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Protein

Fibroblast growth factor 1

Gene

FGF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33Heparin2 Publications1

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: Reactome
  • fibroblast growth factor receptor binding Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • heparin binding Source: UniProtKB
  • Hsp70 protein binding Source: Ensembl
  • integrin binding Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
  • protein tyrosine kinase activity Source: Reactome
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • S100 protein binding Source: UniProtKB

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • activation of protein kinase B activity Source: UniProtKB
  • anatomical structure morphogenesis Source: ProtInc
  • angiogenesis Source: UniProtKB-KW
  • branch elongation involved in ureteric bud branching Source: UniProtKB
  • cell differentiation Source: UniProtKB-KW
  • cell proliferation Source: Ensembl
  • cellular response to heat Source: UniProtKB
  • fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • interleukin-7-mediated signaling pathway Source: Reactome
  • lung development Source: Ensembl
  • MAPK cascade Source: Reactome
  • mesonephric epithelium development Source: UniProtKB
  • multicellular organism development Source: ProtInc
  • organ induction Source: Ensembl
  • phosphatidylinositol-mediated signaling Source: Reactome
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of cell division Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of cholesterol biosynthetic process Source: BHF-UCL
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: Ensembl
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of intracellular signal transduction Source: BHF-UCL
  • positive regulation of MAP kinase activity Source: UniProtKB
  • positive regulation of sprouting angiogenesis Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
  • regulation of endothelial tube morphogenesis Source: UniProtKB
  • regulation of phosphatidylinositol 3-kinase signaling Source: Reactome
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1839122. Signaling by activated point mutants of FGFR1.
R-HSA-1839130. Signaling by activated point mutants of FGFR3.
R-HSA-190322. FGFR4 ligand binding and activation.
R-HSA-190370. FGFR1b ligand binding and activation.
R-HSA-190371. FGFR3b ligand binding and activation.
R-HSA-190372. FGFR3c ligand binding and activation.
R-HSA-190373. FGFR1c ligand binding and activation.
R-HSA-190375. FGFR2c ligand binding and activation.
R-HSA-190377. FGFR2b ligand binding and activation.
R-HSA-2033514. FGFR3 mutant receptor activation.
R-HSA-2033519. Activated point mutants of FGFR2.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-HSA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-HSA-5654227. Phospholipase C-mediated cascade, FGFR3.
R-HSA-5654228. Phospholipase C-mediated cascade, FGFR4.
R-HSA-5654687. Downstream signaling of activated FGFR1.
R-HSA-5654688. SHC-mediated cascade:FGFR1.
R-HSA-5654689. PI-3K cascade:FGFR1.
R-HSA-5654693. FRS-mediated FGFR1 signaling.
R-HSA-5654695. PI-3K cascade:FGFR2.
R-HSA-5654699. SHC-mediated cascade:FGFR2.
R-HSA-5654700. FRS-mediated FGFR2 signaling.
R-HSA-5654704. SHC-mediated cascade:FGFR3.
R-HSA-5654706. FRS-mediated FGFR3 signaling.
R-HSA-5654710. PI-3K cascade:FGFR3.
R-HSA-5654712. FRS-mediated FGFR4 signaling.
R-HSA-5654719. SHC-mediated cascade:FGFR4.
R-HSA-5654720. PI-3K cascade:FGFR4.
R-HSA-5654726. Negative regulation of FGFR1 signaling.
R-HSA-5654727. Negative regulation of FGFR2 signaling.
R-HSA-5654732. Negative regulation of FGFR3 signaling.
R-HSA-5654733. Negative regulation of FGFR4 signaling.
R-HSA-5655253. Signaling by FGFR2 in disease.
R-HSA-5655302. Signaling by FGFR1 in disease.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8851708. Signaling by FGFR2 IIIa TM.
R-HSA-8853338. Signaling by FGFR3 point mutants in cancer.
SignaLinkiP05230.
SIGNORiP05230.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name:
aFGF
Endothelial cell growth factor
Short name:
ECGF
Heparin-binding growth factor 1
Short name:
HBGF-1
Gene namesi
Name:FGF1
Synonyms:FGFA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113578.17.
HGNCiHGNC:3665. FGF1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24 – 27KKPK → AAPA: Loss of nuclear import leading to loss of phosphorylation by PKC/PRKCD. 1 Publication4
Mutagenesisi33N → A: No effect on integrin-binding. 1 Publication1
Mutagenesisi50R → E: Dominant-negative mutant. Defective in integrin-binding and in ternary complex formation with integrin and FGFR1. No effect on heparin- and FGFR1-binding. Defective in inducing FGF1 signaling, cell proliferation and cell migration. Defective in inducing angiogenesis, and suppression of angiogenesis in different in vitro and in vivo angiogenesis models. 3 Publications1
Mutagenesisi102E → A: No effect on integrin-binding. No effect on integrin- and heparin-binding, loss of FGFR1-binding, defective in inducing FGF1 signaling, cell proliferation and cell migration; when associated with A-109 and A-110. 1 Publication1
Mutagenesisi109Y → A: No effect on integrin- and heparin-binding, loss of FGFR1-binding, defective in inducing FGF1 signaling, cell proliferation and cell migration; when associated with A-102 and A-110. 1 Publication1
Mutagenesisi110N → A: No effect on integrin-binding. No effect on integrin- and heparin-binding, loss of FGFR1-binding, defective in inducing FGF1 signaling, cell proliferation and cell migration; when associated with A-102 and A-109. 1 Publication1
Mutagenesisi114S → A: Decrease in LRRC59-binding. 1 Publication1
Mutagenesisi127K → E: Reduced integrin-binding; when associated with E-128. Defective in integrin-, heparin- and FGFR1-binding, and defective in inducing FGF1 signaling, cell proliferation and cell migration; when associated with E-128; E-133 and E-134. 1 Publication1
Mutagenesisi128K → E: Reduced integrin-binding; when associated with E-127. Defective in integrin-, heparin- and FGFR1-binding, and defective in inducing FGF1 signaling, cell proliferation and cell migration; when associated with E-127; E-133 and E-134. 1 Publication1
Mutagenesisi131S → A: Decrease in LRRC59-binding. 1 Publication1
Mutagenesisi131S → E: Decrease in LRRC59-binding. 1 Publication1
Mutagenesisi133K → A: Loss of LRRC59-binding. 1 Publication1
Mutagenesisi133K → E: Loss of CSNK2A-, CSNK2B- and LRRC59-binding. Reduced integrin-binding; when associated with E-134. Defective in integrin-, heparin- and FGFR1-binding, and defective in inducing FGF1 signaling, cell proliferation and cell migration; when associated with E-128; E-133 and E-134. 2 Publications1
Mutagenesisi133K → R: No effect on LRRC59-binding. 1 Publication1
Mutagenesisi134R → E: Reduced integrin-binding; when associated with E-133. Defective in integrin-, heparin- and FGFR1-binding, and defective in inducing FGF1 signaling, cell proliferation and cell migration; when associated with E-127; E-128 and E-133. 1 Publication1

Organism-specific databases

DisGeNETi2246.
OpenTargetsiENSG00000113578.
PharmGKBiPA28105.

Chemistry databases

ChEMBLiCHEMBL2120.
DrugBankiDB08238. 5-AMINO-NAPHTALENE-2-MONOSULFONATE.
DB01025. Amlexanox.
DB01942. Formic Acid.
DB04409. Naphthalene Trisulfonate.
DB02264. O2-Sulfo-Glucuronic Acid.
DB06589. Pazopanib.
DB00686. Pentosan Polysulfate.
DB01901. Sucrosofate.

Polymorphism and mutation databases

BioMutaiFGF1.
DMDMi122737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
PropeptideiPRO_00000089072 – 15Add BLAST14
ChainiPRO_000000890816 – 155Fibroblast growth factor 1Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Post-translational modificationi

In the nucleus, phosphorylated by PKC/PRKCD.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05230.
MaxQBiP05230.
PaxDbiP05230.
PeptideAtlasiP05230.
PRIDEiP05230.
TopDownProteomicsiP05230-1. [P05230-1]

PTM databases

iPTMnetiP05230.
PhosphoSitePlusiP05230.

Expressioni

Tissue specificityi

Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000113578.
CleanExiHS_FGF1.
ExpressionAtlasiP05230. baseline and differential.
GenevisibleiP05230. HS.

Organism-specific databases

HPAiCAB017519.
HPA003265.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu2+-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (PubMed:20422052).13 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • Hsp70 protein binding Source: Ensembl
  • integrin binding Source: UniProtKB
  • S100 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108537. 26 interactors.
DIPiDIP-3787N.
IntActiP05230. 7 interactors.
MINTiMINT-118570.
STRINGi9606.ENSP00000338548.

Chemistry databases

BindingDBiP05230.

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni11 – 13Combined sources3
Beta strandi23 – 25Combined sources3
Beta strandi27 – 31Combined sources5
Turni32 – 35Combined sources4
Beta strandi36 – 40Combined sources5
Turni42 – 44Combined sources3
Beta strandi46 – 49Combined sources4
Helixi55 – 57Combined sources3
Beta strandi59 – 65Combined sources7
Beta strandi68 – 73Combined sources6
Turni74 – 76Combined sources3
Beta strandi79 – 82Combined sources4
Beta strandi84 – 86Combined sources3
Beta strandi88 – 93Combined sources6
Helixi96 – 98Combined sources3
Beta strandi100 – 105Combined sources6
Turni106 – 108Combined sources3
Beta strandi109 – 115Combined sources7
Helixi118 – 120Combined sources3
Beta strandi123 – 126Combined sources4
Beta strandi130 – 132Combined sources3
Helixi135 – 137Combined sources3
Turni138 – 141Combined sources4
Helixi143 – 145Combined sources3
Beta strandi147 – 151Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AXMX-ray3.00A/B/C/D/E/F21-155[»]
1DJSX-ray2.40B21-155[»]
1DZCNMR-A25-155[»]
1DZDNMR-A29-155[»]
1E0OX-ray2.80A/C16-155[»]
1EVTX-ray2.80A/B22-155[»]
1HKNX-ray2.00A/B/C/D/E/F17-155[»]
1JQZX-ray1.65A/B16-155[»]
1JT3X-ray1.95A/B16-155[»]
1JT4X-ray1.78A/B16-155[»]
1JT5X-ray1.85A/B16-155[»]
1JT7X-ray1.70A/B/C/D16-155[»]
1JTCX-ray1.70A/B/C/D16-155[»]
1JY0X-ray1.70A/B16-155[»]
1K5UX-ray2.00A/B/C16-154[»]
1K5VX-ray2.10A/B16-154[»]
1M16X-ray1.70A/B16-155[»]
1NZKX-ray1.95A/B/C/D16-152[»]
1P63X-ray1.60A/B16-155[»]
1PZZX-ray2.00A/B16-155[»]
1Q03X-ray2.05A/B16-152[»]
1Q04X-ray1.80A/B16-155[»]
1QCTmodel-A/D24-153[»]
1RG8X-ray1.10A/B16-155[»]
1RMLNMR-A1-155[»]
1RY7X-ray3.20A1-155[»]
1YTOX-ray2.10A/B/C/D16-155[»]
1Z2VX-ray1.90A/B16-155[»]
1Z4SX-ray2.60A/B/C/D16-155[»]
2AFGX-ray2.00A/B/C/D16-155[»]
2AQZX-ray1.85A/B16-155[»]
2AXMX-ray3.00A/B21-155[»]
2ERMNMR-A17-155[»]
2HW9X-ray1.60A/B16-155[»]
2HWAX-ray1.65A/B16-155[»]
2HWMX-ray1.60A/B16-155[»]
2HZ9X-ray1.70A/B16-155[»]
2K43NMR-A23-155[»]
2K4ANMR-B23-155[»]
2K8RNMR-A23-155[»]
2KI4NMR-A/D23-155[»]
2KI6NMR-B/E23-155[»]
2NTDX-ray2.52A/B/C/D16-155[»]
2Q9XX-ray1.70A16-155[»]
2RQ9NMR-A22-155[»]
3B9UX-ray1.55A16-155[»]
3BA4X-ray1.80A/B16-155[»]
3BA5X-ray1.75A/B16-155[»]
3BA7X-ray1.60A/B16-155[»]
3BADX-ray2.00A/B16-155[»]
3BAGX-ray1.75A/B16-155[»]
3BAHX-ray1.65A/B16-155[»]
3BAOX-ray1.55A/B16-155[»]
3BAQX-ray1.80A/B16-155[»]
3BAUX-ray1.60A/B16-155[»]
3BAVX-ray1.62A/B16-155[»]
3BB2X-ray1.50A/B16-155[»]
3CQAX-ray1.80A/B16-155[»]
3CRGX-ray1.85A/B16-155[»]
3CRHX-ray2.15A/B16-155[»]
3CRIX-ray2.10A/B16-155[»]
3CU1X-ray2.60B/D22-152[»]
3FGMX-ray1.95A/B16-155[»]
3FJ8X-ray2.00A/B16-155[»]
3FJ9X-ray1.90A/B16-155[»]
3FJAX-ray1.95A/B16-155[»]
3FJBX-ray2.00A/B16-155[»]
3FJCX-ray2.00A/B16-155[»]
3FJDX-ray1.90A/B16-155[»]
3FJEX-ray2.10A/B16-155[»]
3FJFX-ray1.90A/B16-155[»]
3FJHX-ray1.90A/B16-155[»]
3FJIX-ray2.55A/B/C/D16-155[»]
3FJJX-ray1.90A/B16-155[»]
3FJKX-ray2.15A/B/C/D16-155[»]
3HOMX-ray2.30A/B16-155[»]
3JUTX-ray2.25A/B/C/D/E/F24-153[»]
3K1XX-ray1.98A/B/C/D/E/F24-153[»]
3O3QX-ray1.60A/B/C/D16-155[»]
3OJ2X-ray2.20A/B1-155[»]
3OJMX-ray2.10A1-155[»]
3OJVX-ray2.60A/B21-155[»]
3UD7X-ray2.80A/B/C16-155[»]
3UD8X-ray2.37A/B/C16-155[»]
3UD9X-ray2.34A/B/C16-155[»]
3UDAX-ray2.51A/B/C16-155[»]
4J23X-ray3.88B21-155[»]
4Q91X-ray1.80A/B16-155[»]
4Q9GX-ray1.55A/B16-155[»]
4Q9PX-ray1.80A/B16-155[»]
4QALX-ray1.50A/B16-155[»]
4QBCX-ray1.52A/B16-155[»]
4QBVX-ray1.50A/B16-155[»]
4QC4X-ray1.49A/B16-155[»]
4QO3X-ray2.05A/B16-155[»]
4XKIX-ray2.00A/B16-155[»]
4YOLX-ray1.97A/B16-155[»]
ProteinModelPortaliP05230.
SMRiP05230.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05230.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 143Heparin-bindingAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi24 – 27Nuclear localization signal4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00730000110923.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP05230.
KOiK18496.
OMAiLGPRTHY.
OrthoDBiEOG091G0NAY.
PhylomeDBiP05230.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF98. PTHR11486:SF98. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
PRINTSiPR00263. HBGFFGF.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00247. HBGF_FGF. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05230-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGEITTFT ALTEKFNLPP GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR
60 70 80 90 100
DRSDQHIQLQ LSAESVGEVY IKSTETGQYL AMDTDGLLYG SQTPNEECLF
110 120 130 140 150
LERLEENHYN TYISKKHAEK NWFVGLKKNG SCKRGPRTHY GQKAILFLPL

PVSSD
Length:155
Mass (Da):17,460
Last modified:August 13, 1987 - v1
Checksum:iF586E8BFB09F1580
GO
Isoform 2 (identifier: P05230-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-60: IQLQ → TDTK
     61-155: Missing.

Show »
Length:60
Mass (Da):6,698
Checksum:iB53E08C406484714
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02135721G → E1 PublicationCorresponds to variant dbSNP:rs17223632Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03653657 – 60IQLQ → TDTK in isoform 2. 1 Publication4
Alternative sequenceiVSP_03653761 – 155Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13361 mRNA. Translation: AAA79245.1.
M30492, M30490, M30491 Genomic DNA. Translation: AAA52446.1.
M23087, M23086 Genomic DNA. Translation: AAA52638.1.
X51943 mRNA. Translation: CAA36206.1.
X65778 mRNA. Translation: CAA46661.1.
S67291 mRNA. Translation: AAB29057.2.
S67292 mRNA. Translation: AAB29058.1.
AY601819 Genomic DNA. Translation: AAS99352.1.
AC005370 Genomic DNA. No translation available.
AK312301 mRNA. Translation: BAG35227.1.
CH471062 Genomic DNA. Translation: EAW61881.1.
CH471062 Genomic DNA. Translation: EAW61882.1.
CH471062 Genomic DNA. Translation: EAW61885.1.
BC032697 mRNA. Translation: AAH32697.1.
M60515 mRNA. Translation: AAA51672.1.
M60516 mRNA. Translation: AAA51673.1.
CCDSiCCDS4275.1. [P05230-1]
CCDS4276.1. [P05230-2]
PIRiA33665.
JH0708.
RefSeqiNP_000791.1. NM_000800.4. [P05230-1]
NP_001138364.1. NM_001144892.2. [P05230-1]
NP_001138406.1. NM_001144934.1. [P05230-1]
NP_001138407.1. NM_001144935.1. [P05230-1]
NP_001244134.1. NM_001257205.1. [P05230-1]
NP_001244136.1. NM_001257207.1. [P05230-1]
NP_001244137.1. NM_001257208.1. [P05230-1]
NP_001244138.1. NM_001257209.1. [P05230-1]
NP_001244139.1. NM_001257210.1. [P05230-1]
NP_149127.1. NM_033136.3. [P05230-2]
NP_149128.1. NM_033137.2.
UniGeneiHs.483635.

Genome annotation databases

EnsembliENST00000337706; ENSP00000338548; ENSG00000113578. [P05230-1]
ENST00000359370; ENSP00000352329; ENSG00000113578. [P05230-1]
ENST00000360966; ENSP00000354231; ENSG00000113578. [P05230-2]
ENST00000378046; ENSP00000367285; ENSG00000113578. [P05230-1]
ENST00000419524; ENSP00000396195; ENSG00000113578. [P05230-1]
ENST00000441680; ENSP00000404742; ENSG00000113578. [P05230-1]
ENST00000610990; ENSP00000481868; ENSG00000113578. [P05230-1]
ENST00000612258; ENSP00000479024; ENSG00000113578. [P05230-1]
ENST00000619447; ENSP00000480980; ENSG00000113578. [P05230-1]
ENST00000621536; ENSP00000480791; ENSG00000113578. [P05230-1]
GeneIDi2246.
KEGGihsa:2246.
UCSCiuc003lmm.5. human. [P05230-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFGF1_HUMAN
AccessioniPrimary (citable) accession number: P05230
Secondary accession number(s): B2R5T0
, D3DQF2, P07502, Q16588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 27, 2017
This is version 209 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families