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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.1 Publication

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

Kineticsi

  1. KM=4 µM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole1 Publication
  2. KM=21 µM for 2-amino-3-methylimidazo[4,5-f]quinoline1 Publication
  3. KM=26 µM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline1 Publication
  4. KM=27 µM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline1 Publication
  5. KM=71 µM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine1 Publication
  6. KM=25 µM for phenacetin1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei226SubstrateCurated1
    Metal bindingi458Iron (heme axial ligand)1

    GO - Molecular functioni

    • aromatase activity Source: UniProtKB-EC
    • caffeine oxidase activity Source: BHF-UCL
    • demethylase activity Source: UniProtKB
    • electron transfer activity Source: UniProtKB
    • enzyme binding Source: BHF-UCL
    • heme binding Source: UniProtKB
    • iron ion binding Source: InterPro
    • monooxygenase activity Source: BHF-UCL
    • oxidoreductase activity Source: BHF-UCL
    • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: UniProtKB

    GO - Biological processi

    • alkaloid metabolic process Source: BHF-UCL
    • cellular respiration Source: Ensembl
    • cellular response to cadmium ion Source: Ensembl
    • cellular response to copper ion Source: Ensembl
    • dibenzo-p-dioxin metabolic process Source: Ensembl
    • drug catabolic process Source: BHF-UCL
    • drug metabolic process Source: BHF-UCL
    • epoxygenase P450 pathway Source: Reactome
    • exogenous drug catabolic process Source: BHF-UCL
    • heterocycle metabolic process Source: BHF-UCL
    • hydrogen peroxide biosynthetic process Source: Ensembl
    • long-chain fatty acid biosynthetic process Source: Reactome
    • lung development Source: Ensembl
    • methylation Source: Reactome
    • monocarboxylic acid metabolic process Source: BHF-UCL
    • monoterpenoid metabolic process Source: BHF-UCL
    • omega-hydroxylase P450 pathway Source: Reactome
    • oxidation-reduction process Source: BHF-UCL
    • oxidative deethylation Source: BHF-UCL
    • oxidative demethylation Source: BHF-UCL
    • porphyrin-containing compound metabolic process Source: Ensembl
    • post-embryonic development Source: Ensembl
    • regulation of gene expression Source: Ensembl
    • response to estradiol Source: Ensembl
    • response to immobilization stress Source: Ensembl
    • response to lipopolysaccharide Source: Ensembl
    • steroid catabolic process Source: BHF-UCL
    • toxin biosynthetic process Source: BHF-UCL
    • xenobiotic metabolic process Source: Reactome

    Keywordsi

    Molecular functionMonooxygenase, Oxidoreductase
    Biological processLipid metabolism, Steroid metabolism, Sterol metabolism
    LigandHeme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS06728-MONOMER
    BRENDAi1.14.14.1 2681
    1.14.99.38 2681
    ReactomeiR-HSA-156581 Methylation
    R-HSA-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
    R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
    R-HSA-5423646 Aflatoxin activation and detoxification
    R-HSA-9018681 Biosynthesis of protectins
    R-HSA-9027307 Biosynthesis of maresin-like SPMs
    SABIO-RKP05177

    Chemistry databases

    SwissLipidsiSLP:000001202

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A2 (EC:1.14.14.11 Publication)
    Alternative name(s):
    CYPIA2
    Cholesterol 25-hydroxylase1 Publication
    Cytochrome P(3)450
    Cytochrome P450 4
    Cytochrome P450-P3
    Gene namesi
    Name:CYP1A2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 15

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000140505.6
    HGNCiHGNC:2596 CYP1A2
    MIMi108330 gene
    124060 gene+phenotype
    neXtProtiNX_P05177

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi1544
    MalaCardsiCYP1A2
    MIMi124060 gene+phenotype
    OpenTargetsiENSG00000140505
    Orphaneti284121 Toxixity or absent response to clozapine
    PharmGKBiPA27093

    Chemistry databases

    ChEMBLiCHEMBL3356
    DrugBankiDB07453 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE
    DB05812 Abiraterone
    DB01418 Acenocoumarol
    DB00316 Acetaminophen
    DB00787 Aciclovir
    DB06594 Agomelatine
    DB00518 Albendazole
    DB00523 Alitretinoin
    DB00918 Almotriptan
    DB00969 Alosetron
    DB00357 Aminoglutethimide
    DB01424 Aminophenazone
    DB01223 Aminophylline
    DB01118 Amiodarone
    DB00321 Amitriptyline
    DB00381 Amlodipine
    DB00261 Anagrelide
    DB01217 Anastrozole
    DB01435 Antipyrine
    DB06605 Apixaban
    DB00714 Apomorphine
    DB00673 Aprepitant
    DB06413 Armodafinil
    DB06216 Asenapine
    DB01072 Atazanavir
    DB00572 Atropine
    DB06626 Axitinib
    DB00972 Azelastine
    DB00207 Azithromycin
    DB06769 Bendamustine
    DB06770 Benzyl alcohol
    DB06732 beta-Naphthoflavone
    DB00195 Betaxolol
    DB00188 Bortezomib
    DB01558 Bromazepam
    DB01200 Bromocriptine
    DB00297 Bupivacaine
    DB00921 Buprenorphine
    DB01156 Bupropion
    DB00201 Caffeine
    DB06774 Capsaicin
    DB00564 Carbamazepine
    DB00389 Carbimazole
    DB00262 Carmustine
    DB01136 Carvedilol
    DB00477 Chlorpromazine
    DB00356 Chlorzoxazone
    DB01166 Cilostazol
    DB00501 Cimetidine
    DB01012 Cinacalcet
    DB00568 Cinnarizine
    DB00537 Ciprofloxacin
    DB00604 Cisapride
    DB00215 Citalopram
    DB01211 Clarithromycin
    DB01407 Clenbuterol
    DB04920 Clevidipine
    DB01013 Clobetasol propionate
    DB00882 Clomifene
    DB01242 Clomipramine
    DB00575 Clonidine
    DB00758 Clopidogrel
    DB00257 Clotrimazole
    DB00363 Clozapine
    DB00286 Conjugated Equine Estrogens
    DB05219 Crisaborole
    DB00924 Cyclobenzaprine
    DB00851 Dacarbazine
    DB04816 Dantron
    DB06292 Dapagliflozin
    DB01254 Dasatinib
    DB00694 Daunorubicin
    DB00705 Delavirdine
    DB01151 Desipramine
    DB00967 Desloratadine
    DB01191 Dexfenfluramine
    DB00633 Dexmedetomidine
    DB00829 Diazepam
    DB00586 Diclofenac
    DB00917 Dinoprostone
    DB01075 Diphenhydramine
    DB00822 Disulfiram
    DB01184 Domperidone
    DB00988 Dopamine
    DB01142 Doxepin
    DB00476 Duloxetine
    DB00974 Edetic Acid
    DB00625 Efavirenz
    DB06210 Eltrombopag
    DB00467 Enoxacin
    DB00494 Entacapone
    DB00668 Epinephrine
    DB00696 Ergotamine
    DB00530 Erlotinib
    DB00199 Erythromycin
    DB00783 Estradiol
    DB00655 Estrone
    DB04574 Estrone sulfate
    DB00898 Ethanol
    DB00773 Etoposide
    DB01628 Etoricoxib
    DB00196 Fluconazole
    DB04841 Flunarizine
    DB01544 Flunitrazepam
    DB00544 Fluorouracil
    DB00472 Fluoxetine
    DB00623 Fluphenazine
    DB00499 Flutamide
    DB01095 Fluvastatin
    DB00176 Fluvoxamine
    DB00998 Frovatriptan
    DB01241 Gemfibrozil
    DB01645 Genistein
    DB08909 Glycerol Phenylbutyrate
    DB00365 Grepafloxacin
    DB00400 Griseofulvin
    DB05708 GTS-21
    DB00629 Guanabenz
    DB00502 Haloperidol
    DB01094 Hesperetin
    DB01355 Hexobarbital
    DB11737 Icotinib
    DB04946 Iloperidone
    DB00619 Imatinib
    DB00458 Imipramine
    DB00724 Imiquimod
    DB01306 Insulin Aspart
    DB09456 Insulin Beef
    DB01307 Insulin Detemir
    DB00047 Insulin Glargine
    DB01309 Insulin Glulisine
    DB00030 Insulin Human
    DB00046 Insulin Lispro
    DB00071 Insulin Pork
    DB00033 Interferon gamma-1b
    DB01029 Irbesartan
    DB00951 Isoniazid
    DB09570 Ixazomib
    DB01026 Ketoconazole
    DB00448 Lansoprazole
    DB01097 Leflunomide
    DB01002 Levobupivacaine
    DB01137 Levofloxacin
    DB00281 Lidocaine
    DB00978 Lomefloxacin
    DB01601 Lopinavir
    DB04871 Lorcaserin
    DB00678 Losartan
    DB01283 Lumiracoxib
    DB00772 Malathion
    DB00934 Maprotiline
    DB00737 Meclizine
    DB01065 Melatonin
    DB00170 Menadione
    DB00532 Mephenytoin
    DB01357 Mestranol
    DB00333 Methadone
    DB00763 Methimazole
    DB01403 Methotrimeprazine
    DB00553 Methoxsalen
    DB01028 Methoxyflurane
    DB00379 Mexiletine
    DB06148 Mianserin
    DB01388 Mibefradil
    DB01110 Miconazole
    DB00834 Mifepristone
    DB00370 Mirtazapine
    DB01171 Moclobemide
    DB00745 Modafinil
    DB00461 Nabumetone
    DB00607 Nafcillin
    DB00788 Naproxen
    DB01149 Nefazodone
    DB00220 Nelfinavir
    DB00238 Nevirapine
    DB06803 Niclosamide
    DB00184 Nicotine
    DB01115 Nifedipine
    DB06712 Nilvadipine
    DB00401 Nisoldipine
    DB00435 Nitric Oxide
    DB00325 Nitroprusside
    DB00368 Norepinephrine
    DB01059 Norfloxacin
    DB00540 Nortriptyline
    DB05990 Obeticholic acid
    DB01165 Ofloxacin
    DB00334 Olanzapine
    DB00338 Omeprazole
    DB00904 Ondansetron
    DB01173 Orphenadrine
    DB09330 Osimertinib
    DB00526 Oxaliplatin
    DB01303 Oxtriphylline
    DB06412 Oxymetholone
    DB00377 Palonosetron
    DB00213 Pantoprazole
    DB00715 Paroxetine
    DB06589 Pazopanib
    DB00487 Pefloxacin
    DB00008 Peginterferon alfa-2a
    DB00022 Peginterferon alfa-2b
    DB00738 Pentamidine
    DB00806 Pentoxifylline
    DB00850 Perphenazine
    DB03783 Phenacetin
    DB01174 Phenobarbital
    DB00191 Phentermine
    DB00388 Phenylephrine
    DB00397 Phenylpropanolamine
    DB01100 Pimozide
    DB01621 Pipotiazine
    DB08910 Pomalidomide
    DB01058 Praziquantel
    DB01087 Primaquine
    DB00794 Primidone
    DB00396 Progesterone
    DB01131 Proguanil
    DB00420 Promazine
    DB01182 Propafenone
    DB00818 Propofol
    DB00571 Propranolol
    DB00339 Pyrazinamide
    DB00908 Quinidine
    DB00468 Quinine
    DB01129 Rabeprazole
    DB00980 Ramelteon
    DB00863 Ranitidine
    DB01367 Rasagiline
    DB02709 Resveratrol
    DB00615 Rifabutin
    DB01045 Rifampicin
    DB08864 Rilpivirine
    DB00740 Riluzole
    DB00503 Ritonavir
    DB00953 Rizatriptan
    DB00533 Rofecoxib
    DB00268 Ropinirole
    DB00296 Ropivacaine
    DB00412 Rosiglitazone
    DB05271 Rotigotine
    DB00778 Roxithromycin
    DB12332 Rucaparib
    DB00418 Secobarbital
    DB01037 Selegiline
    DB01104 Sertraline
    DB06290 Simeprevir
    DB06819 Sodium phenylbutyrate
    DB00398 Sorafenib
    DB00428 Streptozocin
    DB06820 Sulconazole
    DB00605 Sulindac
    DB00382 Tacrine
    DB00675 Tamoxifen
    DB01079 Tegaserod
    DB00976 Telithromycin
    DB01405 Temafloxacin
    DB00300 Tenofovir
    DB00857 Terbinafine
    DB01041 Thalidomide
    DB01412 Theobromine
    DB00277 Theophylline
    DB00730 Thiabendazole
    DB00679 Thioridazine
    DB01623 Thiothixene
    DB00208 Ticlopidine
    DB01007 Tioconazole
    DB00697 Tizanidine
    DB01056 Tocainide
    DB00539 Toremifene
    DB00752 Tranylcypromine
    DB00384 Triamterene
    DB00831 Trifluoperazine
    DB08867 Ulipristal
    DB00577 Valaciclovir
    DB00313 Valproic Acid
    DB08881 Vemurafenib
    DB00661 Verapamil
    DB00682 Warfarin
    DB00549 Zafirlukast
    DB00744 Zileuton
    DB00246 Ziprasidone
    DB00315 Zolmitriptan
    DB00425 Zolpidem
    GuidetoPHARMACOLOGYi1319

    Polymorphism and mutation databases

    BioMutaiCYP1A2
    DMDMi117144

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Initiator methionineiRemoved1 Publication
    ChainiPRO_00000516512 – 515Cytochrome P450 1A2Add BLAST514

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi69O-linked (GlcNAc) serineBy similarity1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP05177
    PaxDbiP05177
    PeptideAtlasiP05177
    PRIDEiP05177

    PTM databases

    iPTMnetiP05177
    PhosphoSitePlusiP05177

    Expressioni

    Tissue specificityi

    Liver.

    Inductioni

    By nicotine, omeprazole, phenobarbital, primidone and rifampicin.

    Gene expression databases

    BgeeiENSG00000140505
    CleanExiHS_CYP1A2
    GenevisibleiP05177 HS

    Organism-specific databases

    HPAiCAB016531

    Interactioni

    GO - Molecular functioni

    • enzyme binding Source: BHF-UCL

    Protein-protein interaction databases

    BioGridi107924, 7 interactors
    STRINGi9606.ENSP00000342007

    Chemistry databases

    BindingDBiP05177

    Structurei

    Secondary structure

    1515
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Turni49 – 51Combined sources3
    Helixi54 – 57Combined sources4
    Helixi61 – 72Combined sources12
    Beta strandi74 – 80Combined sources7
    Beta strandi83 – 88Combined sources6
    Helixi91 – 98Combined sources8
    Turni99 – 101Combined sources3
    Helixi102 – 104Combined sources3
    Helixi112 – 115Combined sources4
    Turni123 – 125Combined sources3
    Helixi131 – 146Combined sources16
    Turni147 – 149Combined sources3
    Helixi160 – 181Combined sources22
    Helixi188 – 205Combined sources18
    Helixi206 – 208Combined sources3
    Helixi214 – 220Combined sources7
    Helixi221 – 223Combined sources3
    Helixi224 – 227Combined sources4
    Helixi235 – 237Combined sources3
    Helixi240 – 244Combined sources5
    Helixi248 – 273Combined sources26
    Helixi283 – 293Combined sources11
    Helixi305 – 308Combined sources4
    Helixi310 – 335Combined sources26
    Helixi337 – 350Combined sources14
    Turni351 – 353Combined sources3
    Helixi359 – 361Combined sources3
    Helixi366 – 379Combined sources14
    Beta strandi394 – 396Combined sources3
    Beta strandi399 – 401Combined sources3
    Beta strandi406 – 410Combined sources5
    Helixi411 – 416Combined sources6
    Turni418 – 420Combined sources3
    Helixi429 – 432Combined sources4
    Beta strandi437 – 440Combined sources4
    Helixi442 – 445Combined sources4
    Helixi454 – 456Combined sources3
    Helixi461 – 478Combined sources18
    Beta strandi480 – 482Combined sources3
    Beta strandi496 – 498Combined sources3
    Beta strandi507 – 510Combined sources4

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2HI4X-ray1.95A27-515[»]
    ProteinModelPortaliP05177
    SMRiP05177
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP05177

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiKOG0156 Eukaryota
    COG2124 LUCA
    GeneTreeiENSGT00900000140831
    HOVERGENiHBG106944
    InParanoidiP05177
    KOiK07409
    OMAiLHEMTKV
    OrthoDBiEOG091G0BT8
    PhylomeDBiP05177
    TreeFamiTF105095

    Family and domain databases

    Gene3Di1.10.630.10, 1 hit
    InterProiView protein in InterPro
    IPR001128 Cyt_P450
    IPR017972 Cyt_P450_CS
    IPR002401 Cyt_P450_E_grp-I
    IPR008066 Cyt_P450_E_grp-I_CYP1
    IPR036396 Cyt_P450_sf
    PfamiView protein in Pfam
    PF00067 p450, 1 hit
    PRINTSiPR00463 EP450I
    PR01683 EP450ICYP1A
    PR00385 P450
    SUPFAMiSSF48264 SSF48264, 1 hit
    PROSITEiView protein in PROSITE
    PS00086 CYTOCHROME_P450, 1 hit

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: P05177-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL
    60 70 80 90 100
    LGHVLTLGKN PHLALSRMSQ RYGDVLQIRI GSTPVLVLSR LDTIRQALVR
    110 120 130 140 150
    QGDDFKGRPD LYTSTLITDG QSLTFSTDSG PVWAARRRLA QNALNTFSIA
    160 170 180 190 200
    SDPASSSSCY LEEHVSKEAK ALISRLQELM AGPGHFDPYN QVVVSVANVI
    210 220 230 240 250
    GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPLDFFP ILRYLPNPAL
    260 270 280 290 300
    QRFKAFNQRF LWFLQKTVQE HYQDFDKNSV RDITGALFKH SKKGPRASGN
    310 320 330 340 350
    LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTV
    360 370 380 390 400
    IGRERRPRLS DRPQLPYLEA FILETFRHSS FLPFTIPHST TRDTTLNGFY
    410 420 430 440 450
    IPKKCCVFVN QWQVNHDPEL WEDPSEFRPE RFLTADGTAI NKPLSEKMML
    460 470 480 490 500
    FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK
    510
    HARCEHVQAR RFSIN
    Length:515
    Mass (Da):58,294
    Last modified:January 23, 2007 - v3
    Checksum:i23AEFEEBDF6806AB
    GO
    Isoform 2 (identifier: P05177-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         510-510: R → RL

    Show »
    Length:516
    Mass (Da):58,407
    Checksum:i8557AB02860C4806
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti79R → S in AAA35738 (PubMed:3462722).Curated1
    Sequence conflicti81G → D in AAH67427 (PubMed:15489334).Curated1
    Sequence conflicti170K → M in AAF13599 (Ref. 5) Curated1
    Sequence conflicti311V → L in AAA52154 (PubMed:3000715).Curated1
    Sequence conflicti450 – 451LF → MLV in AAA52154 (PubMed:3000715).Curated2
    Sequence conflicti492T → I in AAF13599 (Ref. 5) Curated1
    Sequence conflicti511R → LP in AAA35738 (PubMed:3462722).Curated1

    Polymorphismi

    The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02319618S → C2 PublicationsCorresponds to variant dbSNP:rs17861152Ensembl.1
    Natural variantiVAR_00834921F → L in allele CYP1A2*2. 1 PublicationCorresponds to variant dbSNP:rs56160784Ensembl.1
    Natural variantiVAR_02518242P → R in allele CYP1A2*15. 1 Publication1
    Natural variantiVAR_02518373G → R1 PublicationCorresponds to variant dbSNP:rs45565238Ensembl.1
    Natural variantiVAR_02084883T → M in allele CYP1A2*9. 1 Publication1
    Natural variantiVAR_025184104D → N1 PublicationCorresponds to variant dbSNP:rs34067076Ensembl.1
    Natural variantiVAR_025185111L → F1 PublicationCorresponds to variant dbSNP:rs45442197Ensembl.1
    Natural variantiVAR_020849168E → Q in allele CYP1A2*10. 1 Publication1
    Natural variantiVAR_020850186F → L in allele CYP1A2*11; drastic reduction in O-deethylation of phenacetin and 7-ethoxyresorufin; has a Vmax of approximately 5% of that of the wild-type and 5-fold lower Km value. 1 Publication1
    Natural variantiVAR_025186205F → V1 PublicationCorresponds to variant dbSNP:rs45540640Ensembl.1
    Natural variantiVAR_020851212S → C in allele CYP1A2*12. 1 Publication1
    Natural variantiVAR_025187281R → W1 PublicationCorresponds to variant dbSNP:rs45468096Ensembl.1
    Natural variantiVAR_024709298S → R1 PublicationCorresponds to variant dbSNP:rs17861157Ensembl.1
    Natural variantiVAR_020852299G → S in allele CYP1A2*13. 1 PublicationCorresponds to variant dbSNP:rs35796837Ensembl.1
    Natural variantiVAR_024710314I → V2 PublicationsCorresponds to variant dbSNP:rs28399418Ensembl.1
    Natural variantiVAR_020793348D → N in allele CYP1A2*3; increases N-hydroxylation activity of heterocyclic amines; reduces phenacetin O-deethylation activity. 2 PublicationsCorresponds to variant dbSNP:rs56276455Ensembl.1
    Natural variantiVAR_025188377R → Q in allele CYP1A2*16. 1 Publication1
    Natural variantiVAR_020794386I → F in allele CYP1A2*4; increases catalytic efficiency of N-hydroxylation towards some heterocyclic amines and reduces towards others; reduces catalytic efficiency of phenacetin O-deethylation due to a high decrease in the affinity for phenacetin. 2 Publications1
    Natural variantiVAR_020795406C → Y in allele CYP1A2*5; increases N-hydroxylation activity of heterocyclic amines; reduces catalytic efficiency of phenacetin O-deethylation. 2 PublicationsCorresponds to variant dbSNP:rs55889066Ensembl.1
    Natural variantiVAR_020796431R → W in allele CYP1A2*6; not detected when expressed in heterologous system as it may be critical for maintenance of protein tertiary structure. 3 PublicationsCorresponds to variant dbSNP:rs28399424Ensembl.1
    Natural variantiVAR_020853438T → I in allele CYP1A2*14. 2 PublicationsCorresponds to variant dbSNP:rs45486893Ensembl.1
    Natural variantiVAR_025189456R → H in allele CYP1A2*8. 1 Publication1
    Natural variantiVAR_055563457R → W. Corresponds to variant dbSNP:rs34151816Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_017123510R → RL in isoform 2. 2 Publications1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Z00036 mRNA Translation: CAA77335.1
    L00389
    , L00384, L00385, L00386, L00388, L00387 Genomic DNA Translation: AAA35738.1
    M31667
    , M31664, M31665, M31666 Genomic DNA Translation: AAA52163.1
    M12078 mRNA Translation: AAA52154.1
    AF182274 mRNA Translation: AAF13599.1
    AF253322 Genomic DNA Translation: AAK25728.1
    DQ022432 Genomic DNA Translation: AAY26399.1
    BC067424 mRNA Translation: AAH67424.1
    BC067425 mRNA Translation: AAH67425.1
    BC067426 mRNA Translation: AAH67426.1
    BC067427 mRNA Translation: AAH67427.1
    BC067428 mRNA Translation: AAH67428.1
    M55053 mRNA Translation: AAA52146.1
    CCDSiCCDS32293.1 [P05177-2]
    PIRiS16718 O4HU4
    RefSeqiNP_000752.2, NM_000761.4 [P05177-2]
    UniGeneiHs.1361

    Genome annotation databases

    EnsembliENST00000343932; ENSP00000342007; ENSG00000140505 [P05177-2]
    GeneIDi1544
    KEGGihsa:1544
    UCSCiuc002ayr.2 human [P05177-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiCP1A2_HUMAN
    AccessioniPrimary (citable) accession number: P05177
    Secondary accession number(s): Q16754
    , Q6NWU5, Q9BXX7, Q9UK49
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: January 23, 2007
    Last modified: May 23, 2018
    This is version 190 of the entry and version 3 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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    Main funding by: National Institutes of Health