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Protein

Cytochrome P450 2H1

Gene

CYP2H1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2H1 (EC:1.14.14.1)
Alternative name(s):
CYPIIH1
Cytochrome P450 PB15
Cytochrome P450 PCHP3
Gene namesi
Name:CYP2H1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Cytochrome P450 2H1PRO_0000051766Add
BLAST

Proteomic databases

PaxDbiP05180.

Expressioni

Inductioni

By phenobarbital.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039271.

Structurei

3D structure databases

ProteinModelPortaliP05180.
SMRiP05180. Positions 33-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP05180.
KOiK17853.
PhylomeDBiP05180.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLGLPTIL LLVCISCLLI AAWRSTSQRG KEPPGPTPIP IIGNVFQLNP
60 70 80 90 100
WDLMGSFKEL SKKYGPIFTI HLGPKKIVVL YGYDIVKEAL IDNGEAFSGR
110 120 130 140 150
GILPLIEKLF KGTGIVTSNG ETWRQLRRFA LTTLRDFGMG KKGIEERIQE
160 170 180 190 200
EAHFLVERIR KTHEEPFNPG KFLIHAVANI ICSIVFGDRF DYEDKKFLDL
210 220 230 240 250
IEMLEENNKY QNRIQTLLYN FFPTILDSLP GPHKTLIKNT ETVDDFIKEI
260 270 280 290 300
VIAHQESFDA SCPRDFIDAF INKMEQEKEN SYFTVESLTR TTLDLFLAGT
310 320 330 340 350
GTTSTTLRYG LLILLKHPEI EEKMHKEIDR VVGRDRSPCM ADRSQLPYTD
360 370 380 390 400
AVIHEIQRFI DFLPLNVPHA VIKDTKLRDY FIPKDTMIFP LLSPILQDCK
410 420 430 440 450
EFPNPEKFDP GHFLNANGTF RRSDYFMPFS AGKRICAGEG LARMEIFLFL
460 470 480 490
TSILQNFSLK PVKDRKDIDI SPIITSLANM PRPYEVSFIP R
Length:491
Mass (Da):56,261
Last modified:August 13, 1987 - v1
Checksum:iE2345F98AE99CA2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13454 mRNA. Translation: AAA48742.1.
PIRiA24814.
RefSeqiNP_001001616.1. NM_001001616.1.
UniGeneiGga.858.

Genome annotation databases

GeneIDi414746.
KEGGigga:414746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13454 mRNA. Translation: AAA48742.1.
PIRiA24814.
RefSeqiNP_001001616.1. NM_001001616.1.
UniGeneiGga.858.

3D structure databases

ProteinModelPortaliP05180.
SMRiP05180. Positions 33-491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039271.

Proteomic databases

PaxDbiP05180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414746.
KEGGigga:414746.

Organism-specific databases

CTDi414746.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP05180.
KOiK17853.
PhylomeDBiP05180.

Miscellaneous databases

NextBioi20818715.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The cDNA and protein sequence of a phenobarbital-induced chicken cytochrome P-450."
    Hobbs A.A., Mattschoss L.A., May B.K., Williams K.E., Elliott W.H.
    J. Biol. Chem. 261:9444-9449(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP2H1_CHICK
AccessioniPrimary (citable) accession number: P05180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.