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Protein

Cytochrome P450 2C7

Gene

Cyp2c7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

  • epoxygenase P450 pathway Source: GO_Central
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to nutrient Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organonitrogen compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to retinoic acid Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C7 (EC:1.14.14.1)
Alternative name(s):
CYPIIC7
Cytochrome P450F
PTF1
Gene namesi
Name:Cyp2c7
Synonyms:Cyp2c-7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620379. Cyp2c7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516981 – 490Cytochrome P450 2C7Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei144Dimethylated arginine1 Publication1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP05179.
PRIDEiP05179.

PTM databases

iPTMnetiP05179.
PhosphoSitePlusiP05179.

Expressioni

Inductioni

By growth hormone. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.1 Publication

Interactioni

Protein-protein interaction databases

IntActiP05179. 1 interactor.
MINTiMINT-4565026.
STRINGi10116.ENSRNOP00000045029.

Structurei

3D structure databases

ProteinModelPortaliP05179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOVERGENiHBG015789.
InParanoidiP05179.
KOiK07413.
PhylomeDBiP05179.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVTFLVLT LSSLILLSLW RQSSRRRKLP PGPTPLPIIG NFLQIDVKNI
60 70 80 90 100
SQSLTKFSKT YGPVFTLYLG SQPTVILHGY EAIKEALIDN GEKFSGRGSY
110 120 130 140 150
PMNENVTKGF GIVFSNGNRW KEMRRFTIMN FRNLGIGKRN IEDRVQEEAQ
160 170 180 190 200
CLVEELRKTK GSPCDPSLIL NCAPCNVICS ITFQNHFDYK DKEMLTFMEK
210 220 230 240 250
VNENLKIMSS PWMQVCNSFP SLIDYFPGTH HKIAKNINYM KSYLLKKIEE
260 270 280 290 300
HQESLDVTNP RDFVDYYLIK QKQANNIEQS EYSHENLTCS IMDLIGAGTE
310 320 330 340 350
TMSTTLRYAL LLLMKYPHVT AKVQEEIDRV IGRHRSPCMQ DRKHMPYTDA
360 370 380 390 400
MIHEVQRFIN FVPTNLPHAV TCDIKFRNYL IPKGTKVLTS LTSVLHDSKE
410 420 430 440 450
FPNPEMFDPG HFLDENGNFK KSDYFLPFSA GKRACVGEGL ARMQLFLFLT
460 470 480 490
TILQNFNLKS LVHPKDIDTM PVLNGFASLP PTYQLCFIPS
Length:490
Mass (Da):56,187
Last modified:October 1, 1989 - v2
Checksum:i0FBACF3E9C6ABAA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28K → E in AAA41058 (PubMed:3015936).Curated1
Sequence conflicti57 – 65FSKTYGPVF → VSIVGDPVI in CAA31108 (Ref. 2) Curated9
Sequence conflicti87L → V no nucleotide entry (PubMed:3801454).Curated1
Sequence conflicti103N → I in AAA41058 (PubMed:3015936).Curated1
Sequence conflicti103N → I no nucleotide entry (PubMed:3801454).Curated1
Sequence conflicti130N → T no nucleotide entry (PubMed:3801454).Curated1
Sequence conflicti279Q → H in AAA41058 (PubMed:3015936).Curated1
Sequence conflicti351 – 352MI → HD in AAA41058 (PubMed:3015936).Curated2
Sequence conflicti383 – 385KGT → RRA no nucleotide entry (PubMed:3801454).Curated3
Sequence conflicti408 – 411DPGH → VPWP no nucleotide entry (PubMed:3801454).Curated4
Sequence conflicti471P → A no nucleotide entry (PubMed:3801454).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18335 mRNA. Translation: AAA41036.1.
X12595 Genomic DNA. Translation: CAA31108.1.
M31031 mRNA. Translation: AAA41058.1.
PIRiB28516.
RefSeqiNP_058854.1. NM_017158.2.
UniGeneiRn.1247.

Genome annotation databases

GeneIDi29298.
KEGGirno:29298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18335 mRNA. Translation: AAA41036.1.
X12595 Genomic DNA. Translation: CAA31108.1.
M31031 mRNA. Translation: AAA41058.1.
PIRiB28516.
RefSeqiNP_058854.1. NM_017158.2.
UniGeneiRn.1247.

3D structure databases

ProteinModelPortaliP05179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP05179. 1 interactor.
MINTiMINT-4565026.
STRINGi10116.ENSRNOP00000045029.

PTM databases

iPTMnetiP05179.
PhosphoSitePlusiP05179.

Proteomic databases

PaxDbiP05179.
PRIDEiP05179.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29298.
KEGGirno:29298.

Organism-specific databases

CTDi29298.
RGDi620379. Cyp2c7.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOVERGENiHBG015789.
InParanoidiP05179.
KOiK07413.
PhylomeDBiP05179.

Miscellaneous databases

PROiP05179.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2C7_RAT
AccessioniPrimary (citable) accession number: P05179
Secondary accession number(s): Q63706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.