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P05204

- HMGN2_HUMAN

UniProt

P05204 - HMGN2_HUMAN

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Protein

Non-histone chromosomal protein HMG-17

Gene

HMGN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-17
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2
Gene namesi
Name:HMGN2
Synonyms:HMG17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:4986. HMGN2.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication
Note: Cytoplasmic enrichment upon phosphorylation.

GO - Cellular componenti

  1. chromatin Source: InterPro
  2. cytoplasm Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35089.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 9089Non-histone chromosomal protein HMG-17PRO_0000206697Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei29 – 291Phosphoserine1 Publication
Modified residuei82 – 821N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylation favors cytoplasmic localization.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP05204.
PaxDbiP05204.
PRIDEiP05204.

PTM databases

PhosphoSiteiP05204.

Expressioni

Gene expression databases

BgeeiP05204.
CleanExiHS_HMGN2.
GenevestigatoriP05204.

Organism-specific databases

HPAiCAB018371.
HPA048518.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629931EBI-1758689,EBI-401755

Protein-protein interaction databases

BioGridi109394. 9 interactions.
IntActiP05204. 5 interactions.
MINTiMINT-8201765.
STRINGi9606.ENSP00000355228.

Structurei

3D structure databases

DisProtiDP00039.
ProteinModelPortaliP05204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiNOG44189.
GeneTreeiENSGT00730000110660.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiP05204.
KOiK11300.
OMAiENSKICN.
OrthoDBiEOG7FNCBN.
PhylomeDBiP05204.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PANTHERiPTHR23087. PTHR23087. 1 hit.
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05204-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKRKAEGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE
60 70 80 90
KVPKGKKGKA DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK
Length:90
Mass (Da):9,393
Last modified:January 23, 2007 - v3
Checksum:iB1C58E52200422C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51K → N(PubMed:3754870)Curated
Sequence conflicti26 – 272AR → SA AA sequence (PubMed:2040281)Curated

Mass spectrometryi

Molecular mass is 9261.5 Da from positions 2 - 90. Determined by ESI. 1 Publication
Molecular mass is 9341.3±1.9 Da from positions 2 - 90. Determined by ESI. 1 Publication
Molecular mass is 9421.5 Da from positions 2 - 90. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71E → K in variant H17. 1 Publication
VAR_003716

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12623 mRNA. Translation: AAA52678.1.
X13546 Genomic DNA. Translation: CAA31898.1.
CR542122 mRNA. Translation: CAG46919.1.
AL513365 Genomic DNA. Translation: CAI21489.1.
BC000378 mRNA. Translation: AAH00378.1.
BC003050 mRNA. Translation: AAH03050.1.
BC014644 mRNA. Translation: AAH14644.2.
BC032140 mRNA. Translation: AAH32140.2.
BC070297 mRNA. Translation: AAH70297.1.
BC071707 mRNA. Translation: AAH71707.1.
BC072010 mRNA. Translation: AAH72010.1.
BC072011 mRNA. Translation: AAH72011.1.
BC075837 mRNA. Translation: AAH75837.1.
BC081567 mRNA. Translation: AAH81567.1.
BC110390 mRNA. Translation: AAI10391.1.
CCDSiCCDS283.1.
PIRiS03700.
RefSeqiNP_005508.1. NM_005517.3.
UniGeneiHs.181163.

Genome annotation databases

EnsembliENST00000361427; ENSP00000355228; ENSG00000198830.
ENST00000619352; ENSP00000481160; ENSG00000198830.
GeneIDi3151.
KEGGihsa:3151.
UCSCiuc001bmp.4. human.

Polymorphism databases

DMDMi123106.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12623 mRNA. Translation: AAA52678.1 .
X13546 Genomic DNA. Translation: CAA31898.1 .
CR542122 mRNA. Translation: CAG46919.1 .
AL513365 Genomic DNA. Translation: CAI21489.1 .
BC000378 mRNA. Translation: AAH00378.1 .
BC003050 mRNA. Translation: AAH03050.1 .
BC014644 mRNA. Translation: AAH14644.2 .
BC032140 mRNA. Translation: AAH32140.2 .
BC070297 mRNA. Translation: AAH70297.1 .
BC071707 mRNA. Translation: AAH71707.1 .
BC072010 mRNA. Translation: AAH72010.1 .
BC072011 mRNA. Translation: AAH72011.1 .
BC075837 mRNA. Translation: AAH75837.1 .
BC081567 mRNA. Translation: AAH81567.1 .
BC110390 mRNA. Translation: AAI10391.1 .
CCDSi CCDS283.1.
PIRi S03700.
RefSeqi NP_005508.1. NM_005517.3.
UniGenei Hs.181163.

3D structure databases

DisProti DP00039.
ProteinModelPortali P05204.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109394. 9 interactions.
IntActi P05204. 5 interactions.
MINTi MINT-8201765.
STRINGi 9606.ENSP00000355228.

PTM databases

PhosphoSitei P05204.

Polymorphism databases

DMDMi 123106.

Proteomic databases

MaxQBi P05204.
PaxDbi P05204.
PRIDEi P05204.

Protocols and materials databases

DNASUi 3151.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361427 ; ENSP00000355228 ; ENSG00000198830 .
ENST00000619352 ; ENSP00000481160 ; ENSG00000198830 .
GeneIDi 3151.
KEGGi hsa:3151.
UCSCi uc001bmp.4. human.

Organism-specific databases

CTDi 3151.
GeneCardsi GC01P026800.
HGNCi HGNC:4986. HMGN2.
HPAi CAB018371.
HPA048518.
MIMi 163910. gene.
neXtProti NX_P05204.
PharmGKBi PA35089.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44189.
GeneTreei ENSGT00730000110660.
HOGENOMi HOG000116395.
HOVERGENi HBG073479.
InParanoidi P05204.
KOi K11300.
OMAi ENSKICN.
OrthoDBi EOG7FNCBN.
PhylomeDBi P05204.

Miscellaneous databases

ChiTaRSi HMGN2. human.
GeneWikii HMGN2.
GenomeRNAii 3151.
NextBioi 12488.
PROi P05204.
SOURCEi Search...

Gene expression databases

Bgeei P05204.
CleanExi HS_HMGN2.
Genevestigatori P05204.

Family and domain databases

InterProi IPR000079. HMGN_fam.
[Graphical view ]
PANTHERi PTHR23087. PTHR23087. 1 hit.
Pfami PF01101. HMG14_17. 1 hit.
[Graphical view ]
PRINTSi PR00925. NONHISHMG17.
SMARTi SM00527. HMG17. 1 hit.
[Graphical view ]
PROSITEi PS00355. HMG14_17. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family."
    Landsman D., Soares N., Gonzalez F.J., Bustin M.
    J. Biol. Chem. 261:7479-7484(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human non-histone chromosomal protein HMG-17: identification, characterization, chromosome localization and RFLPs of a functional gene from the large multigene family."
    Landsman D., McBride O.W., Bustin M.
    Nucleic Acids Res. 17:2301-2314(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Colon, Eye, Lung, Lymph, Mammary gland, Muscle, Salivary gland and Skin.
  6. "Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein."
    Giancotti V., Bandiera A., Buratti E., Fusco A., Marzari R., Coles B., Goodwin G.H.
    Eur. J. Biochem. 198:211-216(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-28, VARIANT LYS-7.
    Tissue: Peripheral blood lymphocyte.
  7. "Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry."
    Louie D.F., Gloor K.K., Galasinski S.C., Resing K.A., Ahn N.G.
    Protein Sci. 9:170-179(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-31, PHOSPHORYLATION AT SER-25 AND SER-29, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHMGN2_HUMAN
AccessioniPrimary (citable) accession number: P05204
Secondary accession number(s): Q0VGD5, Q6FGI5, Q96C64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3