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P05300

- LAMP1_CHICK

UniProt

P05300 - LAMP1_CHICK

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Protein

Lysosome-associated membrane glycoprotein 1

Gene

LAMP1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
Lysosome membrane glycoprotein LEP100
Gene namesi
Name:LAMP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosome Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 414396Lysosome-associated membrane glycoprotein 1PRO_0000017109Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 67PROSITE-ProRule annotation
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi142 ↔ 178PROSITE-ProRule annotation
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi228 ↔ 266PROSITE-ProRule annotation
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi335 ↔ 372PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05300.
PRIDEiP05300.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029583.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 379361LumenalSequence AnalysisAdd
BLAST
Topological domaini404 – 41411CytoplasmicPROSITE-ProRule annotationAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei380 – 40324HelicalPROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 181163First lumenal domainAdd
BLAST
Regioni182 – 22443HingeAdd
BLAST
Regioni225 – 379155Second lumenal domainAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301998.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP05300.
KOiK06528.
PhylomeDBiP05300.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05300-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGAARAVLL GFLQASSSFD VRDSTGKVCI IANLTVAFSV EYKSSGQKQF
60 70 80 90 100
AHFFLPQNAT SQSHSSCGEG NTSHPILALS FGAGHLISLN FSKTLDKYQV
110 120 130 140 150
EELTFHYNLS DETLFPNATE GKVMVATQKS VIQARIGTEY RCINSKYVRM
160 170 180 190 200
KHVNITFSNV TLEAYPTNDT FSANKTECRE DMVSTTTVAP TTPKHATSQV
210 220 230 240 250
PTTSPAPTAA PSSPAVGKYN VTGANGTCVL ASMGLQLNIT YVKKDEKMGL
260 270 280 290 300
DLLNFIPHNT SASGMCESTS AFLNLAFEKT KITFHFVLNA SSEKFFLQGV
310 320 330 340 350
NVSTTLPSEA KAPTFEASND SMSESRATVG NSYKCSAEEN FQVTDKALVN
360 370 380 390 400
VFNVQVQAFK VDGDKFGAME ECQLDENNML IPIIVGAALA GLVLIVLIAY
410
LIGRKRSHAG YQTI
Length:414
Mass (Da):44,670
Last modified:November 1, 1988 - v1
Checksum:i3D18941BAEA9372C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31G → R in AAA65947. (PubMed:2250003)Curated
Sequence conflicti148 – 1481V → I in AAA65947. (PubMed:2250003)Curated
Sequence conflicti325 – 3251S → L in AAA65947. (PubMed:2250003)Curated
Sequence conflicti369 – 3691M → V in AAA65947. (PubMed:2250003)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07775 mRNA. Translation: CAA30601.1.
M59365
, M59361, M59362, M59363, M59364 Genomic DNA. Translation: AAA65947.1.
PIRiA38331.
RefSeqiNP_990614.1. NM_205283.1.
UniGeneiGga.4173.

Genome annotation databases

GeneIDi396220.
KEGGigga:396220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07775 mRNA. Translation: CAA30601.1 .
M59365
, M59361 , M59362 , M59363 , M59364 Genomic DNA. Translation: AAA65947.1 .
PIRi A38331.
RefSeqi NP_990614.1. NM_205283.1.
UniGenei Gga.4173.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000029583.

Proteomic databases

PaxDbi P05300.
PRIDEi P05300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396220.
KEGGi gga:396220.

Organism-specific databases

CTDi 3916.

Phylogenomic databases

eggNOGi NOG301998.
HOGENOMi HOG000230942.
HOVERGENi HBG052303.
InParanoidi P05300.
KOi K06528.
PhylomeDBi P05300.

Miscellaneous databases

NextBioi 20816272.
PROi P05300.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of LEP100, a glycoprotein that shuttles between lysosomes and the plasma membrane, deduced from the nucleotide sequence of the encoding cDNA."
    Fambrough D.M., Takeyasu K., Lippincott-Schwarz J., Siegel N.R.
    J. Cell Biol. 106:61-67(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Structure of a gene for a lysosomal membrane glycoprotein (LEP100). Housekeeping gene with unexpected exon organization."
    Zot A.S., Fambrough D.M.
    J. Biol. Chem. 265:20988-20995(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLAMP1_CHICK
AccessioniPrimary (citable) accession number: P05300
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3