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P05180 (CP2H1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2H1

EC=1.14.14.1
Alternative name(s):
CYPIIH1
Cytochrome P450 PB15
Cytochrome P450 PCHP3
Gene names
Name:CYP2H1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By phenobarbital.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Cytochrome P450 2H1
PRO_0000051766

Sites

Metal binding4361Iron (heme axial ligand)

Sequences

Sequence LengthMass (Da)Tools
P05180 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: E2345F98AE99CA2F

FASTA49156,261
        10         20         30         40         50         60 
MDFLGLPTIL LLVCISCLLI AAWRSTSQRG KEPPGPTPIP IIGNVFQLNP WDLMGSFKEL 

        70         80         90        100        110        120 
SKKYGPIFTI HLGPKKIVVL YGYDIVKEAL IDNGEAFSGR GILPLIEKLF KGTGIVTSNG 

       130        140        150        160        170        180 
ETWRQLRRFA LTTLRDFGMG KKGIEERIQE EAHFLVERIR KTHEEPFNPG KFLIHAVANI 

       190        200        210        220        230        240 
ICSIVFGDRF DYEDKKFLDL IEMLEENNKY QNRIQTLLYN FFPTILDSLP GPHKTLIKNT 

       250        260        270        280        290        300 
ETVDDFIKEI VIAHQESFDA SCPRDFIDAF INKMEQEKEN SYFTVESLTR TTLDLFLAGT 

       310        320        330        340        350        360 
GTTSTTLRYG LLILLKHPEI EEKMHKEIDR VVGRDRSPCM ADRSQLPYTD AVIHEIQRFI 

       370        380        390        400        410        420 
DFLPLNVPHA VIKDTKLRDY FIPKDTMIFP LLSPILQDCK EFPNPEKFDP GHFLNANGTF 

       430        440        450        460        470        480 
RRSDYFMPFS AGKRICAGEG LARMEIFLFL TSILQNFSLK PVKDRKDIDI SPIITSLANM 

       490 
PRPYEVSFIP R 

« Hide

References

[1]"The cDNA and protein sequence of a phenobarbital-induced chicken cytochrome P-450."
Hobbs A.A., Mattschoss L.A., May B.K., Williams K.E., Elliott W.H.
J. Biol. Chem. 261:9444-9449(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M13454 mRNA. Translation: AAA48742.1.
PIRA24814.
RefSeqNP_001001616.1. NM_001001616.1.
UniGeneGga.858.

3D structure databases

ProteinModelPortalP05180.
SMRP05180. Positions 33-491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000039271.

Proteomic databases

PaxDbP05180.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID414746.
KEGGgga:414746.

Organism-specific databases

CTD414746.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.
KOK17853.
PhylomeDBP05180.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818715.

Entry information

Entry nameCP2H1_CHICK
AccessionPrimary (citable) accession number: P05180
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families