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P05300 (LAMP1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 1

Short name=LAMP-1
Short name=Lysosome-associated membrane protein 1
Alternative name(s):
Lysosome membrane glycoprotein LEP100
Gene names
Name:LAMP1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Sequence similarities

Belongs to the LAMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 414396Lysosome-associated membrane glycoprotein 1
PRO_0000017109

Regions

Topological domain19 – 379361Lumenal Potential
Transmembrane380 – 40324Helical; Potential
Topological domain404 – 41411Cytoplasmic Potential
Region19 – 181163First lumenal domain
Region182 – 22443Hinge
Region225 – 379155Second lumenal domain

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1081N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation1741N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation2381N-linked (GlcNAc...) Potential
Glycosylation2591N-linked (GlcNAc...) Potential
Glycosylation2891N-linked (GlcNAc...) Potential
Glycosylation3011N-linked (GlcNAc...) Potential
Glycosylation3191N-linked (GlcNAc...) Potential
Disulfide bond29 ↔ 67 By similarity
Disulfide bond142 ↔ 178 By similarity
Disulfide bond228 ↔ 266 By similarity
Disulfide bond335 ↔ 372 By similarity

Experimental info

Sequence conflict31G → R in AAA65947. Ref.2
Sequence conflict1481V → I in AAA65947. Ref.2
Sequence conflict3251S → L in AAA65947. Ref.2
Sequence conflict3691M → V in AAA65947. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P05300 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: 3D18941BAEA9372C

FASTA41444,670
        10         20         30         40         50         60 
MGGAARAVLL GFLQASSSFD VRDSTGKVCI IANLTVAFSV EYKSSGQKQF AHFFLPQNAT 

        70         80         90        100        110        120 
SQSHSSCGEG NTSHPILALS FGAGHLISLN FSKTLDKYQV EELTFHYNLS DETLFPNATE 

       130        140        150        160        170        180 
GKVMVATQKS VIQARIGTEY RCINSKYVRM KHVNITFSNV TLEAYPTNDT FSANKTECRE 

       190        200        210        220        230        240 
DMVSTTTVAP TTPKHATSQV PTTSPAPTAA PSSPAVGKYN VTGANGTCVL ASMGLQLNIT 

       250        260        270        280        290        300 
YVKKDEKMGL DLLNFIPHNT SASGMCESTS AFLNLAFEKT KITFHFVLNA SSEKFFLQGV 

       310        320        330        340        350        360 
NVSTTLPSEA KAPTFEASND SMSESRATVG NSYKCSAEEN FQVTDKALVN VFNVQVQAFK 

       370        380        390        400        410 
VDGDKFGAME ECQLDENNML IPIIVGAALA GLVLIVLIAY LIGRKRSHAG YQTI 

« Hide

References

[1]"Structure of LEP100, a glycoprotein that shuttles between lysosomes and the plasma membrane, deduced from the nucleotide sequence of the encoding cDNA."
Fambrough D.M., Takeyasu K., Lippincott-Schwarz J., Siegel N.R.
J. Cell Biol. 106:61-67(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Structure of a gene for a lysosomal membrane glycoprotein (LEP100). Housekeeping gene with unexpected exon organization."
Zot A.S., Fambrough D.M.
J. Biol. Chem. 265:20988-20995(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07775 mRNA. Translation: CAA30601.1.
M59365 expand/collapse EMBL AC list , M59361, M59362, M59363, M59364 Genomic DNA. Translation: AAA65947.1.
PIRA38331.
RefSeqNP_990614.1. NM_205283.1.
UniGeneGga.4173.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000029583.

Proteomic databases

PaxDbP05300.
PRIDEP05300.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396220.
KEGGgga:396220.

Organism-specific databases

CTD3916.

Phylogenomic databases

eggNOGNOG301998.
HOGENOMHOG000230942.
HOVERGENHBG052303.
InParanoidP05300.
KOK06528.
PhylomeDBP05300.

Family and domain databases

InterProIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816272.
PROP05300.

Entry information

Entry nameLAMP1_CHICK
AccessionPrimary (citable) accession number: P05300
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families