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Protein

Cytochrome P450 2E1

Gene

CYP2E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Catalytic activityi

4-nitrophenol + NADPH + O2 = 4-nitrocatechol + NADP+ + H2O.1 Publication

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi437Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

  • benzene metabolic process Source: Reactome
  • carbon tetrachloride metabolic process Source: Reactome
  • drug metabolic process Source: BHF-UCL
  • epoxygenase P450 pathway Source: GO_Central
  • halogenated hydrocarbon metabolic process Source: Reactome
  • heterocycle metabolic process Source: BHF-UCL
  • monoterpenoid metabolic process Source: BHF-UCL
  • oxidation-reduction process Source: BHF-UCL
  • response to drug Source: Ensembl
  • response to ethanol Source: Ensembl
  • response to organonitrogen compound Source: Ensembl
  • response to ozone Source: Ensembl
  • steroid metabolic process Source: BHF-UCL
  • triglyceride metabolic process Source: Ensembl
  • xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS05414-MONOMER.
ZFISH:HS05414-MONOMER.
ReactomeiR-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.
SABIO-RKP05181.

Chemistry databases

SwissLipidsiSLP:000001596.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2E1 (EC:1.14.13.-)
Alternative name(s):
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7)
CYPIIE1
Cytochrome P450-J
Cleaved into the following chain:
Gene namesi
Name:CYP2E1
Synonyms:CYP2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:2631. CYP2E1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1571.
OpenTargetsiENSG00000130649.
PharmGKBiPA129.

Chemistry databases

ChEMBLiCHEMBL5281.
DrugBankiDB00316. Acetaminophen.
DB00041. Aldesleukin.
DB00918. Almotriptan.
DB00969. Alosetron.
DB01223. Aminophylline.
DB00321. Amitriptyline.
DB01435. Antipyrine.
DB00972. Azelastine.
DB06770. Benzyl alcohol.
DB04794. Bifonazole.
DB01558. Bromazepam.
DB00835. Brompheniramine.
DB01156. Bupropion.
DB00201. Caffeine.
DB06774. Capsaicin.
DB00748. Carbinoxamine.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00356. Chlorzoxazone.
DB00501. Cimetidine.
DB00215. Citalopram.
DB04920. Clevidipine.
DB00636. Clofibrate.
DB00882. Clomifene.
DB01068. Clonazepam.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB01394. Colchicine.
DB00851. Dacarbazine.
DB06637. Dalfampridine.
DB00250. Dapsone.
DB01151. Desipramine.
DB01234. Dexamethasone.
DB01191. Dexfenfluramine.
DB00633. Dexmedetomidine.
DB00514. Dextromethorphan.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00255. Diethylstilbestrol.
DB00822. Disulfiram.
DB01127. Econazole.
DB00228. Enflurane.
DB00109. Enfuvirtide.
DB00655. Estrone.
DB00898. Ethanol.
DB06689. Ethanolamine Oleate.
DB00593. Ethosuximide.
DB00773. Etoposide.
DB01628. Etoricoxib.
DB00949. Felbamate.
DB08868. Fingolimod.
DB01544. Flunitrazepam.
DB00623. Fluphenazine.
DB00690. Flurazepam.
DB00176. Fluvoxamine.
DB00158. Folic Acid.
DB01213. Fomepizole.
DB01296. Glucosamine.
DB01159. Halothane.
DB01355. Hexobarbital.
DB04946. Iloperidone.
DB00458. Imipramine.
DB00753. Isoflurane.
DB00951. Isoniazid.
DB00883. Isosorbide Dinitrate.
DB01167. Itraconazole.
DB00170. Menadione.
DB00371. Meprobamate.
DB00703. Methazolamide.
DB00763. Methimazole.
DB01403. Methotrimeprazine.
DB01028. Methoxyflurane.
DB01011. Metyrapone.
DB00379. Mexiletine.
DB01110. Miconazole.
DB00683. Midazolam.
DB01204. Mitoxantrone.
DB00622. Nicardipine.
DB02701. Nicotinamide.
DB00184. Nicotine.
DB01115. Nifedipine.
DB06712. Nilvadipine.
DB01595. Nitrazepam.
DB00540. Nortriptyline.
DB00904. Ondansetron.
DB01173. Orphenadrine.
DB00526. Oxaliplatin.
DB00617. Paramethadione.
DB00780. Phenelzine.
DB01174. Phenobarbital.
DB01085. Pilocarpine.
DB01100. Pimozide.
DB01131. Proguanil.
DB00818. Propofol.
DB00908. Quinidine.
DB00468. Quinine.
DB01045. Rifampicin.
DB00503. Ritonavir.
DB06201. Rufinamide.
DB00118. S-Adenosylmethionine.
DB01037. Selegiline.
DB01236. Sevoflurane.
DB00203. Sildenafil.
DB00428. Streptozocin.
DB00359. Sulfadiazine.
DB00259. Sulfanilamide.
DB00675. Tamoxifen.
DB01041. Thalidomide.
DB01412. Theobromine.
DB00277. Theophylline.
DB00599. Thiopental.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB05109. Trabectedin.
DB00752. Tranylcypromine.
DB00347. Trimethadione.
DB01586. Ursodeoxycholic acid.
DB00549. Zafirlukast.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi1330.

Polymorphism and mutation databases

BioMutaiCYP2E1.
DMDMi117250.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517511 – 493Cytochrome P450 2E1Add BLAST493
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004343472 – 493Cytochrome P450 2E1, N-terminally processedAdd BLAST492

Proteomic databases

PaxDbiP05181.
PeptideAtlasiP05181.
PRIDEiP05181.

PTM databases

iPTMnetiP05181.
PhosphoSitePlusiP05181.

Expressioni

Inductioni

By ethanol and isoniazid.

Gene expression databases

BgeeiENSG00000130649.
CleanExiHS_CYP2E1.
ExpressionAtlasiP05181. baseline and differential.
GenevisibleiP05181. HS.

Organism-specific databases

HPAiHPA009128.
HPA029564.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107944. 17 interactors.
IntActiP05181. 10 interactors.
STRINGi9606.ENSP00000252945.

Chemistry databases

BindingDBiP05181.

Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni40 – 42Combined sources3
Helixi45 – 47Combined sources3
Helixi50 – 52Combined sources3
Helixi53 – 64Combined sources12
Beta strandi66 – 72Combined sources7
Beta strandi75 – 80Combined sources6
Helixi83 – 91Combined sources9
Turni94 – 97Combined sources4
Helixi104 – 109Combined sources6
Beta strandi112 – 114Combined sources3
Helixi122 – 135Combined sources14
Helixi142 – 159Combined sources18
Turni160 – 163Combined sources4
Helixi169 – 172Combined sources4
Helixi174 – 185Combined sources12
Helixi194 – 209Combined sources16
Helixi213 – 220Combined sources8
Helixi222 – 225Combined sources4
Beta strandi228 – 230Combined sources3
Helixi231 – 255Combined sources25
Beta strandi259 – 261Combined sources3
Helixi265 – 274Combined sources10
Beta strandi275 – 278Combined sources4
Beta strandi279 – 281Combined sources3
Helixi286 – 317Combined sources32
Helixi319 – 332Combined sources14
Turni333 – 336Combined sources4
Helixi341 – 346Combined sources6
Helixi348 – 361Combined sources14
Beta strandi376 – 378Combined sources3
Beta strandi381 – 383Combined sources3
Beta strandi388 – 391Combined sources4
Helixi394 – 397Combined sources4
Turni400 – 402Combined sources3
Beta strandi403 – 405Combined sources3
Helixi411 – 414Combined sources4
Beta strandi419 – 421Combined sources3
Helixi433 – 435Combined sources3
Helixi440 – 457Combined sources18
Beta strandi458 – 464Combined sources7
Turni466 – 468Combined sources3
Beta strandi474 – 481Combined sources8
Beta strandi487 – 491Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E4EX-ray2.60A/B32-493[»]
3E6IX-ray2.20A/B32-493[»]
3GPHX-ray2.70A/B32-493[»]
3KOHX-ray2.90A/B32-493[»]
3LC4X-ray3.10A/B32-493[»]
3T3ZX-ray2.35A/B/C/D32-493[»]
ProteinModelPortaliP05181.
SMRiP05181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05181.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni298 – 303Substrate bindingCurated6

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP05181.
KOiK07415.
OMAiGCIPPRY.
OrthoDBiEOG091G0BT8.
PhylomeDBiP05181.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01687. EP450ICYP2E.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALGVTVAL LVWAAFLLLV SMWRQVHSSW NLPPGPFPLP IIGNLFQLEL
60 70 80 90 100
KNIPKSFTRL AQRFGPVFTL YVGSQRMVVM HGYKAVKEAL LDYKDEFSGR
110 120 130 140 150
GDLPAFHAHR DRGIIFNNGP TWKDIRRFSL TTLRNYGMGK QGNESRIQRE
160 170 180 190 200
AHFLLEALRK TQGQPFDPTF LIGCAPCNVI ADILFRKHFD YNDEKFLRLM
210 220 230 240 250
YLFNENFHLL STPWLQLYNN FPSFLHYLPG SHRKVIKNVA EVKEYVSERV
260 270 280 290 300
KEHHQSLDPN CPRDLTDCLL VEMEKEKHSA ERLYTMDGIT VTVADLFFAG
310 320 330 340 350
TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRIPA IKDRQEMPYM
360 370 380 390 400
DAVVHEIQRF ITLVPSNLPH EATRDTIFRG YLIPKGTVVV PTLDSVLYDN
410 420 430 440 450
QEFPDPEKFK PEHFLNENGK FKYSDYFKPF STGKRVCAGE GLARMELFLL
460 470 480 490
LCAILQHFNL KPLVDPKDID LSPIHIGFGC IPPRYKLCVI PRS
Length:493
Mass (Da):56,849
Last modified:April 1, 1988 - v1
Checksum:iED0399E32A005644
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2Missing AA sequence (PubMed:3675576).Curated1
Sequence conflicti23W → A AA sequence (PubMed:8031147).Curated1
Sequence conflicti32L → N AA sequence (PubMed:8031147).Curated1
Sequence conflicti71Y → C in AAH67433 (PubMed:15489334).Curated1
Sequence conflicti235V → A in AAF13601 (Ref. 3) Curated1
Sequence conflicti355H → R in AAH67433 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00836076R → H in allele CYP2E1*2; reduced activity. 1 PublicationCorresponds to variant rs72559710dbSNPEnsembl.1
Natural variantiVAR_008361179V → I in allele CYP2E1*4. 2 PublicationsCorresponds to variant rs6413419dbSNPEnsembl.1
Natural variantiVAR_055382219N → D.1 PublicationCorresponds to variant rs41299426dbSNPEnsembl.1
Natural variantiVAR_055383366S → C.1 PublicationCorresponds to variant rs41299434dbSNPEnsembl.1
Natural variantiVAR_008362389V → I in allele CYP2E1*3. 1 PublicationCorresponds to variant rs55897648dbSNPEnsembl.1
Natural variantiVAR_024727457H → L.2 PublicationsCorresponds to variant rs28969387dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02625 mRNA. Translation: AAA35743.1.
J02843 Genomic DNA. Translation: AAA52155.1.
AF182276 mRNA. Translation: AAF13601.1.
DQ515958 Genomic DNA. Translation: ABF47105.1.
AL161645 Genomic DNA. Translation: CAH70047.1.
CH471211 Genomic DNA. Translation: EAW61357.1.
BC067433 mRNA. Translation: AAH67433.1.
AF084225 mRNA. Translation: AAD13753.1.
D50111 Genomic DNA. Translation: BAA08796.1.
CCDSiCCDS7686.1.
PIRiA31949.
RefSeqiNP_000764.1. NM_000773.3.
UniGeneiHs.12907.

Genome annotation databases

EnsembliENST00000252945; ENSP00000252945; ENSG00000130649.
ENST00000463117; ENSP00000440689; ENSG00000130649.
GeneIDi1571.
KEGGihsa:1571.
UCSCiuc001lnj.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2E1 alleles

Wikipedia

CYP2E1 entry

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02625 mRNA. Translation: AAA35743.1.
J02843 Genomic DNA. Translation: AAA52155.1.
AF182276 mRNA. Translation: AAF13601.1.
DQ515958 Genomic DNA. Translation: ABF47105.1.
AL161645 Genomic DNA. Translation: CAH70047.1.
CH471211 Genomic DNA. Translation: EAW61357.1.
BC067433 mRNA. Translation: AAH67433.1.
AF084225 mRNA. Translation: AAD13753.1.
D50111 Genomic DNA. Translation: BAA08796.1.
CCDSiCCDS7686.1.
PIRiA31949.
RefSeqiNP_000764.1. NM_000773.3.
UniGeneiHs.12907.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E4EX-ray2.60A/B32-493[»]
3E6IX-ray2.20A/B32-493[»]
3GPHX-ray2.70A/B32-493[»]
3KOHX-ray2.90A/B32-493[»]
3LC4X-ray3.10A/B32-493[»]
3T3ZX-ray2.35A/B/C/D32-493[»]
ProteinModelPortaliP05181.
SMRiP05181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107944. 17 interactors.
IntActiP05181. 10 interactors.
STRINGi9606.ENSP00000252945.

Chemistry databases

BindingDBiP05181.
ChEMBLiCHEMBL5281.
DrugBankiDB00316. Acetaminophen.
DB00041. Aldesleukin.
DB00918. Almotriptan.
DB00969. Alosetron.
DB01223. Aminophylline.
DB00321. Amitriptyline.
DB01435. Antipyrine.
DB00972. Azelastine.
DB06770. Benzyl alcohol.
DB04794. Bifonazole.
DB01558. Bromazepam.
DB00835. Brompheniramine.
DB01156. Bupropion.
DB00201. Caffeine.
DB06774. Capsaicin.
DB00748. Carbinoxamine.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00356. Chlorzoxazone.
DB00501. Cimetidine.
DB00215. Citalopram.
DB04920. Clevidipine.
DB00636. Clofibrate.
DB00882. Clomifene.
DB01068. Clonazepam.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB01394. Colchicine.
DB00851. Dacarbazine.
DB06637. Dalfampridine.
DB00250. Dapsone.
DB01151. Desipramine.
DB01234. Dexamethasone.
DB01191. Dexfenfluramine.
DB00633. Dexmedetomidine.
DB00514. Dextromethorphan.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00255. Diethylstilbestrol.
DB00822. Disulfiram.
DB01127. Econazole.
DB00228. Enflurane.
DB00109. Enfuvirtide.
DB00655. Estrone.
DB00898. Ethanol.
DB06689. Ethanolamine Oleate.
DB00593. Ethosuximide.
DB00773. Etoposide.
DB01628. Etoricoxib.
DB00949. Felbamate.
DB08868. Fingolimod.
DB01544. Flunitrazepam.
DB00623. Fluphenazine.
DB00690. Flurazepam.
DB00176. Fluvoxamine.
DB00158. Folic Acid.
DB01213. Fomepizole.
DB01296. Glucosamine.
DB01159. Halothane.
DB01355. Hexobarbital.
DB04946. Iloperidone.
DB00458. Imipramine.
DB00753. Isoflurane.
DB00951. Isoniazid.
DB00883. Isosorbide Dinitrate.
DB01167. Itraconazole.
DB00170. Menadione.
DB00371. Meprobamate.
DB00703. Methazolamide.
DB00763. Methimazole.
DB01403. Methotrimeprazine.
DB01028. Methoxyflurane.
DB01011. Metyrapone.
DB00379. Mexiletine.
DB01110. Miconazole.
DB00683. Midazolam.
DB01204. Mitoxantrone.
DB00622. Nicardipine.
DB02701. Nicotinamide.
DB00184. Nicotine.
DB01115. Nifedipine.
DB06712. Nilvadipine.
DB01595. Nitrazepam.
DB00540. Nortriptyline.
DB00904. Ondansetron.
DB01173. Orphenadrine.
DB00526. Oxaliplatin.
DB00617. Paramethadione.
DB00780. Phenelzine.
DB01174. Phenobarbital.
DB01085. Pilocarpine.
DB01100. Pimozide.
DB01131. Proguanil.
DB00818. Propofol.
DB00908. Quinidine.
DB00468. Quinine.
DB01045. Rifampicin.
DB00503. Ritonavir.
DB06201. Rufinamide.
DB00118. S-Adenosylmethionine.
DB01037. Selegiline.
DB01236. Sevoflurane.
DB00203. Sildenafil.
DB00428. Streptozocin.
DB00359. Sulfadiazine.
DB00259. Sulfanilamide.
DB00675. Tamoxifen.
DB01041. Thalidomide.
DB01412. Theobromine.
DB00277. Theophylline.
DB00599. Thiopental.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB05109. Trabectedin.
DB00752. Tranylcypromine.
DB00347. Trimethadione.
DB01586. Ursodeoxycholic acid.
DB00549. Zafirlukast.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi1330.
SwissLipidsiSLP:000001596.

PTM databases

iPTMnetiP05181.
PhosphoSitePlusiP05181.

Polymorphism and mutation databases

BioMutaiCYP2E1.
DMDMi117250.

Proteomic databases

PaxDbiP05181.
PeptideAtlasiP05181.
PRIDEiP05181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252945; ENSP00000252945; ENSG00000130649.
ENST00000463117; ENSP00000440689; ENSG00000130649.
GeneIDi1571.
KEGGihsa:1571.
UCSCiuc001lnj.1. human.

Organism-specific databases

CTDi1571.
DisGeNETi1571.
GeneCardsiCYP2E1.
HGNCiHGNC:2631. CYP2E1.
HPAiHPA009128.
HPA029564.
MIMi124040. gene.
neXtProtiNX_P05181.
OpenTargetsiENSG00000130649.
PharmGKBiPA129.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP05181.
KOiK07415.
OMAiGCIPPRY.
OrthoDBiEOG091G0BT8.
PhylomeDBiP05181.
TreeFamiTF352043.

Enzyme and pathway databases

BioCyciMetaCyc:HS05414-MONOMER.
ZFISH:HS05414-MONOMER.
ReactomeiR-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.
SABIO-RKP05181.

Miscellaneous databases

EvolutionaryTraceiP05181.
GeneWikiiCYP2E1.
GenomeRNAii1571.
PROiP05181.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130649.
CleanExiHS_CYP2E1.
ExpressionAtlasiP05181. baseline and differential.
GenevisibleiP05181. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01687. EP450ICYP2E.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2E1_HUMAN
AccessioniPrimary (citable) accession number: P05181
Secondary accession number(s): Q5VZD5, Q6NWT9, Q9UK47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 1, 1988
Last modified: November 30, 2016
This is version 180 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.