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Protein

Heterochromatin protein 1

Gene

Su(var)205

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24Histone H3K9me21
Binding sitei45Histone H3K9me21
Binding sitei48Histone H3K9me21

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • histone binding Source: FlyBase
  • methylated histone binding Source: FlyBase
  • mRNA binding Source: FlyBase
  • rDNA binding Source: FlyBase
  • RNA binding Source: FlyBase
  • satellite DNA binding Source: FlyBase

GO - Biological processi

  • chromatin silencing Source: FlyBase
  • chromatin silencing at centromere Source: FlyBase
  • chromosome organization Source: FlyBase
  • DNA hypermethylation Source: FlyBase
  • establishment of chromatin silencing Source: FlyBase
  • gene silencing Source: FlyBase
  • heterochromatin assembly Source: FlyBase
  • histone H4-K20 trimethylation Source: FlyBase
  • mitotic nuclear division Source: CACAO
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • neurogenesis Source: FlyBase
  • positive regulation of extent of heterochromatin assembly Source: FlyBase
  • positive regulation of histone H3-K9 dimethylation Source: FlyBase
  • positive regulation of methylation-dependent chromatin silencing Source: FlyBase
  • positive regulation of transcription, DNA-templated Source: FlyBase
  • regulation of apoptotic process Source: FlyBase
  • regulation of histone methylation Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • telomere maintenance Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-73777. RNA Polymerase I Chain Elongation.
R-DME-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP05205.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterochromatin protein 1
Short name:
HP1
Alternative name(s):
Non-histone chromosomal protein C1A9 antigen
Gene namesi
Name:Su(var)205
Synonyms:HP1
ORF Names:CG8409
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0003607. Su(var)205.

Subcellular locationi

  • Nucleusnucleoplasm 1 Publication

  • Note: Colocalizes with Arp6 on centric heterochromatin.

GO - Cellular componenti

  • chromosome Source: FlyBase
  • chromosome, centromeric region Source: FlyBase
  • chromosome, telomeric region Source: FlyBase
  • condensed chromosome Source: FlyBase
  • condensed nuclear chromosome, centromeric region Source: FlyBase
  • euchromatin Source: FlyBase
  • heterochromatin Source: FlyBase
  • nuclear heterochromatin Source: FlyBase
  • nucleoplasm Source: UniProtKB-SubCell
  • nucleus Source: FlyBase
  • pericentric heterochromatin Source: FlyBase
  • polytene chromosome Source: FlyBase
  • polytene chromosome, telomeric region Source: FlyBase
  • polytene chromosome band Source: FlyBase
  • polytene chromosome chromocenter Source: FlyBase
  • polytene chromosome puff Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi10S → A: 3-fold lower H3 binding affinity. 1 Publication1
Mutagenesisi26V → M: Abolishes H3 binding. Does not affect piwi binding. 2 Publications1
Mutagenesisi191I → E: Abolishes piwi binding. 1 Publication1
Mutagenesisi200W → A: Abolishes piwi binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801971 – 206Heterochromatin protein 1Add BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11Phosphoserine1 Publication1
Modified residuei15Phosphoserine2 Publications1
Modified residuei102Phosphoserine1 Publication1
Modified residuei103Phosphoserine1 Publication1
Modified residuei113Phosphoserine1 Publication1
Modified residuei127Phosphothreonine1 Publication1
Modified residuei128Phosphothreonine2 Publications1
Modified residuei134Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP05205.
PRIDEiP05205.

PTM databases

iPTMnetiP05205.

Expressioni

Gene expression databases

BgeeiFBgn0003607.
GenevisibleiP05205. DM.

Interactioni

Subunit structurei

Homodimer; probably associates with Su(var)3-9. Interacts with Mcm10. Interacts (via chromoshadow domain) with piwi (via N-terminal region).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Atf-2-RBQ9W0Z53EBI-155532,EBI-94769
cavQ95RV24EBI-155532,EBI-104820
His3:CG33854P022993EBI-155532,EBI-522090
Mcm10Q9VIE62EBI-155532,EBI-91264

GO - Molecular functioni

  • histone binding Source: FlyBase
  • methylated histone binding Source: FlyBase

Protein-protein interaction databases

BioGridi60248. 34 interactors.
DIPiDIP-21869N.
IntActiP05205. 29 interactors.
MINTiMINT-271388.
STRINGi7227.FBpp0079251.

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 35Combined sources12
Beta strandi38 – 45Combined sources8
Helixi50 – 52Combined sources3
Beta strandi54 – 57Combined sources4
Helixi58 – 60Combined sources3
Helixi64 – 73Combined sources10
Turni142 – 146Combined sources5
Beta strandi149 – 158Combined sources10
Beta strandi161 – 168Combined sources8
Beta strandi175 – 178Combined sources4
Helixi179 – 185Combined sources7
Helixi187 – 196Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KNAX-ray2.10A17-76[»]
1KNEX-ray2.40A17-76[»]
1Q3LX-ray1.64A17-76[»]
3P7JX-ray2.30A/B131-206[»]
ProteinModelPortaliP05205.
SMRiP05205.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05205.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 82Chromo 1PROSITE-ProRule annotationAdd BLAST59
Domaini147 – 205Chromo 2PROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 206Binds to Su(var)39Add BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 23Poly-Glu6

Sequence similaritiesi

Contains 2 chromo domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1911. Eukaryota.
ENOG4111JKD. LUCA.
GeneTreeiENSGT00510000046310.
InParanoidiP05205.
KOiK11587.
OMAiPETENTW.
OrthoDBiEOG091G0RBS.
PhylomeDBiP05205.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR008251. Chromo_shadow_dom.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF01393. Chromo_shadow. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 2 hits.
SM00300. ChSh. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 2 hits.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKIDNPES SAKVSDAEEE EEEYAVEKII DRRVRKGKVE YYLKWKGYPE
60 70 80 90 100
TENTWEPENN LDCQDLIQQY EASRKDEEKS AASKKDRPSS SAKAKETQGR
110 120 130 140 150
ASSSTSTASK RKSEEPTAPS GNKSKRTTDA EQDTIPVSGS TGFDRGLEAE
160 170 180 190 200
KILGASDNNG RLTFLIQFKG VDQAEMVPSS VANEKIPRMV IHFYEERLSW

YSDNED
Length:206
Mass (Da):23,185
Last modified:November 1, 1995 - v2
Checksum:i6A5B204C487526B7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti105T → A in strain: NC322, NC358 and NC359. 1 Publication1
Natural varianti126R → C in strain: NC390. 1 Publication1
Natural varianti134T → S in strain: MW25. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57574 Genomic DNA. Translation: AAA28620.1.
M14131 mRNA. Translation: AAA28402.1. Sequence problems.
FJ218607 Genomic DNA. Translation: ACI96755.1.
FJ218612 Genomic DNA. Translation: ACI96760.1.
FJ218613 Genomic DNA. Translation: ACI96761.1.
FJ218614 Genomic DNA. Translation: ACI96762.1.
FJ218615 Genomic DNA. Translation: ACI96763.1.
FJ218616 Genomic DNA. Translation: ACI96764.1.
FJ218617 Genomic DNA. Translation: ACI96765.1.
FJ218618 Genomic DNA. Translation: ACI96766.1.
FJ218619 Genomic DNA. Translation: ACI96767.1.
FJ218620 Genomic DNA. Translation: ACI96768.1.
FJ218621 Genomic DNA. Translation: ACI96769.1.
FJ218622 Genomic DNA. Translation: ACI96770.1.
FJ218623 Genomic DNA. Translation: ACI96771.1.
FJ218624 Genomic DNA. Translation: ACI96772.1.
FJ218625 Genomic DNA. Translation: ACI96773.1.
FJ218626 Genomic DNA. Translation: ACI96774.1.
FJ218627 Genomic DNA. Translation: ACI96775.1.
FJ218628 Genomic DNA. Translation: ACI96776.1.
FJ218629 Genomic DNA. Translation: ACI96777.1.
FJ218630 Genomic DNA. Translation: ACI96778.1.
FJ218631 Genomic DNA. Translation: ACI96779.1.
FJ218632 Genomic DNA. Translation: ACI96780.1.
FJ218633 Genomic DNA. Translation: ACI96781.1.
FJ218634 Genomic DNA. Translation: ACI96782.1.
FJ218635 Genomic DNA. Translation: ACI96783.1.
FJ218636 Genomic DNA. Translation: ACI96784.1.
FJ218637 Genomic DNA. Translation: ACI96785.1.
FJ218638 Genomic DNA. Translation: ACI96786.1.
FJ218639 Genomic DNA. Translation: ACI96787.1.
AE014134 Genomic DNA. Translation: AAF52618.1.
AE014134 Genomic DNA. Translation: AAN11156.1.
AY061119 mRNA. Translation: AAL28667.1.
PIRiA39268.
RefSeqiNP_476755.1. NM_057407.4.
NP_723361.1. NM_164799.2.
UniGeneiDm.3713.

Genome annotation databases

EnsemblMetazoaiFBtr0079635; FBpp0079251; FBgn0003607.
FBtr0079636; FBpp0079252; FBgn0003607.
GeneIDi34119.
KEGGidme:Dmel_CG8409.
UCSCiCG8409-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57574 Genomic DNA. Translation: AAA28620.1.
M14131 mRNA. Translation: AAA28402.1. Sequence problems.
FJ218607 Genomic DNA. Translation: ACI96755.1.
FJ218612 Genomic DNA. Translation: ACI96760.1.
FJ218613 Genomic DNA. Translation: ACI96761.1.
FJ218614 Genomic DNA. Translation: ACI96762.1.
FJ218615 Genomic DNA. Translation: ACI96763.1.
FJ218616 Genomic DNA. Translation: ACI96764.1.
FJ218617 Genomic DNA. Translation: ACI96765.1.
FJ218618 Genomic DNA. Translation: ACI96766.1.
FJ218619 Genomic DNA. Translation: ACI96767.1.
FJ218620 Genomic DNA. Translation: ACI96768.1.
FJ218621 Genomic DNA. Translation: ACI96769.1.
FJ218622 Genomic DNA. Translation: ACI96770.1.
FJ218623 Genomic DNA. Translation: ACI96771.1.
FJ218624 Genomic DNA. Translation: ACI96772.1.
FJ218625 Genomic DNA. Translation: ACI96773.1.
FJ218626 Genomic DNA. Translation: ACI96774.1.
FJ218627 Genomic DNA. Translation: ACI96775.1.
FJ218628 Genomic DNA. Translation: ACI96776.1.
FJ218629 Genomic DNA. Translation: ACI96777.1.
FJ218630 Genomic DNA. Translation: ACI96778.1.
FJ218631 Genomic DNA. Translation: ACI96779.1.
FJ218632 Genomic DNA. Translation: ACI96780.1.
FJ218633 Genomic DNA. Translation: ACI96781.1.
FJ218634 Genomic DNA. Translation: ACI96782.1.
FJ218635 Genomic DNA. Translation: ACI96783.1.
FJ218636 Genomic DNA. Translation: ACI96784.1.
FJ218637 Genomic DNA. Translation: ACI96785.1.
FJ218638 Genomic DNA. Translation: ACI96786.1.
FJ218639 Genomic DNA. Translation: ACI96787.1.
AE014134 Genomic DNA. Translation: AAF52618.1.
AE014134 Genomic DNA. Translation: AAN11156.1.
AY061119 mRNA. Translation: AAL28667.1.
PIRiA39268.
RefSeqiNP_476755.1. NM_057407.4.
NP_723361.1. NM_164799.2.
UniGeneiDm.3713.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KNAX-ray2.10A17-76[»]
1KNEX-ray2.40A17-76[»]
1Q3LX-ray1.64A17-76[»]
3P7JX-ray2.30A/B131-206[»]
ProteinModelPortaliP05205.
SMRiP05205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60248. 34 interactors.
DIPiDIP-21869N.
IntActiP05205. 29 interactors.
MINTiMINT-271388.
STRINGi7227.FBpp0079251.

PTM databases

iPTMnetiP05205.

Proteomic databases

PaxDbiP05205.
PRIDEiP05205.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079635; FBpp0079251; FBgn0003607.
FBtr0079636; FBpp0079252; FBgn0003607.
GeneIDi34119.
KEGGidme:Dmel_CG8409.
UCSCiCG8409-RB. d. melanogaster.

Organism-specific databases

CTDi34119.
FlyBaseiFBgn0003607. Su(var)205.

Phylogenomic databases

eggNOGiKOG1911. Eukaryota.
ENOG4111JKD. LUCA.
GeneTreeiENSGT00510000046310.
InParanoidiP05205.
KOiK11587.
OMAiPETENTW.
OrthoDBiEOG091G0RBS.
PhylomeDBiP05205.

Enzyme and pathway databases

ReactomeiR-DME-73777. RNA Polymerase I Chain Elongation.
R-DME-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP05205.

Miscellaneous databases

EvolutionaryTraceiP05205.
GenomeRNAii34119.
PROiP05205.

Gene expression databases

BgeeiFBgn0003607.
GenevisibleiP05205. DM.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR008251. Chromo_shadow_dom.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF01393. Chromo_shadow. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 2 hits.
SM00300. ChSh. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 2 hits.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHP1_DROME
AccessioniPrimary (citable) accession number: P05205
Secondary accession number(s): A4V0F1
, B6UVR4, B6UVS1, B6UVS2, B6UVS3, B6UVT2, B6UVT6, B6UVT7, Q9VLR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 173 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.