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P05231

- IL6_HUMAN

UniProt

P05231 - IL6_HUMAN

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Protein
Interleukin-6
Gene
IL6, IFNB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

GO - Molecular functioni

  1. cytokine activity Source: BHF-UCL
  2. growth factor activity Source: BHF-UCL
  3. interleukin-6 receptor binding Source: UniProtKB
  4. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. T-helper 17 cell lineage commitment Source: UniProtKB
  2. acute-phase response Source: BHF-UCL
  3. aging Source: Ensembl
  4. bone remodeling Source: Ensembl
  5. branching involved in salivary gland morphogenesis Source: Ensembl
  6. cell growth Source: Ensembl
  7. cell redox homeostasis Source: Ensembl
  8. cellular response to hydrogen peroxide Source: BHF-UCL
  9. cellular response to lipopolysaccharide Source: MGI
  10. cytokine-mediated signaling pathway Source: BHF-UCL
  11. defense response to Gram-negative bacterium Source: BHF-UCL
  12. defense response to Gram-positive bacterium Source: BHF-UCL
  13. defense response to protozoan Source: Ensembl
  14. defense response to virus Source: BHF-UCL
  15. endocrine pancreas development Source: BHF-UCL
  16. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  17. glucagon secretion Source: BHF-UCL
  18. hepatic immune response Source: BHF-UCL
  19. humoral immune response Source: BHF-UCL
  20. inflammatory response Source: BHF-UCL
  21. interleukin-6-mediated signaling pathway Source: BHF-UCL
  22. monocyte chemotaxis Source: BHF-UCL
  23. muscle cell cellular homeostasis Source: Ensembl
  24. negative regulation of apoptotic process Source: UniProtKB
  25. negative regulation of cell proliferation Source: ProtInc
  26. negative regulation of chemokine biosynthetic process Source: UniProtKB
  27. negative regulation of collagen biosynthetic process Source: BHF-UCL
  28. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  29. negative regulation of cytokine secretion Source: Ensembl
  30. negative regulation of fat cell differentiation Source: BHF-UCL
  31. negative regulation of gluconeogenesis Source: Ensembl
  32. negative regulation of hormone secretion Source: Ensembl
  33. negative regulation of lipid storage Source: BHF-UCL
  34. negative regulation of muscle organ development Source: Ensembl
  35. negative regulation of neuron death Source: Ensembl
  36. negative regulation of protein kinase activity Source: Ensembl
  37. neuron projection development Source: BHF-UCL
  38. neutrophil apoptotic process Source: UniProtKB
  39. neutrophil mediated immunity Source: BHF-UCL
  40. platelet activation Source: BHF-UCL
  41. positive regulation of B cell activation Source: BHF-UCL
  42. positive regulation of DNA replication Source: Ensembl
  43. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  44. positive regulation of JAK-STAT cascade Source: BHF-UCL
  45. positive regulation of MAPK cascade Source: BHF-UCL
  46. positive regulation of STAT protein import into nucleus Source: BHF-UCL
  47. positive regulation of T cell proliferation Source: BHF-UCL
  48. positive regulation of T-helper 2 cell differentiation Source: Ensembl
  49. positive regulation of acute inflammatory response Source: BHF-UCL
  50. positive regulation of apoptotic process Source: UniProtKB
  51. positive regulation of cell proliferation Source: BHF-UCL
  52. positive regulation of chemokine production Source: BHF-UCL
  53. positive regulation of epithelial cell proliferation Source: Ensembl
  54. positive regulation of immunoglobulin secretion Source: BHF-UCL
  55. positive regulation of interleukin-6 production Source: BHF-UCL
  56. positive regulation of leukocyte chemotaxis Source: BHF-UCL
  57. positive regulation of neuron differentiation Source: Ensembl
  58. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  59. positive regulation of osteoblast differentiation Source: BHF-UCL
  60. positive regulation of peptidyl-serine phosphorylation Source: MGI
  61. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  62. positive regulation of protein import into nucleus, translocation Source: Ensembl
  63. positive regulation of protein kinase B signaling Source: Ensembl
  64. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  65. positive regulation of smooth muscle cell proliferation Source: BHF-UCL
  66. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  67. positive regulation of transcription, DNA-templated Source: BHF-UCL
  68. positive regulation of translation Source: UniProtKB
  69. positive regulation of transmission of nerve impulse Source: Ensembl
  70. positive regulation of type B pancreatic cell apoptotic process Source: BHF-UCL
  71. positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
  72. regulation of angiogenesis Source: BHF-UCL
  73. regulation of cell shape Source: Ensembl
  74. regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  75. regulation of vascular endothelial growth factor production Source: BHF-UCL
  76. response to amino acid Source: Ensembl
  77. response to antibiotic Source: Ensembl
  78. response to caffeine Source: Ensembl
  79. response to calcium ion Source: Ensembl
  80. response to cold Source: Ensembl
  81. response to drug Source: Ensembl
  82. response to electrical stimulus Source: Ensembl
  83. response to glucocorticoid Source: BHF-UCL
  84. response to heat Source: Ensembl
  85. response to insulin Source: Ensembl
  86. response to mechanical stimulus Source: Ensembl
  87. response to nutrient levels Source: Ensembl
  88. response to peptidoglycan Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Acute phase

Enzyme and pathway databases

ReactomeiREACT_169168. Senescence-Associated Secretory Phenotype (SASP).
REACT_27307. Interleukin-6 signaling.
SignaLinkiP05231.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Alternative name(s):
B-cell stimulatory factor 2
Short name:
BSF-2
CTL differentiation factor
Short name:
CDF
Hybridoma growth factor
Interferon beta-2
Short name:
IFN-beta-2
Gene namesi
Name:IL6
Synonyms:IFNB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:6018. IL6.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular region Source: Reactome
  3. extracellular space Source: BHF-UCL
  4. interleukin-6 receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi173 – 1731A → V: Almost no loss of activity.
Mutagenesisi185 – 1851W → R: No loss of activity.
Mutagenesisi204 – 2041S → P: 87% loss of activity.
Mutagenesisi210 – 2101R → K, E, Q, T, A or P: Loss of activity.
Mutagenesisi212 – 2121M → T, N, S or R: Loss of activity.

Organism-specific databases

MIMi148000. phenotype.
604302. phenotype.
Orphaneti206. Crohn disease.
85414. Systemic-onset juvenile idiopathic arthritis.
PharmGKBiPA198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29293 Publications
Add
BLAST
Chaini30 – 212183Interleukin-6
PRO_0000015582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi72 ↔ 782 Publications
Glycosylationi73 – 731N-linked (GlcNAc...)
Disulfide bondi101 ↔ 1112 Publications

Post-translational modificationi

N- and O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05231.
PRIDEiP05231.

PTM databases

PhosphoSiteiP05231.

Miscellaneous databases

PMAP-CutDBP05231.

Expressioni

Gene expression databases

ArrayExpressiP05231.
BgeeiP05231.
CleanExiHS_IL6.
GenevestigatoriP05231.

Organism-specific databases

HPAiCAB023406.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IL6RP088875EBI-720533,EBI-299383

Protein-protein interaction databases

BioGridi109783. 2 interactions.
DIPiDIP-482N.
IntActiP05231. 4 interactions.
MINTiMINT-190042.
STRINGi9606.ENSP00000258743.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi49 – 7527
Beta strandi76 – 794
Turni81 – 833
Helixi84 – 874
Helixi97 – 993
Beta strandi102 – 1054
Helixi108 – 13225
Beta strandi134 – 1363
Helixi137 – 15721
Beta strandi159 – 1613
Helixi169 – 18012
Helixi184 – 20926

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ALUX-ray1.90A28-212[»]
1IL6NMR-A28-212[»]
1N2Qmodel-E/F30-212[»]
1P9MX-ray3.65B29-212[»]
2IL6NMR-A28-212[»]
4CNIX-ray2.20C/D42-212[»]
4J4LX-ray2.30C/D47-212[»]
4NI7X-ray2.40A28-212[»]
4NI9X-ray2.55A/C28-212[»]
ProteinModelPortaliP05231.
SMRiP05231. Positions 47-212.

Miscellaneous databases

EvolutionaryTraceiP05231.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG48083.
HOGENOMiHOG000236330.
HOVERGENiHBG000471.
InParanoidiP05231.
KOiK05405.
OMAiFNQETCL.
OrthoDBiEOG7QG453.
PhylomeDBiP05231.
TreeFamiTF335984.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
PR00434. INTERLEUKIN6.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05231-1 [UniParc]FASTAAdd to Basket

« Hide

MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS    50
ERIDKQIRYI LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG 100
CFQSGFNEET CLVKIITGLL EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL 150
IQFLQKKAKN LDAITTPDPT TNASLLTKLQ AQNQWLQDMT THLILRSFKE 200
FLQSSLRALR QM 212
Length:212
Mass (Da):23,718
Last modified:August 13, 1987 - v1
Checksum:i1F1ED1FE1B734079
GO

Polymorphismi

Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321P → S.1 Publication
Corresponds to variant rs2069830 [ dbSNP | Ensembl ].
VAR_013075
Natural varianti162 – 1621D → E.
Corresponds to variant rs13306435 [ dbSNP | Ensembl ].
VAR_029266
Natural varianti162 – 1621D → V.1 Publication
Corresponds to variant rs2069860 [ dbSNP | Ensembl ].
VAR_013076

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04430 mRNA. Translation: CAA28026.1.
M14584 mRNA. Translation: AAA52728.1.
X04602 mRNA. Translation: CAA28268.1.
Y00081 Genomic DNA. Translation: CAA68278.1.
M18403 mRNA. Translation: AAA52729.1.
M29150 mRNA. Translation: AAA59154.1.
X04402 Genomic DNA. Translation: CAA27990.1.
X04403 mRNA. Translation: CAA27991.1.
M54894 mRNA. Translation: AAC41704.1.
S56892 mRNA. Translation: AAD13886.1.
AF372214 Genomic DNA. Translation: AAK48987.1.
BC015511 mRNA. Translation: AAH15511.1.
CCDSiCCDS5375.1.
PIRiA32648. IVHUB2.
RefSeqiNP_000591.1. NM_000600.3.
UniGeneiHs.654458.

Genome annotation databases

EnsembliENST00000258743; ENSP00000258743; ENSG00000136244.
ENST00000404625; ENSP00000385675; ENSG00000136244.
GeneIDi3569.
KEGGihsa:3569.
UCSCiuc003svj.4. human.

Polymorphism databases

DMDMi124347.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

R&D Systems' cytokine mini-reviews: IL-6
Wikipedia

Interleukin-6 entry

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04430 mRNA. Translation: CAA28026.1 .
M14584 mRNA. Translation: AAA52728.1 .
X04602 mRNA. Translation: CAA28268.1 .
Y00081 Genomic DNA. Translation: CAA68278.1 .
M18403 mRNA. Translation: AAA52729.1 .
M29150 mRNA. Translation: AAA59154.1 .
X04402 Genomic DNA. Translation: CAA27990.1 .
X04403 mRNA. Translation: CAA27991.1 .
M54894 mRNA. Translation: AAC41704.1 .
S56892 mRNA. Translation: AAD13886.1 .
AF372214 Genomic DNA. Translation: AAK48987.1 .
BC015511 mRNA. Translation: AAH15511.1 .
CCDSi CCDS5375.1.
PIRi A32648. IVHUB2.
RefSeqi NP_000591.1. NM_000600.3.
UniGenei Hs.654458.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ALU X-ray 1.90 A 28-212 [» ]
1IL6 NMR - A 28-212 [» ]
1N2Q model - E/F 30-212 [» ]
1P9M X-ray 3.65 B 29-212 [» ]
2IL6 NMR - A 28-212 [» ]
4CNI X-ray 2.20 C/D 42-212 [» ]
4J4L X-ray 2.30 C/D 47-212 [» ]
4NI7 X-ray 2.40 A 28-212 [» ]
4NI9 X-ray 2.55 A/C 28-212 [» ]
ProteinModelPortali P05231.
SMRi P05231. Positions 47-212.
ModBasei Search...

Protein-protein interaction databases

BioGridi 109783. 2 interactions.
DIPi DIP-482N.
IntActi P05231. 4 interactions.
MINTi MINT-190042.
STRINGi 9606.ENSP00000258743.

Chemistry

ChEMBLi CHEMBL1795129.
DrugBanki DB01169. Arsenic trioxide.
DB01128. Bicalutamide.
DB01404. Ginseng.
DB00641. Simvastatin.

PTM databases

PhosphoSitei P05231.

Polymorphism databases

DMDMi 124347.

Proteomic databases

PaxDbi P05231.
PRIDEi P05231.

Protocols and materials databases

DNASUi 3569.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258743 ; ENSP00000258743 ; ENSG00000136244 .
ENST00000404625 ; ENSP00000385675 ; ENSG00000136244 .
GeneIDi 3569.
KEGGi hsa:3569.
UCSCi uc003svj.4. human.

Organism-specific databases

CTDi 3569.
GeneCardsi GC07P022732.
H-InvDB HIX0167872.
HGNCi HGNC:6018. IL6.
HPAi CAB023406.
MIMi 147620. gene.
148000. phenotype.
604302. phenotype.
neXtProti NX_P05231.
Orphaneti 206. Crohn disease.
85414. Systemic-onset juvenile idiopathic arthritis.
PharmGKBi PA198.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG48083.
HOGENOMi HOG000236330.
HOVERGENi HBG000471.
InParanoidi P05231.
KOi K05405.
OMAi FNQETCL.
OrthoDBi EOG7QG453.
PhylomeDBi P05231.
TreeFami TF335984.

Enzyme and pathway databases

Reactomei REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
REACT_27307. Interleukin-6 signaling.
SignaLinki P05231.

Miscellaneous databases

ChiTaRSi IL6. human.
EvolutionaryTracei P05231.
GeneWikii Interleukin_6.
GenomeRNAii 3569.
NextBioi 13950.
PMAP-CutDB P05231.
PROi P05231.
SOURCEi Search...

Gene expression databases

ArrayExpressi P05231.
Bgeei P05231.
CleanExi HS_IL6.
Genevestigatori P05231.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view ]
PANTHERi PTHR11457. PTHR11457. 1 hit.
Pfami PF00489. IL6. 1 hit.
[Graphical view ]
PIRSFi PIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSi PR00433. IL6GCSFMGF.
PR00434. INTERLEUKIN6.
SMARTi SM00126. IL6. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00254. INTERLEUKIN_6. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin."
    Hirano T., Yasukawa K., Harada H., Taga T., Watanabe Y., Matsuda T., Kashiwamura S., Nakajima K., Koyama K., Iwamatsu A., Tsunasawa S., Sakiyama F., Matsui H., Takahara Y., Taniguchi T., Kishimoto T.
    Nature 324:73-76(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene."
    Yasukawa K., Hirano T., Watanabe Y., Muratani K., Matsuda T., Nakai S., Kishimoto T.
    EMBO J. 6:2939-2945(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved."
    May L.T., Helfgott D.C., Sehgal P.B.
    Proc. Natl. Acad. Sci. U.S.A. 83:8957-8961(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines."
    Zilberstein A., Ruggieri R., Korn J.H., Revel M.
    EMBO J. 5:2529-2537(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Molecular cloning and expression of hybridoma growth factor in Escherichia coli."
    Brakenhoff J.P.J., de Groot E.R., Evers R.F., Pannekoek H., Aarden L.A.
    J. Immunol. 139:4116-4121(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells."
    Tonouchi N., Miwa K., Karasuyama H., Matsui H.
    Biochem. Biophys. Res. Commun. 163:1056-1062(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. "Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts."
    Haegeman G., Content J., Volckaert G., Derynck R., Tavernier J., Fiers W.
    Eur. J. Biochem. 159:625-632(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Fibroblast.
  8. "Interleukin 6: identification as a hematopoietic colony-stimulating factor."
    Wong G., Witek-Giannotti J., Hewick R., Clark S., Ogawa M.
    Behring Inst. Mitt. 83:40-47(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  9. "Stable and efficient expression of human interleukin-6 cDNA in mammalian cells after gene transfer."
    Chen Q.Y.
    Zhonghua Zhong Liu Za Zhi 14:340-344(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  10. SeattleSNPs variation discovery resource
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-32 AND VAL-162.
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  12. "Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6."
    van Damme J., van Beeumen J., Decock B., van Snick J., de Ley M., Billiau A.
    J. Immunol. 140:1534-1541(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-63.
  13. "Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium."
    Ming J.E., Cernetti C., Steinman R.M., Granelli-Piperno A.
    J. Mol. Cell. Immunol. 4:203-211(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-50.
  14. "Marked cell-type-specific differences in glycosylation of human interleukin-6."
    May L.T., Shaw J.E., Khanna A.K., Zabriskie J.B., Sehgal P.B.
    Cytokine 3:204-211(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-40, GLYCOSYLATION.
  15. "Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond."
    Breton J., la Fiura A., Bertolero F., Orsini G., Valsasina B., Ziliotto R., de Filippis V., Polverino de Laureto P., Fontana A.
    Eur. J. Biochem. 227:573-581(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 50-212 OF RECOMBINANT FORM LACKING FIRST DISULFIDE BOND.
  16. "Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor."
    Clogston C.L., Boone T.C., Crandall B.C., Mendiaz E.A., Lu H.S.
    Arch. Biochem. Biophys. 272:144-151(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  17. "Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6."
    Luetticken C., Kruettgen A., Moeller C., Heinrich P.C., Rose-John S.
    FEBS Lett. 282:265-267(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.
  18. "Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy."
    Nishimura C., Watanabe A., Gouda H., Shimada I., Arata Y.
    Biochemistry 35:273-281(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  19. Cited for: STRUCTURE BY NMR.
  20. "1.9-A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling."
    Somers W., Stahl M., Seehra J.S.
    EMBO J. 16:989-997(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
  21. "The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis."
    Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., Woo P.
    J. Clin. Invest. 102:1369-1376(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SYSTEMIC JUVENILE RHEUMATOID ARTHRITIS.
  22. "An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus."
    Foster C.B., Lehrnbecher T., Samuels S., Stein S., Mol F., Metcalf J.A., Wyvill K., Steinberg S.M., Kovacs J., Blauvelt A., Yarchoan R., Chanock S.J.
    Blood 96:2562-2567(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO KAPOSI SARCOMA.
  23. "A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density."
    Ota N., Nakajima T., Nakazawa I., Suzuki T., Hosoi T., Orimo H., Inoue S., Shirai Y., Emi M.
    J. Hum. Genet. 46:267-272(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN BMD.
  24. "Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women."
    Chung H.W., Seo J.-S., Hur S.E., Kim H.L., Kim J.Y., Jung J.H., Kim L.H., Park B.L., Shin H.D.
    J. Hum. Genet. 48:243-248(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN BMD.

Entry informationi

Entry nameiIL6_HUMAN
AccessioniPrimary (citable) accession number: P05231
Secondary accession number(s): Q9UCU2, Q9UCU3, Q9UCU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 3, 2014
This is version 177 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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