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P05178

- CP2C6_RAT

UniProt

P05178 - CP2C6_RAT

Protein

Cytochrome P450 2C6

Gene

Cyp2c6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: RGD

    GO - Biological processi

    1. drug metabolic process Source: RGD
    2. response to drug Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    SABIO-RKP05178.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C6 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC6
    Cytochrome P450 PB1
    PTF2
    Gene namesi
    Name:Cyp2c6
    Synonyms:Cyp2c-6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619934. Cyp2c6.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C6PRO_0000051697Add
    BLAST

    Proteomic databases

    PaxDbiP05178.
    PRIDEiP05178.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    GenevestigatoriP05178.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4564303.

    Structurei

    3D structure databases

    ProteinModelPortaliP05178.
    SMRiP05178. Positions 30-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    PhylomeDBiP05178.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P05178-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLVMLLVLT LTCLILLSIW RQSSGRGKLP PGPIPLPIIG NIFQLNVKNI    50
    TQSLTSFSKV YGPVFTLYFG TKPTVILHGY EAVKEALIDH GEEFAERGSF 100
    PVAEKINKDL GIVFSHGNRW KEIRRFTLTT LRNLGMGKRN IEDRVQEEAR 150
    CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQNRFDYK DQDFLNLMEK 200
    LNENMKILSS PWTQFCSFFP VLIDYCPGSH TTLAKNVYHI RNYLLKKIKE 250
    HQESLDVTNP RDFIDYYLIK WKQENHNPHS EFTLENLSIT VTDLFGAGTE 300
    TTSTTLRYAL LLLLKCPEVT AKVQEEIDRV VGKHRSPCMQ DRSRMPYTDA 350
    HDHEVQRFID LIPTNLPHAV TCDIKFRNYL IPKGTTIITS LSSVLHDSKE 400
    FPDPEIFDPG HFLDGNGKFK KSDYFMPFSA GKRMCAGEGL ARMELFLFLT 450
    TILQNFKLKS VLHPKDIDTT PVFNGFASLP PFYELCFIPL 490
    Length:490
    Mass (Da):56,003
    Last modified:October 1, 1989 - v2
    Checksum:i42B3AAF53CFBAF8D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti133 – 1331N → D no nucleotide entry (PubMed:3801454)Curated
    Sequence conflicti212 – 2121W → S no nucleotide entry (PubMed:3801454)Curated
    Sequence conflicti262 – 2621D → N no nucleotide entry (PubMed:3801454)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K03501 mRNA. Translation: AAA41066.1.
    M13711 mRNA. Translation: AAA41065.1.
    X06712 Genomic DNA. Translation: CAA29899.1.
    PIRiS00955. A25954.
    UniGeneiRn.91122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K03501 mRNA. Translation: AAA41066.1 .
    M13711 mRNA. Translation: AAA41065.1 .
    X06712 Genomic DNA. Translation: CAA29899.1 .
    PIRi S00955. A25954.
    UniGenei Rn.91122.

    3D structure databases

    ProteinModelPortali P05178.
    SMRi P05178. Positions 30-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4564303.

    Chemistry

    ChEMBLi CHEMBL1907986.

    Proteomic databases

    PaxDbi P05178.
    PRIDEi P05178.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 619934. Cyp2c6.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    PhylomeDBi P05178.

    Enzyme and pathway databases

    SABIO-RK P05178.

    Gene expression databases

    Genevestigatori P05178.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression."
      Kimura H., Yoshioka H., Sogawa K., Sakai Y., Fujii-Kuriyama Y.
      J. Biol. Chem. 263:701-707(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Liver.
    2. "Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA."
      Gonzalez F.J., Kimura S., Song B.-J., Pastewka J., Gelboin H.V., Hardwick J.P.
      J. Biol. Chem. 261:10667-10672(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-490.
    3. "Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1."
      Friedberg T., Waxman D.J., Atchison M., Kumar A., Haaparanta T., Raphael C., Adesnik M.
      Biochemistry 25:7975-7983(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 132-267.
    4. "Sequence of the 5' end of the developmentally regulated rat P450 PB1 (P450IIC6) gene."
      Umeno M., Matsunaga E., Morris S., Gelboin H.V., Gonzalez F.J.
      Nucleic Acids Res. 16:6249-6249(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.

    Entry informationi

    Entry nameiCP2C6_RAT
    AccessioniPrimary (citable) accession number: P05178
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3