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Protein

Interleukin-6

Gene

IL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • growth factor activity Source: BHF-UCL
  • interleukin-6 receptor binding Source: UniProtKB

GO - Biological processi

  • acute-phase response Source: BHF-UCL
  • aging Source: Ensembl
  • bone remodeling Source: Ensembl
  • branching involved in salivary gland morphogenesis Source: Ensembl
  • cell growth Source: Ensembl
  • cell redox homeostasis Source: Ensembl
  • cellular response to dexamethasone stimulus Source: Ensembl
  • cellular response to hydrogen peroxide Source: BHF-UCL
  • cellular response to interleukin-1 Source: Ensembl
  • cellular response to interleukin-6 Source: BHF-UCL
  • cellular response to lipopolysaccharide Source: MGI
  • cellular response to tumor necrosis factor Source: Ensembl
  • cytokine-mediated signaling pathway Source: BHF-UCL
  • defense response to Gram-negative bacterium Source: BHF-UCL
  • defense response to Gram-positive bacterium Source: BHF-UCL
  • defense response to protozoan Source: Ensembl
  • defense response to virus Source: BHF-UCL
  • endocrine pancreas development Source: BHF-UCL
  • epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  • glucagon secretion Source: BHF-UCL
  • glucose homeostasis Source: Ensembl
  • hepatic immune response Source: BHF-UCL
  • humoral immune response Source: BHF-UCL
  • inflammatory response Source: BHF-UCL
  • interleukin-6-mediated signaling pathway Source: BHF-UCL
  • monocyte chemotaxis Source: BHF-UCL
  • muscle cell cellular homeostasis Source: Ensembl
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cell proliferation Source: ProtInc
  • negative regulation of chemokine biosynthetic process Source: UniProtKB
  • negative regulation of collagen biosynthetic process Source: BHF-UCL
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  • negative regulation of cytokine secretion Source: Ensembl
  • negative regulation of fat cell differentiation Source: BHF-UCL
  • negative regulation of gluconeogenesis Source: Ensembl
  • negative regulation of hormone secretion Source: Ensembl
  • negative regulation of lipid storage Source: BHF-UCL
  • negative regulation of muscle organ development Source: Ensembl
  • negative regulation of neuron death Source: Ensembl
  • negative regulation of protein kinase activity Source: Ensembl
  • neuron projection development Source: BHF-UCL
  • neutrophil apoptotic process Source: UniProtKB
  • neutrophil mediated immunity Source: BHF-UCL
  • platelet activation Source: BHF-UCL
  • positive regulation of acute inflammatory response Source: BHF-UCL
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of B cell activation Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of chemokine production Source: BHF-UCL
  • positive regulation of DNA replication Source: Ensembl
  • positive regulation of epithelial cell proliferation Source: Ensembl
  • positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  • positive regulation of immunoglobulin secretion Source: BHF-UCL
  • positive regulation of interleukin-6 production Source: BHF-UCL
  • positive regulation of JAK-STAT cascade Source: BHF-UCL
  • positive regulation of leukocyte chemotaxis Source: BHF-UCL
  • positive regulation of MAPK cascade Source: BHF-UCL
  • positive regulation of neuron differentiation Source: Ensembl
  • positive regulation of nitric oxide biosynthetic process Source: Ensembl
  • positive regulation of osteoblast differentiation Source: BHF-UCL
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of protein import into nucleus, translocation Source: Ensembl
  • positive regulation of protein kinase B signaling Source: Ensembl
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  • positive regulation of smooth muscle cell proliferation Source: BHF-UCL
  • positive regulation of STAT protein import into nucleus Source: BHF-UCL
  • positive regulation of T cell proliferation Source: BHF-UCL
  • positive regulation of T-helper 2 cell differentiation Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of translation Source: UniProtKB
  • positive regulation of transmission of nerve impulse Source: Ensembl
  • positive regulation of type B pancreatic cell apoptotic process Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
  • regulation of angiogenesis Source: BHF-UCL
  • regulation of cell shape Source: Ensembl
  • regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  • regulation of vascular endothelial growth factor production Source: BHF-UCL
  • response to amino acid Source: Ensembl
  • response to antibiotic Source: Ensembl
  • response to auditory stimulus Source: Ensembl
  • response to caffeine Source: Ensembl
  • response to calcium ion Source: Ensembl
  • response to cold Source: Ensembl
  • response to drug Source: Ensembl
  • response to electrical stimulus Source: Ensembl
  • response to glucocorticoid Source: BHF-UCL
  • response to heat Source: Ensembl
  • response to insulin Source: Ensembl
  • response to nutrient levels Source: Ensembl
  • response to peptidoglycan Source: BHF-UCL
  • T-helper 17 cell lineage commitment Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Acute phase

Enzyme and pathway databases

ReactomeiREACT_1183. ERK2 activation.
REACT_1391. ERK1 activation.
REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
REACT_27307. Interleukin-6 signaling.
SignaLinkiP05231.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Alternative name(s):
B-cell stimulatory factor 2
Short name:
BSF-2
CTL differentiation factor
Short name:
CDF
Hybridoma growth factor
Interferon beta-2
Short name:
IFN-beta-2
Gene namesi
Name:IL6
Synonyms:IFNB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:6018. IL6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • external side of plasma membrane Source: Ensembl
  • extracellular region Source: Reactome
  • extracellular space Source: BHF-UCL
  • interleukin-6 receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Rheumatoid arthritis systemic juvenile (RASJ)

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionAn inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

See also OMIM:604302

A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi173 – 1731A → V: Almost no loss of activity. 1 Publication
Mutagenesisi185 – 1851W → R: No loss of activity. 1 Publication
Mutagenesisi204 – 2041S → P: 87% loss of activity. 1 Publication
Mutagenesisi210 – 2101R → K, E, Q, T, A or P: Loss of activity. 1 Publication
Mutagenesisi212 – 2121M → T, N, S or R: Loss of activity. 1 Publication

Organism-specific databases

MIMi148000. phenotype.
604302. phenotype.
Orphaneti206. Crohn disease.
85414. Systemic-onset juvenile idiopathic arthritis.
PharmGKBiPA198.

Chemistry

DrugBankiDB01404. Ginseng.

Polymorphism and mutation databases

BioMutaiIL6.
DMDMi124347.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29293 PublicationsAdd
BLAST
Chaini30 – 212183Interleukin-6PRO_0000015582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 ↔ 781 Publication
Glycosylationi73 – 731N-linked (GlcNAc...)1 Publication
Disulfide bondi101 ↔ 1111 Publication

Post-translational modificationi

N- and O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP05231.
PaxDbiP05231.
PRIDEiP05231.

PTM databases

PhosphoSiteiP05231.

Miscellaneous databases

PMAP-CutDBP05231.

Expressioni

Gene expression databases

BgeeiP05231.
CleanExiHS_IL6.
ExpressionAtlasiP05231. baseline and differential.
GenevisibleiP05231. HS.

Organism-specific databases

HPAiCAB023406.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IL6RP088875EBI-720533,EBI-299383
ZBTB16Q055162EBI-720533,EBI-711925

Protein-protein interaction databases

BioGridi109783. 2 interactions.
DIPiDIP-482N.
IntActiP05231. 5 interactions.
MINTiMINT-190042.
STRINGi9606.ENSP00000258743.

Structurei

Secondary structure

1
212
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi49 – 7527Combined sources
Beta strandi76 – 794Combined sources
Turni81 – 833Combined sources
Helixi84 – 874Combined sources
Helixi97 – 993Combined sources
Beta strandi102 – 1054Combined sources
Helixi108 – 13225Combined sources
Beta strandi134 – 1363Combined sources
Helixi137 – 15721Combined sources
Beta strandi159 – 1613Combined sources
Helixi169 – 18012Combined sources
Helixi184 – 20926Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ALUX-ray1.90A28-212[»]
1IL6NMR-A28-212[»]
1N2Qmodel-E/F30-212[»]
1P9MX-ray3.65B29-212[»]
2IL6NMR-A28-212[»]
4CNIX-ray2.20C/D42-212[»]
4J4LX-ray2.30C/D47-212[»]
4NI7X-ray2.40A28-212[»]
4NI9X-ray2.55A/C28-212[»]
4O9HX-ray2.42A28-212[»]
ProteinModelPortaliP05231.
SMRiP05231. Positions 42-212.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05231.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG48083.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiP05231.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG7QG453.
PhylomeDBiP05231.
TreeFamiTF335984.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR003573. IL-6/IL-23/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS
60 70 80 90 100
ERIDKQIRYI LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG
110 120 130 140 150
CFQSGFNEET CLVKIITGLL EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL
160 170 180 190 200
IQFLQKKAKN LDAITTPDPT TNASLLTKLQ AQNQWLQDMT THLILRSFKE
210
FLQSSLRALR QM
Length:212
Mass (Da):23,718
Last modified:August 13, 1987 - v1
Checksum:i1F1ED1FE1B734079
GO

Polymorphismi

Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321P → S.1 Publication
Corresponds to variant rs2069830 [ dbSNP | Ensembl ].
VAR_013075
Natural varianti162 – 1621D → E.
Corresponds to variant rs13306435 [ dbSNP | Ensembl ].
VAR_029266
Natural varianti162 – 1621D → V.1 Publication
Corresponds to variant rs2069860 [ dbSNP | Ensembl ].
VAR_013076

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04430 mRNA. Translation: CAA28026.1.
M14584 mRNA. Translation: AAA52728.1.
X04602 mRNA. Translation: CAA28268.1.
Y00081 Genomic DNA. Translation: CAA68278.1.
M18403 mRNA. Translation: AAA52729.1.
M29150 mRNA. Translation: AAA59154.1.
X04402 Genomic DNA. Translation: CAA27990.1.
X04403 mRNA. Translation: CAA27991.1.
M54894 mRNA. Translation: AAC41704.1.
S56892 mRNA. Translation: AAD13886.1.
AF372214 Genomic DNA. Translation: AAK48987.1.
BC015511 mRNA. Translation: AAH15511.1.
CCDSiCCDS5375.1.
PIRiA32648. IVHUB2.
RefSeqiNP_000591.1. NM_000600.3.
UniGeneiHs.654458.

Genome annotation databases

EnsembliENST00000258743; ENSP00000258743; ENSG00000136244.
ENST00000404625; ENSP00000385675; ENSG00000136244.
GeneIDi3569.
KEGGihsa:3569.
UCSCiuc003svj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

R&D Systems' cytokine mini-reviews: IL-6
Wikipedia

Interleukin-6 entry

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04430 mRNA. Translation: CAA28026.1.
M14584 mRNA. Translation: AAA52728.1.
X04602 mRNA. Translation: CAA28268.1.
Y00081 Genomic DNA. Translation: CAA68278.1.
M18403 mRNA. Translation: AAA52729.1.
M29150 mRNA. Translation: AAA59154.1.
X04402 Genomic DNA. Translation: CAA27990.1.
X04403 mRNA. Translation: CAA27991.1.
M54894 mRNA. Translation: AAC41704.1.
S56892 mRNA. Translation: AAD13886.1.
AF372214 Genomic DNA. Translation: AAK48987.1.
BC015511 mRNA. Translation: AAH15511.1.
CCDSiCCDS5375.1.
PIRiA32648. IVHUB2.
RefSeqiNP_000591.1. NM_000600.3.
UniGeneiHs.654458.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ALUX-ray1.90A28-212[»]
1IL6NMR-A28-212[»]
1N2Qmodel-E/F30-212[»]
1P9MX-ray3.65B29-212[»]
2IL6NMR-A28-212[»]
4CNIX-ray2.20C/D42-212[»]
4J4LX-ray2.30C/D47-212[»]
4NI7X-ray2.40A28-212[»]
4NI9X-ray2.55A/C28-212[»]
4O9HX-ray2.42A28-212[»]
ProteinModelPortaliP05231.
SMRiP05231. Positions 42-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109783. 2 interactions.
DIPiDIP-482N.
IntActiP05231. 5 interactions.
MINTiMINT-190042.
STRINGi9606.ENSP00000258743.

Chemistry

ChEMBLiCHEMBL1795129.
DrugBankiDB01404. Ginseng.

PTM databases

PhosphoSiteiP05231.

Polymorphism and mutation databases

BioMutaiIL6.
DMDMi124347.

Proteomic databases

MaxQBiP05231.
PaxDbiP05231.
PRIDEiP05231.

Protocols and materials databases

DNASUi3569.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258743; ENSP00000258743; ENSG00000136244.
ENST00000404625; ENSP00000385675; ENSG00000136244.
GeneIDi3569.
KEGGihsa:3569.
UCSCiuc003svj.4. human.

Organism-specific databases

CTDi3569.
GeneCardsiGC07P022765.
H-InvDBHIX0167872.
HGNCiHGNC:6018. IL6.
HPAiCAB023406.
MIMi147620. gene.
148000. phenotype.
604302. phenotype.
neXtProtiNX_P05231.
Orphaneti206. Crohn disease.
85414. Systemic-onset juvenile idiopathic arthritis.
PharmGKBiPA198.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG48083.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiP05231.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG7QG453.
PhylomeDBiP05231.
TreeFamiTF335984.

Enzyme and pathway databases

ReactomeiREACT_1183. ERK2 activation.
REACT_1391. ERK1 activation.
REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
REACT_27307. Interleukin-6 signaling.
SignaLinkiP05231.

Miscellaneous databases

ChiTaRSiIL6. human.
EvolutionaryTraceiP05231.
GeneWikiiInterleukin_6.
GenomeRNAii3569.
NextBioi13950.
PMAP-CutDBP05231.
PROiP05231.
SOURCEiSearch...

Gene expression databases

BgeeiP05231.
CleanExiHS_IL6.
ExpressionAtlasiP05231. baseline and differential.
GenevisibleiP05231. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR030474. IL-6/GCSF/MGF.
IPR003573. IL-6/IL-23/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin."
    Hirano T., Yasukawa K., Harada H., Taga T., Watanabe Y., Matsuda T., Kashiwamura S., Nakajima K., Koyama K., Iwamatsu A., Tsunasawa S., Sakiyama F., Matsui H., Takahara Y., Taniguchi T., Kishimoto T.
    Nature 324:73-76(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene."
    Yasukawa K., Hirano T., Watanabe Y., Muratani K., Matsuda T., Nakai S., Kishimoto T.
    EMBO J. 6:2939-2945(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved."
    May L.T., Helfgott D.C., Sehgal P.B.
    Proc. Natl. Acad. Sci. U.S.A. 83:8957-8961(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines."
    Zilberstein A., Ruggieri R., Korn J.H., Revel M.
    EMBO J. 5:2529-2537(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Molecular cloning and expression of hybridoma growth factor in Escherichia coli."
    Brakenhoff J.P.J., de Groot E.R., Evers R.F., Pannekoek H., Aarden L.A.
    J. Immunol. 139:4116-4121(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells."
    Tonouchi N., Miwa K., Karasuyama H., Matsui H.
    Biochem. Biophys. Res. Commun. 163:1056-1062(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. "Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts."
    Haegeman G., Content J., Volckaert G., Derynck R., Tavernier J., Fiers W.
    Eur. J. Biochem. 159:625-632(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Fibroblast.
  8. "Interleukin 6: identification as a hematopoietic colony-stimulating factor."
    Wong G., Witek-Giannotti J., Hewick R., Clark S., Ogawa M.
    Behring Inst. Mitt. 83:40-47(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  9. "Stable and efficient expression of human interleukin-6 cDNA in mammalian cells after gene transfer."
    Chen Q.Y.
    Zhonghua Zhong Liu Za Zhi 14:340-344(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  10. SeattleSNPs variation discovery resource
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-32 AND VAL-162.
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  12. "Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6."
    van Damme J., van Beeumen J., Decock B., van Snick J., de Ley M., Billiau A.
    J. Immunol. 140:1534-1541(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-63.
  13. "Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium."
    Ming J.E., Cernetti C., Steinman R.M., Granelli-Piperno A.
    J. Mol. Cell. Immunol. 4:203-211(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-50.
  14. "Marked cell-type-specific differences in glycosylation of human interleukin-6."
    May L.T., Shaw J.E., Khanna A.K., Zabriskie J.B., Sehgal P.B.
    Cytokine 3:204-211(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-40, GLYCOSYLATION.
  15. "Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond."
    Breton J., la Fiura A., Bertolero F., Orsini G., Valsasina B., Ziliotto R., de Filippis V., Polverino de Laureto P., Fontana A.
    Eur. J. Biochem. 227:573-581(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 50-212 OF RECOMBINANT FORM LACKING FIRST DISULFIDE BOND.
  16. "Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor."
    Clogston C.L., Boone T.C., Crandall B.C., Mendiaz E.A., Lu H.S.
    Arch. Biochem. Biophys. 272:144-151(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  17. "Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6."
    Luetticken C., Kruettgen A., Moeller C., Heinrich P.C., Rose-John S.
    FEBS Lett. 282:265-267(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.
  18. "Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy."
    Nishimura C., Watanabe A., Gouda H., Shimada I., Arata Y.
    Biochemistry 35:273-281(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  19. Cited for: STRUCTURE BY NMR.
  20. "1.9-A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling."
    Somers W., Stahl M., Seehra J.S.
    EMBO J. 16:989-997(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
  21. "The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis."
    Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., Woo P.
    J. Clin. Invest. 102:1369-1376(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SYSTEMIC JUVENILE RHEUMATOID ARTHRITIS.
  22. "An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus."
    Foster C.B., Lehrnbecher T., Samuels S., Stein S., Mol F., Metcalf J.A., Wyvill K., Steinberg S.M., Kovacs J., Blauvelt A., Yarchoan R., Chanock S.J.
    Blood 96:2562-2567(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO KAPOSI SARCOMA.
  23. "A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density."
    Ota N., Nakajima T., Nakazawa I., Suzuki T., Hosoi T., Orimo H., Inoue S., Shirai Y., Emi M.
    J. Hum. Genet. 46:267-272(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN BMD.
  24. "Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women."
    Chung H.W., Seo J.-S., Hur S.E., Kim H.L., Kim J.Y., Jung J.H., Kim L.H., Park B.L., Shin H.D.
    J. Hum. Genet. 48:243-248(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN BMD.

Entry informationi

Entry nameiIL6_HUMAN
AccessioniPrimary (citable) accession number: P05231
Secondary accession number(s): Q9UCU2, Q9UCU3, Q9UCU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 24, 2015
This is version 186 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.