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Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228SubstrateBy similarity1
Metal bindingi461Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Cytochrome P-450 PHPAH1
Cytochrome P450 isozyme 6
Short name:
Cytochrome P450 LM6
Gene namesi
Name:CYP1A1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516321 – 518Cytochrome P450 1A1Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71O-linked (GlcNAc) serineBy similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP05176.

Expressioni

Inductioni

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and by 3-methylcholanthrene (3MC).

Gene expression databases

BgeeiENSOCUG00000017744.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000015239.

Structurei

3D structure databases

ProteinModelPortaliP05176.
SMRiP05176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00900000140831.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP05176.
KOiK07408.
OMAiNNWQDYI.
OrthoDBiEOG091G0BT8.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P05176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSDFGLPTF ISATELLLAS AVFCLVFWVA GASKPRVPKG LKRLPGPWGW
60 70 80 90 100
PLLGHVLTLG KNPHVALARL SRRYGDVFQI RLGSTPVVVL SGLDTIKQAL
110 120 130 140 150
VRQGDDFKGR PDLYSFSFVT KGQSMIFGSD SGPVWAARRR LAQNALNSFS
160 170 180 190 200
VASDPASSSS CYLEEHVSQE AENLISKFQE LMAAVGHFDP YRYVVMSVAN
210 220 230 240 250
VICAMCFGRR YDHDDQELLS LVNLNDEFGK VAASGSPADF FLILRYLPNP
260 270 280 290 300
ALDTFKDLNE RFYSFTQERV KEHCRSFEKG HIRDITDSLI KHYRVDRLDE
310 320 330 340 350
NANVQVSDEK TVGIVLDLFG AGFDTVTTAI SWSLMYLVTK PRIQRKIQEE
360 370 380 390 400
LDAVVGRARR PRFSDRPQLP YLEAVIMETF RHTSFLPFTI PHSTTRDTSL
410 420 430 440 450
GGFYIPKGRC VFVNQWQNNH DPELWGDPEA FRPERFLTPS GAVDKALTEK
460 470 480 490 500
VLLFGLGKRK CIGETIGRLE VFLFLATLLQ QVEFSVSPGT TVDMTPIYGL
510
TMKHARCEHF QAKLRFEA
Length:518
Mass (Da):58,278
Last modified:August 1, 1988 - v1
Checksum:iA9D382C5DF122A5A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73R → P in AAA31431 (PubMed:2991917).Curated1
Sequence conflicti146L → R in AAA31431 (PubMed:2991917).Curated1
Sequence conflicti176 – 177SK → GR in AAA31431 (PubMed:2991917).Curated2
Sequence conflicti341 – 345PRIQR → RQHTRE in AAA31431 (PubMed:2991917).Curated5
Sequence conflicti422P → R in AAA31431 (PubMed:2991917).Curated1
Sequence conflicti427D → V in AAA31431 (PubMed:2991917).Curated1
Sequence conflicti429 – 430EA → RS in AAA31431 (PubMed:2991917).Curated2
Sequence conflicti442 – 443AV → TL in AAA31431 (PubMed:2991917).Curated2
Sequence conflicti446 – 449ALTE → GPDD in AAA31431 (PubMed:2991917).Curated4
Sequence conflicti463G → A in AAA31431 (PubMed:2991917).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05685 mRNA. Translation: CAA29170.1.
M11727 mRNA. Translation: AAA31431.1.
PIRiA27821.
RefSeqiNP_001164543.1. NM_001171072.1.
XP_008250622.1. XM_008252400.2.
UniGeneiOcu.2041.

Genome annotation databases

EnsembliENSOCUT00000017743; ENSOCUP00000015239; ENSOCUG00000017744.
GeneIDi100328613.
KEGGiocu:100328613.

Similar proteinsi

Entry informationi

Entry nameiCP1A1_RABIT
AccessioniPrimary (citable) accession number: P05176
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 1, 1988
Last modified: October 25, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families