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P05176

- CP1A1_RABIT

UniProt

P05176 - CP1A1_RABIT

Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei228 – 2281SubstrateBy similarity
    Metal bindingi461 – 4611Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. vitamin D 24-hydroxylase activity Source: Ensembl

    GO - Biological processi

    1. amine metabolic process Source: Ensembl
    2. drug metabolic process Source: Ensembl
    3. heterocycle metabolic process Source: Ensembl
    4. hydrogen peroxide biosynthetic process Source: Ensembl
    5. response to toxic substance Source: Ensembl
    6. toxin metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Cytochrome P-450 PHPAH1
    Cytochrome P450 isozyme 6
    Short name:
    Cytochrome P450 LM6
    Gene namesi
    Name:CYP1A1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Cytochrome P450 1A1PRO_0000051632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Inductioni

    By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and by 3-methylcholanthrene (3MC).

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000015239.

    Structurei

    3D structure databases

    ProteinModelPortaliP05176.
    SMRiP05176. Positions 36-516.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117317.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    OMAiITKISAM.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF105095.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P05176-1 [UniParc]FASTAAdd to Basket

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    MVSDFGLPTF ISATELLLAS AVFCLVFWVA GASKPRVPKG LKRLPGPWGW    50
    PLLGHVLTLG KNPHVALARL SRRYGDVFQI RLGSTPVVVL SGLDTIKQAL 100
    VRQGDDFKGR PDLYSFSFVT KGQSMIFGSD SGPVWAARRR LAQNALNSFS 150
    VASDPASSSS CYLEEHVSQE AENLISKFQE LMAAVGHFDP YRYVVMSVAN 200
    VICAMCFGRR YDHDDQELLS LVNLNDEFGK VAASGSPADF FLILRYLPNP 250
    ALDTFKDLNE RFYSFTQERV KEHCRSFEKG HIRDITDSLI KHYRVDRLDE 300
    NANVQVSDEK TVGIVLDLFG AGFDTVTTAI SWSLMYLVTK PRIQRKIQEE 350
    LDAVVGRARR PRFSDRPQLP YLEAVIMETF RHTSFLPFTI PHSTTRDTSL 400
    GGFYIPKGRC VFVNQWQNNH DPELWGDPEA FRPERFLTPS GAVDKALTEK 450
    VLLFGLGKRK CIGETIGRLE VFLFLATLLQ QVEFSVSPGT TVDMTPIYGL 500
    TMKHARCEHF QAKLRFEA 518
    Length:518
    Mass (Da):58,278
    Last modified:August 1, 1988 - v1
    Checksum:iA9D382C5DF122A5A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731R → P in AAA31431. (PubMed:2991917)Curated
    Sequence conflicti146 – 1461L → R in AAA31431. (PubMed:2991917)Curated
    Sequence conflicti176 – 1772SK → GR in AAA31431. (PubMed:2991917)Curated
    Sequence conflicti341 – 3455PRIQR → RQHTRE in AAA31431. (PubMed:2991917)Curated
    Sequence conflicti422 – 4221P → R in AAA31431. (PubMed:2991917)Curated
    Sequence conflicti427 – 4271D → V in AAA31431. (PubMed:2991917)Curated
    Sequence conflicti429 – 4302EA → RS in AAA31431. (PubMed:2991917)Curated
    Sequence conflicti442 – 4432AV → TL in AAA31431. (PubMed:2991917)Curated
    Sequence conflicti446 – 4494ALTE → GPDD in AAA31431. (PubMed:2991917)Curated
    Sequence conflicti463 – 4631G → A in AAA31431. (PubMed:2991917)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05685 mRNA. Translation: CAA29170.1.
    M11727 mRNA. Translation: AAA31431.1.
    PIRiA27821.
    RefSeqiNP_001164543.1. NM_001171072.1.
    UniGeneiOcu.2041.

    Genome annotation databases

    EnsembliENSOCUT00000017743; ENSOCUP00000015239; ENSOCUG00000017744.
    GeneIDi100328613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05685 mRNA. Translation: CAA29170.1 .
    M11727 mRNA. Translation: AAA31431.1 .
    PIRi A27821.
    RefSeqi NP_001164543.1. NM_001171072.1.
    UniGenei Ocu.2041.

    3D structure databases

    ProteinModelPortali P05176.
    SMRi P05176. Positions 36-516.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000015239.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOCUT00000017743 ; ENSOCUP00000015239 ; ENSOCUG00000017744 .
    GeneIDi 100328613.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117317.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    OMAi ITKISAM.
    OrthoDBi EOG7RBZ85.
    TreeFami TF105095.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of cloned cDNAs for polycyclic hydrocarbon-inducible forms of rabbit liver microsomal cytochrome P-450."
      Kagawa N., Mihara K., Sato R.
      J. Biochem. 101:1471-1479(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6."
      Okino S.T., Quattrochi L.C., Barnes H.J., Osanto S., Griffin K.J., Johnson E.F., Tukey R.H.
      Proc. Natl. Acad. Sci. U.S.A. 82:5310-5314(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-518.

    Entry informationi

    Entry nameiCP1A1_RABIT
    AccessioniPrimary (citable) accession number: P05176
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3