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Protein

Modification methylase DdeI

Gene

ddeIM

Organism
Desulfomicrobium norvegicum (strain DSM 1741 / NCIMB 8310) (Desulfovibrio baculatus (strain Norway 4)) (Desulfovibrio desulfuricans (strain Norway 4))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CTNAG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the DdeI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3357 M.DdeI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase DdeI (EC:2.1.1.37)
Short name:
M.DdeI
Alternative name(s):
Cytosine-specific methyltransferase DdeI
Gene namesi
Name:ddeIM
Synonyms:ddeM
OrganismiDesulfomicrobium norvegicum (strain DSM 1741 / NCIMB 8310) (Desulfovibrio baculatus (strain Norway 4)) (Desulfovibrio desulfuricans (strain Norway 4))
Taxonomic identifieri52561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfomicrobiaceaeDesulfomicrobium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878731 – 415Modification methylase DdeIAdd BLAST415

Structurei

3D structure databases

ProteinModelPortaliP05302
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 373SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST373

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P05302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIIDLFAGC GGFSHGFKMA GYNSILAIEK DLWASQTYSF NNPNVSVITE
60 70 80 90 100
DITTLDPGDL KISVSDVDGI IGGPPCQGFS LSGNRDQKDP RNSLFVDFVR
110 120 130 140 150
FVKFFSPKFF VMENVLGILS MKTKSRQYVK DIIAEEFSNV GYKVCVIILN
160 170 180 190 200
ACDYGVPQSR QRVFFIGLKS DRPLNQQILT PPSKVIESEY TSLEEAISDL
210 220 230 240 250
PVIEAGEGGE VQDYPVAPRN KYQENMRKGS TCVYNHVAMR HTQRLVDRFA
260 270 280 290 300
AIKFGQSVKH VSEEHSQRKR GDANSISGKV FSQNNMRPYP YKPCPTVAAS
310 320 330 340 350
FQSNFIHPFY NRNFTAREGA RIQSFPDTYI FQGKRTTMSW EKHLSQYQQI
360 370 380 390 400
GNAVPPLLAQ ALAERISWYF ENINLINDSN VSIKRMVQRS FMSQLNLENN
410
VNVRQDDNYD KVHSF
Length:415
Mass (Da):47,081
Last modified:November 1, 1988 - v1
Checksum:i34DF5968E0414EED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00449 Genomic DNA Translation: CAA68505.1

Similar proteinsi

Entry informationi

Entry nameiMTD1_DESNO
AccessioniPrimary (citable) accession number: P05302
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health