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Protein

Galectin-2

Gene

LGALS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds beta-galactoside. Its physiological function is not yet known.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100079-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-2
Short name:
Gal-2
Alternative name(s):
Beta-galactoside-binding lectin L-14-II
HL14
Lactose-binding lectin 2
S-Lac lectin 2
Gene namesi
Name:LGALS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:6562. LGALS2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi3957.
MalaCardsiLGALS2.
OpenTargetsiENSG00000100079.
PharmGKBiPA164741896.

Chemistry databases

ChEMBLiCHEMBL5977.

Polymorphism and mutation databases

BioMutaiLGALS2.
DMDMi585388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769241 – 132Galectin-2Add BLAST132

Proteomic databases

MaxQBiP05162.
PaxDbiP05162.
PeptideAtlasiP05162.
PRIDEiP05162.

PTM databases

iPTMnetiP05162.
PhosphoSitePlusiP05162.

Expressioni

Gene expression databases

BgeeiENSG00000100079.
CleanExiHS_LGALS2.
ExpressionAtlasiP05162. baseline and differential.
GenevisibleiP05162. HS.

Organism-specific databases

HPAiCAB025198.
HPA003536.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBPO005607EBI-7181544,EBI-727004
SDCBP2Q9H1905EBI-7181544,EBI-742426

Protein-protein interaction databases

BioGridi110148. 7 interactors.
IntActiP05162. 2 interactors.
MINTiMINT-5000474.
STRINGi9606.ENSP00000215886.

Chemistry databases

BindingDBiP05162.

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi17 – 24Combined sources8
Beta strandi29 – 38Combined sources10
Beta strandi41 – 49Combined sources9
Turni50 – 53Combined sources4
Beta strandi54 – 61Combined sources8
Beta strandi69 – 71Combined sources3
Beta strandi81 – 88Combined sources8
Beta strandi90 – 96Combined sources7
Beta strandi98 – 100Combined sources3
Beta strandi102 – 106Combined sources5
Beta strandi116 – 131Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLCX-ray2.90A/B4-132[»]
5DG1X-ray3.20A/B/C/D/H/I1-132[»]
5DG2X-ray1.61A/B1-132[»]
5EWSX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-131[»]
ProteinModelPortaliP05162.
SMRiP05162.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05162.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 131GalectinPROSITE-ProRule annotationAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 71Beta-galactoside bindingSequence analysis7

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00440000034263.
HOGENOMiHOG000059539.
HOVERGENiHBG006255.
InParanoidiP05162.
KOiK10090.
OMAiLNLHFNP.
OrthoDBiEOG091G0S7H.
PhylomeDBiP05162.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGELEVKNM DMKPGSTLKI TGSIADGTDG FVINLGQGTD KLNLHFNPRF
60 70 80 90 100
SESTIVCNSL DGSNWGQEQR EDHLCFSPGS EVKFTVTFES DKFKVKLPDG
110 120 130
HELTFPNRLG HSHLSYLSVR GGFNMSSFKL KE
Length:132
Mass (Da):14,644
Last modified:October 1, 1994 - v3
Checksum:iE30B8768630A2ACB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049767119V → I.1 PublicationCorresponds to variant rs2235339dbSNPEnsembl.1
Natural variantiVAR_036570132E → Q in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87860
, M87857, M87858, M87859 Genomic DNA. Translation: AAA59512.1.
M87842 mRNA. Translation: AAA59513.1.
CR456512 mRNA. Translation: CAG30398.1.
CR541972 mRNA. Translation: CAG46770.1.
CR542000 mRNA. Translation: CAG46797.1.
AL022315 Genomic DNA. Translation: CAB42834.1.
CH471095 Genomic DNA. Translation: EAW60167.1.
BC059782 mRNA. Translation: AAH59782.1.
M14079 mRNA. Translation: AAA36171.1.
CCDSiCCDS13950.1.
PIRiA38140.
RefSeqiNP_006489.1. NM_006498.2.
UniGeneiHs.531776.

Genome annotation databases

EnsembliENST00000215886; ENSP00000215886; ENSG00000100079.
GeneIDi3957.
KEGGihsa:3957.
UCSCiuc003ata.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87860
, M87857, M87858, M87859 Genomic DNA. Translation: AAA59512.1.
M87842 mRNA. Translation: AAA59513.1.
CR456512 mRNA. Translation: CAG30398.1.
CR541972 mRNA. Translation: CAG46770.1.
CR542000 mRNA. Translation: CAG46797.1.
AL022315 Genomic DNA. Translation: CAB42834.1.
CH471095 Genomic DNA. Translation: EAW60167.1.
BC059782 mRNA. Translation: AAH59782.1.
M14079 mRNA. Translation: AAA36171.1.
CCDSiCCDS13950.1.
PIRiA38140.
RefSeqiNP_006489.1. NM_006498.2.
UniGeneiHs.531776.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLCX-ray2.90A/B4-132[»]
5DG1X-ray3.20A/B/C/D/H/I1-132[»]
5DG2X-ray1.61A/B1-132[»]
5EWSX-ray2.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-131[»]
ProteinModelPortaliP05162.
SMRiP05162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110148. 7 interactors.
IntActiP05162. 2 interactors.
MINTiMINT-5000474.
STRINGi9606.ENSP00000215886.

Chemistry databases

BindingDBiP05162.
ChEMBLiCHEMBL5977.

PTM databases

iPTMnetiP05162.
PhosphoSitePlusiP05162.

Polymorphism and mutation databases

BioMutaiLGALS2.
DMDMi585388.

Proteomic databases

MaxQBiP05162.
PaxDbiP05162.
PeptideAtlasiP05162.
PRIDEiP05162.

Protocols and materials databases

DNASUi3957.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215886; ENSP00000215886; ENSG00000100079.
GeneIDi3957.
KEGGihsa:3957.
UCSCiuc003ata.4. human.

Organism-specific databases

CTDi3957.
DisGeNETi3957.
GeneCardsiLGALS2.
HGNCiHGNC:6562. LGALS2.
HPAiCAB025198.
HPA003536.
MalaCardsiLGALS2.
MIMi150571. gene.
neXtProtiNX_P05162.
OpenTargetsiENSG00000100079.
PharmGKBiPA164741896.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00440000034263.
HOGENOMiHOG000059539.
HOVERGENiHBG006255.
InParanoidiP05162.
KOiK10090.
OMAiLNLHFNP.
OrthoDBiEOG091G0S7H.
PhylomeDBiP05162.
TreeFamiTF315551.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100079-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP05162.
GeneWikiiLGALS2.
GenomeRNAii3957.
PROiP05162.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100079.
CleanExiHS_LGALS2.
ExpressionAtlasiP05162. baseline and differential.
GenevisibleiP05162. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEG2_HUMAN
AccessioniPrimary (citable) accession number: P05162
Secondary accession number(s): Q6FGY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 163 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.