Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P05204 (HMGN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 141. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-histone chromosomal protein HMG-17
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2
Gene names
Name:HMGN2
Synonyms:HMG17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length90 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation By similarity.

Subcellular location

Nucleus. Cytoplasm. Note: Cytoplasmic enrichment upon phosphorylation. Ref.7

Post-translational modification

Phosphorylation favors cytoplasmic localization.

Sequence similarities

Belongs to the HMGN family.

Mass spectrometry

Molecular mass is 9261.5 Da from positions 2 - 90. Determined by ESI. Ref.7

Molecular mass is 9341.3±1.9 Da from positions 2 - 90. Determined by ESI. Ref.7

Molecular mass is 9421.5 Da from positions 2 - 90. Determined by ESI. Ref.7

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentchromatin

Inferred from electronic annotation. Source: InterPro

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

poly(A) RNA binding

Inferred from direct assay PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GRB2P629931EBI-1758689,EBI-401755

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 9089Non-histone chromosomal protein HMG-17
PRO_0000206697

Amino acid modifications

Modified residue251Phosphoserine Ref.7
Modified residue291Phosphoserine Ref.7
Modified residue821N6-acetyllysine Ref.8

Natural variations

Natural variant71E → K in variant H17. Ref.6
VAR_003716

Experimental info

Sequence conflict51K → N Ref.1
Sequence conflict26 – 272AR → SA AA sequence Ref.6

Sequences

Sequence LengthMass (Da)Tools
P05204 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: B1C58E52200422C8

FASTA909,393
        10         20         30         40         50         60 
MPKRKAEGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE KVPKGKKGKA 

        70         80         90 
DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK 

« Hide

References

« Hide 'large scale' references
[1]"Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family."
Landsman D., Soares N., Gonzalez F.J., Bustin M.
J. Biol. Chem. 261:7479-7484(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human non-histone chromosomal protein HMG-17: identification, characterization, chromosome localization and RFLPs of a functional gene from the large multigene family."
Landsman D., McBride O.W., Bustin M.
Nucleic Acids Res. 17:2301-2314(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Colon, Eye, Lung, Lymph, Mammary gland, Muscle, Salivary gland and Skin.
[6]"Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein."
Giancotti V., Bandiera A., Buratti E., Fusco A., Marzari R., Coles B., Goodwin G.H.
Eur. J. Biochem. 198:211-216(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-28, VARIANT LYS-7.
Tissue: Peripheral blood lymphocyte.
[7]"Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry."
Louie D.F., Gloor K.K., Galasinski S.C., Resing K.A., Ahn N.G.
Protein Sci. 9:170-179(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-31, PHOSPHORYLATION AT SER-25 AND SER-29, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M12623 mRNA. Translation: AAA52678.1.
X13546 Genomic DNA. Translation: CAA31898.1.
CR542122 mRNA. Translation: CAG46919.1.
AL513365 Genomic DNA. Translation: CAI21489.1.
BC000378 mRNA. Translation: AAH00378.1.
BC003050 mRNA. Translation: AAH03050.1.
BC014644 mRNA. Translation: AAH14644.2.
BC032140 mRNA. Translation: AAH32140.2.
BC070297 mRNA. Translation: AAH70297.1.
BC071707 mRNA. Translation: AAH71707.1.
BC072010 mRNA. Translation: AAH72010.1.
BC072011 mRNA. Translation: AAH72011.1.
BC075837 mRNA. Translation: AAH75837.1.
BC081567 mRNA. Translation: AAH81567.1.
BC110390 mRNA. Translation: AAI10391.1.
CCDSCCDS283.1.
PIRS03700.
RefSeqNP_005508.1. NM_005517.3.
UniGeneHs.181163.

3D structure databases

DisProtDP00039.
ProteinModelPortalP05204.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109394. 13 interactions.
IntActP05204. 4 interactions.
MINTMINT-8201765.
STRING9606.ENSP00000355228.

PTM databases

PhosphoSiteP05204.

Polymorphism databases

DMDM123106.

Proteomic databases

MaxQBP05204.
PaxDbP05204.
PRIDEP05204.

Protocols and materials databases

DNASU3151.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361427; ENSP00000355228; ENSG00000198830.
GeneID3151.
KEGGhsa:3151.
UCSCuc001bmp.4. human.

Organism-specific databases

CTD3151.
GeneCardsGC01P026800.
HGNCHGNC:4986. HMGN2.
HPACAB018371.
HPA048518.
MIM163910. gene.
neXtProtNX_P05204.
PharmGKBPA35089.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44189.
HOGENOMHOG000116395.
HOVERGENHBG073479.
InParanoidP05204.
KOK11300.
OMAENSKICN.
OrthoDBEOG7FNCBN.
PhylomeDBP05204.

Gene expression databases

BgeeP05204.
CleanExHS_HMGN2.
GenevestigatorP05204.

Family and domain databases

InterProIPR000079. HMGN_fam.
[Graphical view]
PANTHERPTHR23087. PTHR23087. 1 hit.
PfamPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSPR00925. NONHISHMG17.
SMARTSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHMGN2. human.
GeneWikiHMGN2.
GenomeRNAi3151.
NextBio12488.
PROP05204.
SOURCESearch...

Entry information

Entry nameHMGN2_HUMAN
AccessionPrimary (citable) accession number: P05204
Secondary accession number(s): Q0VGD5, Q6FGI5, Q96C64
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM