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P05305

- EDN1_HUMAN

UniProt

P05305 - EDN1_HUMAN

Protein

Endothelin-1

Gene

EDN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 164 (01 Oct 2014)
      Sequence version 1 (01 Nov 1988)
      Previous versions | rss
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    Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei73 – 742Cleavage; by KEL

    GO - Molecular functioni

    1. cytokine activity Source: BHF-UCL
    2. endothelin A receptor binding Source: BHF-UCL
    3. endothelin B receptor binding Source: BHF-UCL
    4. hormone activity Source: BHF-UCL
    5. protein binding Source: IntAct

    GO - Biological processi

    1. artery smooth muscle contraction Source: BHF-UCL
    2. body fluid secretion Source: Ensembl
    3. calcium-mediated signaling Source: BHF-UCL
    4. cartilage development Source: Ensembl
    5. cell-cell signaling Source: BHF-UCL
    6. cell growth Source: Ensembl
    7. cell surface receptor signaling pathway Source: BHF-UCL
    8. cellular response to interleukin-1 Source: Ensembl
    9. cellular response to tumor necrosis factor Source: Ensembl
    10. dorsal/ventral pattern formation Source: Ensembl
    11. epithelial fluid transport Source: Ensembl
    12. glucose transport Source: Ensembl
    13. G-protein coupled receptor signaling pathway Source: BHF-UCL
    14. heart development Source: Ensembl
    15. histamine secretion Source: Ensembl
    16. inositol phosphate-mediated signaling Source: BHF-UCL
    17. in utero embryonic development Source: Ensembl
    18. leukocyte activation Source: BHF-UCL
    19. maternal process involved in parturition Source: Ensembl
    20. membrane depolarization Source: Ensembl
    21. middle ear morphogenesis Source: Ensembl
    22. multicellular organismal aging Source: Ensembl
    23. negative regulation of blood coagulation Source: BHF-UCL
    24. negative regulation of cAMP biosynthetic process Source: Ensembl
    25. negative regulation of cellular protein metabolic process Source: BHF-UCL
    26. negative regulation of hormone secretion Source: Ensembl
    27. negative regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
    28. negative regulation of smooth muscle cell apoptotic process Source: Ensembl
    29. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    30. neural crest cell development Source: Ensembl
    31. nitric oxide transport Source: BHF-UCL
    32. patterning of blood vessels Source: Ensembl
    33. peptide hormone secretion Source: BHF-UCL
    34. phosphatidylinositol 3-kinase signaling Source: BHF-UCL
    35. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
    36. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
    37. positive regulation of cell migration Source: BHF-UCL
    38. positive regulation of cell proliferation Source: BHF-UCL
    39. positive regulation of cell size Source: BHF-UCL
    40. positive regulation of chemokine-mediated signaling pathway Source: BHF-UCL
    41. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
    42. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    43. positive regulation of endothelial cell migration Source: BHF-UCL
    44. positive regulation of heart rate Source: BHF-UCL
    45. positive regulation of hormone secretion Source: BHF-UCL
    46. positive regulation of JUN kinase activity Source: BHF-UCL
    47. positive regulation of MAP kinase activity Source: BHF-UCL
    48. positive regulation of mitosis Source: BHF-UCL
    49. positive regulation of neutrophil chemotaxis Source: Ensembl
    50. positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
    51. positive regulation of odontogenesis Source: Ensembl
    52. positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
    53. positive regulation of receptor biosynthetic process Source: BHF-UCL
    54. positive regulation of renal sodium excretion Source: Ensembl
    55. positive regulation of sarcomere organization Source: BHF-UCL
    56. positive regulation of smooth muscle cell proliferation Source: BHF-UCL
    57. positive regulation of smooth muscle contraction Source: Ensembl
    58. positive regulation of urine volume Source: Ensembl
    59. prostaglandin biosynthetic process Source: BHF-UCL
    60. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    61. protein kinase C deactivation Source: BHF-UCL
    62. regulation of pH Source: Ensembl
    63. regulation of sensory perception of pain Source: Ensembl
    64. regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
    65. regulation of vasoconstriction Source: InterPro
    66. respiratory gaseous exchange Source: Ensembl
    67. response to amino acid Source: Ensembl
    68. response to drug Source: Ensembl
    69. response to hypoxia Source: Ensembl
    70. response to lipopolysaccharide Source: Ensembl
    71. response to nicotine Source: Ensembl
    72. response to testosterone Source: Ensembl
    73. rhythmic excitation Source: Ensembl
    74. sensory perception of pain Source: Ensembl
    75. superoxide anion generation Source: Ensembl
    76. vasoconstriction Source: BHF-UCL
    77. vein smooth muscle contraction Source: BHF-UCL

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-1
    Alternative name(s):
    Preproendothelin-1
    Short name:
    PPET1
    Cleaved into the following 2 chains:
    Gene namesi
    Name:EDN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:3176. EDN1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. extracellular region Source: Reactome
    3. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Question mark ears, isolated (QME) [MIM:612798]: An auricular abnormality characterized by a cleft between the lobule and the lower part of the helix, sometimes accompanied by a prominent or deficient upper part of the helix, shallow skin dimple on the posterior surface of the ear, or transposition of the ear lobe/antitragus.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti64 – 641V → D in QME. 1 Publication
    VAR_071152
    Auriculocondylar syndrome 3 (ARCND3) [MIM:615706]: A craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771P → H in ARCND3. 1 Publication
    VAR_071153
    Natural varianti91 – 911K → E in ARCND3. 1 Publication
    VAR_071154

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi612798. phenotype.
    615706. phenotype.
    Orphaneti137888. Auriculocondylar syndrome.
    PharmGKBiPA27614.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Add
    BLAST
    Propeptidei18 – 5033PRO_0000008058Add
    BLAST
    Peptidei53 – 9038Big endothelin-1PRO_0000008059Add
    BLAST
    Peptidei53 – 7321Endothelin-1PRO_0000008060Add
    BLAST
    Propeptidei74 – 212139PRO_0000008061Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 671 Publication
    Disulfide bondi55 ↔ 631 Publication
    Disulfide bondi109 ↔ 123By similarity
    Disulfide bondi111 ↔ 119By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiP05305.
    PRIDEiP05305.

    PTM databases

    PhosphoSiteiP05305.

    Miscellaneous databases

    PMAP-CutDBP05305.

    Expressioni

    Tissue specificityi

    Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.1 Publication

    Gene expression databases

    ArrayExpressiP05305.
    BgeeiP05305.
    CleanExiHS_EDN1.
    GenevestigatoriP05305.

    Organism-specific databases

    HPAiCAB032500.
    CAB037291.
    HPA031976.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EDNRAP251012EBI-715181,EBI-6624559
    EDNRBP245302EBI-715181,EBI-6624656

    Protein-protein interaction databases

    BioGridi108228. 5 interactions.
    IntActiP05305. 5 interactions.
    MINTiMINT-1387120.
    STRINGi9606.ENSP00000368683.

    Structurei

    Secondary structure

    1
    212
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi53 – 564
    Beta strandi57 – 593
    Helixi61 – 677
    Turni68 – 703

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EDNX-ray2.18A53-73[»]
    1EDPNMR-A53-69[»]
    1T7HX-ray1.13A/B51-68[»]
    1V6RNMR-A53-73[»]
    ProteinModelPortaliP05305.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP05305.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni109 – 12315Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46593.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051441.
    InParanoidiP05305.
    KOiK16366.
    OMAiMDYFPMI.
    OrthoDBiEOG7PS1H7.
    PhylomeDBiP05305.
    TreeFamiTF333184.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05305-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS    50
    KRCSCSSLMD KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT 100
    KATDRENRCQ CASQKDKKCW NFCQAGKELR AEDIMEKDWN NHKKGKDCSK 150
    LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE TMRNSVKSSF HDPKLKGKPS 200
    RERYVTHNRA HW 212
    Length:212
    Mass (Da):24,425
    Last modified:November 1, 1988 - v1
    Checksum:iE2DA0EB86755BC3D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti64 – 641V → D in QME. 1 Publication
    VAR_071152
    Natural varianti77 – 771P → H in ARCND3. 1 Publication
    VAR_071153
    Natural varianti91 – 911K → E in ARCND3. 1 Publication
    VAR_071154
    Natural varianti186 – 1861V → I.
    Corresponds to variant rs6413478 [ dbSNP | Ensembl ].
    VAR_048933
    Natural varianti198 – 1981K → N Polymorphism associated with HDL cholesterol levels is some populations and in a sex-specific manner. 6 Publications
    Corresponds to variant rs5370 [ dbSNP | Ensembl ].
    VAR_014188

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00749 mRNA. Translation: CAA68718.1.
    M25380
    , M25377, M25378, M25379 Genomic DNA. Translation: AAA52407.1.
    J05008 Genomic DNA. Translation: AAA52339.1.
    S56805 mRNA. Translation: AAB25760.1.
    AY434104 Genomic DNA. Translation: AAQ96600.1.
    Z98050 Genomic DNA. Translation: CAB10846.1.
    BC009720 mRNA. Translation: AAH09720.1.
    M25549 Genomic DNA. Translation: AAA52338.1.
    CCDSiCCDS4522.1.
    PIRiA36517. ANHU1.
    RefSeqiNP_001161791.1. NM_001168319.1.
    NP_001946.3. NM_001955.4.
    UniGeneiHs.511899.
    Hs.713645.

    Genome annotation databases

    EnsembliENST00000379375; ENSP00000368683; ENSG00000078401.
    GeneIDi1906.
    KEGGihsa:1906.
    UCSCiuc003nad.3. human.

    Polymorphism databases

    DMDMi119610.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs
    R&D Systems' cytokine source book: Endothelin-1
    Wikipedia

    Endothelin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00749 mRNA. Translation: CAA68718.1 .
    M25380
    , M25377 , M25378 , M25379 Genomic DNA. Translation: AAA52407.1 .
    J05008 Genomic DNA. Translation: AAA52339.1 .
    S56805 mRNA. Translation: AAB25760.1 .
    AY434104 Genomic DNA. Translation: AAQ96600.1 .
    Z98050 Genomic DNA. Translation: CAB10846.1 .
    BC009720 mRNA. Translation: AAH09720.1 .
    M25549 Genomic DNA. Translation: AAA52338.1 .
    CCDSi CCDS4522.1.
    PIRi A36517. ANHU1.
    RefSeqi NP_001161791.1. NM_001168319.1.
    NP_001946.3. NM_001955.4.
    UniGenei Hs.511899.
    Hs.713645.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EDN X-ray 2.18 A 53-73 [» ]
    1EDP NMR - A 53-69 [» ]
    1T7H X-ray 1.13 A/B 51-68 [» ]
    1V6R NMR - A 53-73 [» ]
    ProteinModelPortali P05305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108228. 5 interactions.
    IntActi P05305. 5 interactions.
    MINTi MINT-1387120.
    STRINGi 9606.ENSP00000368683.

    PTM databases

    PhosphoSitei P05305.

    Polymorphism databases

    DMDMi 119610.

    Proteomic databases

    PaxDbi P05305.
    PRIDEi P05305.

    Protocols and materials databases

    DNASUi 1906.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379375 ; ENSP00000368683 ; ENSG00000078401 .
    GeneIDi 1906.
    KEGGi hsa:1906.
    UCSCi uc003nad.3. human.

    Organism-specific databases

    CTDi 1906.
    GeneCardsi GC06P012290.
    H-InvDB HIX0033211.
    HGNCi HGNC:3176. EDN1.
    HPAi CAB032500.
    CAB037291.
    HPA031976.
    MIMi 131240. gene.
    612798. phenotype.
    615706. phenotype.
    neXtProti NX_P05305.
    Orphaneti 137888. Auriculocondylar syndrome.
    PharmGKBi PA27614.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46593.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051441.
    InParanoidi P05305.
    KOi K16366.
    OMAi MDYFPMI.
    OrthoDBi EOG7PS1H7.
    PhylomeDBi P05305.
    TreeFami TF333184.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P05305.
    GeneWikii Endothelin_1.
    GenomeRNAii 1906.
    NextBioi 7757.
    PMAP-CutDB P05305.
    PROi P05305.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P05305.
    Bgeei P05305.
    CleanExi HS_EDN1.
    Genevestigatori P05305.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin."
      Itoh Y., Yanagisawa M., Ohkubo S., Kimura C., Kosaka T., Inoue A., Ishida N., Mitsui Y., Onda H., Fujino M., Masaki T.
      FEBS Lett. 231:440-444(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression."
      Inoue A., Yanagisawa M., Takuwa Y., Mitsui Y., Kobayashi M., Masaki T.
      J. Biol. Chem. 264:14954-14959(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Structural organization and chromosomal assignment of the gene encoding endothelin."
      Bloch K.D., Friedrich S.P., Lee M.E., Eddy R.L., Shows T.B., Quertermous T.
      J. Biol. Chem. 264:10851-10857(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Two preproendothelin 1 mRNAs transcribed by alternative promoters."
      Benatti L., Bonecchi L., Cozzi L., Sarmientos P.
      J. Clin. Invest. 91:1149-1156(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. NIEHS SNPs program
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-198.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-198.
      Tissue: Pancreas.
    8. "The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."
      Inoue A., Yanagisawa M., Kimura S., Kasuya Y., Miyauchi T., Goto K., Masaki T.
      Proc. Natl. Acad. Sci. U.S.A. 86:2863-2867(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-67.
    9. "Proteolytic processing of big endothelin-3 by the kell blood group protein."
      Lee S., Lin M., Mele A., Cao Y., Farmar J., Russo D., Redman C.
      Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, CLEAVAGE BY KELL, IDENTIFICATION BY MASS SPECTROMETRY.
    10. Cited for: PROTEOLYTIC PROCESSING.
    11. "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
      Bourgeois C., Robert B., Rebourcet R., Mondon F., Mignot T.-M., Duc-Goiran P., Ferre F.
      J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    12. "Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol."
      Pare G., Serre D., Brisson D., Anand S.S., Montpetit A., Tremblay G., Engert J.C., Hudson T.J., Gaudet D.
      Am. J. Hum. Genet. 80:673-682(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ASN-198, CHARACTERIZATION OF VARIANT ASN-198.
    13. "Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease."
      Wiltshire S., Powell B.L., Jennens M., McCaskie P.A., Carter K.W., Palmer L.J., Thompson P.L., McQuillan B.M., Hung J., Beilby J.P.
      Hum. Genet. 123:307-313(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ASN-198.
    14. "Crystallization and preliminary X-ray analysis of human endothelin."
      Wolff M., Day J., Greenwood A., Larson S., McPherson A.
      Acta Crystallogr. B 48:239-240(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF ET-1.
    15. Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF ET-1, DISULFIDE BONDS.
    16. "The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations."
      Reily M.D., Dunbar J.B. Jr.
      Biochem. Biophys. Res. Commun. 178:570-577(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF ET-1.
    17. "Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis."
      Andersen N.H., Chen C., Marschner T.M., Krystek S.R. Jr., Bassolino D.A.
      Biochemistry 31:1280-1295(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF ET-1.
    18. "Solution conformation of human big endothelin-1."
      Donlan M.L., Brown F.K., Jeffs P.W.
      J. Biomol. NMR 2:407-420(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 53-90.
    19. "A comparison of X-ray and NMR structures for human endothelin-1."
      Wallace B.A., Janes R.W., Bassolino D.A., Krystek S.R. Jr.
      Protein Sci. 4:75-83(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPARISON OF NMR STRUCTURE WITH X-RAY STRUCTURE.
    20. "Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling."
      Hewage C.M., Jiang L., Parkinson J.A., Ramage R., Sadler I.H.
      J. Pept. Res. 53:223-233(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF ET1 AGONIST.
    21. "The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people."
      Tiret L., Poirier O., Hallet V., McDonagh T.A., Morrison C., McMurray J.J., Dargie H.J., Arveiler D., Ruidavets J.B., Luc G., Evans A., Cambien F.
      Hypertension 33:1169-1174(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ASN-198.
    22. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
      Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
      Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ASN-198.
    23. Cited for: VARIANT QME ASP-64, VARIANTS ARCND3 HIS-77 AND GLU-91.

    Entry informationi

    Entry nameiEDN1_HUMAN
    AccessioniPrimary (citable) accession number: P05305
    Secondary accession number(s): Q96DA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 164 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3