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P05181

- CP2E1_HUMAN

UniProt

P05181 - CP2E1_HUMAN

Protein

Cytochrome P450 2E1

Gene

CYP2E1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 160 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

    Catalytic activityi

    4-nitrophenol + NADPH + O2 = 4-nitrocatechol + NADP+ + H2O.1 Publication

    Cofactori

    Heme group.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)

    GO - Molecular functioni

    1. enzyme binding Source: BHF-UCL
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: BHF-UCL
    5. oxidoreductase activity Source: BHF-UCL
    6. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Source: UniProtKB
    7. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: Ensembl
    8. oxygen binding Source: ProtInc

    GO - Biological processi

    1. drug metabolic process Source: BHF-UCL
    2. heterocycle metabolic process Source: BHF-UCL
    3. monoterpenoid metabolic process Source: BHF-UCL
    4. oxidation-reduction process Source: BHF-UCL
    5. response to drug Source: Ensembl
    6. response to ethanol Source: Ensembl
    7. response to organonitrogen compound Source: Ensembl
    8. response to ozone Source: Ensembl
    9. small molecule metabolic process Source: Reactome
    10. steroid metabolic process Source: BHF-UCL
    11. triglyceride metabolic process Source: Ensembl
    12. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciMetaCyc:HS05414-MONOMER.
    ReactomeiREACT_13543. Xenobiotics.
    REACT_13797. CYP2E1 reactions.
    SABIO-RKP05181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2E1 (EC:1.14.13.-)
    Alternative name(s):
    4-nitrophenol 2-hydroxylase (EC:1.14.13.n7)
    CYPIIE1
    Cytochrome P450-J
    Cleaved into the following chain:
    Gene namesi
    Name:CYP2E1
    Synonyms:CYP2E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:2631. CYP2E1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. Golgi membrane Source: Ensembl
    3. intrinsic component of endoplasmic reticulum membrane Source: Ensembl
    4. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA129.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Cytochrome P450 2E1PRO_0000051751Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 493492Cytochrome P450 2E1, N-terminally processedPRO_0000421771Add
    BLAST

    Proteomic databases

    PaxDbiP05181.
    PeptideAtlasiP05181.
    PRIDEiP05181.

    PTM databases

    PhosphoSiteiP05181.

    Expressioni

    Inductioni

    By ethanol and isoniazid.

    Gene expression databases

    ArrayExpressiP05181.
    BgeeiP05181.
    CleanExiHS_CYP2E1.
    GenevestigatoriP05181.

    Organism-specific databases

    HPAiHPA009128.
    HPA029564.

    Interactioni

    Protein-protein interaction databases

    BioGridi107944. 17 interactions.
    IntActiP05181. 10 interactions.
    STRINGi9606.ENSP00000252945.

    Structurei

    Secondary structure

    1
    493
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni40 – 423
    Helixi45 – 473
    Helixi50 – 523
    Helixi53 – 6412
    Beta strandi66 – 727
    Beta strandi75 – 806
    Helixi83 – 919
    Turni94 – 974
    Helixi104 – 1096
    Beta strandi112 – 1143
    Helixi122 – 13514
    Helixi142 – 15918
    Turni160 – 1634
    Helixi169 – 1724
    Helixi174 – 18512
    Helixi194 – 20916
    Helixi213 – 2208
    Helixi222 – 2254
    Beta strandi228 – 2303
    Helixi231 – 25525
    Beta strandi259 – 2613
    Helixi265 – 27410
    Beta strandi275 – 2784
    Beta strandi279 – 2813
    Helixi286 – 31732
    Helixi319 – 33214
    Turni333 – 3364
    Helixi341 – 3466
    Helixi348 – 36114
    Beta strandi376 – 3783
    Beta strandi381 – 3833
    Beta strandi388 – 3914
    Helixi394 – 3974
    Turni400 – 4023
    Beta strandi403 – 4053
    Helixi411 – 4144
    Beta strandi419 – 4213
    Helixi433 – 4353
    Helixi440 – 45718
    Beta strandi458 – 4647
    Turni466 – 4683
    Beta strandi474 – 4818
    Beta strandi487 – 4915

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3E4EX-ray2.60A/B32-493[»]
    3E6IX-ray2.20A/B32-493[»]
    3GPHX-ray2.70A/B32-493[»]
    3KOHX-ray2.90A/B32-493[»]
    3LC4X-ray3.10A/B32-493[»]
    3T3ZX-ray2.35A/B/C/D32-493[»]
    ProteinModelPortaliP05181.
    SMRiP05181. Positions 32-493.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP05181.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni298 – 3036Substrate bindingCurated

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP05181.
    KOiK07415.
    OMAiGCIPPRY.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP05181.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01687. EP450ICYP2E.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05181-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSALGVTVAL LVWAAFLLLV SMWRQVHSSW NLPPGPFPLP IIGNLFQLEL    50
    KNIPKSFTRL AQRFGPVFTL YVGSQRMVVM HGYKAVKEAL LDYKDEFSGR 100
    GDLPAFHAHR DRGIIFNNGP TWKDIRRFSL TTLRNYGMGK QGNESRIQRE 150
    AHFLLEALRK TQGQPFDPTF LIGCAPCNVI ADILFRKHFD YNDEKFLRLM 200
    YLFNENFHLL STPWLQLYNN FPSFLHYLPG SHRKVIKNVA EVKEYVSERV 250
    KEHHQSLDPN CPRDLTDCLL VEMEKEKHSA ERLYTMDGIT VTVADLFFAG 300
    TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRIPA IKDRQEMPYM 350
    DAVVHEIQRF ITLVPSNLPH EATRDTIFRG YLIPKGTVVV PTLDSVLYDN 400
    QEFPDPEKFK PEHFLNENGK FKYSDYFKPF STGKRVCAGE GLARMELFLL 450
    LCAILQHFNL KPLVDPKDID LSPIHIGFGC IPPRYKLCVI PRS 493
    Length:493
    Mass (Da):56,849
    Last modified:April 1, 1988 - v1
    Checksum:iED0399E32A005644
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21Missing AA sequence (PubMed:3675576)Curated
    Sequence conflicti23 – 231W → A AA sequence (PubMed:8031147)Curated
    Sequence conflicti32 – 321L → N AA sequence (PubMed:8031147)Curated
    Sequence conflicti71 – 711Y → C in AAH67433. (PubMed:15489334)Curated
    Sequence conflicti235 – 2351V → A in AAF13601. 1 PublicationCurated
    Sequence conflicti355 – 3551H → R in AAH67433. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti76 – 761R → H in allele CYP2E1*2; reduced activity. 1 Publication
    Corresponds to variant rs72559710 [ dbSNP | Ensembl ].
    VAR_008360
    Natural varianti179 – 1791V → I in allele CYP2E1*4. 2 Publications
    Corresponds to variant rs6413419 [ dbSNP | Ensembl ].
    VAR_008361
    Natural varianti219 – 2191N → D.1 Publication
    Corresponds to variant rs41299426 [ dbSNP | Ensembl ].
    VAR_055382
    Natural varianti366 – 3661S → C.1 Publication
    Corresponds to variant rs41299434 [ dbSNP | Ensembl ].
    VAR_055383
    Natural varianti389 – 3891V → I in allele CYP2E1*3. 1 Publication
    Corresponds to variant rs55897648 [ dbSNP | Ensembl ].
    VAR_008362
    Natural varianti457 – 4571H → L.2 Publications
    Corresponds to variant rs28969387 [ dbSNP | Ensembl ].
    VAR_024727

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02625 mRNA. Translation: AAA35743.1.
    J02843 Genomic DNA. Translation: AAA52155.1.
    AF182276 mRNA. Translation: AAF13601.1.
    DQ515958 Genomic DNA. Translation: ABF47105.1.
    AL161645 Genomic DNA. Translation: CAH70047.1.
    CH471211 Genomic DNA. Translation: EAW61357.1.
    BC067433 mRNA. Translation: AAH67433.1.
    AF084225 mRNA. Translation: AAD13753.1.
    D50111 Genomic DNA. Translation: BAA08796.1.
    CCDSiCCDS7686.1.
    PIRiA31949.
    RefSeqiNP_000764.1. NM_000773.3.
    UniGeneiHs.12907.

    Genome annotation databases

    EnsembliENST00000252945; ENSP00000252945; ENSG00000130649.
    ENST00000463117; ENSP00000440689; ENSG00000130649.
    GeneIDi1571.
    KEGGihsa:1571.
    UCSCiuc001lnj.1. human.

    Polymorphism databases

    DMDMi117250.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Cytochrome P450 Allele Nomenclature Committee

    CYP2E1 alleles

    Wikipedia

    CYP2E1 entry

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02625 mRNA. Translation: AAA35743.1 .
    J02843 Genomic DNA. Translation: AAA52155.1 .
    AF182276 mRNA. Translation: AAF13601.1 .
    DQ515958 Genomic DNA. Translation: ABF47105.1 .
    AL161645 Genomic DNA. Translation: CAH70047.1 .
    CH471211 Genomic DNA. Translation: EAW61357.1 .
    BC067433 mRNA. Translation: AAH67433.1 .
    AF084225 mRNA. Translation: AAD13753.1 .
    D50111 Genomic DNA. Translation: BAA08796.1 .
    CCDSi CCDS7686.1.
    PIRi A31949.
    RefSeqi NP_000764.1. NM_000773.3.
    UniGenei Hs.12907.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3E4E X-ray 2.60 A/B 32-493 [» ]
    3E6I X-ray 2.20 A/B 32-493 [» ]
    3GPH X-ray 2.70 A/B 32-493 [» ]
    3KOH X-ray 2.90 A/B 32-493 [» ]
    3LC4 X-ray 3.10 A/B 32-493 [» ]
    3T3Z X-ray 2.35 A/B/C/D 32-493 [» ]
    ProteinModelPortali P05181.
    SMRi P05181. Positions 32-493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107944. 17 interactions.
    IntActi P05181. 10 interactions.
    STRINGi 9606.ENSP00000252945.

    Chemistry

    BindingDBi P05181.
    ChEMBLi CHEMBL5281.
    DrugBanki DB00316. Acetaminophen.
    DB00356. Chlorzoxazone.
    DB00568. Cinnarizine.
    DB00636. Clofibrate.
    DB00851. Dacarbazine.
    DB00250. Dapsone.
    DB00228. Enflurane.
    DB00402. Eszopiclone.
    DB00898. Ethanol.
    DB00593. Ethosuximide.
    DB01213. Fomepizole.
    DB00143. Glutathione.
    DB01159. Halothane.
    DB01355. Hexobarbital.
    DB00753. Isoflurane.
    DB00951. Isoniazid.
    DB00170. Menadione.
    DB00532. Mephenytoin.
    DB01028. Methoxyflurane.
    DB00683. Midazolam.
    DB01204. Mitoxantrone.
    DB00184. Nicotine.
    DB01115. Nifedipine.
    DB00698. Nitrofurantoin.
    DB01173. Orphenadrine.
    DB00780. Phenelzine.
    DB00908. Quinidine.
    DB00118. S-Adenosylmethionine.
    DB01236. Sevoflurane.
    DB00277. Theophylline.
    DB01124. Tolbutamide.

    PTM databases

    PhosphoSitei P05181.

    Polymorphism databases

    DMDMi 117250.

    Proteomic databases

    PaxDbi P05181.
    PeptideAtlasi P05181.
    PRIDEi P05181.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252945 ; ENSP00000252945 ; ENSG00000130649 .
    ENST00000463117 ; ENSP00000440689 ; ENSG00000130649 .
    GeneIDi 1571.
    KEGGi hsa:1571.
    UCSCi uc001lnj.1. human.

    Organism-specific databases

    CTDi 1571.
    GeneCardsi GC10P135352.
    HGNCi HGNC:2631. CYP2E1.
    HPAi HPA009128.
    HPA029564.
    MIMi 124040. gene.
    neXtProti NX_P05181.
    PharmGKBi PA129.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi P05181.
    KOi K07415.
    OMAi GCIPPRY.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P05181.
    TreeFami TF352043.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS05414-MONOMER.
    Reactomei REACT_13543. Xenobiotics.
    REACT_13797. CYP2E1 reactions.
    SABIO-RK P05181.

    Miscellaneous databases

    EvolutionaryTracei P05181.
    GeneWikii CYP2E1.
    GenomeRNAii 1571.
    NextBioi 6461.
    PROi P05181.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P05181.
    Bgeei P05181.
    CleanExi HS_CYP2E1.
    Genevestigatori P05181.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01687. EP450ICYP2E.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme."
      Song B.-J., Gelboin H.V., Park S.-S., Yang C.S., Gonzalez F.J.
      J. Biol. Chem. 261:16689-16697(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression."
      Umeno M., McBride O.W., Yang C.S., Gelboin H.V., Gonzalez F.J.
      Biochemistry 27:9006-9013(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Sequence of a new human cytochrome P450-2E1 cDNA and establishing the transgenic cell line."
      Zhuge J., Qian Y., Xie H., Yu Y.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    4. NIEHS SNPs program
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-219; CYS-366 AND LEU-457.
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Partial sequence of human brain cytochrome P450 2E1."
      Yoo M., Shin S.W.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-493.
      Tissue: Brain.
    9. "Rapid detection of a novel mutation in the human CYP2EI exon VIII by the PCR method."
      Iwahashi K., Okuyama E., Nakamura K., Furukawa A., Ichikawa Y.
      Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 387-432.
    10. "Purification and characterization of human liver cytochrome P-450-ALC."
      Lasker J.M., Raucy J., Kubota S., Bloswick B.P., Black M., Lieber C.S.
      Biochem. Biophys. Res. Commun. 148:232-238(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-20.
      Tissue: Liver.
    11. "Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation."
      Robinson R.C., Shorr R.G., Varrichio A., Park S.S., Gelboin H.V., Miller H., Friedman F.K.
      Pharmacology 39:137-144(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 3-20.
    12. "Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties."
      Gillam E.M., Guo Z., Guengerich F.P.
      Arch. Biochem. Biophys. 312:59-66(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-42.
    13. "Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1."
      Zerilli A., Ratanasavanh D., Lucas D., Goasduff T., Dreano Y., Menard C., Picart D., Berthou F.
      Chem. Res. Toxicol. 10:1205-1212(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY.
    14. "Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates."
      Porubsky P.R., Meneely K.M., Scott E.E.
      J. Biol. Chem. 283:33698-33707(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 32-493 IN COMPLEX WITH THE INHIBITORS INDAZOLE AND 4-METHYLPYRAZOLE AND HEME.
    15. "Genetic polymorphism of human CYP2E1: characterization of two variant alleles."
      Hu Y., Oscarson M., Johansson I., Yue Q.Y., Dahl M.L., Tabone M., Arinco S., Albano E., Ingelman-Sundberg M.
      Mol. Pharmacol. 51:370-376(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CYP2E1*2 HIS-76 AND CYP2E1*3 ILE-389.
    16. "Detection and characterization of novel polymorphisms in the CYP2E1 gene."
      Fairbrother K.S., Grove J., de Waziers I., Steimel D.T., Day C.P., Crespi C.L., Daly A.K.
      Pharmacogenetics 8:543-552(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYP2E1*4 ILE-179.
    17. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
      Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
      Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ILE-179 AND LEU-457.

    Entry informationi

    Entry nameiCP2E1_HUMAN
    AccessioniPrimary (citable) accession number: P05181
    Secondary accession number(s): Q5VZD5, Q6NWT9, Q9UK47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 160 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3