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Protein

Lysosome-associated membrane glycoprotein 1

Gene

LAMP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
Lysosome membrane glycoprotein LEP100
Gene namesi
Name:LAMP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 379LumenalSequence analysisAdd BLAST361
Transmembranei380 – 403HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini404 – 414CytoplasmicPROSITE-ProRule annotationAdd BLAST11

GO - Cellular componenti

  • endosome membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB
  • membrane Source: AgBase
  • plasma membrane Source: UniProtKB

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001710919 – 414Lysosome-associated membrane glycoprotein 1Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 67PROSITE-ProRule annotation
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi142 ↔ 178PROSITE-ProRule annotation
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi228 ↔ 266PROSITE-ProRule annotation
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi335 ↔ 372PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05300.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029583.

Structurei

3D structure databases

SMRiP05300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 181First lumenal domainAdd BLAST163
Regioni182 – 224HingeAdd BLAST43
Regioni225 – 379Second lumenal domainAdd BLAST155

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP05300.
KOiK06528.
PhylomeDBiP05300.

Family and domain databases

InterProiView protein in InterPro
IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiView protein in Pfam
PF01299. Lamp. 1 hit.
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiView protein in PROSITE
PS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAARAVLL GFLQASSSFD VRDSTGKVCI IANLTVAFSV EYKSSGQKQF
60 70 80 90 100
AHFFLPQNAT SQSHSSCGEG NTSHPILALS FGAGHLISLN FSKTLDKYQV
110 120 130 140 150
EELTFHYNLS DETLFPNATE GKVMVATQKS VIQARIGTEY RCINSKYVRM
160 170 180 190 200
KHVNITFSNV TLEAYPTNDT FSANKTECRE DMVSTTTVAP TTPKHATSQV
210 220 230 240 250
PTTSPAPTAA PSSPAVGKYN VTGANGTCVL ASMGLQLNIT YVKKDEKMGL
260 270 280 290 300
DLLNFIPHNT SASGMCESTS AFLNLAFEKT KITFHFVLNA SSEKFFLQGV
310 320 330 340 350
NVSTTLPSEA KAPTFEASND SMSESRATVG NSYKCSAEEN FQVTDKALVN
360 370 380 390 400
VFNVQVQAFK VDGDKFGAME ECQLDENNML IPIIVGAALA GLVLIVLIAY
410
LIGRKRSHAG YQTI
Length:414
Mass (Da):44,670
Last modified:November 1, 1988 - v1
Checksum:i3D18941BAEA9372C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3G → R in AAA65947 (PubMed:2250003).Curated1
Sequence conflicti148V → I in AAA65947 (PubMed:2250003).Curated1
Sequence conflicti325S → L in AAA65947 (PubMed:2250003).Curated1
Sequence conflicti369M → V in AAA65947 (PubMed:2250003).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07775 mRNA. Translation: CAA30601.1.
M59365
, M59361, M59362, M59363, M59364 Genomic DNA. Translation: AAA65947.1.
PIRiA38331.
RefSeqiNP_990614.2. NM_205283.2.
UniGeneiGga.4173.

Genome annotation databases

GeneIDi396220.
KEGGigga:396220.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLAMP1_CHICK
AccessioniPrimary (citable) accession number: P05300
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: July 5, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families