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P05231 (IL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 173. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-6

Short name=IL-6
Alternative name(s):
B-cell stimulatory factor 2
Short name=BSF-2
CTL differentiation factor
Short name=CDF
Hybridoma growth factor
Interferon beta-2
Short name=IFN-beta-2
Gene names
Name:IL6
Synonyms:IFNB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Subcellular location

Secreted.

Post-translational modification

N- and O-glycosylated. Ref.14

Polymorphism

Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Involvement in disease

Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

Sequence similarities

Belongs to the IL-6 superfamily.

Ontologies

Keywords
   Biological processAcute phase
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processT-helper 17 cell lineage commitment

Inferred from sequence or structural similarity. Source: UniProtKB

acute-phase response

Traceable author statement PubMed 12832423. Source: BHF-UCL

aging

Inferred from electronic annotation. Source: Ensembl

bone remodeling

Inferred from electronic annotation. Source: Ensembl

branching involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

cell growth

Inferred from electronic annotation. Source: Ensembl

cell redox homeostasis

Inferred from electronic annotation. Source: Ensembl

cellular response to hydrogen peroxide

Inferred from direct assay PubMed 19168699. Source: BHF-UCL

cytokine-mediated signaling pathway

Inferred from direct assay PubMed 12643274PubMed 2261637. Source: BHF-UCL

defense response to Gram-negative bacterium

Inferred from expression pattern PubMed 16034137. Source: BHF-UCL

defense response to Gram-positive bacterium

Inferred from expression pattern PubMed 16034137. Source: BHF-UCL

defense response to protozoan

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from direct assay Ref.4. Source: BHF-UCL

endocrine pancreas development

Inferred from sequence or structural similarity PubMed 18719127. Source: BHF-UCL

epithelial cell proliferation involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

glucagon secretion

Inferred from sequence or structural similarity PubMed 18719127. Source: BHF-UCL

hepatic immune response

Inferred from direct assay PubMed 2444978. Source: BHF-UCL

humoral immune response

Inferred by curator Ref.1. Source: BHF-UCL

inflammatory response

Inferred from direct assay PubMed 10443688. Source: BHF-UCL

interleukin-6-mediated signaling pathway

Inferred from direct assay PubMed 12552091. Source: BHF-UCL

monocyte chemotaxis

Inferred by curator PubMed 10510402. Source: BHF-UCL

muscle cell cellular homeostasis

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from direct assay PubMed 7595060. Source: UniProtKB

negative regulation of cell proliferation

Traceable author statement Ref.4. Source: ProtInc

negative regulation of chemokine biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of collagen biosynthetic process

Inferred from direct assay PubMed 12419823. Source: BHF-UCL

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cytokine secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of fat cell differentiation

Non-traceable author statement PubMed 16464856. Source: BHF-UCL

negative regulation of gluconeogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of lipid storage

Non-traceable author statement PubMed 16464856. Source: BHF-UCL

negative regulation of muscle organ development

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron death

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein kinase activity

Inferred from electronic annotation. Source: Ensembl

neuron projection development

Inferred from mutant phenotype PubMed 3264880. Source: BHF-UCL

neutrophil apoptotic process

Inferred from direct assay PubMed 7595060. Source: UniProtKB

neutrophil mediated immunity

Inferred by curator PubMed 16034137. Source: BHF-UCL

platelet activation

Traceable author statement PubMed 7831669. Source: BHF-UCL

positive regulation of B cell activation

Inferred from direct assay Ref.1. Source: BHF-UCL

positive regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of JAK-STAT cascade

Inferred from direct assay PubMed 12419823PubMed 12552091PubMed 17324931. Source: BHF-UCL

positive regulation of MAPK cascade

Inferred from direct assay PubMed 12419823. Source: BHF-UCL

positive regulation of STAT protein import into nucleus

Inferred by curator PubMed 17324931. Source: BHF-UCL

positive regulation of T cell proliferation

Inferred from direct assay PubMed 3130269. Source: BHF-UCL

positive regulation of T-helper 2 cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of acute inflammatory response

Inferred from direct assay PubMed 2444978. Source: BHF-UCL

positive regulation of apoptotic process

Inferred from direct assay PubMed 9949178. Source: UniProtKB

positive regulation of cell proliferation

Inferred from direct assay PubMed 2261637. Source: BHF-UCL

positive regulation of chemokine production

Inferred from direct assay PubMed 10510402. Source: BHF-UCL

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of immunoglobulin secretion

Inferred from direct assay Ref.1. Source: BHF-UCL

positive regulation of interleukin-6 production

Inferred from direct assay PubMed 10510402. Source: BHF-UCL

positive regulation of leukocyte chemotaxis

Inferred by curator PubMed 16034137. Source: BHF-UCL

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric oxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoblast differentiation

Traceable author statement PubMed 12372336. Source: BHF-UCL

positive regulation of peptidyl-serine phosphorylation

Inferred from direct assay PubMed 7508917. Source: MGI

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 7508917. Source: MGI

positive regulation of protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 7749983. Source: BHF-UCL

positive regulation of smooth muscle cell proliferation

Inferred from direct assay PubMed 10510402. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 17324931. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 7749983. Source: BHF-UCL

positive regulation of translation

Inferred from direct assay PubMed 16732314. Source: UniProtKB

positive regulation of transmission of nerve impulse

Inferred from electronic annotation. Source: Ensembl

positive regulation of type B pancreatic cell apoptotic process

Traceable author statement PubMed 18719127. Source: BHF-UCL

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from direct assay PubMed 12643274. Source: BHF-UCL

regulation of angiogenesis

Inferred by curator PubMed 8557680. Source: BHF-UCL

regulation of cell shape

Inferred from electronic annotation. Source: Ensembl

regulation of circadian sleep/wake cycle, non-REM sleep

Inferred from electronic annotation. Source: Ensembl

regulation of vascular endothelial growth factor production

Inferred from direct assay PubMed 8557680. Source: BHF-UCL

response to amino acid

Inferred from electronic annotation. Source: Ensembl

response to antibiotic

Inferred from electronic annotation. Source: Ensembl

response to caffeine

Inferred from electronic annotation. Source: Ensembl

response to calcium ion

Inferred from electronic annotation. Source: Ensembl

response to cold

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to electrical stimulus

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from direct assay PubMed 10443688. Source: BHF-UCL

response to heat

Inferred from electronic annotation. Source: Ensembl

response to insulin

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

response to nutrient levels

Inferred from electronic annotation. Source: Ensembl

response to peptidoglycan

Inferred from expression pattern PubMed 16034137. Source: BHF-UCL

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 10443688PubMed 16034137Ref.4. Source: BHF-UCL

interleukin-6 receptor complex

Inferred from direct assay PubMed 12829785PubMed 2261637. Source: BHF-UCL

   Molecular_functioncytokine activity

Inferred from direct assay Ref.4Ref.1. Source: BHF-UCL

growth factor activity

Inferred from direct assay PubMed 12643274PubMed 2261637. Source: BHF-UCL

interleukin-6 receptor binding

Non-traceable author statement Ref.14. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

IL6RP088875EBI-720533,EBI-299383

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Ref.12 Ref.13 Ref.14
Chain30 – 212183Interleukin-6
PRO_0000015582

Amino acid modifications

Glycosylation731N-linked (GlcNAc...)
Disulfide bond72 ↔ 78 Ref.15 Ref.16
Disulfide bond101 ↔ 111 Ref.15 Ref.16

Natural variations

Natural variant321P → S. Ref.10
Corresponds to variant rs2069830 [ dbSNP | Ensembl ].
VAR_013075
Natural variant1621D → E.
Corresponds to variant rs13306435 [ dbSNP | Ensembl ].
VAR_029266
Natural variant1621D → V. Ref.10
Corresponds to variant rs2069860 [ dbSNP | Ensembl ].
VAR_013076

Experimental info

Mutagenesis1731A → V: Almost no loss of activity.
Mutagenesis1851W → R: No loss of activity.
Mutagenesis2041S → P: 87% loss of activity.
Mutagenesis2101R → K, E, Q, T, A or P: Loss of activity.
Mutagenesis2121M → T, N, S or R: Loss of activity.

Secondary structure

................... 212
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P05231 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 1F1ED1FE1B734079

FASTA21223,718
        10         20         30         40         50         60 
MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS ERIDKQIRYI 

        70         80         90        100        110        120 
LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG CFQSGFNEET CLVKIITGLL 

       130        140        150        160        170        180 
EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL IQFLQKKAKN LDAITTPDPT TNASLLTKLQ 

       190        200        210 
AQNQWLQDMT THLILRSFKE FLQSSLRALR QM 

« Hide

References

« Hide 'large scale' references
[1]"Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin."
Hirano T., Yasukawa K., Harada H., Taga T., Watanabe Y., Matsuda T., Kashiwamura S., Nakajima K., Koyama K., Iwamatsu A., Tsunasawa S., Sakiyama F., Matsui H., Takahara Y., Taniguchi T., Kishimoto T.
Nature 324:73-76(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]"Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene."
Yasukawa K., Hirano T., Watanabe Y., Muratani K., Matsuda T., Nakai S., Kishimoto T.
EMBO J. 6:2939-2945(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved."
May L.T., Helfgott D.C., Sehgal P.B.
Proc. Natl. Acad. Sci. U.S.A. 83:8957-8961(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines."
Zilberstein A., Ruggieri R., Korn J.H., Revel M.
EMBO J. 5:2529-2537(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Molecular cloning and expression of hybridoma growth factor in Escherichia coli."
Brakenhoff J.P.J., de Groot E.R., Evers R.F., Pannekoek H., Aarden L.A.
J. Immunol. 139:4116-4121(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells."
Tonouchi N., Miwa K., Karasuyama H., Matsui H.
Biochem. Biophys. Res. Commun. 163:1056-1062(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[7]"Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts."
Haegeman G., Content J., Volckaert G., Derynck R., Tavernier J., Fiers W.
Eur. J. Biochem. 159:625-632(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Fibroblast.
[8]"Interleukin 6: identification as a hematopoietic colony-stimulating factor."
Wong G., Witek-Giannotti J., Hewick R., Clark S., Ogawa M.
Behring Inst. Mitt. 83:40-47(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[9]"Stable and efficient expression of human interleukin-6 cDNA in mammalian cells after gene transfer."
Chen Q.Y.
Zhonghua Zhong Liu Za Zhi 14:340-344(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[10]SeattleSNPs variation discovery resource
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-32 AND VAL-162.
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[12]"Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6."
van Damme J., van Beeumen J., Decock B., van Snick J., de Ley M., Billiau A.
J. Immunol. 140:1534-1541(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 30-63.
[13]"Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium."
Ming J.E., Cernetti C., Steinman R.M., Granelli-Piperno A.
J. Mol. Cell. Immunol. 4:203-211(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 30-50.
[14]"Marked cell-type-specific differences in glycosylation of human interleukin-6."
May L.T., Shaw J.E., Khanna A.K., Zabriskie J.B., Sehgal P.B.
Cytokine 3:204-211(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 30-40, GLYCOSYLATION.
[15]"Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond."
Breton J., la Fiura A., Bertolero F., Orsini G., Valsasina B., Ziliotto R., de Filippis V., Polverino de Laureto P., Fontana A.
Eur. J. Biochem. 227:573-581(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 50-212 OF RECOMBINANT FORM LACKING FIRST DISULFIDE BOND.
[16]"Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor."
Clogston C.L., Boone T.C., Crandall B.C., Mendiaz E.A., Lu H.S.
Arch. Biochem. Biophys. 272:144-151(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
[17]"Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6."
Luetticken C., Kruettgen A., Moeller C., Heinrich P.C., Rose-John S.
FEBS Lett. 282:265-267(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS.
[18]"Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy."
Nishimura C., Watanabe A., Gouda H., Shimada I., Arata Y.
Biochemistry 35:273-281(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
[19]"Solution structure of recombinant human interleukin-6."
Xu G.-Y., Yu H.-A., Hong J., Stahl M., McDonagh T., Kay L.E., Cumming D.A.
J. Mol. Biol. 268:468-481(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
[20]"1.9-A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling."
Somers W., Stahl M., Seehra J.S.
EMBO J. 16:989-997(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
[21]"The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis."
Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., Woo P.
J. Clin. Invest. 102:1369-1376(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SYSTEMIC JUVENILE RHEUMATOID ARTHRITIS.
[22]"An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus."
Foster C.B., Lehrnbecher T., Samuels S., Stein S., Mol F., Metcalf J.A., Wyvill K., Steinberg S.M., Kovacs J., Blauvelt A., Yarchoan R., Chanock S.J.
Blood 96:2562-2567(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO KAPOSI SARCOMA.
[23]"A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density."
Ota N., Nakajima T., Nakazawa I., Suzuki T., Hosoi T., Orimo H., Inoue S., Shirai Y., Emi M.
J. Hum. Genet. 46:267-272(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN BMD.
[24]"Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women."
Chung H.W., Seo J.-S., Hur S.E., Kim H.L., Kim J.Y., Jung J.H., Kim L.H., Park B.L., Shin H.D.
J. Hum. Genet. 48:243-248(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN BMD.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04430 mRNA. Translation: CAA28026.1.
M14584 mRNA. Translation: AAA52728.1.
X04602 mRNA. Translation: CAA28268.1.
Y00081 Genomic DNA. Translation: CAA68278.1.
M18403 mRNA. Translation: AAA52729.1.
M29150 mRNA. Translation: AAA59154.1.
X04402 Genomic DNA. Translation: CAA27990.1.
X04403 mRNA. Translation: CAA27991.1.
M54894 mRNA. Translation: AAC41704.1.
S56892 mRNA. Translation: AAD13886.1.
AF372214 Genomic DNA. Translation: AAK48987.1.
BC015511 mRNA. Translation: AAH15511.1.
PIRIVHUB2. A32648.
RefSeqNP_000591.1. NM_000600.3.
UniGeneHs.654458.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ALUX-ray1.90A28-212[»]
1IL6NMR-A28-212[»]
1N2Qmodel-E/F30-212[»]
1P9MX-ray3.65B29-212[»]
2IL6NMR-A28-212[»]
4J4LX-ray2.30C/D47-212[»]
4NI7X-ray2.40A28-212[»]
4NI9X-ray2.55A/C28-212[»]
ProteinModelPortalP05231.
SMRP05231. Positions 47-212.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109783. 2 interactions.
DIPDIP-482N.
IntActP05231. 4 interactions.
MINTMINT-190042.
STRING9606.ENSP00000258743.

Chemistry

ChEMBLCHEMBL1795129.
DrugBankDB01169. Arsenic trioxide.
DB01128. Bicalutamide.
DB01404. Ginseng.
DB00641. Simvastatin.

PTM databases

PhosphoSiteP05231.

Polymorphism databases

DMDM124347.

Proteomic databases

PaxDbP05231.
PRIDEP05231.

Protocols and materials databases

DNASU3569.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258743; ENSP00000258743; ENSG00000136244.
ENST00000404625; ENSP00000385675; ENSG00000136244.
GeneID3569.
KEGGhsa:3569.
UCSCuc003svj.4. human.

Organism-specific databases

CTD3569.
GeneCardsGC07P022732.
H-InvDBHIX0167872.
HGNCHGNC:6018. IL6.
HPACAB023406.
MIM147620. gene.
148000. phenotype.
604302. phenotype.
neXtProtNX_P05231.
Orphanet206. Crohn disease.
85414. Systemic-onset juvenile idiopathic arthritis.
PharmGKBPA198.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG48083.
HOGENOMHOG000236330.
HOVERGENHBG000471.
InParanoidP05231.
KOK05405.
OMALQFSLRA.
OrthoDBEOG7QG453.
PhylomeDBP05231.
TreeFamTF335984.

Enzyme and pathway databases

ReactomeREACT_120956. Cellular responses to stress.
REACT_6900. Immune System.
SignaLinkP05231.

Gene expression databases

ArrayExpressP05231.
BgeeP05231.
CleanExHS_IL6.
GenevestigatorP05231.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PANTHERPTHR11457. PTHR11457. 1 hit.
PfamPF00489. IL6. 1 hit.
[Graphical view]
PIRSFPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSPR00433. IL6GCSFMGF.
PR00434. INTERLEUKIN6.
SMARTSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIL6. human.
EvolutionaryTraceP05231.
GeneWikiInterleukin_6.
GenomeRNAi3569.
NextBio13950.
PMAP-CutDBP05231.
PROP05231.
SOURCESearch...

Entry information

Entry nameIL6_HUMAN
AccessionPrimary (citable) accession number: P05231
Secondary accession number(s): Q9UCU2, Q9UCU3, Q9UCU4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: April 16, 2014
This is version 173 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM