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P05176 (CP1A1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A1

EC=1.14.14.1
Alternative name(s):
CYPIA1
Cytochrome P-450 PHPAH1
Cytochrome P450 isozyme 6
Short name=Cytochrome P450 LM6
Gene names
Name:CYP1A1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and by 3-methylcholanthrene (3MC).

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Cytochrome P450 1A1
PRO_0000051632

Sites

Metal binding4611Iron (heme axial ligand)
Binding site2281Substrate By similarity

Experimental info

Sequence conflict731R → P in AAA31431. Ref.2
Sequence conflict1461L → R in AAA31431. Ref.2
Sequence conflict176 – 1772SK → GR in AAA31431. Ref.2
Sequence conflict341 – 3455PRIQR → RQHTRE in AAA31431. Ref.2
Sequence conflict4221P → R in AAA31431. Ref.2
Sequence conflict4271D → V in AAA31431. Ref.2
Sequence conflict429 – 4302EA → RS in AAA31431. Ref.2
Sequence conflict442 – 4432AV → TL in AAA31431. Ref.2
Sequence conflict446 – 4494ALTE → GPDD in AAA31431. Ref.2
Sequence conflict4631G → A in AAA31431. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P05176 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: A9D382C5DF122A5A

FASTA51858,278
        10         20         30         40         50         60 
MVSDFGLPTF ISATELLLAS AVFCLVFWVA GASKPRVPKG LKRLPGPWGW PLLGHVLTLG 

        70         80         90        100        110        120 
KNPHVALARL SRRYGDVFQI RLGSTPVVVL SGLDTIKQAL VRQGDDFKGR PDLYSFSFVT 

       130        140        150        160        170        180 
KGQSMIFGSD SGPVWAARRR LAQNALNSFS VASDPASSSS CYLEEHVSQE AENLISKFQE 

       190        200        210        220        230        240 
LMAAVGHFDP YRYVVMSVAN VICAMCFGRR YDHDDQELLS LVNLNDEFGK VAASGSPADF 

       250        260        270        280        290        300 
FLILRYLPNP ALDTFKDLNE RFYSFTQERV KEHCRSFEKG HIRDITDSLI KHYRVDRLDE 

       310        320        330        340        350        360 
NANVQVSDEK TVGIVLDLFG AGFDTVTTAI SWSLMYLVTK PRIQRKIQEE LDAVVGRARR 

       370        380        390        400        410        420 
PRFSDRPQLP YLEAVIMETF RHTSFLPFTI PHSTTRDTSL GGFYIPKGRC VFVNQWQNNH 

       430        440        450        460        470        480 
DPELWGDPEA FRPERFLTPS GAVDKALTEK VLLFGLGKRK CIGETIGRLE VFLFLATLLQ 

       490        500        510 
QVEFSVSPGT TVDMTPIYGL TMKHARCEHF QAKLRFEA 

« Hide

References

[1]"Structural analysis of cloned cDNAs for polycyclic hydrocarbon-inducible forms of rabbit liver microsomal cytochrome P-450."
Kagawa N., Mihara K., Sato R.
J. Biochem. 101:1471-1479(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6."
Okino S.T., Quattrochi L.C., Barnes H.J., Osanto S., Griffin K.J., Johnson E.F., Tukey R.H.
Proc. Natl. Acad. Sci. U.S.A. 82:5310-5314(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-518.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05685 mRNA. Translation: CAA29170.1.
M11727 mRNA. Translation: AAA31431.1.
PIRA27821.
RefSeqNP_001164543.1. NM_001171072.1.
UniGeneOcu.2041.

3D structure databases

ProteinModelPortalP05176.
SMRP05176. Positions 36-516.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000015239.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSOCUT00000017743; ENSOCUP00000015239; ENSOCUG00000017744.
GeneID100328613.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117317.
HOGENOMHOG000036991.
HOVERGENHBG106944.
OrthoDBEOG7RBZ85.
TreeFamTF105095.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_RABIT
AccessionPrimary (citable) accession number: P05176
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 1, 1988
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families