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P05185

- CP17A_BOVIN

UniProt

P05185 - CP17A_BOVIN

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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

hemeBy similarity

Enzyme regulationi

Regulated predominantly by intracellular cAMP levels.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB
  2. progesterone metabolic process Source: UniProtKB
  3. steroid biosynthetic process Source: UniProtKB-UniPathway
  4. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Membrane Curated

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051926Add
BLAST

Proteomic databases

PRIDEiP05185.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019061.

Structurei

3D structure databases

ProteinModelPortaliP05185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP05185.
KOiK00512.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05185-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWLLLAVFLL TLAYLFWPKT KHSGAKYPRS LPSLPLVGSL PFLPRRGQQH
60 70 80 90 100
KNFFKLQEKY GPIYSFRLGS KTTVMIGHHQ LAREVLLKKG KEFSGRPKVA
110 120 130 140 150
TLDILSDNQK GIAFADHGAH WQLHRKLALN AFALFKDGNL KLEKIINQEA
160 170 180 190 200
NVLCDFLATQ HGEAIDLSEP LSLAVTNIIS FICFNFSFKN EDPALKAIQN
210 220 230 240 250
VNDGILEVLS KEVLLDIFPV LKIFPSKAME KMKGCVQTRN ELLNEILEKC
260 270 280 290 300
QENFSSDSIT NLLHILIQAK VNADNNNAGP DQDSKLLSNR HMLATIGDIF
310 320 330 340 350
GAGVETTTSV IKWIVAYLLH HPSLKKRIQD DIDQIIGFNR TPTISDRNRL
360 370 380 390 400
VLLEATIREV LRIRPVAPTL IPHKAVIDSS IGDLTIDKGT DVVVNLWALH
410 420 430 440 450
HSEKEWQHPD LFMPERFLDP TGTQLISPSL SYLPFGAGPR SCVGEMLARQ
460 470 480 490 500
ELFLFMSRLL QRFNLEIPDD GKLPSLEGHA SLVLQIKPFK VKIEVRQAWK

EAQAEGSTP
Length:509
Mass (Da):57,244
Last modified:August 13, 1987 - v1
Checksum:i64B0E5537A474BB7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2401N → K in AAI10170. 1 PublicationCurated
Sequence conflicti423 – 4231T → A no nucleotide entry (PubMed:2543297)Curated
Sequence conflicti458 – 4581R → W no nucleotide entry (PubMed:2543297)Curated
Sequence conflicti509 – 5091P → S no nucleotide entry (PubMed:2543297)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12547 mRNA. Translation: AAA30485.1.
BC110169 mRNA. Translation: AAI10170.1.
PIRiS04346.
RefSeqiNP_776729.1. NM_174304.2.
XP_005200162.1. XM_005200105.1.
UniGeneiBt.89153.

Genome annotation databases

GeneIDi101908425.
281739.
KEGGibta:101908425.
bta:281739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12547 mRNA. Translation: AAA30485.1 .
BC110169 mRNA. Translation: AAI10170.1 .
PIRi S04346.
RefSeqi NP_776729.1. NM_174304.2.
XP_005200162.1. XM_005200105.1.
UniGenei Bt.89153.

3D structure databases

ProteinModelPortali P05185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000019061.

Proteomic databases

PRIDEi P05185.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101908425.
281739.
KEGGi bta:101908425.
bta:281739.

Organism-specific databases

CTDi 1586.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi P05185.
KOi K00512.

Enzyme and pathway databases

UniPathwayi UPA00062 .

Miscellaneous databases

NextBioi 20805659.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bovine adrenocortical cytochrome P-450(17 alpha). Regulation of gene expression by ACTH and elucidation of primary sequence."
    Zuber M.X., John M.E., Okamura T., Simpson E.R., Waterman M.R.
    J. Biol. Chem. 261:2475-2482(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiCP17A_BOVIN
AccessioniPrimary (citable) accession number: P05185
Secondary accession number(s): Q2YDL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3