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P05226 (CAER4_XENBO) Reviewed, UniProtKB/Swiss-Prot

Last modified March 2, 2010. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Preprocaerulein type-4
Alternative name(s):
Preprocaerulein type IV

Cleaved into the following chain:

  1. Caerulein
OrganismXenopus borealis (Kenyan clawed frog)
Taxonomic identifier8354 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraMesobatrachiaPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The pharmacological activities of caerulein are quite similar to the physiological activities of gastrin and related peptides.

Subcellular location

Secreted.

Tissue specificity

Expressed by the skin glands.

Sequence similarities

Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   Molecular functionAmphibian defense peptide
   PTMAmidation
Cleavage on pair of basic residues
Sulfation
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processdefense response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhormone activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Propeptide27 – 7347
PRO_0000010504
Peptide74 – 8310Caerulein
PRO_0000010505
Propeptide87 – 13751
PRO_0000010506
Peptide138 – 14710Caerulein
PRO_0000010507
Propeptide151 – 1522
PRO_0000010508
Peptide153 – 16210Caerulein
PRO_0000010509
Propeptide166 – 21651
PRO_0000010510
Peptide217 – 22610Caerulein
PRO_0000010511
Propeptide230 – 2345
PRO_0000010512

Amino acid modifications

Modified residue771Sulfotyrosine
Modified residue831Phenylalanine amide
Modified residue1411Sulfotyrosine
Modified residue1471Phenylalanine amide
Modified residue1561Sulfotyrosine
Modified residue1621Phenylalanine amide
Modified residue2201Sulfotyrosine
Modified residue2261Phenylalanine amide

Sequences

Sequence LengthMass (Da)Tools
P05226 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 052D82F910541147

FASTA23426,055
        10         20         30         40         50         60 
MFKGILLCVL FAVLSANPLS QPEGFADEEE RDVRGLASLL GKALKAALKI GANALGGSPQ 

        70         80         90        100        110        120 
QREANDERRF ADGQQDYTGW MDFGRRDDED DVNERDVRGF GSFLGKALKA GLKIGTHFLG 

       130        140        150        160        170        180 
GAPQQREAND ERRFADGQQD YTGWMDFGRR DGQQDYTGWM DFGRRDDEDD VHERDVRGFG 

       190        200        210        220        230 
SFLGKALKAA LKIGANALGG SPQQREANDE RRFADGQQDY TGWMDFGRRN GEDD 

« Hide

References

[1]"Complete nucleotide sequence of mRNA for caerulein precursor from Xenopus skin: the mRNA contains an unusual repetitive structure."
Wakabayashi T., Kato H., Tachibana S.
Nucleic Acids Res. 13:1817-1828(1985) [PubMed: 4000945] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skin.
[2]"Presence of caerulein in extracts of the skin of Leptodactylus pentadactylus labyrinthicus and of Xenopus laevis."
Anastasi A., Bertaccini G., Cei J.M., de Daro G., Erspamer V., Impicciatore M., Roseghini M.
Br. J. Pharmacol. 38:221-228(1970) [PubMed: 5413288] [Abstract]
Cited for: PROTEIN SEQUENCE OF CAERULEIN.
Tissue: Skin secretion.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02310 mRNA. Translation: CAA26180.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG050778.

Family and domain databases

InterProIPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PfamPF00918. Gastrin. 4 hits.
[Graphical view]
SMARTSM00029. GASTRIN. 4 hits.
[Graphical view]
PROSITEPS00259. GASTRIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAER4_XENBO
AccessionPrimary (citable) accession number: P05226
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: March 2, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families