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Protein

Cytochrome P450 2E1

Gene

Cyp2e1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.By similarity

Catalytic activityi

4-nitrophenol + NADPH + O2 = 4-nitrocatechol + NADP+ + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi437Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

  • drug metabolic process Source: Ensembl
  • epoxygenase P450 pathway Source: GO_Central
  • heterocycle metabolic process Source: Ensembl
  • monoterpenoid metabolic process Source: Ensembl
  • oxidation-reduction process Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to ozone Source: RGD
  • steroid metabolic process Source: Ensembl
  • triglyceride metabolic process Source: RGD
  • xenobiotic metabolic process Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BRENDAi1.14.14.1 5301
ReactomeiR-RNO-211981 Xenobiotics
R-RNO-211999 CYP2E1 reactions
R-RNO-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKP05182

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2E1 (EC:1.14.13.-)
Alternative name(s):
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7)
CYPIIE1
Cytochrome P450-J
Cytochrome P450RLM6
Gene namesi
Name:Cyp2e1
Synonyms:Cyp2e, Cyp2e-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2475 Cyp2e1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5978

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000517582 – 493Cytochrome P450 2E1Add BLAST492

Proteomic databases

PaxDbiP05182
PRIDEiP05182

PTM databases

iPTMnetiP05182
PhosphoSitePlusiP05182

Expressioni

Inductioni

By ethanol.

Gene expression databases

BgeeiENSRNOG00000012458
ExpressionAtlasiP05182 baseline and differential
GenevisibleiP05182 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247159, 4 interactors
IntActiP05182, 1 interactor
STRINGi10116.ENSRNOP00000016883

Chemistry databases

BindingDBiP05182

Structurei

3D structure databases

ProteinModelPortaliP05182
SMRiP05182
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni298 – 303Substrate bindingBy similarity6

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP05182
KOiK07415
OMAiHEATQDT
OrthoDBiEOG091G0BT8
PhylomeDBiP05182
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008070 Cyt_P450_E_grp-I_CYP2E-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01687 EP450ICYP2E
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLGITIAL LVWVATLLVI SIWKQIYNSW NLPPGPFPLP ILGNIFQLDL
60 70 80 90 100
KDIPKSFTKL AKRFGPVFTL HLGSRRIVVL HGYKAVKEVL LNHKNEFSGR
110 120 130 140 150
GDIPVFQEYK NKGIIFNNGP TWKDVRRFSL SILRDWGMGK QGNEARIQRE
160 170 180 190 200
AQFLVEELKK TKGQPFDPTF LIGCAPCNVI ADILFNKRFD YNDKKCLRLM
210 220 230 240 250
SLFNENFYLL STPWIQLYNN FADYLRYLPG SHRKIMKNVS EIKQYTLEKA
260 270 280 290 300
KEHLQSLDIN CARDVTDCLL IEMEKEKHSQ EPMYTMENVS VTLADLFFAG
310 320 330 340 350
TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRVPA VRDRLDMPYM
360 370 380 390 400
DAVVHEIQRF INLVPSNLPH EATRDTVFQG YVIPKGTVVI PTLDSLLYDS
410 420 430 440 450
HEFPDPEKFK PEHFLNENGK FKYSDYFKAF SAGKRVCVGE GLARMELFLL
460 470 480 490
LSAILQHFNL KSLVDPKDID LSPVTVGFGS IPPQFKLCVI PRS
Length:493
Mass (Da):56,627
Last modified:January 23, 2007 - v4
Checksum:i7600B9D28AED5EDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25Q → K in AAA41060 (PubMed:3782137).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02627 mRNA Translation: AAA41060.1
M20131 Genomic DNA Translation: AAA41033.1
AF061442 mRNA Translation: AAC15991.1
BC081774 mRNA Translation: AAH81774.1
S48325 mRNA Translation: AAB24151.1
PIRiA25341
RefSeqiNP_113731.1, NM_031543.1
UniGeneiRn.1372

Genome annotation databases

EnsembliENSRNOT00000016883; ENSRNOP00000016883; ENSRNOG00000012458
GeneIDi25086
KEGGirno:25086
UCSCiRGD:2475 rat

Similar proteinsi

Entry informationi

Entry nameiCP2E1_RAT
AccessioniPrimary (citable) accession number: P05182
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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