##gff-version 3
P05186	UniProtKB	Signal peptide	1	17	.	.	.	Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1458595,ECO:0000269|PubMed:3954357;Dbxref=PMID:1458595,PMID:3954357	
P05186	UniProtKB	Chain	18	501	.	.	.	ID=PRO_0000024023;Note=Alkaline phosphatase%2C tissue-nonspecific isozyme	
P05186	UniProtKB	Propeptide	502	524	.	.	.	ID=PRO_0000024024;Note=Removed in mature form;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P05186	UniProtKB	Active site	110	110	.	.	.	Note=Phosphoserine intermediate;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P05187,ECO:0000255|PROSITE-ProRule:PRU10042	
P05186	UniProtKB	Binding site	60	60	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Binding site	60	60	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Binding site	110	110	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Binding site	173	173	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Binding site	235	235	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11395499;Dbxref=PMID:11395499	
P05186	UniProtKB	Binding site	290	290	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11395499;Dbxref=PMID:11395499	
P05186	UniProtKB	Binding site	291	291	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11395499;Dbxref=PMID:11395499	
P05186	UniProtKB	Binding site	306	306	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11395499;Dbxref=PMID:11395499	
P05186	UniProtKB	Binding site	332	332	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Binding site	337	337	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Binding site	341	341	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Binding site	378	378	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Binding site	379	379	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Binding site	454	454	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Modified residue	110	110	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09242	
P05186	UniProtKB	Lipidation	501	501	.	.	.	Note=GPI-anchor amidated serine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P05186	UniProtKB	Glycosylation	140	140	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P05186	UniProtKB	Glycosylation	230	230	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P05186	UniProtKB	Glycosylation	271	271	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P05186	UniProtKB	Glycosylation	303	303	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P05186	UniProtKB	Glycosylation	430	430	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218	
P05186	UniProtKB	Disulfide bond	139	201	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Disulfide bond	489	497	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05187	
P05186	UniProtKB	Alternative sequence	1	99	.	.	.	ID=VSP_042711;Note=In isoform 2. MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSK->MPWSFRSSTPTWLRMSSCSWEM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
P05186	UniProtKB	Alternative sequence	1	55	.	.	.	ID=VSP_044228;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
P05186	UniProtKB	Natural variant	17	17	.	.	.	ID=VAR_025903;Note=In HOPS. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9781036;Dbxref=PMID:9781036	
P05186	UniProtKB	Natural variant	28	28	.	.	.	ID=VAR_013972;Note=In HPPI%3B 7%25 of activity. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11438998;Dbxref=PMID:11438998	
P05186	UniProtKB	Natural variant	33	33	.	.	.	ID=VAR_006147;Note=In HOPS%3B strongly reduced alkaline phosphatase activity. A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:1409720,ECO:0000269|PubMed:15694177;Dbxref=dbSNP:rs121918005,PMID:12162492,PMID:1409720,PMID:15694177	
P05186	UniProtKB	Natural variant	40	40	.	.	.	ID=VAR_011081;Note=In HOPS%3B 2%25 of activity. A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:10679946,ECO:0000269|PubMed:11438998,ECO:0000269|PubMed:11479741,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs770093969,PMID:10332035,PMID:10679946,PMID:11438998,PMID:11479741,PMID:9781036	
P05186	UniProtKB	Natural variant	51	51	.	.	.	ID=VAR_025904;Note=In HOPS. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11855933;Dbxref=PMID:11855933	
P05186	UniProtKB	Natural variant	51	51	.	.	.	ID=VAR_013973;Note=In HOPS. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11438998;Dbxref=dbSNP:rs1470389268,PMID:11438998	
P05186	UniProtKB	Natural variant	62	62	.	.	.	ID=VAR_006148;Note=In HOPS%3B moderate%3B 27%25 of activity. M->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10094560,ECO:0000269|PubMed:10332035;Dbxref=PMID:10094560,PMID:10332035	
P05186	UniProtKB	Natural variant	62	62	.	.	.	ID=VAR_025905;Note=In HOPS. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815606;Dbxref=PMID:12815606	
P05186	UniProtKB	Natural variant	63	63	.	.	.	ID=VAR_025906;Note=In HOPS. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815606;Dbxref=PMID:12815606	
P05186	UniProtKB	Natural variant	63	63	.	.	.	ID=VAR_013974;Note=In HOPS%3B loss of activity. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11479741;Dbxref=PMID:11479741	
P05186	UniProtKB	Natural variant	68	68	.	.	.	ID=VAR_025907;Note=In HPPC%3B severe allele. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11760847;Dbxref=PMID:11760847	
P05186	UniProtKB	Natural variant	71	71	.	.	.	ID=VAR_006149;Note=In HOPS%3B abolished alkaline phosphatase activity. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:1409720,ECO:0000269|PubMed:19500388;Dbxref=dbSNP:rs121918001,PMID:12162492,PMID:1409720,PMID:19500388	
P05186	UniProtKB	Natural variant	71	71	.	.	.	ID=VAR_013975;Note=In HOPS%3B loss of alkaline phosphatase activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11438998,ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:19500388;Dbxref=dbSNP:rs121918003,PMID:11438998,PMID:11855933,PMID:19500388	
P05186	UniProtKB	Natural variant	71	71	.	.	.	ID=VAR_006150;Note=In HOPS%3B abolished alkaline phosphatase activity. R->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:1409720;Dbxref=dbSNP:rs121918003,PMID:12162492,PMID:1409720	
P05186	UniProtKB	Natural variant	71	71	.	.	.	ID=VAR_025908;Note=In HPPC%3B severe allele. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11760847;Dbxref=dbSNP:rs121918001,PMID:11760847	
P05186	UniProtKB	Natural variant	75	75	.	.	.	ID=VAR_013976;Note=In HOPS%3B severe%3B 3.5%25 of activity. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs1304394441,PMID:10332035,PMID:9781036	
P05186	UniProtKB	Natural variant	76	76	.	.	.	ID=VAR_025909;Note=In HOPS. Q->R;Dbxref=dbSNP:rs1057521085	
P05186	UniProtKB	Natural variant	82	82	.	.	.	ID=VAR_085155;Note=In HOPS%3B dominant-negative mutant%3B abolished alkaline phosphatase activity. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33821301;Dbxref=PMID:33821301	
P05186	UniProtKB	Natural variant	108	108	.	.	.	ID=VAR_025910;Note=In HOPS%3B 0.4%25 of alkaline phosphatase activity%3B severe allele%3B no effect on subcellular location%3B fails to assemble into dimeric structure%3B dominant negative effect. P->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12920074,ECO:0000269|PubMed:25982064;Dbxref=dbSNP:rs121918015,PMID:12920074,PMID:25982064	
P05186	UniProtKB	Natural variant	111	111	.	.	.	ID=VAR_006151;Note=In HOPS%3B odonto%3B abolished alkaline phosphatase activity. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:10679946,ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:12815606,ECO:0000269|PubMed:19500388,ECO:0000269|PubMed:9452105;Dbxref=dbSNP:rs773257111,PMID:10332035,PMID:10679946,PMID:11855933,PMID:12162492,PMID:12815606,PMID:19500388,PMID:9452105	
P05186	UniProtKB	Natural variant	114	114	.	.	.	ID=VAR_025911;Note=In HOPS. A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15135428;Dbxref=PMID:15135428	
P05186	UniProtKB	Natural variant	116	116	.	.	.	ID=VAR_013977;Note=In HOPS%3B loss of alkaline phosphatase activity. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11438998,ECO:0000269|PubMed:11479741,ECO:0000269|PubMed:12920074,ECO:0000269|PubMed:25982064;Dbxref=dbSNP:rs121918013,PMID:11438998,PMID:11479741,PMID:12920074,PMID:25982064	
P05186	UniProtKB	Natural variant	120	120	.	.	.	ID=VAR_013978;Note=In HOPS. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs954135116,PMID:10332035,PMID:9781036	
P05186	UniProtKB	Natural variant	128	128	.	.	.	ID=VAR_025912;Note=In HOPS. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11855933;Dbxref=dbSNP:rs1159854007,PMID:11855933	
P05186	UniProtKB	Natural variant	129	129	.	.	.	ID=VAR_013979;Note=In HOPS. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:9781036;Dbxref=PMID:10332035,PMID:9781036	
P05186	UniProtKB	Natural variant	132	132	.	.	.	ID=VAR_013146;Note=In HOPS%3B strongly reduced alkaline phosphatase activity. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11834095,ECO:0000269|PubMed:12162492;Dbxref=PMID:11834095,PMID:12162492	
P05186	UniProtKB	Natural variant	134	134	.	.	.	ID=VAR_025913;Note=In HOPS%3B requires 2 nucleotide substitutions. T->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11855933;Dbxref=dbSNP:rs786204530,PMID:11855933	
P05186	UniProtKB	Natural variant	134	134	.	.	.	ID=VAR_011082;Note=In HOPS%3B 9%25 of activity. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10679946;Dbxref=dbSNP:rs780583917,PMID:10679946	
P05186	UniProtKB	Natural variant	136	136	.	.	.	ID=VAR_006152;Note=In HOPS%3B moderate%3B 33%25 of activity. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10094560,ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:11438998,ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:15694177;Dbxref=dbSNP:rs121918011,PMID:10094560,PMID:10332035,PMID:11438998,PMID:11855933,PMID:15694177	
P05186	UniProtKB	Natural variant	148	148	.	.	.	ID=VAR_025914;Note=In HOPS. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815606;Dbxref=dbSNP:rs1376937780,PMID:12815606	
P05186	UniProtKB	Natural variant	152	152	.	.	.	ID=VAR_085156;Note=In HOPS%3B uncertain significance. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23791648;Dbxref=PMID:23791648	
P05186	UniProtKB	Natural variant	152	152	.	.	.	ID=VAR_013980;Note=In HOPS%3B benign%3B lethal form. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11438998,ECO:0000269|Ref.6;Dbxref=dbSNP:rs149344982,PMID:11438998	
P05186	UniProtKB	Natural variant	162	162	.	.	.	ID=VAR_025915;Note=In HOPS. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815606;Dbxref=dbSNP:rs760029254,PMID:12815606	
P05186	UniProtKB	Natural variant	162	162	.	.	.	ID=VAR_006153;Note=In HOPS%3B severe%3B 1%25 of activity. G->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10094560,ECO:0000269|PubMed:10332035;Dbxref=dbSNP:rs121918012,PMID:10094560,PMID:10332035	
P05186	UniProtKB	Natural variant	170	170	.	.	.	ID=VAR_013981;Note=In HOPS. N->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:9781036;Dbxref=PMID:10332035,PMID:9781036	
P05186	UniProtKB	Natural variant	171	171	.	.	.	ID=VAR_025916;Note=In HOPS. H->R;Dbxref=dbSNP:rs778232217	
P05186	UniProtKB	Natural variant	171	171	.	.	.	ID=VAR_006154;Note=In HOPS%3B severe%3B 2%25 of activity. H->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10094560,ECO:0000269|PubMed:10332035;Dbxref=PMID:10094560,PMID:10332035	
P05186	UniProtKB	Natural variant	176	176	.	.	.	ID=VAR_011083;Note=In HOPS%3B 30%25 of alkaline phosphatase activity. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10679946,ECO:0000269|PubMed:11438998,ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:19500388;Dbxref=dbSNP:rs121918019,PMID:10679946,PMID:11438998,PMID:11855933,PMID:19500388	
P05186	UniProtKB	Natural variant	177	177	.	.	.	ID=VAR_006155;Note=In HOPS and HPPC%3B moderate allele%3B normal alkaline phosphatase activity toward diphosphate and increased activity toward pyridoxal 5'-phosphate. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11760847,ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:9452105;Dbxref=dbSNP:rs199669988,PMID:11760847,PMID:12162492,PMID:9452105	
P05186	UniProtKB	Natural variant	179	179	.	.	.	ID=VAR_006156;Note=In HOPS%3B reduced alkaline phosphatase activity toward diphosphate and pyridoxal 5'-phosphate. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11438998,ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:3174660;Dbxref=dbSNP:rs121918000,PMID:11438998,PMID:12162492,PMID:3174660	
P05186	UniProtKB	Natural variant	181	181	.	.	.	ID=VAR_013982;Note=In HOPS%3B 1%25 of activity. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11479741;Dbxref=dbSNP:rs199590449,PMID:11479741	
P05186	UniProtKB	Natural variant	184	184	.	.	.	ID=VAR_013983;Note=In HOPS%3B loss of activity. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:11479741,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs763159520,PMID:10332035,PMID:11479741,PMID:9781036	
P05186	UniProtKB	Natural variant	188	188	.	.	.	ID=VAR_085157;Note=In HOPS%3B uncertain significance. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30083035;Dbxref=PMID:30083035	
P05186	UniProtKB	Natural variant	189	189	.	.	.	ID=VAR_025917;Note=In HOPS. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815606;Dbxref=PMID:12815606	
P05186	UniProtKB	Natural variant	191	191	.	.	.	ID=VAR_006157;Note=In HOPS%3B odonto%3B slightly reduced alkaline phosphatase activity. E->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:9452105;Dbxref=PMID:12162492,PMID:9452105	
P05186	UniProtKB	Natural variant	191	191	.	.	.	ID=VAR_006158;Note=In HOPS%3B moderate%3B frequent mutation in European countries%3B slightly reduced alkaline phosphatase activity. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10094560,ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:10679946,ECO:0000269|PubMed:11438998,ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:1409720,ECO:0000269|PubMed:19500388,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs121918007,PMID:10094560,PMID:10332035,PMID:10679946,PMID:11438998,PMID:11855933,PMID:12162492,PMID:1409720,PMID:19500388,PMID:9781036	
P05186	UniProtKB	Natural variant	201	201	.	.	.	ID=VAR_006159;Note=In HOPS%3B weak alkaline phosphatase activity%3B severely affects homodimerization%3B reduced cell surface expression. C->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10094560,ECO:0000269|PubMed:10679946,ECO:0000269|PubMed:22266140;Dbxref=PMID:10094560,PMID:10679946,PMID:22266140	
P05186	UniProtKB	Natural variant	207	207	.	.	.	ID=VAR_006160;Note=In HOPS. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409720;Dbxref=dbSNP:rs121918004,PMID:1409720	
P05186	UniProtKB	Natural variant	211	211	.	.	.	ID=VAR_013984;Note=In HOPS. N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11438998;Dbxref=PMID:11438998	
P05186	UniProtKB	Natural variant	212	212	.	.	.	ID=VAR_025918;Note=In HOPS. I->F	
P05186	UniProtKB	Natural variant	218	218	.	.	.	ID=VAR_085158;Note=In HOPS%3B uncertain significance. I->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32983484;Dbxref=PMID:32983484	
P05186	UniProtKB	Natural variant	220	220	.	.	.	ID=VAR_025919;Note=In HOPS. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815606;Dbxref=PMID:12815606	
P05186	UniProtKB	Natural variant	220	220	.	.	.	ID=VAR_013985;Note=In HOPS%3B odonto. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11438998;Dbxref=PMID:11438998	
P05186	UniProtKB	Natural variant	223	223	.	.	.	ID=VAR_025920;Note=In HOPS. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:15694177;Dbxref=dbSNP:rs199665722,PMID:11855933,PMID:15694177	
P05186	UniProtKB	Natural variant	223	223	.	.	.	ID=VAR_013986;Note=In HOPS and HPPC%3B severe allele%3B abolished alkaline phosphatase activity. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:11479741,ECO:0000269|PubMed:11760847,ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:15694177,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs766076920,PMID:10332035,PMID:11479741,PMID:11760847,PMID:11855933,PMID:12162492,PMID:15694177,PMID:9781036	
P05186	UniProtKB	Natural variant	224	224	.	.	.	ID=VAR_011084;Note=In HPPI%3B partial loss of activity. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10834525;Dbxref=dbSNP:rs1226800998,PMID:10834525	
P05186	UniProtKB	Natural variant	235	235	.	.	.	ID=VAR_013987;Note=In HOPS. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11438998;Dbxref=PMID:11438998	
P05186	UniProtKB	Natural variant	246	246	.	.	.	ID=VAR_011085;Note=In HOPS%3B 4%25 of activity. R->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10679946,ECO:0000269|PubMed:11855933;Dbxref=dbSNP:rs1223142821,PMID:10679946,PMID:11855933	
P05186	UniProtKB	Natural variant	249	249	.	.	.	ID=VAR_013988;Note=In HOPS%3B partial loss of activity. G->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10094560,ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:11479741;Dbxref=dbSNP:rs121918018,PMID:10094560,PMID:10332035,PMID:11479741	
P05186	UniProtKB	Natural variant	263	263	.	.	.	ID=VAR_006161;Note=Y->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:1409720,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:2928120,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs3200254,PMID:11855933,PMID:1409720,PMID:15489334,PMID:2928120,PMID:9781036	
P05186	UniProtKB	Natural variant	272	272	.	.	.	ID=VAR_025921;Note=In HOPS%3B 6.8%25 of wild-type activity. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15694177;Dbxref=dbSNP:rs781272386,PMID:15694177	
P05186	UniProtKB	Natural variant	272	272	.	.	.	ID=VAR_025922;Note=In HOPS. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815606;Dbxref=dbSNP:rs781272386,PMID:12815606	
P05186	UniProtKB	Natural variant	275	275	.	.	.	ID=VAR_025923;Note=In HPPC%3B severe allele. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11760847;Dbxref=dbSNP:rs1237252052,PMID:11760847	
P05186	UniProtKB	Natural variant	289	289	.	.	.	ID=VAR_006162;Note=In HOPS. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9747027;Dbxref=PMID:9747027	
P05186	UniProtKB	Natural variant	291	291	.	.	.	ID=VAR_013989;Note=In HOPS%3B moderate%3B 8%25 of activity. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:11999978,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs786204473,PMID:10332035,PMID:11999978,PMID:9781036	
P05186	UniProtKB	Natural variant	292	292	.	.	.	ID=VAR_025924;Note=In HOPS%3B 4%25 of wild-type activity. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15694177;Dbxref=dbSNP:rs765458125,PMID:15694177	
P05186	UniProtKB	Natural variant	293	294	.	.	.	ID=VAR_025925;Note=In HOPS. Missing	
P05186	UniProtKB	Natural variant	294	294	.	.	.	ID=VAR_006163;Note=In HOPS%3B reduced alkaline phosphatase toward diphosphate and pyridoxal 5'-phosphate. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:1409720,ECO:0000269|PubMed:15694177;Dbxref=dbSNP:rs121918002,PMID:11855933,PMID:12162492,PMID:1409720,PMID:15694177	
P05186	UniProtKB	Natural variant	294	294	.	.	.	ID=VAR_013990;Note=In HOPS. D->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11438998;Dbxref=dbSNP:rs1553414079,PMID:11438998	
P05186	UniProtKB	Natural variant	295	295	.	.	.	ID=VAR_025926;Note=In HOPS%3B 8.5%25 of wild-type activity. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15694177;Dbxref=dbSNP:rs1220125702,PMID:15694177	
P05186	UniProtKB	Natural variant	297	297	.	.	.	ID=VAR_025927;Note=In HOPS%3B 1.3%25 of wild-type activity. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15694177;Dbxref=PMID:15694177	
P05186	UniProtKB	Natural variant	298	298	.	.	.	ID=VAR_025928;Note=In HPPI%3B does not affect alkaline phosphatase activity. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:7833929;Dbxref=dbSNP:rs121918017,PMID:12162492,PMID:7833929	
P05186	UniProtKB	Natural variant	299	299	.	.	.	ID=VAR_025929;Note=In HOPS. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11855933;Dbxref=PMID:11855933	
P05186	UniProtKB	Natural variant	306	306	.	.	.	ID=VAR_006164;Note=In HOPS. D->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10094560,ECO:0000269|PubMed:10332035;Dbxref=PMID:10094560,PMID:10332035	
P05186	UniProtKB	Natural variant	311	311	.	.	.	ID=VAR_025930;Note=In HOPS. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815606;Dbxref=dbSNP:rs763457259,PMID:12815606	
P05186	UniProtKB	Natural variant	326	326	.	.	.	ID=VAR_013991;Note=In HOPS%3B in a patient carrying also K-291. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11999978;Dbxref=PMID:11999978	
P05186	UniProtKB	Natural variant	327	327	.	.	.	ID=VAR_013992;Note=In HOPS%3B requires 2 nucleotide substitutions. F->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11438998;Dbxref=PMID:11438998	
P05186	UniProtKB	Natural variant	327	327	.	.	.	ID=VAR_006165;Note=In HOPS and HPPI. F->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8954059,ECO:0000269|PubMed:9452105;Dbxref=dbSNP:rs121918010,PMID:8954059,PMID:9452105	
P05186	UniProtKB	Natural variant	327	327	.	.	.	ID=VAR_025931;Note=In HOPS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11855933;Dbxref=PMID:11855933	
P05186	UniProtKB	Natural variant	334	334	.	.	.	ID=VAR_006166;Note=In HOPS%3B abolished alkaline phosphatase activity. G->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:15694177,ECO:0000269|PubMed:19500388,ECO:0000269|PubMed:8406453,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs121918009,PMID:10332035,PMID:12162492,PMID:15694177,PMID:19500388,PMID:8406453,PMID:9781036	
P05186	UniProtKB	Natural variant	334	334	.	.	.	ID=VAR_075557;Note=In HOPS%3B weak alkaline phosphatase activity. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19500388;Dbxref=PMID:19500388	
P05186	UniProtKB	Natural variant	339	339	.	.	.	ID=VAR_025932;Note=In HOPS%3B loss of alkaline phosphatase activity. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:19500388;Dbxref=PMID:11855933,PMID:19500388	
P05186	UniProtKB	Natural variant	348	348	.	.	.	ID=VAR_011086;Note=In HOPS. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10679946,ECO:0000269|PubMed:11855933;Dbxref=dbSNP:rs1553414563,PMID:10679946,PMID:11855933	
P05186	UniProtKB	Natural variant	354	354	.	.	.	ID=VAR_025933;Note=In HOPS. E->D;Dbxref=dbSNP:rs1553414568	
P05186	UniProtKB	Natural variant	378	378	.	.	.	ID=VAR_006167;Note=In HOPS%3B strongly reduced alkaline phosphatase activity. D->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10690885,ECO:0000269|PubMed:11479741,ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:1409720;Dbxref=dbSNP:rs121918008,PMID:10690885,PMID:11479741,PMID:11855933,PMID:12162492,PMID:1409720	
P05186	UniProtKB	Natural variant	381	381	.	.	.	ID=VAR_011087;Note=In HOPS. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10679946;Dbxref=PMID:10679946	
P05186	UniProtKB	Natural variant	382	382	.	.	.	ID=VAR_006168;Note=In HOPS%3B abolished alkaline phosphatase activity. V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:19500388,ECO:0000269|PubMed:9452105;Dbxref=dbSNP:rs771540767,PMID:12162492,PMID:19500388,PMID:9452105	
P05186	UniProtKB	Natural variant	391	391	.	.	.	ID=VAR_013993;Note=In HOPS%3B moderate%3B 4-10%25 of alkaline phosphatase activity. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:19500388;Dbxref=dbSNP:rs371243939,PMID:10332035,PMID:19500388	
P05186	UniProtKB	Natural variant	391	391	.	.	.	ID=VAR_025934;Note=In HPPC and HOPS%3B severe allele%3B loss of alkaline phosphatase activity. R->H;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11760847,ECO:0000269|PubMed:19500388;Dbxref=dbSNP:rs1442918125,PMID:11760847,PMID:19500388	
P05186	UniProtKB	Natural variant	399	399	.	.	.	ID=VAR_013994;Note=In HOPS. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11438998;Dbxref=PMID:11438998	
P05186	UniProtKB	Natural variant	406	406	.	.	.	ID=VAR_011088;Note=In HOPS%3B 15%25 of activity. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10679946;Dbxref=PMID:10679946	
P05186	UniProtKB	Natural variant	411	411	.	.	.	ID=VAR_025935;Note=In HOPS%3B absence of residual enzymatic activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15694177;Dbxref=PMID:15694177	
P05186	UniProtKB	Natural variant	414	414	.	.	.	ID=VAR_025936;Note=In HOPS%3B loss of alkaline phosphatase activity. L->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11855933,ECO:0000269|PubMed:12920074,ECO:0000269|PubMed:19500388;Dbxref=PMID:11855933,PMID:12920074,PMID:19500388	
P05186	UniProtKB	Natural variant	417	417	.	.	.	ID=VAR_025937;Note=In HOPS%3B very low alkaline phosphatase activity%3B does not affect subcellular location%3B fails to assemble into dimeric structure. N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11745997,ECO:0000269|PubMed:23688511;Dbxref=dbSNP:rs121918014,PMID:11745997,PMID:23688511	
P05186	UniProtKB	Natural variant	420	420	.	.	.	ID=VAR_075558;Note=In HOPS%3B very low alkaline phosphatase activity%3B does not affect subcellular location. G->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19500388,ECO:0000269|PubMed:23039266;Dbxref=PMID:19500388,PMID:23039266	
P05186	UniProtKB	Natural variant	420	420	.	.	.	ID=VAR_075559;Note=In HOPS%3B very low alkaline phosphatase activity%3B does not affect subcellular location. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23039266;Dbxref=PMID:23039266	
P05186	UniProtKB	Natural variant	423	423	.	.	.	ID=VAR_013995;Note=In HOPS%3B 16%25 alkaline of phosphatase activity. V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11438998,ECO:0000269|PubMed:23039266;Dbxref=PMID:11438998,PMID:23039266	
P05186	UniProtKB	Natural variant	426	426	.	.	.	ID=VAR_011089;Note=In HPPI%3B partial loss of activity. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10834525;Dbxref=PMID:10834525	
P05186	UniProtKB	Natural variant	426	426	.	.	.	ID=VAR_025938;Note=In HOPS. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11855933;Dbxref=PMID:11855933	
P05186	UniProtKB	Natural variant	436	436	.	.	.	ID=VAR_006169;Note=In HOPS. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409720;Dbxref=dbSNP:rs121918006,PMID:1409720	
P05186	UniProtKB	Natural variant	440	440	.	.	.	ID=VAR_085159;Note=In HOPS%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23791648;Dbxref=PMID:23791648	
P05186	UniProtKB	Natural variant	445	445	.	.	.	ID=VAR_013996;Note=In HOPS%3B severe%3B 2%25 of activity. S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs1553415041,PMID:10332035,PMID:9781036	
P05186	UniProtKB	Natural variant	450	450	.	.	.	ID=VAR_013997;Note=In HOPS%3B severe%3B 4%25 of activity. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs138690664,PMID:10332035,PMID:9781036	
P05186	UniProtKB	Natural variant	450	450	.	.	.	ID=VAR_011090;Note=In HOPS. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10679946;Dbxref=dbSNP:rs150799088,PMID:10679946	
P05186	UniProtKB	Natural variant	452	452	.	.	.	ID=VAR_025939;Note=In HOPS%3B loss of alkaline phosphatase activity. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12815606,ECO:0000269|PubMed:19500388;Dbxref=dbSNP:rs966212736,PMID:12815606,PMID:19500388	
P05186	UniProtKB	Natural variant	456	456	.	.	.	ID=VAR_011091;Note=In HPPI and HOPS%3B strongly reduced alkaline phosphatase activity. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12162492,ECO:0000269|PubMed:8954059;Dbxref=dbSNP:rs121918016,PMID:12162492,PMID:8954059	
P05186	UniProtKB	Natural variant	459	459	.	.	.	ID=VAR_075560;Note=In HOPS%3B loss of alkaline phosphatase activity. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19500388;Dbxref=PMID:19500388	
P05186	UniProtKB	Natural variant	459	459	.	.	.	ID=VAR_013998;Note=In HPPI. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11438998;Dbxref=dbSNP:rs1054159992,PMID:11438998	
P05186	UniProtKB	Natural variant	468	468	.	.	.	ID=VAR_025940;Note=In HOPS. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12815606;Dbxref=dbSNP:rs1196976671,PMID:12815606	
P05186	UniProtKB	Natural variant	473	473	.	.	.	ID=VAR_013999;Note=In HOPS. G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:9781036;Dbxref=PMID:10332035,PMID:9781036	
P05186	UniProtKB	Natural variant	476	476	.	.	.	ID=VAR_075561;Note=In HOPS%3B loss of alkaline phosphatase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19500388;Dbxref=PMID:19500388	
P05186	UniProtKB	Natural variant	476	476	.	.	.	ID=VAR_006170;Note=In HOPS. E->K;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10094560,ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:11855933;Dbxref=PMID:10094560,PMID:10332035,PMID:11855933	
P05186	UniProtKB	Natural variant	478	478	.	.	.	ID=VAR_011092;Note=In HOPS%3B 9%25 of activity. N->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10679946,ECO:0000269|PubMed:11479741;Dbxref=PMID:10679946,PMID:11479741	
P05186	UniProtKB	Natural variant	489	489	.	.	.	ID=VAR_011093;Note=In HOPS%3B reduces alkaline phosphatase activity. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10679946,ECO:0000269|PubMed:22266140;Dbxref=PMID:10679946,PMID:22266140	
P05186	UniProtKB	Natural variant	490	490	.	.	.	ID=VAR_014000;Note=In HOPS%3B odonto%3B partial loss of activity. I->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11479741;Dbxref=PMID:11479741	
P05186	UniProtKB	Natural variant	491	491	.	.	.	ID=VAR_014001;Note=In HOPS. G->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10332035,ECO:0000269|PubMed:9781036;Dbxref=dbSNP:rs1413274209,PMID:10332035,PMID:9781036	
P05186	UniProtKB	Natural variant	522	522	.	.	.	ID=VAR_011094;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10690885,ECO:0000269|PubMed:11760847,ECO:0000269|PubMed:11855933;Dbxref=dbSNP:rs34605986,PMID:10690885,PMID:11760847,PMID:11855933	
P05186	UniProtKB	Mutagenesis	235	235	.	.	.	Note=Abolished alkaline phosphatase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25775211;Dbxref=PMID:25775211	
P05186	UniProtKB	Mutagenesis	270	270	.	.	.	Note=Reduced alkaline phosphatase activity. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25775211;Dbxref=PMID:25775211	
P05186	UniProtKB	Mutagenesis	272	272	.	.	.	Note=Reduced alkaline phosphatase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25775211;Dbxref=PMID:25775211	
P05186	UniProtKB	Mutagenesis	290	290	.	.	.	Note=Abolished alkaline phosphatase activity. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25775211;Dbxref=PMID:25775211	
P05186	UniProtKB	Mutagenesis	291	291	.	.	.	Note=Reduced alkaline phosphatase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25775211;Dbxref=PMID:25775211	
P05186	UniProtKB	Mutagenesis	306	306	.	.	.	Note=Abolished alkaline phosphatase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25775211;Dbxref=PMID:25775211	
P05186	UniProtKB	Sequence conflict	29	29	.	.	.	Note=W->A;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P05186	UniProtKB	Sequence conflict	104	104	.	.	.	Note=N->K;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P05186	UniProtKB	Sequence conflict	361	361	.	.	.	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P05186	UniProtKB	Sequence conflict	446	446	.	.	.	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305