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P05180

- CP2H1_CHICK

UniProt

P05180 - CP2H1_CHICK

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Protein

Cytochrome P450 2H1

Gene
CYP2H1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2H1 (EC:1.14.14.1)
Alternative name(s):
CYPIIH1
Cytochrome P450 PB15
Cytochrome P450 PCHP3
Gene namesi
Name:CYP2H1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Cytochrome P450 2H1PRO_0000051766Add
BLAST

Proteomic databases

PaxDbiP05180.

Expressioni

Inductioni

By phenobarbital.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039271.

Structurei

3D structure databases

ProteinModelPortaliP05180.
SMRiP05180. Positions 33-491.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
KOiK17853.
PhylomeDBiP05180.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05180-1 [UniParc]FASTAAdd to Basket

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MDFLGLPTIL LLVCISCLLI AAWRSTSQRG KEPPGPTPIP IIGNVFQLNP    50
WDLMGSFKEL SKKYGPIFTI HLGPKKIVVL YGYDIVKEAL IDNGEAFSGR 100
GILPLIEKLF KGTGIVTSNG ETWRQLRRFA LTTLRDFGMG KKGIEERIQE 150
EAHFLVERIR KTHEEPFNPG KFLIHAVANI ICSIVFGDRF DYEDKKFLDL 200
IEMLEENNKY QNRIQTLLYN FFPTILDSLP GPHKTLIKNT ETVDDFIKEI 250
VIAHQESFDA SCPRDFIDAF INKMEQEKEN SYFTVESLTR TTLDLFLAGT 300
GTTSTTLRYG LLILLKHPEI EEKMHKEIDR VVGRDRSPCM ADRSQLPYTD 350
AVIHEIQRFI DFLPLNVPHA VIKDTKLRDY FIPKDTMIFP LLSPILQDCK 400
EFPNPEKFDP GHFLNANGTF RRSDYFMPFS AGKRICAGEG LARMEIFLFL 450
TSILQNFSLK PVKDRKDIDI SPIITSLANM PRPYEVSFIP R 491
Length:491
Mass (Da):56,261
Last modified:August 13, 1987 - v1
Checksum:iE2345F98AE99CA2F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13454 mRNA. Translation: AAA48742.1.
PIRiA24814.
RefSeqiNP_001001616.1. NM_001001616.1.
UniGeneiGga.858.

Genome annotation databases

GeneIDi414746.
KEGGigga:414746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13454 mRNA. Translation: AAA48742.1 .
PIRi A24814.
RefSeqi NP_001001616.1. NM_001001616.1.
UniGenei Gga.858.

3D structure databases

ProteinModelPortali P05180.
SMRi P05180. Positions 33-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000039271.

Proteomic databases

PaxDbi P05180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414746.
KEGGi gga:414746.

Organism-specific databases

CTDi 414746.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
KOi K17853.
PhylomeDBi P05180.

Miscellaneous databases

NextBioi 20818715.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cDNA and protein sequence of a phenobarbital-induced chicken cytochrome P-450."
    Hobbs A.A., Mattschoss L.A., May B.K., Williams K.E., Elliott W.H.
    J. Biol. Chem. 261:9444-9449(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP2H1_CHICK
AccessioniPrimary (citable) accession number: P05180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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