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P05177

- CP1A2_HUMAN

UniProt

P05177 - CP1A2_HUMAN

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Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.1 Publication

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.

Kineticsi

  1. KM=4 µM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole1 Publication
  2. KM=21 µM for 2-amino-3-methylimidazo[4,5-f]quinoline1 Publication
  3. KM=26 µM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline1 Publication
  4. KM=27 µM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline1 Publication
  5. KM=71 µM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine1 Publication
  6. KM=25 µM for phenacetin1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei226 – 2261SubstrateCurated
Metal bindingi458 – 4581Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. caffeine oxidase activity Source: BHF-UCL
  3. demethylase activity Source: UniProtKB
  4. electron carrier activity Source: UniProtKB
  5. enzyme binding Source: BHF-UCL
  6. heme binding Source: UniProtKB
  7. iron ion binding Source: InterPro
  8. monooxygenase activity Source: BHF-UCL
  9. oxidoreductase activity Source: BHF-UCL
  10. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: UniProtKB

GO - Biological processi

  1. alkaloid metabolic process Source: BHF-UCL
  2. arachidonic acid metabolic process Source: Reactome
  3. cellular respiration Source: Ensembl
  4. cellular response to cadmium ion Source: Ensembl
  5. dibenzo-p-dioxin metabolic process Source: Ensembl
  6. drug catabolic process Source: BHF-UCL
  7. drug metabolic process Source: BHF-UCL
  8. epoxygenase P450 pathway Source: Reactome
  9. exogenous drug catabolic process Source: BHF-UCL
  10. heterocycle metabolic process Source: BHF-UCL
  11. hydrogen peroxide biosynthetic process Source: Ensembl
  12. lung development Source: Ensembl
  13. methylation Source: Reactome
  14. monocarboxylic acid metabolic process Source: BHF-UCL
  15. monoterpenoid metabolic process Source: BHF-UCL
  16. omega-hydroxylase P450 pathway Source: Reactome
  17. oxidation-reduction process Source: BHF-UCL
  18. oxidative deethylation Source: BHF-UCL
  19. oxidative demethylation Source: BHF-UCL
  20. porphyrin-containing compound metabolic process Source: Ensembl
  21. post-embryonic development Source: Ensembl
  22. regulation of gene expression Source: Ensembl
  23. response to estradiol Source: Ensembl
  24. response to lipopolysaccharide Source: Ensembl
  25. small molecule metabolic process Source: Reactome
  26. steroid catabolic process Source: BHF-UCL
  27. toxin biosynthetic process Source: BHF-UCL
  28. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06728-MONOMER.
ReactomeiREACT_13721. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_6946. Methylation.
SABIO-RKP05177.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A2 (EC:1.14.14.1)
Alternative name(s):
CYPIA2
Cytochrome P(3)450
Cytochrome P450 4
Cytochrome P450-P3
Gene namesi
Name:CYP1A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:2596. CYP1A2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. intracellular membrane-bounded organelle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

MIMi124060. gene+phenotype.
Orphaneti284121. Susceptibility to adverse reaction due to clozapine.
PharmGKBiPA27093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 515514Cytochrome P450 1A2PRO_0000051651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP05177.
PaxDbiP05177.
PRIDEiP05177.

PTM databases

PhosphoSiteiP05177.

Expressioni

Tissue specificityi

Liver.

Inductioni

By nicotine, omeprazole, phenobarbital, primidone and rifampicin.

Gene expression databases

BgeeiP05177.
CleanExiHS_CYP1A2.
GenevestigatoriP05177.

Organism-specific databases

HPAiCAB016531.

Interactioni

Protein-protein interaction databases

BioGridi107924. 2 interactions.
STRINGi9606.ENSP00000342007.

Structurei

Secondary structure

1
515
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni49 – 513
Helixi54 – 574
Helixi61 – 7212
Beta strandi74 – 807
Beta strandi83 – 886
Helixi91 – 988
Turni99 – 1013
Helixi102 – 1043
Helixi112 – 1154
Turni123 – 1253
Helixi131 – 14616
Turni147 – 1493
Helixi160 – 18122
Helixi188 – 20518
Helixi206 – 2083
Helixi214 – 2207
Helixi221 – 2233
Helixi224 – 2274
Helixi235 – 2373
Helixi240 – 2445
Helixi248 – 27326
Helixi283 – 29311
Helixi305 – 3084
Helixi310 – 33526
Helixi337 – 35014
Turni351 – 3533
Helixi359 – 3613
Helixi366 – 37914
Beta strandi394 – 3963
Beta strandi399 – 4013
Beta strandi406 – 4105
Helixi411 – 4166
Turni418 – 4203
Helixi429 – 4324
Beta strandi437 – 4404
Helixi442 – 4454
Helixi454 – 4563
Helixi461 – 47818
Beta strandi480 – 4823
Beta strandi496 – 4983
Beta strandi507 – 5104

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HI4X-ray1.95A27-515[»]
ProteinModelPortaliP05177.
SMRiP05177. Positions 34-513.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05177.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118992.
HOVERGENiHBG106944.
InParanoidiP05177.
KOiK07409.
OMAiHARCEHV.
OrthoDBiEOG7RBZ85.
PhylomeDBiP05177.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P05177-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL
60 70 80 90 100
LGHVLTLGKN PHLALSRMSQ RYGDVLQIRI GSTPVLVLSR LDTIRQALVR
110 120 130 140 150
QGDDFKGRPD LYTSTLITDG QSLTFSTDSG PVWAARRRLA QNALNTFSIA
160 170 180 190 200
SDPASSSSCY LEEHVSKEAK ALISRLQELM AGPGHFDPYN QVVVSVANVI
210 220 230 240 250
GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPLDFFP ILRYLPNPAL
260 270 280 290 300
QRFKAFNQRF LWFLQKTVQE HYQDFDKNSV RDITGALFKH SKKGPRASGN
310 320 330 340 350
LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTV
360 370 380 390 400
IGRERRPRLS DRPQLPYLEA FILETFRHSS FLPFTIPHST TRDTTLNGFY
410 420 430 440 450
IPKKCCVFVN QWQVNHDPEL WEDPSEFRPE RFLTADGTAI NKPLSEKMML
460 470 480 490 500
FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK
510
HARCEHVQAR RFSIN
Length:515
Mass (Da):58,294
Last modified:January 23, 2007 - v3
Checksum:i23AEFEEBDF6806AB
GO
Isoform 2 (identifier: P05177-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     510-510: R → RL

Show »
Length:516
Mass (Da):58,407
Checksum:i8557AB02860C4806
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791R → S in AAA35738. (PubMed:3462722)Curated
Sequence conflicti81 – 811G → D in AAH67427. (PubMed:15489334)Curated
Sequence conflicti170 – 1701K → M in AAF13599. 1 PublicationCurated
Sequence conflicti311 – 3111V → L in AAA52154. (PubMed:3000715)Curated
Sequence conflicti450 – 4512LF → MLV in AAA52154. (PubMed:3000715)Curated
Sequence conflicti492 – 4921T → I in AAF13599. 1 PublicationCurated
Sequence conflicti511 – 5111R → LP in AAA35738. (PubMed:3462722)Curated

Polymorphismi

The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181S → C.2 Publications
Corresponds to variant rs17861152 [ dbSNP | Ensembl ].
VAR_023196
Natural varianti21 – 211F → L in allele CYP1A2*2. 1 Publication
Corresponds to variant rs56160784 [ dbSNP | Ensembl ].
VAR_008349
Natural varianti42 – 421P → R in allele CYP1A2*15. 1 Publication
VAR_025182
Natural varianti73 – 731G → R.1 Publication
Corresponds to variant rs45565238 [ dbSNP | Ensembl ].
VAR_025183
Natural varianti83 – 831T → M in allele CYP1A2*9. 1 Publication
VAR_020848
Natural varianti104 – 1041D → N.1 Publication
Corresponds to variant rs34067076 [ dbSNP | Ensembl ].
VAR_025184
Natural varianti111 – 1111L → F.1 Publication
Corresponds to variant rs45442197 [ dbSNP | Ensembl ].
VAR_025185
Natural varianti168 – 1681E → Q in allele CYP1A2*10. 1 Publication
VAR_020849
Natural varianti186 – 1861F → L in allele CYP1A2*11; drastic reduction in O-deethylation of phenacetin and 7-ethoxyresorufin; has a Vmax of approximately 5% of that of the wild-type and 5-fold lower Km value. 1 Publication
VAR_020850
Natural varianti205 – 2051F → V.1 Publication
Corresponds to variant rs45540640 [ dbSNP | Ensembl ].
VAR_025186
Natural varianti212 – 2121S → C in allele CYP1A2*12. 1 Publication
VAR_020851
Natural varianti281 – 2811R → W.1 Publication
Corresponds to variant rs45468096 [ dbSNP | Ensembl ].
VAR_025187
Natural varianti298 – 2981S → R.1 Publication
Corresponds to variant rs17861157 [ dbSNP | Ensembl ].
VAR_024709
Natural varianti299 – 2991G → S in allele CYP1A2*13. 1 Publication
Corresponds to variant rs35796837 [ dbSNP | Ensembl ].
VAR_020852
Natural varianti314 – 3141I → V.2 Publications
Corresponds to variant rs28399418 [ dbSNP | Ensembl ].
VAR_024710
Natural varianti348 – 3481D → N in allele CYP1A2*3; increases N-hydroxylation activity of heterocyclic amines; reduces phenacetin O-deethylation activity. 1 Publication
Corresponds to variant rs56276455 [ dbSNP | Ensembl ].
VAR_020793
Natural varianti377 – 3771R → Q in allele CYP1A2*16. 1 Publication
VAR_025188
Natural varianti386 – 3861I → F in allele CYP1A2*4; increases catalytic efficiency of N-hydroxylation towards some heterocyclic amines and reduces towards others; reduces catalytic efficiency of phenacetin O-deethylation due to a high decrease in the affinity for phenacetin. 1 Publication
VAR_020794
Natural varianti406 – 4061C → Y in allele CYP1A2*5; increases N-hydroxylation activity of heterocyclic amines; reduces catalytic efficiency of phenacetin O-deethylation. 1 Publication
Corresponds to variant rs55889066 [ dbSNP | Ensembl ].
VAR_020795
Natural varianti431 – 4311R → W in allele CYP1A2*6; not detected when expressed in heterologous system as it may be critical for maintenance of protein tertiary structure. 2 Publications
Corresponds to variant rs28399424 [ dbSNP | Ensembl ].
VAR_020796
Natural varianti438 – 4381T → I in allele CYP1A2*14. 2 Publications
Corresponds to variant rs45486893 [ dbSNP | Ensembl ].
VAR_020853
Natural varianti456 – 4561R → H in allele CYP1A2*8. 1 Publication
VAR_025189
Natural varianti457 – 4571R → W.
Corresponds to variant rs34151816 [ dbSNP | Ensembl ].
VAR_055563

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei510 – 5101R → RL in isoform 2. 2 PublicationsVSP_017123

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z00036 mRNA. Translation: CAA77335.1.
L00389
, L00384, L00385, L00386, L00388, L00387 Genomic DNA. Translation: AAA35738.1.
M31667
, M31664, M31665, M31666 Genomic DNA. Translation: AAA52163.1.
M12078 mRNA. Translation: AAA52154.1.
AF182274 mRNA. Translation: AAF13599.1.
AF253322 Genomic DNA. Translation: AAK25728.1.
DQ022432 Genomic DNA. Translation: AAY26399.1.
BC067424 mRNA. Translation: AAH67424.1.
BC067425 mRNA. Translation: AAH67425.1.
BC067426 mRNA. Translation: AAH67426.1.
BC067427 mRNA. Translation: AAH67427.1.
BC067428 mRNA. Translation: AAH67428.1.
M55053 mRNA. Translation: AAA52146.1.
CCDSiCCDS32293.1. [P05177-2]
PIRiS16718. O4HU4.
RefSeqiNP_000752.2. NM_000761.4. [P05177-2]
UniGeneiHs.1361.

Genome annotation databases

EnsembliENST00000343932; ENSP00000342007; ENSG00000140505. [P05177-2]
GeneIDi1544.
KEGGihsa:1544.
UCSCiuc002ayr.1. human. [P05177-2]

Polymorphism databases

DMDMi117144.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP1A2 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z00036 mRNA. Translation: CAA77335.1 .
L00389
, L00384 , L00385 , L00386 , L00388 , L00387 Genomic DNA. Translation: AAA35738.1 .
M31667
, M31664 , M31665 , M31666 Genomic DNA. Translation: AAA52163.1 .
M12078 mRNA. Translation: AAA52154.1 .
AF182274 mRNA. Translation: AAF13599.1 .
AF253322 Genomic DNA. Translation: AAK25728.1 .
DQ022432 Genomic DNA. Translation: AAY26399.1 .
BC067424 mRNA. Translation: AAH67424.1 .
BC067425 mRNA. Translation: AAH67425.1 .
BC067426 mRNA. Translation: AAH67426.1 .
BC067427 mRNA. Translation: AAH67427.1 .
BC067428 mRNA. Translation: AAH67428.1 .
M55053 mRNA. Translation: AAA52146.1 .
CCDSi CCDS32293.1. [P05177-2 ]
PIRi S16718. O4HU4.
RefSeqi NP_000752.2. NM_000761.4. [P05177-2 ]
UniGenei Hs.1361.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HI4 X-ray 1.95 A 27-515 [» ]
ProteinModelPortali P05177.
SMRi P05177. Positions 34-513.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107924. 2 interactions.
STRINGi 9606.ENSP00000342007.

Chemistry

BindingDBi P05177.
ChEMBLi CHEMBL3356.
DrugBanki DB00071. "Insulin.
DB01418. Acenocoumarol.
DB00316. Acetaminophen.
DB06594. Agomelatine.
DB00518. Albendazole.
DB00523. Alitretinoin.
DB00918. Almotriptan.
DB00969. Alosetron.
DB00357. Aminoglutethimide.
DB01424. Aminophenazone.
DB01223. Aminophylline.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00261. Anagrelide.
DB01217. Anastrozole.
DB01435. Antipyrine.
DB06605. Apixaban.
DB00673. Aprepitant.
DB06216. Asenapine.
DB00572. Atropine.
DB06626. Axitinib.
DB00972. Azelastine.
DB00207. Azithromycin.
DB06770. Benzyl alcohol.
DB00195. Betaxolol.
DB00188. Bortezomib.
DB01558. Bromazepam.
DB01200. Bromocriptine.
DB00297. Bupivacaine.
DB00921. Buprenorphine.
DB01156. Bupropion.
DB00201. Caffeine.
DB00564. Carbamazepine.
DB00262. Carmustine.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00356. Chlorzoxazone.
DB01166. Cilostazol.
DB00501. Cimetidine.
DB01012. Cinacalcet.
DB00568. Cinnarizine.
DB00537. Ciprofloxacin.
DB00604. Cisapride.
DB00215. Citalopram.
DB01211. Clarithromycin.
DB01407. Clenbuterol.
DB04920. Clevidipine.
DB01013. Clobetasol propionate.
DB00882. Clomifene.
DB01242. Clomipramine.
DB00575. Clonidine.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00286. Conjugated Estrogens.
DB00924. Cyclobenzaprine.
DB00851. Dacarbazine.
DB06292. Dapagliflozin.
DB01254. Dasatinib.
DB00694. Daunorubicin.
DB00705. Delavirdine.
DB01151. Desipramine.
DB00967. Desloratadine.
DB01191. Dexfenfluramine.
DB00633. Dexmedetomidine.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00917. Dinoprostone.
DB01075. Diphenhydramine.
DB01184. Domperidone.
DB00988. Dopamine.
DB01142. Doxepin.
DB00476. Duloxetine.
DB00974. Edetic Acid.
DB00625. Efavirenz.
DB06210. Eltrombopag.
DB00467. Enoxacin.
DB00668. Epinephrine.
DB00696. Ergotamine.
DB00530. Erlotinib.
DB00199. Erythromycin.
DB00783. Estradiol.
DB00655. Estrone.
DB04574. Estropipate.
DB00898. Ethanol.
DB00773. Etoposide.
DB01628. Etoricoxib.
DB04841. Flunarizine.
DB01544. Flunitrazepam.
DB00544. Fluorouracil.
DB00472. Fluoxetine.
DB00623. Fluphenazine.
DB00499. Flutamide.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB00998. Frovatriptan.
DB01241. Gemfibrozil.
DB00400. Griseofulvin.
DB00629. Guanabenz.
DB00502. Haloperidol.
DB01094. Hesperetin.
DB01355. Hexobarbital.
DB04946. Iloperidone.
DB00619. Imatinib.
DB00458. Imipramine.
DB00724. Imiquimod.
DB05278. inhaled insulin.
DB01306. Insulin Aspart.
DB01307. Insulin Detemir.
DB00047. Insulin Glargine.
DB01309. Insulin Glulisine.
DB00046. Insulin Lispro.
DB00030. Insulin Regular.
DB01029. Irbesartan.
DB00951. Isoniazid.
DB01026. Ketoconazole.
DB00448. Lansoprazole.
DB01097. Leflunomide.
DB01002. Levobupivacaine.
DB01137. Levofloxacin.
DB00281. Lidocaine.
DB00978. Lomefloxacin.
DB01601. Lopinavir.
DB04871. Lorcaserin.
DB00678. Losartan.
DB01283. Lumiracoxib.
DB00772. Malathion.
DB00934. Maprotiline.
DB00737. Meclizine.
DB01065. Melatonin.
DB00170. Menadione.
DB00333. Methadone.
DB00763. Methimazole.
DB01403. Methotrimeprazine.
DB00553. Methoxsalen.
DB01028. Methoxyflurane.
DB00379. Mexiletine.
DB06148. Mianserin.
DB01110. Miconazole.
DB00370. Mirtazapine.
DB01171. Moclobemide.
DB00745. Modafinil.
DB00461. Nabumetone.
DB00607. Nafcillin.
DB00788. Naproxen.
DB00220. Nelfinavir.
DB00238. Nevirapine.
DB06803. Niclosamide.
DB00184. Nicotine.
DB01115. Nifedipine.
DB06712. Nilvadipine.
DB00401. Nisoldipine.
DB00435. Nitric Oxide.
DB00325. Nitroprusside.
DB00368. Norepinephrine.
DB01059. Norfloxacin.
DB00540. Nortriptyline.
DB01165. Ofloxacin.
DB00334. Olanzapine.
DB00338. Omeprazole.
DB00904. Ondansetron.
DB00526. Oxaliplatin.
DB01303. Oxtriphylline.
DB00377. Palonosetron.
DB00213. Pantoprazole.
DB06589. Pazopanib.
DB00487. Pefloxacin.
DB00738. Pentamidine.
DB00806. Pentoxifylline.
DB00850. Perphenazine.
DB01174. Phenobarbital.
DB00191. Phentermine.
DB00388. Phenylephrine.
DB00397. Phenylpropanolamine.
DB01100. Pimozide.
DB01621. Pipotiazine.
DB08910. Pomalidomide.
DB01058. Praziquantel.
DB01087. Primaquine.
DB00794. Primidone.
DB00396. Progesterone.
DB01131. Proguanil.
DB00420. Promazine.
DB01182. Propafenone.
DB00818. Propofol.
DB00571. Propranolol.
DB00339. Pyrazinamide.
DB00908. Quinidine.
DB00468. Quinine.
DB01129. Rabeprazole.
DB00980. Ramelteon.
DB00863. Ranitidine.
DB01367. Rasagiline.
DB00615. Rifabutin.
DB01045. Rifampicin.
DB08864. Rilpivirine.
DB00740. Riluzole.
DB00503. Ritonavir.
DB00953. Rizatriptan.
DB00268. Ropinirole.
DB00296. Ropivacaine.
DB00412. Rosiglitazone.
DB05271. Rotigotine.
DB00778. Roxithromycin.
DB00418. Secobarbital.
DB01037. Selegiline.
DB01104. Sertraline.
DB06290. SIMEPREVIR.
DB00398. Sorafenib.
DB00428. Streptozocin.
DB00605. Sulindac.
DB00675. Tamoxifen.
DB00976. Telithromycin.
DB00300. Tenofovir.
DB00857. Terbinafine.
DB01041. Thalidomide.
DB01412. Theobromine.
DB00277. Theophylline.
DB00730. Thiabendazole.
DB00679. Thioridazine.
DB01623. Thiothixene.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB00697. Tizanidine.
DB01056. Tocainide.
DB00539. Toremifene.
DB00752. Tranylcypromine.
DB00384. Triamterene.
DB00831. Trifluoperazine.
DB00313. Valproic Acid.
DB08881. Vemurafenib.
DB00661. Verapamil.
DB00682. Warfarin.
DB00549. Zafirlukast.
DB00744. Zileuton.
DB00246. Ziprasidone.
DB00315. Zolmitriptan.
DB00425. Zolpidem.

PTM databases

PhosphoSitei P05177.

Polymorphism databases

DMDMi 117144.

Proteomic databases

MaxQBi P05177.
PaxDbi P05177.
PRIDEi P05177.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343932 ; ENSP00000342007 ; ENSG00000140505 . [P05177-2 ]
GeneIDi 1544.
KEGGi hsa:1544.
UCSCi uc002ayr.1. human. [P05177-2 ]

Organism-specific databases

CTDi 1544.
GeneCardsi GC15P075041.
HGNCi HGNC:2596. CYP1A2.
HPAi CAB016531.
MIMi 108330. gene.
124060. gene+phenotype.
neXtProti NX_P05177.
Orphaneti 284121. Susceptibility to adverse reaction due to clozapine.
PharmGKBi PA27093.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118992.
HOVERGENi HBG106944.
InParanoidi P05177.
KOi K07409.
OMAi HARCEHV.
OrthoDBi EOG7RBZ85.
PhylomeDBi P05177.
TreeFami TF105095.

Enzyme and pathway databases

BioCyci MetaCyc:HS06728-MONOMER.
Reactomei REACT_13721. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_6946. Methylation.
SABIO-RK P05177.

Miscellaneous databases

EvolutionaryTracei P05177.
GeneWikii CYP1A2.
GenomeRNAii 1544.
NextBioi 6391.
PROi P05177.
SOURCEi Search...

Gene expression databases

Bgeei P05177.
CleanExi HS_CYP1A2.
Genevestigatori P05177.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human P3(450): cDNA and complete amino acid sequence."
    Jaiswal A.K., Nebert D.W., Gonzalez F.J.
    Nucleic Acids Res. 14:6773-6774(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA."
    Quattrochi L.C., Pendurthi U.R., Okino S.T., Potenza C., Tukey R.H.
    Proc. Natl. Acad. Sci. U.S.A. 83:6731-6735(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression."
    Ikeya K., Jaiswal A.K., Owens R.A., Jones J.E., Nebert D.W., Kimura S.
    Mol. Endocrinol. 3:1399-1408(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15."
    Jaiswal A.K., Nebert D.W., McBride O.W., Gonzalez F.J.
    J. Exp. Pathol. 3:1-17(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  5. "Sequence of a new human cytochrome P450-1A2 cDNA."
    Zhuge J., Qian Y., Xie H., Yu Y.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-314.
    Tissue: Liver.
  6. "Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation."
    Corchero J., Pimprale S., Kimura S., Gonzalez F.J.
    Pharmacogenetics 11:1-6(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. NIEHS SNPs program
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-73; ASN-104; PHE-111; VAL-205; TRP-281 AND ILE-438.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  9. "Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat."
    Wrighton S.A., Campanile C., Thomas P.E., Maines S.L., Watkins P.B., Parker G., Mendez-Picon G., Haniu M., Shively J.E., Levin W., Guzelian P.S.
    Mol. Pharmacol. 29:405-410(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-19.
  10. "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6."
    Quattrochi L.C., Okino S.T., Pendurthi U.R., Tukey R.H.
    DNA 4:395-400(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 295-485.
    Tissue: Liver.
  11. "Functional characterization of four allelic variants of human cytochrome P450 1A2."
    Zhou H., Josephy P.D., Kim D., Guengerich F.P.
    Arch. Biochem. Biophys. 422:23-30(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, CHARACTERIZATION OF VARIANTS ASN-348; PHE-386; TYR-406 AND TRP-431.
  12. "Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2."
    Sansen S., Yano J.K., Reynald R.L., Schoch G.A., Griffin K.J., Stout C.D., Johnson E.F.
    J. Biol. Chem. 282:14348-14355(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 27-515 IN COMPLEX WITH THE INHIBITOR ALPHA-NAPHTHOFLAVONE AND HEME.
  13. "Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese."
    Huang J.D., Guo W.C., Lai M.D., Guo Y.L., Lambert G.H.
    Drug Metab. Dispos. 27:98-101(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-21.
  14. "Five novel natural allelic variants-951A->C, 1042G->A (D348N), 1156A->T (I386F), 1217G->A (C406Y) and 1291C->T (C431Y)-of the human CYP1A2 gene in a French Caucasian population."
    Chevalier D., Cauffiez C., Allorge D., Lo-Guidice J.-M., Lhermitte M., Lafitte J.-J., Broly F.
    Hum. Mutat. 17:355-356(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASN-348; PHE-386; TYR-406 AND TRP-431.
  15. Cited for: VARIANTS MET-83; GLN-168; LEU-186; CYS-212; SER-299 AND ILE-438.
  16. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
    Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
    Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYS-18; ARG-298; VAL-314 AND TRP-431.
  17. Cited for: VARIANTS ARG-42; GLN-377 AND HIS-456.
  18. "Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus."
    Jiang Z., Dalton T.P., Jin L., Wang B., Tsuneoka Y., Shertzer H.G., Deka R., Nebert D.W.
    Hum. Mutat. 25:196-206(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYS-18.
  19. "Coffee, CYP1A2 genotype, and risk of myocardial infarction."
    Cornelis M.C., El-Sohemy A., Kabagambe E.K., Campos H.
    JAMA 295:1135-1141(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: EFFECT OF CAFFEINE METABOLISM ON RISKS OF MYOCARDIAL INFARCTION.

Entry informationi

Entry nameiCP1A2_HUMAN
AccessioniPrimary (citable) accession number: P05177
Secondary accession number(s): Q16754
, Q6NWU5, Q9BXX7, Q9UK49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3