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P05300

- LAMP1_CHICK

UniProt

P05300 - LAMP1_CHICK

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Protein

Lysosome-associated membrane glycoprotein 1

Gene
LAMP1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
Lysosome membrane glycoprotein LEP100
Gene namesi
Name:LAMP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 379361Lumenal Reviewed predictionAdd
BLAST
Transmembranei380 – 40324Helical; Reviewed predictionAdd
BLAST
Topological domaini404 – 41411Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosomal membrane Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 414396Lysosome-associated membrane glycoprotein 1PRO_0000017109Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 67 By similarity
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi108 – 1081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi142 ↔ 178 By similarity
Glycosylationi154 – 1541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi159 – 1591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi228 ↔ 266 By similarity
Glycosylationi238 – 2381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi259 – 2591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi289 – 2891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi319 – 3191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi335 ↔ 372 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05300.
PRIDEiP05300.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029583.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 181163First lumenal domainAdd
BLAST
Regioni182 – 22443HingeAdd
BLAST
Regioni225 – 379155Second lumenal domainAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301998.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP05300.
KOiK06528.
PhylomeDBiP05300.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05300-1 [UniParc]FASTAAdd to Basket

« Hide

MGGAARAVLL GFLQASSSFD VRDSTGKVCI IANLTVAFSV EYKSSGQKQF    50
AHFFLPQNAT SQSHSSCGEG NTSHPILALS FGAGHLISLN FSKTLDKYQV 100
EELTFHYNLS DETLFPNATE GKVMVATQKS VIQARIGTEY RCINSKYVRM 150
KHVNITFSNV TLEAYPTNDT FSANKTECRE DMVSTTTVAP TTPKHATSQV 200
PTTSPAPTAA PSSPAVGKYN VTGANGTCVL ASMGLQLNIT YVKKDEKMGL 250
DLLNFIPHNT SASGMCESTS AFLNLAFEKT KITFHFVLNA SSEKFFLQGV 300
NVSTTLPSEA KAPTFEASND SMSESRATVG NSYKCSAEEN FQVTDKALVN 350
VFNVQVQAFK VDGDKFGAME ECQLDENNML IPIIVGAALA GLVLIVLIAY 400
LIGRKRSHAG YQTI 414
Length:414
Mass (Da):44,670
Last modified:November 1, 1988 - v1
Checksum:i3D18941BAEA9372C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31G → R in AAA65947. 1 Publication
Sequence conflicti148 – 1481V → I in AAA65947. 1 Publication
Sequence conflicti325 – 3251S → L in AAA65947. 1 Publication
Sequence conflicti369 – 3691M → V in AAA65947. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07775 mRNA. Translation: CAA30601.1.
M59365
, M59361, M59362, M59363, M59364 Genomic DNA. Translation: AAA65947.1.
PIRiA38331.
RefSeqiNP_990614.1. NM_205283.1.
UniGeneiGga.4173.

Genome annotation databases

GeneIDi396220.
KEGGigga:396220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07775 mRNA. Translation: CAA30601.1 .
M59365
, M59361 , M59362 , M59363 , M59364 Genomic DNA. Translation: AAA65947.1 .
PIRi A38331.
RefSeqi NP_990614.1. NM_205283.1.
UniGenei Gga.4173.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000029583.

Proteomic databases

PaxDbi P05300.
PRIDEi P05300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396220.
KEGGi gga:396220.

Organism-specific databases

CTDi 3916.

Phylogenomic databases

eggNOGi NOG301998.
HOGENOMi HOG000230942.
HOVERGENi HBG052303.
InParanoidi P05300.
KOi K06528.
PhylomeDBi P05300.

Miscellaneous databases

NextBioi 20816272.
PROi P05300.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of LEP100, a glycoprotein that shuttles between lysosomes and the plasma membrane, deduced from the nucleotide sequence of the encoding cDNA."
    Fambrough D.M., Takeyasu K., Lippincott-Schwarz J., Siegel N.R.
    J. Cell Biol. 106:61-67(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Structure of a gene for a lysosomal membrane glycoprotein (LEP100). Housekeeping gene with unexpected exon organization."
    Zot A.S., Fambrough D.M.
    J. Biol. Chem. 265:20988-20995(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLAMP1_CHICK
AccessioniPrimary (citable) accession number: P05300
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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