Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P05179

- CP2C7_RAT

UniProt

P05179 - CP2C7_RAT

Protein

Cytochrome P450 2C7

Gene

Cyp2c7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Oct 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. response to drug Source: RGD
    2. response to ethanol Source: RGD
    3. response to lipopolysaccharide Source: RGD
    4. response to nutrient Source: RGD
    5. response to organic cyclic compound Source: RGD
    6. response to organonitrogen compound Source: RGD
    7. response to peptide hormone Source: RGD
    8. response to retinoic acid Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C7 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC7
    Cytochrome P450F
    PTF1
    Gene namesi
    Name:Cyp2c7
    Synonyms:Cyp2c-7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620379. Cyp2c7.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C7PRO_0000051698Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei144 – 1441Omega-N-methylated arginine1 Publication

    Keywords - PTMi

    Methylation

    Proteomic databases

    PRIDEiP05179.

    PTM databases

    PhosphoSiteiP05179.

    Expressioni

    Inductioni

    By growth hormone. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.1 Publication

    Gene expression databases

    GenevestigatoriP05179.

    Interactioni

    Protein-protein interaction databases

    IntActiP05179. 1 interaction.
    MINTiMINT-4565026.

    Structurei

    3D structure databases

    ProteinModelPortaliP05179.
    SMRiP05179. Positions 30-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG015789.
    InParanoidiP05179.
    KOiK07413.
    PhylomeDBiP05179.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P05179-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLVTFLVLT LSSLILLSLW RQSSRRRKLP PGPTPLPIIG NFLQIDVKNI    50
    SQSLTKFSKT YGPVFTLYLG SQPTVILHGY EAIKEALIDN GEKFSGRGSY 100
    PMNENVTKGF GIVFSNGNRW KEMRRFTIMN FRNLGIGKRN IEDRVQEEAQ 150
    CLVEELRKTK GSPCDPSLIL NCAPCNVICS ITFQNHFDYK DKEMLTFMEK 200
    VNENLKIMSS PWMQVCNSFP SLIDYFPGTH HKIAKNINYM KSYLLKKIEE 250
    HQESLDVTNP RDFVDYYLIK QKQANNIEQS EYSHENLTCS IMDLIGAGTE 300
    TMSTTLRYAL LLLMKYPHVT AKVQEEIDRV IGRHRSPCMQ DRKHMPYTDA 350
    MIHEVQRFIN FVPTNLPHAV TCDIKFRNYL IPKGTKVLTS LTSVLHDSKE 400
    FPNPEMFDPG HFLDENGNFK KSDYFLPFSA GKRACVGEGL ARMQLFLFLT 450
    TILQNFNLKS LVHPKDIDTM PVLNGFASLP PTYQLCFIPS 490
    Length:490
    Mass (Da):56,187
    Last modified:October 1, 1989 - v2
    Checksum:i0FBACF3E9C6ABAA5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281K → E in AAA41058. (PubMed:3015936)Curated
    Sequence conflicti57 – 659FSKTYGPVF → VSIVGDPVI in CAA31108. 1 PublicationCurated
    Sequence conflicti87 – 871L → V no nucleotide entry (PubMed:3801454)Curated
    Sequence conflicti103 – 1031N → I in AAA41058. (PubMed:3015936)Curated
    Sequence conflicti103 – 1031N → I no nucleotide entry (PubMed:3801454)Curated
    Sequence conflicti130 – 1301N → T no nucleotide entry (PubMed:3801454)Curated
    Sequence conflicti279 – 2791Q → H in AAA41058. (PubMed:3015936)Curated
    Sequence conflicti351 – 3522MI → HD in AAA41058. (PubMed:3015936)Curated
    Sequence conflicti383 – 3853KGT → RRA no nucleotide entry (PubMed:3801454)Curated
    Sequence conflicti408 – 4114DPGH → VPWP no nucleotide entry (PubMed:3801454)Curated
    Sequence conflicti471 – 4711P → A no nucleotide entry (PubMed:3801454)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18335 mRNA. Translation: AAA41036.1.
    X12595 Genomic DNA. Translation: CAA31108.1.
    M31031 mRNA. Translation: AAA41058.1.
    PIRiB28516.
    RefSeqiNP_058854.1. NM_017158.2.
    UniGeneiRn.1247.

    Genome annotation databases

    GeneIDi29298.
    KEGGirno:29298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18335 mRNA. Translation: AAA41036.1 .
    X12595 Genomic DNA. Translation: CAA31108.1 .
    M31031 mRNA. Translation: AAA41058.1 .
    PIRi B28516.
    RefSeqi NP_058854.1. NM_017158.2.
    UniGenei Rn.1247.

    3D structure databases

    ProteinModelPortali P05179.
    SMRi P05179. Positions 30-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P05179. 1 interaction.
    MINTi MINT-4565026.

    PTM databases

    PhosphoSitei P05179.

    Proteomic databases

    PRIDEi P05179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29298.
    KEGGi rno:29298.

    Organism-specific databases

    CTDi 29298.
    RGDi 620379. Cyp2c7.

    Phylogenomic databases

    HOVERGENi HBG015789.
    InParanoidi P05179.
    KOi K07413.
    PhylomeDBi P05179.

    Miscellaneous databases

    NextBioi 608708.

    Gene expression databases

    Genevestigatori P05179.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression."
      Kimura H., Yoshioka H., Sogawa K., Sakai Y., Fujii-Kuriyama Y.
      J. Biol. Chem. 263:701-707(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "5' flanking sequence of the gene for rat cytochrome p-450f."
      Stroem A., Nilsson A.G., Zaphiropoulos P.G.
      Submitted (AUG-1988) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-66.
      Strain: Sprague-Dawley.
    3. "Growth hormone regulation of the cytochrome P-450IIC subfamily in the rat: inductive, repressive, and transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression."
      Westin S., Stroem A., Gustafsson J.-A., Zaphiropoulos P.G.
      Mol. Pharmacol. 38:192-197(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-56, INDUCTION.
    4. "Responses to insulin by two forms of rat hepatic microsomal cytochrome P-450 that undergo major (RLM6) and minor (RLM5b) elevations in diabetes."
      Favreau L.V., Malchoff D.M., Mole J.E., Schenkman J.B.
      J. Biol. Chem. 262:14319-14326(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-23.
      Tissue: Liver.
    5. "Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA."
      Gonzalez F.J., Kimura S., Song B.-J., Pastewka J., Gelboin H.V., Hardwick J.P.
      J. Biol. Chem. 261:10667-10672(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-490.
    6. "Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1."
      Friedberg T., Waxman D.J., Atchison M., Kumar A., Haaparanta T., Raphael C., Adesnik M.
      Biochemistry 25:7975-7983(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 87-490.
    7. Cited for: METHYLATION AT ARG-144, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiCP2C7_RAT
    AccessioniPrimary (citable) accession number: P05179
    Secondary accession number(s): Q63706
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3