960. Source: BHF-UCL

positive regulation of cell size

Inferred from direct assay PubMed 12847114. Source: BHF-UCL

positive regulation of chemokine-mediated signaling pathway

Inferred by curator PubMed 17178876. Source: BHF-UCL

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay PubMed 1917960. Source: BHF-UCL

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell migration

Traceable author statement PubMed 8999856. Source: BHF-UCL

positive regulation of heart rate

Inferred from direct assay Ref.8. Source: BHF-UCL

positive regulation of hormone secretion

Inferred from direct assay PubMed 10770212. Source: BHF-UCL

positive regulation of mitosis

Inferred from direct assay PubMed 10770212. Source: BHF-UCL

positive regulation of neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric oxide biosynthetic process

Traceable author statement PubMed 8999856. Source: BHF-UCL

positive regulation of odontogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of prostaglandin-endoperoxide synthase activity

Inferred from mutant phenotype PubMed 9492062. Source: BHF-UCL

positive regulation of receptor biosynthetic process

Inferred from direct assay PubMed 17178876. Source: BHF-UCL

positive regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of sarcomere organization

Inferred from mutant phenotype PubMed 12847114. Source: BHF-UCL

positive regulation of smooth muscle cell proliferation

Inferred from direct assay PubMed 10393673. Source: BHF-UCL

positive regulation of smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of urine volume

Inferred from electronic annotation. Source: Ensembl

prostaglandin biosynthetic process

Inferred from direct assay PubMed 9492062. Source: BHF-UCL

protein kinase C deactivation

Inferred from direct assay PubMed 16820593. Source: BHF-UCL

protein kinase C-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of pH

Inferred from electronic annotation. Source: Ensembl

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

regulation of systemic arterial blood pressure by endothelin

Inferred from direct assay Ref.8. Source: BHF-UCL

regulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

respiratory gaseous exchange

Inferred from electronic annotation. Source: Ensembl

response to amino acid

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to nicotine

Inferred from electronic annotation. Source: Ensembl

response to testosterone

Inferred from electronic annotation. Source: Ensembl

rhythmic excitation

Inferred from electronic annotation. Source: Ensembl

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

superoxide anion generation

Inferred from electronic annotation. Source: Ensembl

vasoconstriction

Inferred from direct assay PubMed 11410113Ref.8. Source: BHF-UCL

vein smooth muscle contraction

Inferred from direct assay PubMed 9422810. Source: BHF-UCL

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 12379507. Source: BHF-UCL

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 10770212PubMed 15691296PubMed 16820593. Source: BHF-UCL

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 19767294. Source: BHF-UCL

endothelin A receptor binding

Inferred from direct assay PubMed 10770212. Source: BHF-UCL

endothelin B receptor binding

Inferred from direct assay PubMed 10770212. Source: BHF-UCL

hormone activity

Inferred from direct assay PubMed 10770212Ref.8. Source: BHF-UCL

protein binding

Inferred from physical interaction PubMed 23597562. Source: IntAct

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717
Propeptide18 – 5033
PRO_0000008058
Peptide53 – 9038Big endothelin-1
PRO_0000008059
Peptide53 – 7321Endothelin-1
PRO_0000008060
Propeptide74 – 212139
PRO_0000008061

Regions

Region109 – 12315Endothelin-like

Sites

Site73 – 742Cleavage; by KEL

Amino acid modifications

Disulfide bond53 ↔ 67 Ref.13
Disulfide bond55 ↔ 63 Ref.13
Disulfide bond109 ↔ 123 By similarity
Disulfide bond111 ↔ 119 By similarity

Natural variations

Natural variant1861V → I.
Corresponds to variant rs6413478 [ dbSNP | Ensembl ].
VAR_048933
Natural variant1981K → N. Ref.5 Ref.7 Ref.19 Ref.20
Corresponds to variant rs5370 [ dbSNP | Ensembl ].
VAR_014188

Secondary structure

....... 212
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P05305 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: E2DA0EB86755BC3D

FASTA21224,425
        10         20         30         40         50         60 
MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS KRCSCSSLMD 

        70         80         90        100        110        120 
KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT KATDRENRCQ CASQKDKKCW 

       130        140        150        160        170        180 
NFCQAGKELR AEDIMEKDWN NHKKGKDCSK LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE 

       190        200        210 
TMRNSVKSSF HDPKLKGKPS RERYVTHNRA HW 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin."
Itoh Y., Yanagisawa M., Ohkubo S., Kimura C., Kosaka T., Inoue A., Ishida N., Mitsui Y., Onda H., Fujino M., Masaki T.
FEBS Lett. 231:440-444(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression."
Inoue A., Yanagisawa M., Takuwa Y., Mitsui Y., Kobayashi M., Masaki T.
J. Biol. Chem. 264:14954-14959(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structural organization and chromosomal assignment of the gene encoding endothelin."
Bloch K.D., Friedrich S.P., Lee M.E., Eddy R.L., Shows T.B., Quertermous T.
J. Biol. Chem. 264:10851-10857(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Two preproendothelin 1 mRNAs transcribed by alternative promoters."
Benatti L., Bonecchi L., Cozzi L., Sarmientos P.
J. Clin. Invest. 91:1149-1156(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]NIEHS SNPs program
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-198.
[6]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-198.
Tissue: Pancreas.
[8]"The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."
Inoue A., Yanagisawa M., Kimura S., Kasuya Y., Miyauchi T., Goto K., Masaki T.
Proc. Natl. Acad. Sci. U.S.A. 86:2863-2867(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-67.
[9]"Proteolytic processing of big endothelin-3 by the kell blood group protein."
Lee S., Lin M., Mele A., Cao Y., Farmar J., Russo D., Redman C.
Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, CLEAVAGE BY KELL, IDENTIFICATION BY MASS SPECTROMETRY.
[10]"The signal peptide of human preproendothelin-1."
Fabbrini M.S., Valsasina B., Nitti G., Benatti L., Vitale A.
FEBS Lett. 286:91-94(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC PROCESSING.
[11]"Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
Bourgeois C., Robert B., Rebourcet R., Mondon F., Mignot T.-M., Duc-Goiran P., Ferre F.
J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[12]"Crystallization and preliminary X-ray analysis of human endothelin."
Wolff M., Day J., Greenwood A., Larson S., McPherson A.
Acta Crystallogr. B 48:239-240(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF ET-1.
[13]"The crystal structure of human endothelin."
Janes R.W., Peapus D.H., Wallace B.A.
Nat. Struct. Biol. 1:311-319(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF ET-1, DISULFIDE BONDS.
[14]"The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations."
Reily M.D., Dunbar J.B. Jr.
Biochem. Biophys. Res. Commun. 178:570-577(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF ET-1.
[15]"Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis."
Andersen N.H., Chen C., Marschner T.M., Krystek S.R. Jr., Bassolino D.A.
Biochemistry 31:1280-1295(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF ET-1.
[16]"Solution conformation of human big endothelin-1."
Donlan M.L., Brown F.K., Jeffs P.W.
J. Biomol. NMR 2:407-420(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 53-90.
[17]"A comparison of X-ray and NMR structures for human endothelin-1."
Wallace B.A., Janes R.W., Bassolino D.A., Krystek S.R. Jr.
Protein Sci. 4:75-83(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: COMPARISON OF NMR STRUCTURE WITH X-RAY STRUCTURE.
[18]"Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling."
Hewage C.M., Jiang L., Parkinson J.A., Ramage R., Sadler I.H.
J. Pept. Res. 53:223-233(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF ET1 AGONIST.
[19]"The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people."
Tiret L., Poirier O., Hallet V., McDonagh T.A., Morrison C., McMurray J.J., Dargie H.J., Arveiler D., Ruidavets J.B., Luc G., Evans A., Cambien F.
Hypertension 33:1169-1174(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ASN-198.
[20]"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ASN-198.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00749 mRNA. Translation: CAA68718.1.
M25380 expand/collapse EMBL AC list , M25377, M25378, M25379 Genomic DNA. Translation: AAA52407.1.
J05008 Genomic DNA. Translation: AAA52339.1.
S56805 mRNA. Translation: AAB25760.1.
AY434104 Genomic DNA. Translation: AAQ96600.1.
Z98050 Genomic DNA. Translation: CAB10846.1.
BC009720 mRNA. Translation: AAH09720.1.
M25549 Genomic DNA. Translation: AAA52338.1.
CCDSCCDS4522.1.
PIRANHU1. A36517.
RefSeqNP_001161791.1. NM_001168319.1.
NP_001946.3. NM_001955.4.
UniGeneHs.511899.
Hs.713645.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EDNX-ray2.18A53-73[»]
1EDPNMR-A53-69[»]
1T7HX-ray1.13A/B51-68[»]
1V6RNMR-A53-73[»]
ProteinModelPortalP05305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108228. 5 interactions.
IntActP05305. 5 interactions.
MINTMINT-1387120.
STRING9606.ENSP00000368683.

PTM databases

PhosphoSiteP05305.

Polymorphism databases

DMDM119610.

Proteomic databases

PaxDbP05305.
PRIDEP05305.

Protocols and materials databases

DNASU1906.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379375; ENSP00000368683; ENSG00000078401.
GeneID1906.
KEGGhsa:1906.
UCSCuc003nad.3. human.

Organism-specific databases

CTD1906.
GeneCardsGC06P012290.
H-InvDBHIX0033211.
HGNCHGNC:3176. EDN1.
HPACAB032500.
CAB037291.
HPA031976.
MIM131240. gene.
neXtProtNX_P05305.
Orphanet137888. Auriculocondylar syndrome.
PharmGKBPA27614.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46593.
HOGENOMHOG000231110.
HOVERGENHBG051441.
InParanoidP05305.
KOK16366.
OMAMDYFPMI.
OrthoDBEOG7PS1H7.
PhylomeDBP05305.
TreeFamTF333184.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP05305.
BgeeP05305.
CleanExHS_EDN1.
GenevestigatorP05305.

Family and domain databases

InterProIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSPR00365. ENDOTHELIN.
SMARTSM00272. END. 2 hits.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP05305.
GeneWikiEndothelin_1.
GenomeRNAi1906.
NextBio7757.
PMAP-CutDBP05305.
PROP05305.
SOURCESearch...

Entry information

Entry nameEDN1_HUMAN
AccessionPrimary (citable) accession number: P05305
Secondary accession number(s): Q96DA1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: July 9, 2014
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM