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P05176

- CP1A1_RABIT

UniProt

P05176 - CP1A1_RABIT

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Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei228 – 2281SubstrateBy similarity
Metal bindingi461 – 4611Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. vitamin D 24-hydroxylase activity Source: Ensembl

GO - Biological processi

  1. amine metabolic process Source: Ensembl
  2. cellular response to organic cyclic compound Source: Ensembl
  3. drug metabolic process Source: Ensembl
  4. heterocycle metabolic process Source: Ensembl
  5. hydrogen peroxide biosynthetic process Source: Ensembl
  6. response to toxic substance Source: Ensembl
  7. toxin metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Cytochrome P-450 PHPAH1
Cytochrome P450 isozyme 6
Short name:
Cytochrome P450 LM6
Gene namesi
Name:CYP1A1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Cytochrome P450 1A1PRO_0000051632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and by 3-methylcholanthrene (3MC).

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000015239.

Structurei

3D structure databases

ProteinModelPortaliP05176.
SMRiP05176. Positions 36-516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP05176.
OMAiITKISAM.
OrthoDBiEOG7RBZ85.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05176-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSDFGLPTF ISATELLLAS AVFCLVFWVA GASKPRVPKG LKRLPGPWGW
60 70 80 90 100
PLLGHVLTLG KNPHVALARL SRRYGDVFQI RLGSTPVVVL SGLDTIKQAL
110 120 130 140 150
VRQGDDFKGR PDLYSFSFVT KGQSMIFGSD SGPVWAARRR LAQNALNSFS
160 170 180 190 200
VASDPASSSS CYLEEHVSQE AENLISKFQE LMAAVGHFDP YRYVVMSVAN
210 220 230 240 250
VICAMCFGRR YDHDDQELLS LVNLNDEFGK VAASGSPADF FLILRYLPNP
260 270 280 290 300
ALDTFKDLNE RFYSFTQERV KEHCRSFEKG HIRDITDSLI KHYRVDRLDE
310 320 330 340 350
NANVQVSDEK TVGIVLDLFG AGFDTVTTAI SWSLMYLVTK PRIQRKIQEE
360 370 380 390 400
LDAVVGRARR PRFSDRPQLP YLEAVIMETF RHTSFLPFTI PHSTTRDTSL
410 420 430 440 450
GGFYIPKGRC VFVNQWQNNH DPELWGDPEA FRPERFLTPS GAVDKALTEK
460 470 480 490 500
VLLFGLGKRK CIGETIGRLE VFLFLATLLQ QVEFSVSPGT TVDMTPIYGL
510
TMKHARCEHF QAKLRFEA
Length:518
Mass (Da):58,278
Last modified:August 1, 1988 - v1
Checksum:iA9D382C5DF122A5A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731R → P in AAA31431. (PubMed:2991917)Curated
Sequence conflicti146 – 1461L → R in AAA31431. (PubMed:2991917)Curated
Sequence conflicti176 – 1772SK → GR in AAA31431. (PubMed:2991917)Curated
Sequence conflicti341 – 3455PRIQR → RQHTRE in AAA31431. (PubMed:2991917)Curated
Sequence conflicti422 – 4221P → R in AAA31431. (PubMed:2991917)Curated
Sequence conflicti427 – 4271D → V in AAA31431. (PubMed:2991917)Curated
Sequence conflicti429 – 4302EA → RS in AAA31431. (PubMed:2991917)Curated
Sequence conflicti442 – 4432AV → TL in AAA31431. (PubMed:2991917)Curated
Sequence conflicti446 – 4494ALTE → GPDD in AAA31431. (PubMed:2991917)Curated
Sequence conflicti463 – 4631G → A in AAA31431. (PubMed:2991917)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05685 mRNA. Translation: CAA29170.1.
M11727 mRNA. Translation: AAA31431.1.
PIRiA27821.
RefSeqiNP_001164543.1. NM_001171072.1.
XP_008250622.1. XM_008252400.1.
UniGeneiOcu.2041.

Genome annotation databases

EnsembliENSOCUT00000017743; ENSOCUP00000015239; ENSOCUG00000017744.
GeneIDi100328613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05685 mRNA. Translation: CAA29170.1 .
M11727 mRNA. Translation: AAA31431.1 .
PIRi A27821.
RefSeqi NP_001164543.1. NM_001171072.1.
XP_008250622.1. XM_008252400.1.
UniGenei Ocu.2041.

3D structure databases

ProteinModelPortali P05176.
SMRi P05176. Positions 36-516.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000015239.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSOCUT00000017743 ; ENSOCUP00000015239 ; ENSOCUG00000017744 .
GeneIDi 100328613.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118992.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi P05176.
OMAi ITKISAM.
OrthoDBi EOG7RBZ85.
TreeFami TF105095.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structural analysis of cloned cDNAs for polycyclic hydrocarbon-inducible forms of rabbit liver microsomal cytochrome P-450."
    Kagawa N., Mihara K., Sato R.
    J. Biochem. 101:1471-1479(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6."
    Okino S.T., Quattrochi L.C., Barnes H.J., Osanto S., Griffin K.J., Johnson E.F., Tukey R.H.
    Proc. Natl. Acad. Sci. U.S.A. 82:5310-5314(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-518.

Entry informationi

Entry nameiCP1A1_RABIT
AccessioniPrimary (citable) accession number: P05176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 1, 1988
Last modified: November 26, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3