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P05192 (BLAC_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase
OrganismKlebsiella pneumoniae
Taxonomic identifier573 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 279258Beta-lactamase
PRO_0000016999

Regions

Region230 – 2323Substrate binding By similarity

Sites

Active site661Acyl-ester intermediate By similarity

Amino acid modifications

Disulfide bond73 ↔ 119 By similarity

Sequences

Sequence LengthMass (Da)Tools
P05192 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: C5C88E34E6BCDAEB

FASTA27930,269
        10         20         30         40         50         60 
MRYVRLCVIS LLATLPLVVY AGPQPLEQIK QSESQLSGRV GMVEMDLANG RTLAAWRADE 

        70         80         90        100        110        120 
RFPMVSTFKV LLCGAVLARV DAGLEQLDRR IHYRQQDLVD YSPVSEKHLV DGMTIGELCA 

       130        140        150        160        170        180 
AAITLSDNSA GNLLLATVGG PAGLTAFLRQ IGDNVTRLDR WETALNEALP GDARDTTTPA 

       190        200        210        220        230        240 
SMAATLRKLL TAQHLSARSQ QQLLQWMVDD RVAGPLIRAV LPPGWFIADK TGAGERGARG 

       250        260        270 
IVALLGPDGK PERIVVIYLR DTPASMAERN QHIAGIGQR 

« Hide

References

[1]"Close evolutionary relationship between the chromosomally encoded beta-lactamase gene of Klebsiella pneumoniae and the TEM beta-lactamase gene mediated by R plasmids."
Arakawa Y., Ohta M., Kido N., Fujii Y., Komatsu T., Kato N.
FEBS Lett. 207:69-74(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LEN-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04515 Genomic DNA. Translation: CAA28198.1.
PIRA24469.

3D structure databases

ProteinModelPortalP05192.
SMRP05192. Positions 23-277.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_KLEPN
AccessionPrimary (citable) accession number: P05192
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families