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P05204

- HMGN2_HUMAN

UniProt

P05204 - HMGN2_HUMAN

Protein

Non-histone chromosomal protein HMG-17

Gene

HMGN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-histone chromosomal protein HMG-17
    Alternative name(s):
    High mobility group nucleosome-binding domain-containing protein 2
    Gene namesi
    Name:HMGN2
    Synonyms:HMG17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4986. HMGN2.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: Cytoplasmic enrichment upon phosphorylation.

    GO - Cellular componenti

    1. chromatin Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35089.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 9089Non-histone chromosomal protein HMG-17PRO_0000206697Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Phosphoserine1 Publication
    Modified residuei29 – 291Phosphoserine1 Publication
    Modified residuei82 – 821N6-acetyllysine1 Publication

    Post-translational modificationi

    Phosphorylation favors cytoplasmic localization.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP05204.
    PaxDbiP05204.
    PRIDEiP05204.

    PTM databases

    PhosphoSiteiP05204.

    Expressioni

    Gene expression databases

    BgeeiP05204.
    CleanExiHS_HMGN2.
    GenevestigatoriP05204.

    Organism-specific databases

    HPAiCAB018371.
    HPA048518.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GRB2P629931EBI-1758689,EBI-401755

    Protein-protein interaction databases

    BioGridi109394. 9 interactions.
    IntActiP05204. 5 interactions.
    MINTiMINT-8201765.
    STRINGi9606.ENSP00000355228.

    Structurei

    3D structure databases

    DisProtiDP00039.
    ProteinModelPortaliP05204.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMGN family.Curated

    Phylogenomic databases

    eggNOGiNOG44189.
    HOGENOMiHOG000116395.
    HOVERGENiHBG073479.
    InParanoidiP05204.
    KOiK11300.
    OMAiENSKICN.
    OrthoDBiEOG7FNCBN.
    PhylomeDBiP05204.

    Family and domain databases

    InterProiIPR000079. HMGN_fam.
    [Graphical view]
    PANTHERiPTHR23087. PTHR23087. 1 hit.
    PfamiPF01101. HMG14_17. 1 hit.
    [Graphical view]
    PRINTSiPR00925. NONHISHMG17.
    SMARTiSM00527. HMG17. 1 hit.
    [Graphical view]
    PROSITEiPS00355. HMG14_17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05204-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKRKAEGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE   50
    KVPKGKKGKA DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK 90
    Length:90
    Mass (Da):9,393
    Last modified:January 23, 2007 - v3
    Checksum:iB1C58E52200422C8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51K → N(PubMed:3754870)Curated
    Sequence conflicti26 – 272AR → SA AA sequence (PubMed:2040281)Curated

    Mass spectrometryi

    Molecular mass is 9261.5 Da from positions 2 - 90. Determined by ESI. 1 Publication
    Molecular mass is 9341.3±1.9 Da from positions 2 - 90. Determined by ESI. 1 Publication
    Molecular mass is 9421.5 Da from positions 2 - 90. Determined by ESI. 1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71E → K in variant H17. 1 Publication
    VAR_003716

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12623 mRNA. Translation: AAA52678.1.
    X13546 Genomic DNA. Translation: CAA31898.1.
    CR542122 mRNA. Translation: CAG46919.1.
    AL513365 Genomic DNA. Translation: CAI21489.1.
    BC000378 mRNA. Translation: AAH00378.1.
    BC003050 mRNA. Translation: AAH03050.1.
    BC014644 mRNA. Translation: AAH14644.2.
    BC032140 mRNA. Translation: AAH32140.2.
    BC070297 mRNA. Translation: AAH70297.1.
    BC071707 mRNA. Translation: AAH71707.1.
    BC072010 mRNA. Translation: AAH72010.1.
    BC072011 mRNA. Translation: AAH72011.1.
    BC075837 mRNA. Translation: AAH75837.1.
    BC081567 mRNA. Translation: AAH81567.1.
    BC110390 mRNA. Translation: AAI10391.1.
    CCDSiCCDS283.1.
    PIRiS03700.
    RefSeqiNP_005508.1. NM_005517.3.
    UniGeneiHs.181163.

    Genome annotation databases

    EnsembliENST00000361427; ENSP00000355228; ENSG00000198830.
    GeneIDi3151.
    KEGGihsa:3151.
    UCSCiuc001bmp.4. human.

    Polymorphism databases

    DMDMi123106.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12623 mRNA. Translation: AAA52678.1 .
    X13546 Genomic DNA. Translation: CAA31898.1 .
    CR542122 mRNA. Translation: CAG46919.1 .
    AL513365 Genomic DNA. Translation: CAI21489.1 .
    BC000378 mRNA. Translation: AAH00378.1 .
    BC003050 mRNA. Translation: AAH03050.1 .
    BC014644 mRNA. Translation: AAH14644.2 .
    BC032140 mRNA. Translation: AAH32140.2 .
    BC070297 mRNA. Translation: AAH70297.1 .
    BC071707 mRNA. Translation: AAH71707.1 .
    BC072010 mRNA. Translation: AAH72010.1 .
    BC072011 mRNA. Translation: AAH72011.1 .
    BC075837 mRNA. Translation: AAH75837.1 .
    BC081567 mRNA. Translation: AAH81567.1 .
    BC110390 mRNA. Translation: AAI10391.1 .
    CCDSi CCDS283.1.
    PIRi S03700.
    RefSeqi NP_005508.1. NM_005517.3.
    UniGenei Hs.181163.

    3D structure databases

    DisProti DP00039.
    ProteinModelPortali P05204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109394. 9 interactions.
    IntActi P05204. 5 interactions.
    MINTi MINT-8201765.
    STRINGi 9606.ENSP00000355228.

    PTM databases

    PhosphoSitei P05204.

    Polymorphism databases

    DMDMi 123106.

    Proteomic databases

    MaxQBi P05204.
    PaxDbi P05204.
    PRIDEi P05204.

    Protocols and materials databases

    DNASUi 3151.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361427 ; ENSP00000355228 ; ENSG00000198830 .
    GeneIDi 3151.
    KEGGi hsa:3151.
    UCSCi uc001bmp.4. human.

    Organism-specific databases

    CTDi 3151.
    GeneCardsi GC01P026800.
    HGNCi HGNC:4986. HMGN2.
    HPAi CAB018371.
    HPA048518.
    MIMi 163910. gene.
    neXtProti NX_P05204.
    PharmGKBi PA35089.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44189.
    HOGENOMi HOG000116395.
    HOVERGENi HBG073479.
    InParanoidi P05204.
    KOi K11300.
    OMAi ENSKICN.
    OrthoDBi EOG7FNCBN.
    PhylomeDBi P05204.

    Miscellaneous databases

    ChiTaRSi HMGN2. human.
    GeneWikii HMGN2.
    GenomeRNAii 3151.
    NextBioi 12488.
    PROi P05204.
    SOURCEi Search...

    Gene expression databases

    Bgeei P05204.
    CleanExi HS_HMGN2.
    Genevestigatori P05204.

    Family and domain databases

    InterProi IPR000079. HMGN_fam.
    [Graphical view ]
    PANTHERi PTHR23087. PTHR23087. 1 hit.
    Pfami PF01101. HMG14_17. 1 hit.
    [Graphical view ]
    PRINTSi PR00925. NONHISHMG17.
    SMARTi SM00527. HMG17. 1 hit.
    [Graphical view ]
    PROSITEi PS00355. HMG14_17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family."
      Landsman D., Soares N., Gonzalez F.J., Bustin M.
      J. Biol. Chem. 261:7479-7484(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human non-histone chromosomal protein HMG-17: identification, characterization, chromosome localization and RFLPs of a functional gene from the large multigene family."
      Landsman D., McBride O.W., Bustin M.
      Nucleic Acids Res. 17:2301-2314(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Colon, Eye, Lung, Lymph, Mammary gland, Muscle, Salivary gland and Skin.
    6. "Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein."
      Giancotti V., Bandiera A., Buratti E., Fusco A., Marzari R., Coles B., Goodwin G.H.
      Eur. J. Biochem. 198:211-216(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-28, VARIANT LYS-7.
      Tissue: Peripheral blood lymphocyte.
    7. "Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry."
      Louie D.F., Gloor K.K., Galasinski S.C., Resing K.A., Ahn N.G.
      Protein Sci. 9:170-179(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-31, PHOSPHORYLATION AT SER-25 AND SER-29, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHMGN2_HUMAN
    AccessioniPrimary (citable) accession number: P05204
    Secondary accession number(s): Q0VGD5, Q6FGI5, Q96C64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 143 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3