Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P05180

- CP2H1_CHICK

UniProt

P05180 - CP2H1_CHICK

Protein

Cytochrome P450 2H1

Gene

CYP2H1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi436 – 4361Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2H1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIH1
    Cytochrome P450 PB15
    Cytochrome P450 PCHP3
    Gene namesi
    Name:CYP2H1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Cytochrome P450 2H1PRO_0000051766Add
    BLAST

    Proteomic databases

    PaxDbiP05180.

    Expressioni

    Inductioni

    By phenobarbital.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000039271.

    Structurei

    3D structure databases

    ProteinModelPortaliP05180.
    SMRiP05180. Positions 33-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    KOiK17853.
    PhylomeDBiP05180.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P05180-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFLGLPTIL LLVCISCLLI AAWRSTSQRG KEPPGPTPIP IIGNVFQLNP    50
    WDLMGSFKEL SKKYGPIFTI HLGPKKIVVL YGYDIVKEAL IDNGEAFSGR 100
    GILPLIEKLF KGTGIVTSNG ETWRQLRRFA LTTLRDFGMG KKGIEERIQE 150
    EAHFLVERIR KTHEEPFNPG KFLIHAVANI ICSIVFGDRF DYEDKKFLDL 200
    IEMLEENNKY QNRIQTLLYN FFPTILDSLP GPHKTLIKNT ETVDDFIKEI 250
    VIAHQESFDA SCPRDFIDAF INKMEQEKEN SYFTVESLTR TTLDLFLAGT 300
    GTTSTTLRYG LLILLKHPEI EEKMHKEIDR VVGRDRSPCM ADRSQLPYTD 350
    AVIHEIQRFI DFLPLNVPHA VIKDTKLRDY FIPKDTMIFP LLSPILQDCK 400
    EFPNPEKFDP GHFLNANGTF RRSDYFMPFS AGKRICAGEG LARMEIFLFL 450
    TSILQNFSLK PVKDRKDIDI SPIITSLANM PRPYEVSFIP R 491
    Length:491
    Mass (Da):56,261
    Last modified:August 13, 1987 - v1
    Checksum:iE2345F98AE99CA2F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13454 mRNA. Translation: AAA48742.1.
    PIRiA24814.
    RefSeqiNP_001001616.1. NM_001001616.1.
    UniGeneiGga.858.

    Genome annotation databases

    GeneIDi414746.
    KEGGigga:414746.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13454 mRNA. Translation: AAA48742.1 .
    PIRi A24814.
    RefSeqi NP_001001616.1. NM_001001616.1.
    UniGenei Gga.858.

    3D structure databases

    ProteinModelPortali P05180.
    SMRi P05180. Positions 33-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000039271.

    Proteomic databases

    PaxDbi P05180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 414746.
    KEGGi gga:414746.

    Organism-specific databases

    CTDi 414746.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    KOi K17853.
    PhylomeDBi P05180.

    Miscellaneous databases

    NextBioi 20818715.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cDNA and protein sequence of a phenobarbital-induced chicken cytochrome P-450."
      Hobbs A.A., Mattschoss L.A., May B.K., Williams K.E., Elliott W.H.
      J. Biol. Chem. 261:9444-9449(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP2H1_CHICK
    AccessioniPrimary (citable) accession number: P05180
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3