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Protein

Chymotrypsin-like elastase family member 2A

Gene

Cela2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts upon elastin.

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemBy similarity1
Active sitei123Charge relay systemBy similarity1
Active sitei218Charge relay systemBy similarity1

GO - Molecular functioni

  • serine hydrolase activity Source: MGI
  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

  • establishment of skin barrier Source: MGI
  • proteolysis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-MMU-6809371. Formation of the cornified envelope.

Protein family/group databases

MEROPSiS01.155.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 2A (EC:3.4.21.71)
Alternative name(s):
Elastase-2
Elastase-2A
Gene namesi
Name:Cela2a
Synonyms:Ela-2, Ela2, Ela2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95316. Cela2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
PropeptideiPRO_000002768717 – 30Activation peptideAdd BLAST14
ChainiPRO_000002768831 – 271Chymotrypsin-like elastase family member 2AAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Disulfide bondi157 ↔ 224PROSITE-ProRule annotation
Disulfide bondi188 ↔ 204PROSITE-ProRule annotation
Disulfide bondi214 ↔ 245PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

MaxQBiP05208.
PaxDbiP05208.
PeptideAtlasiP05208.
PRIDEiP05208.

PTM databases

PhosphoSitePlusiP05208.

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

BgeeiENSMUSG00000058579.
CleanExiMM_ELA2.
GenevisibleiP05208. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099539.

Structurei

3D structure databases

ProteinModelPortaliP05208.
SMRiP05208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 269Peptidase S1PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
InParanoidiP05208.
KOiK01346.
OMAiASNGQWQ.
OrthoDBiEOG091G0DF7.
PhylomeDBiP05208.
TreeFamiTF330455.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRTLLLSAL VAGALSCGYP TYEVEDDVSR VVGGQEATPN TWPWQVSLQV
60 70 80 90 100
LSSGRWRHNC GGSLVANNWV LTAAHCLSNY QTYRVLLGAH SLSNPGAGSA
110 120 130 140 150
AVQVSKLVVH QRWNSQNVGN GYDIALIKLA SPVTLSKNIQ TACLPPAGTI
160 170 180 190 200
LPRNYVCYVT GWGLLQTNGN SPDTLRQGRL LVVDYATCSS ASWWGSSVKS
210 220 230 240 250
SMVCAGGDGV TSSCNGDSGG PLNCRASNGQ WQVHGIVSFG SSLGCNYPRK
260 270
PSVFTRVSNY IDWINSVMAR N
Length:271
Mass (Da):28,914
Last modified:August 13, 1987 - v1
Checksum:iFA542AE38FED3B4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04573 mRNA. Translation: CAA28242.1.
X04576 Genomic DNA. Translation: CAA28244.1.
BC026552 mRNA. Translation: AAH26552.1.
CCDSiCCDS18884.1.
PIRiA25528.
RefSeqiNP_031945.1. NM_007919.3.
UniGeneiMm.45316.

Genome annotation databases

EnsembliENSMUST00000102481; ENSMUSP00000099539; ENSMUSG00000058579.
GeneIDi13706.
KEGGimmu:13706.
UCSCiuc008vpj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04573 mRNA. Translation: CAA28242.1.
X04576 Genomic DNA. Translation: CAA28244.1.
BC026552 mRNA. Translation: AAH26552.1.
CCDSiCCDS18884.1.
PIRiA25528.
RefSeqiNP_031945.1. NM_007919.3.
UniGeneiMm.45316.

3D structure databases

ProteinModelPortaliP05208.
SMRiP05208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099539.

Protein family/group databases

MEROPSiS01.155.

PTM databases

PhosphoSitePlusiP05208.

Proteomic databases

MaxQBiP05208.
PaxDbiP05208.
PeptideAtlasiP05208.
PRIDEiP05208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102481; ENSMUSP00000099539; ENSMUSG00000058579.
GeneIDi13706.
KEGGimmu:13706.
UCSCiuc008vpj.1. mouse.

Organism-specific databases

CTDi63036.
MGIiMGI:95316. Cela2a.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
InParanoidiP05208.
KOiK01346.
OMAiASNGQWQ.
OrthoDBiEOG091G0DF7.
PhylomeDBiP05208.
TreeFamiTF330455.

Enzyme and pathway databases

ReactomeiR-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiCela2a. mouse.
PROiP05208.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058579.
CleanExiMM_ELA2.
GenevisibleiP05208. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEL2A_MOUSE
AccessioniPrimary (citable) accession number: P05208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.