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P05177

- CP1A2_HUMAN

UniProt

P05177 - CP1A2_HUMAN

Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.1 Publication

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.

    Kineticsi

    1. KM=4 µM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole1 Publication
    2. KM=21 µM for 2-amino-3-methylimidazo[4,5-f]quinoline1 Publication
    3. KM=26 µM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline1 Publication
    4. KM=27 µM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline1 Publication
    5. KM=71 µM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine1 Publication
    6. KM=25 µM for phenacetin1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei226 – 2261SubstrateCurated
    Metal bindingi458 – 4581Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. caffeine oxidase activity Source: BHF-UCL
    3. demethylase activity Source: UniProtKB
    4. electron carrier activity Source: UniProtKB
    5. enzyme binding Source: BHF-UCL
    6. heme binding Source: UniProtKB
    7. iron ion binding Source: InterPro
    8. monooxygenase activity Source: BHF-UCL
    9. oxidoreductase activity Source: BHF-UCL
    10. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: UniProtKB

    GO - Biological processi

    1. alkaloid metabolic process Source: BHF-UCL
    2. arachidonic acid metabolic process Source: Reactome
    3. cellular respiration Source: Ensembl
    4. cellular response to cadmium ion Source: Ensembl
    5. dibenzo-p-dioxin metabolic process Source: Ensembl
    6. drug catabolic process Source: BHF-UCL
    7. drug metabolic process Source: BHF-UCL
    8. epoxygenase P450 pathway Source: Reactome
    9. exogenous drug catabolic process Source: BHF-UCL
    10. heterocycle metabolic process Source: BHF-UCL
    11. hydrogen peroxide biosynthetic process Source: Ensembl
    12. lung development Source: Ensembl
    13. methylation Source: Reactome
    14. monocarboxylic acid metabolic process Source: BHF-UCL
    15. monoterpenoid metabolic process Source: BHF-UCL
    16. omega-hydroxylase P450 pathway Source: Reactome
    17. oxidation-reduction process Source: BHF-UCL
    18. oxidative deethylation Source: BHF-UCL
    19. oxidative demethylation Source: BHF-UCL
    20. porphyrin-containing compound metabolic process Source: Ensembl
    21. post-embryonic development Source: Ensembl
    22. regulation of gene expression Source: Ensembl
    23. response to estradiol Source: Ensembl
    24. response to lipopolysaccharide Source: Ensembl
    25. small molecule metabolic process Source: Reactome
    26. steroid catabolic process Source: BHF-UCL
    27. toxin biosynthetic process Source: BHF-UCL
    28. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS06728-MONOMER.
    ReactomeiREACT_13721. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
    REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_6946. Methylation.
    SABIO-RKP05177.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A2 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA2
    Cytochrome P(3)450
    Cytochrome P450 4
    Cytochrome P450-P3
    Gene namesi
    Name:CYP1A2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:2596. CYP1A2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. intracellular membrane-bounded organelle Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    MIMi124060. gene+phenotype.
    Orphaneti284121. Susceptibility to adverse reaction due to clozapine.
    PharmGKBiPA27093.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 515514Cytochrome P450 1A2PRO_0000051651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP05177.
    PaxDbiP05177.
    PRIDEiP05177.

    PTM databases

    PhosphoSiteiP05177.

    Expressioni

    Tissue specificityi

    Liver.

    Inductioni

    By nicotine, omeprazole, phenobarbital, primidone and rifampicin.

    Gene expression databases

    BgeeiP05177.
    CleanExiHS_CYP1A2.
    GenevestigatoriP05177.

    Organism-specific databases

    HPAiCAB016531.

    Interactioni

    Protein-protein interaction databases

    BioGridi107924. 2 interactions.
    STRINGi9606.ENSP00000342007.

    Structurei

    Secondary structure

    1
    515
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni49 – 513
    Helixi54 – 574
    Helixi61 – 7212
    Beta strandi74 – 807
    Beta strandi83 – 886
    Helixi91 – 988
    Turni99 – 1013
    Helixi102 – 1043
    Helixi112 – 1154
    Turni123 – 1253
    Helixi131 – 14616
    Turni147 – 1493
    Helixi160 – 18122
    Helixi188 – 20518
    Helixi206 – 2083
    Helixi214 – 2207
    Helixi221 – 2233
    Helixi224 – 2274
    Helixi235 – 2373
    Helixi240 – 2445
    Helixi248 – 27326
    Helixi283 – 29311
    Helixi305 – 3084
    Helixi310 – 33526
    Helixi337 – 35014
    Turni351 – 3533
    Helixi359 – 3613
    Helixi366 – 37914
    Beta strandi394 – 3963
    Beta strandi399 – 4013
    Beta strandi406 – 4105
    Helixi411 – 4166
    Turni418 – 4203
    Helixi429 – 4324
    Beta strandi437 – 4404
    Helixi442 – 4454
    Helixi454 – 4563
    Helixi461 – 47818
    Beta strandi480 – 4823
    Beta strandi496 – 4983
    Beta strandi507 – 5104

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HI4X-ray1.95A27-515[»]
    ProteinModelPortaliP05177.
    SMRiP05177. Positions 34-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP05177.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOVERGENiHBG106944.
    InParanoidiP05177.
    KOiK07409.
    OMAiHARCEHV.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP05177.
    TreeFamiTF105095.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P05177-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL    50
    LGHVLTLGKN PHLALSRMSQ RYGDVLQIRI GSTPVLVLSR LDTIRQALVR 100
    QGDDFKGRPD LYTSTLITDG QSLTFSTDSG PVWAARRRLA QNALNTFSIA 150
    SDPASSSSCY LEEHVSKEAK ALISRLQELM AGPGHFDPYN QVVVSVANVI 200
    GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPLDFFP ILRYLPNPAL 250
    QRFKAFNQRF LWFLQKTVQE HYQDFDKNSV RDITGALFKH SKKGPRASGN 300
    LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTV 350
    IGRERRPRLS DRPQLPYLEA FILETFRHSS FLPFTIPHST TRDTTLNGFY 400
    IPKKCCVFVN QWQVNHDPEL WEDPSEFRPE RFLTADGTAI NKPLSEKMML 450
    FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK 500
    HARCEHVQAR RFSIN 515
    Length:515
    Mass (Da):58,294
    Last modified:January 23, 2007 - v3
    Checksum:i23AEFEEBDF6806AB
    GO
    Isoform 2 (identifier: P05177-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         510-510: R → RL

    Show »
    Length:516
    Mass (Da):58,407
    Checksum:i8557AB02860C4806
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791R → S in AAA35738. (PubMed:3462722)Curated
    Sequence conflicti81 – 811G → D in AAH67427. (PubMed:15489334)Curated
    Sequence conflicti170 – 1701K → M in AAF13599. 1 PublicationCurated
    Sequence conflicti311 – 3111V → L in AAA52154. (PubMed:3000715)Curated
    Sequence conflicti450 – 4512LF → MLV in AAA52154. (PubMed:3000715)Curated
    Sequence conflicti492 – 4921T → I in AAF13599. 1 PublicationCurated
    Sequence conflicti511 – 5111R → LP in AAA35738. (PubMed:3462722)Curated

    Polymorphismi

    The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181S → C.2 Publications
    Corresponds to variant rs17861152 [ dbSNP | Ensembl ].
    VAR_023196
    Natural varianti21 – 211F → L in allele CYP1A2*2. 1 Publication
    Corresponds to variant rs56160784 [ dbSNP | Ensembl ].
    VAR_008349
    Natural varianti42 – 421P → R in allele CYP1A2*15. 1 Publication
    VAR_025182
    Natural varianti73 – 731G → R.1 Publication
    Corresponds to variant rs45565238 [ dbSNP | Ensembl ].
    VAR_025183
    Natural varianti83 – 831T → M in allele CYP1A2*9. 1 Publication
    VAR_020848
    Natural varianti104 – 1041D → N.1 Publication
    Corresponds to variant rs34067076 [ dbSNP | Ensembl ].
    VAR_025184
    Natural varianti111 – 1111L → F.1 Publication
    Corresponds to variant rs45442197 [ dbSNP | Ensembl ].
    VAR_025185
    Natural varianti168 – 1681E → Q in allele CYP1A2*10. 1 Publication
    VAR_020849
    Natural varianti186 – 1861F → L in allele CYP1A2*11; drastic reduction in O-deethylation of phenacetin and 7-ethoxyresorufin; has a Vmax of approximately 5% of that of the wild-type and 5-fold lower Km value. 1 Publication
    VAR_020850
    Natural varianti205 – 2051F → V.1 Publication
    Corresponds to variant rs45540640 [ dbSNP | Ensembl ].
    VAR_025186
    Natural varianti212 – 2121S → C in allele CYP1A2*12. 1 Publication
    VAR_020851
    Natural varianti281 – 2811R → W.1 Publication
    Corresponds to variant rs45468096 [ dbSNP | Ensembl ].
    VAR_025187
    Natural varianti298 – 2981S → R.1 Publication
    Corresponds to variant rs17861157 [ dbSNP | Ensembl ].
    VAR_024709
    Natural varianti299 – 2991G → S in allele CYP1A2*13. 1 Publication
    Corresponds to variant rs35796837 [ dbSNP | Ensembl ].
    VAR_020852
    Natural varianti314 – 3141I → V.2 Publications
    Corresponds to variant rs28399418 [ dbSNP | Ensembl ].
    VAR_024710
    Natural varianti348 – 3481D → N in allele CYP1A2*3; increases N-hydroxylation activity of heterocyclic amines; reduces phenacetin O-deethylation activity. 1 Publication
    Corresponds to variant rs56276455 [ dbSNP | Ensembl ].
    VAR_020793
    Natural varianti377 – 3771R → Q in allele CYP1A2*16. 1 Publication
    VAR_025188
    Natural varianti386 – 3861I → F in allele CYP1A2*4; increases catalytic efficiency of N-hydroxylation towards some heterocyclic amines and reduces towards others; reduces catalytic efficiency of phenacetin O-deethylation due to a high decrease in the affinity for phenacetin. 1 Publication
    VAR_020794
    Natural varianti406 – 4061C → Y in allele CYP1A2*5; increases N-hydroxylation activity of heterocyclic amines; reduces catalytic efficiency of phenacetin O-deethylation. 1 Publication
    Corresponds to variant rs55889066 [ dbSNP | Ensembl ].
    VAR_020795
    Natural varianti431 – 4311R → W in allele CYP1A2*6; not detected when expressed in heterologous system as it may be critical for maintenance of protein tertiary structure. 2 Publications
    Corresponds to variant rs28399424 [ dbSNP | Ensembl ].
    VAR_020796
    Natural varianti438 – 4381T → I in allele CYP1A2*14. 2 Publications
    Corresponds to variant rs45486893 [ dbSNP | Ensembl ].
    VAR_020853
    Natural varianti456 – 4561R → H in allele CYP1A2*8. 1 Publication
    VAR_025189
    Natural varianti457 – 4571R → W.
    Corresponds to variant rs34151816 [ dbSNP | Ensembl ].
    VAR_055563

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei510 – 5101R → RL in isoform 2. 2 PublicationsVSP_017123

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z00036 mRNA. Translation: CAA77335.1.
    L00389
    , L00384, L00385, L00386, L00388, L00387 Genomic DNA. Translation: AAA35738.1.
    M31667
    , M31664, M31665, M31666 Genomic DNA. Translation: AAA52163.1.
    M12078 mRNA. Translation: AAA52154.1.
    AF182274 mRNA. Translation: AAF13599.1.
    AF253322 Genomic DNA. Translation: AAK25728.1.
    DQ022432 Genomic DNA. Translation: AAY26399.1.
    BC067424 mRNA. Translation: AAH67424.1.
    BC067425 mRNA. Translation: AAH67425.1.
    BC067426 mRNA. Translation: AAH67426.1.
    BC067427 mRNA. Translation: AAH67427.1.
    BC067428 mRNA. Translation: AAH67428.1.
    M55053 mRNA. Translation: AAA52146.1.
    CCDSiCCDS32293.1. [P05177-2]
    PIRiS16718. O4HU4.
    RefSeqiNP_000752.2. NM_000761.4. [P05177-2]
    UniGeneiHs.1361.

    Genome annotation databases

    EnsembliENST00000343932; ENSP00000342007; ENSG00000140505. [P05177-2]
    GeneIDi1544.
    KEGGihsa:1544.
    UCSCiuc002ayr.1. human. [P05177-2]

    Polymorphism databases

    DMDMi117144.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Cytochrome P450 Allele Nomenclature Committee

    CYP1A2 alleles

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z00036 mRNA. Translation: CAA77335.1 .
    L00389
    , L00384 , L00385 , L00386 , L00388 , L00387 Genomic DNA. Translation: AAA35738.1 .
    M31667
    , M31664 , M31665 , M31666 Genomic DNA. Translation: AAA52163.1 .
    M12078 mRNA. Translation: AAA52154.1 .
    AF182274 mRNA. Translation: AAF13599.1 .
    AF253322 Genomic DNA. Translation: AAK25728.1 .
    DQ022432 Genomic DNA. Translation: AAY26399.1 .
    BC067424 mRNA. Translation: AAH67424.1 .
    BC067425 mRNA. Translation: AAH67425.1 .
    BC067426 mRNA. Translation: AAH67426.1 .
    BC067427 mRNA. Translation: AAH67427.1 .
    BC067428 mRNA. Translation: AAH67428.1 .
    M55053 mRNA. Translation: AAA52146.1 .
    CCDSi CCDS32293.1. [P05177-2 ]
    PIRi S16718. O4HU4.
    RefSeqi NP_000752.2. NM_000761.4. [P05177-2 ]
    UniGenei Hs.1361.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HI4 X-ray 1.95 A 27-515 [» ]
    ProteinModelPortali P05177.
    SMRi P05177. Positions 34-513.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107924. 2 interactions.
    STRINGi 9606.ENSP00000342007.

    Chemistry

    BindingDBi P05177.
    ChEMBLi CHEMBL3356.
    DrugBanki DB01418. Acenocoumarol.
    DB00316. Acetaminophen.
    DB00787. Aciclovir.
    DB00969. Alosetron.
    DB01424. Aminophenazone.
    DB00321. Amitriptyline.
    DB00261. Anagrelide.
    DB00972. Azelastine.
    DB00188. Bortezomib.
    DB00201. Caffeine.
    DB00262. Carmustine.
    DB00475. Chlordiazepoxide.
    DB00477. Chlorpromazine.
    DB00356. Chlorzoxazone.
    DB00501. Cimetidine.
    DB01012. Cinacalcet.
    DB00537. Ciprofloxacin.
    DB01242. Clomipramine.
    DB00257. Clotrimazole.
    DB00363. Clozapine.
    DB00286. Conjugated Estrogens.
    DB00924. Cyclobenzaprine.
    DB00851. Dacarbazine.
    DB00967. Desloratadine.
    DB00829. Diazepam.
    DB00527. Dibucaine.
    DB00586. Diclofenac.
    DB00476. Duloxetine.
    DB00467. Enoxacin.
    DB00736. Esomeprazole.
    DB00783. Estradiol.
    DB00655. Estrone.
    DB00544. Fluorouracil.
    DB00499. Flutamide.
    DB00176. Fluvoxamine.
    DB00998. Frovatriptan.
    DB00365. Grepafloxacin.
    DB00502. Haloperidol.
    DB01094. Hesperetin.
    DB00458. Imipramine.
    DB01026. Ketoconazole.
    DB01097. Leflunomide.
    DB01002. Levobupivacaine.
    DB01137. Levofloxacin.
    DB00281. Lidocaine.
    DB00978. Lomefloxacin.
    DB01065. Melatonin.
    DB00532. Mephenytoin.
    DB00379. Mexiletine.
    DB00370. Mirtazapine.
    DB01059. Norfloxacin.
    DB00540. Nortriptyline.
    DB01165. Ofloxacin.
    DB00334. Olanzapine.
    DB00904. Ondansetron.
    DB00377. Palonosetron.
    DB00213. Pantoprazole.
    DB00487. Pefloxacin.
    DB01100. Pimozide.
    DB01182. Propafenone.
    DB00571. Propranolol.
    DB00908. Quinidine.
    DB00980. Ramelteon.
    DB00863. Ranitidine.
    DB01367. Rasagiline.
    DB01045. Rifampin.
    DB00740. Riluzole.
    DB00533. Rofecoxib.
    DB00268. Ropinirole.
    DB00296. Ropivacaine.
    DB00382. Tacrine.
    DB00976. Telithromycin.
    DB00342. Terfenadine.
    DB00277. Theophylline.
    DB00730. Thiabendazole.
    DB00697. Tizanidine.
    DB01124. Tolbutamide.
    DB00661. Verapamil.
    DB00682. Warfarin.
    DB00744. Zileuton.
    DB00315. Zolmitriptan.

    PTM databases

    PhosphoSitei P05177.

    Polymorphism databases

    DMDMi 117144.

    Proteomic databases

    MaxQBi P05177.
    PaxDbi P05177.
    PRIDEi P05177.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343932 ; ENSP00000342007 ; ENSG00000140505 . [P05177-2 ]
    GeneIDi 1544.
    KEGGi hsa:1544.
    UCSCi uc002ayr.1. human. [P05177-2 ]

    Organism-specific databases

    CTDi 1544.
    GeneCardsi GC15P075041.
    HGNCi HGNC:2596. CYP1A2.
    HPAi CAB016531.
    MIMi 108330. gene.
    124060. gene+phenotype.
    neXtProti NX_P05177.
    Orphaneti 284121. Susceptibility to adverse reaction due to clozapine.
    PharmGKBi PA27093.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOVERGENi HBG106944.
    InParanoidi P05177.
    KOi K07409.
    OMAi HARCEHV.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P05177.
    TreeFami TF105095.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS06728-MONOMER.
    Reactomei REACT_13721. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
    REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_6946. Methylation.
    SABIO-RK P05177.

    Miscellaneous databases

    EvolutionaryTracei P05177.
    GeneWikii CYP1A2.
    GenomeRNAii 1544.
    NextBioi 6391.
    PROi P05177.
    SOURCEi Search...

    Gene expression databases

    Bgeei P05177.
    CleanExi HS_CYP1A2.
    Genevestigatori P05177.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human P3(450): cDNA and complete amino acid sequence."
      Jaiswal A.K., Nebert D.W., Gonzalez F.J.
      Nucleic Acids Res. 14:6773-6774(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA."
      Quattrochi L.C., Pendurthi U.R., Okino S.T., Potenza C., Tukey R.H.
      Proc. Natl. Acad. Sci. U.S.A. 83:6731-6735(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression."
      Ikeya K., Jaiswal A.K., Owens R.A., Jones J.E., Nebert D.W., Kimura S.
      Mol. Endocrinol. 3:1399-1408(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15."
      Jaiswal A.K., Nebert D.W., McBride O.W., Gonzalez F.J.
      J. Exp. Pathol. 3:1-17(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    5. "Sequence of a new human cytochrome P450-1A2 cDNA."
      Zhuge J., Qian Y., Xie H., Yu Y.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-314.
      Tissue: Liver.
    6. "Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation."
      Corchero J., Pimprale S., Kimura S., Gonzalez F.J.
      Pharmacogenetics 11:1-6(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. NIEHS SNPs program
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-73; ASN-104; PHE-111; VAL-205; TRP-281 AND ILE-438.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    9. "Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat."
      Wrighton S.A., Campanile C., Thomas P.E., Maines S.L., Watkins P.B., Parker G., Mendez-Picon G., Haniu M., Shively J.E., Levin W., Guzelian P.S.
      Mol. Pharmacol. 29:405-410(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-19.
    10. "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6."
      Quattrochi L.C., Okino S.T., Pendurthi U.R., Tukey R.H.
      DNA 4:395-400(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 295-485.
      Tissue: Liver.
    11. "Functional characterization of four allelic variants of human cytochrome P450 1A2."
      Zhou H., Josephy P.D., Kim D., Guengerich F.P.
      Arch. Biochem. Biophys. 422:23-30(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, CHARACTERIZATION OF VARIANTS ASN-348; PHE-386; TYR-406 AND TRP-431.
    12. "Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2."
      Sansen S., Yano J.K., Reynald R.L., Schoch G.A., Griffin K.J., Stout C.D., Johnson E.F.
      J. Biol. Chem. 282:14348-14355(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 27-515 IN COMPLEX WITH THE INHIBITOR ALPHA-NAPHTHOFLAVONE AND HEME.
    13. "Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese."
      Huang J.D., Guo W.C., Lai M.D., Guo Y.L., Lambert G.H.
      Drug Metab. Dispos. 27:98-101(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-21.
    14. "Five novel natural allelic variants-951A->C, 1042G->A (D348N), 1156A->T (I386F), 1217G->A (C406Y) and 1291C->T (C431Y)-of the human CYP1A2 gene in a French Caucasian population."
      Chevalier D., Cauffiez C., Allorge D., Lo-Guidice J.-M., Lhermitte M., Lafitte J.-J., Broly F.
      Hum. Mutat. 17:355-356(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASN-348; PHE-386; TYR-406 AND TRP-431.
    15. Cited for: VARIANTS MET-83; GLN-168; LEU-186; CYS-212; SER-299 AND ILE-438.
    16. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
      Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
      Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CYS-18; ARG-298; VAL-314 AND TRP-431.
    17. Cited for: VARIANTS ARG-42; GLN-377 AND HIS-456.
    18. "Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus."
      Jiang Z., Dalton T.P., Jin L., Wang B., Tsuneoka Y., Shertzer H.G., Deka R., Nebert D.W.
      Hum. Mutat. 25:196-206(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYS-18.
    19. "Coffee, CYP1A2 genotype, and risk of myocardial infarction."
      Cornelis M.C., El-Sohemy A., Kabagambe E.K., Campos H.
      JAMA 295:1135-1141(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: EFFECT OF CAFFEINE METABOLISM ON RISKS OF MYOCARDIAL INFARCTION.

    Entry informationi

    Entry nameiCP1A2_HUMAN
    AccessioniPrimary (citable) accession number: P05177
    Secondary accession number(s): Q16754
    , Q6NWU5, Q9BXX7, Q9UK49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 157 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3