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P05179

- CP2C7_RAT

UniProt

P05179 - CP2C7_RAT

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Protein

Cytochrome P450 2C7

Gene

Cyp2c7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. response to drug Source: RGD
  2. response to ethanol Source: RGD
  3. response to lipopolysaccharide Source: RGD
  4. response to nutrient Source: RGD
  5. response to organic cyclic compound Source: RGD
  6. response to organonitrogen compound Source: RGD
  7. response to peptide hormone Source: RGD
  8. response to retinoic acid Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C7 (EC:1.14.14.1)
Alternative name(s):
CYPIIC7
Cytochrome P450F
PTF1
Gene namesi
Name:Cyp2c7
Synonyms:Cyp2c-7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620379. Cyp2c7.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. intracellular membrane-bounded organelle Source: RGD
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C7PRO_0000051698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei144 – 1441Dimethylated arginine1 Publication

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiP05179.

PTM databases

PhosphoSiteiP05179.

Expressioni

Inductioni

By growth hormone. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.1 Publication

Gene expression databases

GenevestigatoriP05179.

Interactioni

Protein-protein interaction databases

IntActiP05179. 1 interaction.
MINTiMINT-4565026.

Structurei

3D structure databases

ProteinModelPortaliP05179.
SMRiP05179. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.
InParanoidiP05179.
KOiK07413.
PhylomeDBiP05179.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05179-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLVTFLVLT LSSLILLSLW RQSSRRRKLP PGPTPLPIIG NFLQIDVKNI
60 70 80 90 100
SQSLTKFSKT YGPVFTLYLG SQPTVILHGY EAIKEALIDN GEKFSGRGSY
110 120 130 140 150
PMNENVTKGF GIVFSNGNRW KEMRRFTIMN FRNLGIGKRN IEDRVQEEAQ
160 170 180 190 200
CLVEELRKTK GSPCDPSLIL NCAPCNVICS ITFQNHFDYK DKEMLTFMEK
210 220 230 240 250
VNENLKIMSS PWMQVCNSFP SLIDYFPGTH HKIAKNINYM KSYLLKKIEE
260 270 280 290 300
HQESLDVTNP RDFVDYYLIK QKQANNIEQS EYSHENLTCS IMDLIGAGTE
310 320 330 340 350
TMSTTLRYAL LLLMKYPHVT AKVQEEIDRV IGRHRSPCMQ DRKHMPYTDA
360 370 380 390 400
MIHEVQRFIN FVPTNLPHAV TCDIKFRNYL IPKGTKVLTS LTSVLHDSKE
410 420 430 440 450
FPNPEMFDPG HFLDENGNFK KSDYFLPFSA GKRACVGEGL ARMQLFLFLT
460 470 480 490
TILQNFNLKS LVHPKDIDTM PVLNGFASLP PTYQLCFIPS
Length:490
Mass (Da):56,187
Last modified:October 1, 1989 - v2
Checksum:i0FBACF3E9C6ABAA5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281K → E in AAA41058. (PubMed:3015936)Curated
Sequence conflicti57 – 659FSKTYGPVF → VSIVGDPVI in CAA31108. 1 PublicationCurated
Sequence conflicti87 – 871L → V no nucleotide entry (PubMed:3801454)Curated
Sequence conflicti103 – 1031N → I in AAA41058. (PubMed:3015936)Curated
Sequence conflicti103 – 1031N → I no nucleotide entry (PubMed:3801454)Curated
Sequence conflicti130 – 1301N → T no nucleotide entry (PubMed:3801454)Curated
Sequence conflicti279 – 2791Q → H in AAA41058. (PubMed:3015936)Curated
Sequence conflicti351 – 3522MI → HD in AAA41058. (PubMed:3015936)Curated
Sequence conflicti383 – 3853KGT → RRA no nucleotide entry (PubMed:3801454)Curated
Sequence conflicti408 – 4114DPGH → VPWP no nucleotide entry (PubMed:3801454)Curated
Sequence conflicti471 – 4711P → A no nucleotide entry (PubMed:3801454)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18335 mRNA. Translation: AAA41036.1.
X12595 Genomic DNA. Translation: CAA31108.1.
M31031 mRNA. Translation: AAA41058.1.
PIRiB28516.
RefSeqiNP_058854.1. NM_017158.2.
UniGeneiRn.1247.

Genome annotation databases

GeneIDi29298.
KEGGirno:29298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18335 mRNA. Translation: AAA41036.1 .
X12595 Genomic DNA. Translation: CAA31108.1 .
M31031 mRNA. Translation: AAA41058.1 .
PIRi B28516.
RefSeqi NP_058854.1. NM_017158.2.
UniGenei Rn.1247.

3D structure databases

ProteinModelPortali P05179.
SMRi P05179. Positions 30-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P05179. 1 interaction.
MINTi MINT-4565026.

PTM databases

PhosphoSitei P05179.

Proteomic databases

PRIDEi P05179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29298.
KEGGi rno:29298.

Organism-specific databases

CTDi 29298.
RGDi 620379. Cyp2c7.

Phylogenomic databases

HOVERGENi HBG015789.
InParanoidi P05179.
KOi K07413.
PhylomeDBi P05179.

Miscellaneous databases

NextBioi 608708.

Gene expression databases

Genevestigatori P05179.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression."
    Kimura H., Yoshioka H., Sogawa K., Sakai Y., Fujii-Kuriyama Y.
    J. Biol. Chem. 263:701-707(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "5' flanking sequence of the gene for rat cytochrome p-450f."
    Stroem A., Nilsson A.G., Zaphiropoulos P.G.
    Submitted (AUG-1988) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-66.
    Strain: Sprague-Dawley.
  3. "Growth hormone regulation of the cytochrome P-450IIC subfamily in the rat: inductive, repressive, and transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression."
    Westin S., Stroem A., Gustafsson J.-A., Zaphiropoulos P.G.
    Mol. Pharmacol. 38:192-197(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-56, INDUCTION.
  4. "Responses to insulin by two forms of rat hepatic microsomal cytochrome P-450 that undergo major (RLM6) and minor (RLM5b) elevations in diabetes."
    Favreau L.V., Malchoff D.M., Mole J.E., Schenkman J.B.
    J. Biol. Chem. 262:14319-14326(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-23.
    Tissue: Liver.
  5. "Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA."
    Gonzalez F.J., Kimura S., Song B.-J., Pastewka J., Gelboin H.V., Hardwick J.P.
    J. Biol. Chem. 261:10667-10672(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-490.
  6. "Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1."
    Friedberg T., Waxman D.J., Atchison M., Kumar A., Haaparanta T., Raphael C., Adesnik M.
    Biochemistry 25:7975-7983(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 87-490.
  7. Cited for: METHYLATION AT ARG-144, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCP2C7_RAT
AccessioniPrimary (citable) accession number: P05179
Secondary accession number(s): Q63706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 1, 1989
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3