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P05178

- CP2C6_RAT

UniProt

P05178 - CP2C6_RAT

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Protein

Cytochrome P450 2C6

Gene
Cyp2c6, Cyp2c-6
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: RGD

GO - Biological processi

  1. drug metabolic process Source: RGD
  2. response to drug Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP05178.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C6 (EC:1.14.14.1)
Alternative name(s):
CYPIIC6
Cytochrome P450 PB1
PTF2
Gene namesi
Name:Cyp2c6
Synonyms:Cyp2c-6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619934. Cyp2c6.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C6PRO_0000051697Add
BLAST

Proteomic databases

PaxDbiP05178.
PRIDEiP05178.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP05178.

Interactioni

Protein-protein interaction databases

MINTiMINT-4564303.

Structurei

3D structure databases

ProteinModelPortaliP05178.
SMRiP05178. Positions 30-490.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
PhylomeDBiP05178.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05178-1 [UniParc]FASTAAdd to Basket

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MDLVMLLVLT LTCLILLSIW RQSSGRGKLP PGPIPLPIIG NIFQLNVKNI    50
TQSLTSFSKV YGPVFTLYFG TKPTVILHGY EAVKEALIDH GEEFAERGSF 100
PVAEKINKDL GIVFSHGNRW KEIRRFTLTT LRNLGMGKRN IEDRVQEEAR 150
CLVEELRKTN GSPCDPTFIL GCAPCNVICS IIFQNRFDYK DQDFLNLMEK 200
LNENMKILSS PWTQFCSFFP VLIDYCPGSH TTLAKNVYHI RNYLLKKIKE 250
HQESLDVTNP RDFIDYYLIK WKQENHNPHS EFTLENLSIT VTDLFGAGTE 300
TTSTTLRYAL LLLLKCPEVT AKVQEEIDRV VGKHRSPCMQ DRSRMPYTDA 350
HDHEVQRFID LIPTNLPHAV TCDIKFRNYL IPKGTTIITS LSSVLHDSKE 400
FPDPEIFDPG HFLDGNGKFK KSDYFMPFSA GKRMCAGEGL ARMELFLFLT 450
TILQNFKLKS VLHPKDIDTT PVFNGFASLP PFYELCFIPL 490
Length:490
Mass (Da):56,003
Last modified:October 1, 1989 - v2
Checksum:i42B3AAF53CFBAF8D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331N → D no nucleotide entry 1 Publication
Sequence conflicti212 – 2121W → S no nucleotide entry 1 Publication
Sequence conflicti262 – 2621D → N no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K03501 mRNA. Translation: AAA41066.1.
M13711 mRNA. Translation: AAA41065.1.
X06712 Genomic DNA. Translation: CAA29899.1.
PIRiS00955. A25954.
UniGeneiRn.91122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K03501 mRNA. Translation: AAA41066.1 .
M13711 mRNA. Translation: AAA41065.1 .
X06712 Genomic DNA. Translation: CAA29899.1 .
PIRi S00955. A25954.
UniGenei Rn.91122.

3D structure databases

ProteinModelPortali P05178.
SMRi P05178. Positions 30-490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4564303.

Chemistry

ChEMBLi CHEMBL1907986.

Proteomic databases

PaxDbi P05178.
PRIDEi P05178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 619934. Cyp2c6.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
PhylomeDBi P05178.

Enzyme and pathway databases

SABIO-RK P05178.

Gene expression databases

Genevestigatori P05178.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression."
    Kimura H., Yoshioka H., Sogawa K., Sakai Y., Fujii-Kuriyama Y.
    J. Biol. Chem. 263:701-707(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Liver.
  2. "Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA."
    Gonzalez F.J., Kimura S., Song B.-J., Pastewka J., Gelboin H.V., Hardwick J.P.
    J. Biol. Chem. 261:10667-10672(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-490.
  3. "Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1."
    Friedberg T., Waxman D.J., Atchison M., Kumar A., Haaparanta T., Raphael C., Adesnik M.
    Biochemistry 25:7975-7983(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 132-267.
  4. "Sequence of the 5' end of the developmentally regulated rat P450 PB1 (P450IIC6) gene."
    Umeno M., Matsunaga E., Morris S., Gelboin H.V., Gonzalez F.J.
    Nucleic Acids Res. 16:6249-6249(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.

Entry informationi

Entry nameiCP2C6_RAT
AccessioniPrimary (citable) accession number: P05178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 1, 1989
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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