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P05178 (CP2C6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome P450 2C6
EC=1.14.14.1
Alternative name(s):
CYPIIC6
Cytochrome P450 PB1
PTF2
Gene names
Name:Cyp2c6
Synonyms:Cyp2c-6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C6
PRO_0000051697

Sites

Metal binding4351Iron (heme axial ligand)

Experimental info

Sequence conflict1331N → D no nucleotide entry Ref.3
Sequence conflict2121W → S no nucleotide entry Ref.3
Sequence conflict2621D → N no nucleotide entry Ref.3

Sequences

Sequence LengthMass (Da)Tools
P05178 [UniParc].

Last modified October 1, 1989. Version 2.
Checksum: 42B3AAF53CFBAF8D

FASTA49056,003
        10         20         30         40         50         60 
MDLVMLLVLT LTCLILLSIW RQSSGRGKLP PGPIPLPIIG NIFQLNVKNI TQSLTSFSKV 

        70         80         90        100        110        120 
YGPVFTLYFG TKPTVILHGY EAVKEALIDH GEEFAERGSF PVAEKINKDL GIVFSHGNRW 

       130        140        150        160        170        180 
KEIRRFTLTT LRNLGMGKRN IEDRVQEEAR CLVEELRKTN GSPCDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
IIFQNRFDYK DQDFLNLMEK LNENMKILSS PWTQFCSFFP VLIDYCPGSH TTLAKNVYHI 

       250        260        270        280        290        300 
RNYLLKKIKE HQESLDVTNP RDFIDYYLIK WKQENHNPHS EFTLENLSIT VTDLFGAGTE 

       310        320        330        340        350        360 
TTSTTLRYAL LLLLKCPEVT AKVQEEIDRV VGKHRSPCMQ DRSRMPYTDA HDHEVQRFID 

       370        380        390        400        410        420 
LIPTNLPHAV TCDIKFRNYL IPKGTTIITS LSSVLHDSKE FPDPEIFDPG HFLDGNGKFK 

       430        440        450        460        470        480 
KSDYFMPFSA GKRMCAGEGL ARMELFLFLT TILQNFKLKS VLHPKDIDTT PVFNGFASLP 

       490 
PFYELCFIPL

« Hide

References

[1]"Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression."
Kimura H., Yoshioka H., Sogawa K., Sakai Y., Fujii-Kuriyama Y.
J. Biol. Chem. 263:701-707(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Liver.
[2]"Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA."
Gonzalez F.J., Kimura S., Song B.-J., Pastewka J., Gelboin H.V., Hardwick J.P.
J. Biol. Chem. 261:10667-10672(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-490.
[3]"Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1."
Friedberg T., Waxman D.J., Atchison M., Kumar A., Haaparanta T., Raphael C., Adesnik M.
Biochemistry 25:7975-7983(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 132-267.
[4]"Sequence of the 5' end of the developmentally regulated rat P450 PB1 (P450IIC6) gene."
Umeno M., Matsunaga E., Morris S., Gelboin H.V., Gonzalez F.J.
Nucleic Acids Res. 16:6249-6249(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		K03501 mRNA. Translation: AAA41066.1.
M13711 mRNA. Translation: AAA41065.1.
X06712 Genomic DNA. Translation: CAA29899.1.
IPIIPI00390958.
PIRA25954. S00955.
UniGeneRn.91122.

3D structure databases

ProteinModelPortalP05178.
SMRP05178. Positions 30-490.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4564303.

Proteomic databases

PaxDbP05178.
PRIDEP05178.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD619934. Cyp2c6.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.
OrthoDBEOG48WC22.

Enzyme and pathway databases

SABIO-RKP05178.

Gene expression databases

ArrayExpressP05178.
GenevestigatorP05178.
GermOnlineENSRNOG00000024016. Rattus norvegicus.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. Cytochrome_P450. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChEMBLCHEMBL1907986.

Entry information

Entry nameCP2C6_RAT
AccessionPrimary (citable) accession number: P05178
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 1, 1989
Last modified: May 29, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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