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P05160

- F13B_HUMAN

UniProt

P05160 - F13B_HUMAN

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Protein

Coagulation factor XIII B chain

Gene
F13B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.

GO - Biological processi

  1. blood coagulation Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_1439. Common Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII B chain
Alternative name(s):
Fibrin-stabilizing factor B subunit
Protein-glutamine gamma-glutamyltransferase B chain
Transglutaminase B chain
Gene namesi
Name:F13B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3534. F13B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Factor XIII subunit B deficiency (FA13BD) [MIM:613235]: An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti450 – 4501C → F in FA13BD. 1 Publication
VAR_007475

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi134580. gene+phenotype.
613235. phenotype.
Orphaneti331. Congenital factor XIII deficiency.
PharmGKBiPA27944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 661641Coagulation factor XIII B chainPRO_0000021222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 76 By similarity
Disulfide bondi59 ↔ 87 By similarity
Disulfide bondi91 ↔ 135 By similarity
Disulfide bondi118 ↔ 146 By similarity
Disulfide bondi153 ↔ 197 By similarity
Glycosylationi162 – 1621N-linked (GlcNAc...)1 Publication
Disulfide bondi180 ↔ 208 By similarity
Disulfide bondi213 ↔ 255 By similarity
Disulfide bondi241 ↔ 267 By similarity
Disulfide bondi274 ↔ 316 By similarity
Disulfide bondi302 ↔ 327 By similarity
Disulfide bondi336 ↔ 378 By similarity
Disulfide bondi364 ↔ 389 By similarity
Disulfide bondi396 ↔ 439 By similarity
Disulfide bondi425 ↔ 450 By similarity
Disulfide bondi454 ↔ 505 By similarity
Disulfide bondi486 ↔ 515 By similarity
Disulfide bondi524 ↔ 567 By similarity
Glycosylationi545 – 5451N-linked (GlcNAc...)1 Publication
Disulfide bondi553 ↔ 578 By similarity
Disulfide bondi582 ↔ 636 By similarity
Disulfide bondi616 ↔ 646 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05160.
PeptideAtlasiP05160.
PRIDEiP05160.

PTM databases

PhosphoSiteiP05160.

Expressioni

Gene expression databases

BgeeiP05160.
CleanExiHS_F13B.
GenevestigatoriP05160.

Organism-specific databases

HPAiHPA003827.

Interactioni

Subunit structurei

Tetramer of two A chains and two B chains.

Protein-protein interaction databases

BioGridi108463. 2 interactions.
STRINGi9606.ENSP00000356382.

Structurei

3D structure databases

ProteinModelPortaliP05160.
SMRiP05160. Positions 23-649.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8865Sushi 1Add
BLAST
Domaini89 – 14860Sushi 2Add
BLAST
Domaini151 – 21060Sushi 3Add
BLAST
Domaini211 – 26959Sushi 4Add
BLAST
Domaini272 – 32958Sushi 5Add
BLAST
Domaini334 – 39158Sushi 6Add
BLAST
Domaini394 – 45259Sushi 7Add
BLAST
Domaini453 – 51664Sushi 8Add
BLAST
Domaini522 – 58059Sushi 9Add
BLAST
Domaini581 – 64767Sushi 10Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi617 – 6193Cell attachment site

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG146710.
HOGENOMiHOG000049250.
HOVERGENiHBG005626.
InParanoidiP05160.
KOiK03906.
OMAiNFGWYPE.
OrthoDBiEOG7CNZF8.
PhylomeDBiP05160.
TreeFamiTF326157.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00084. Sushi. 8 hits.
[Graphical view]
SMARTiSM00032. CCP. 8 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 10 hits.
PROSITEiPS50923. SUSHI. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05160-1 [UniParc]FASTAAdd to Basket

« Hide

MRLKNLTFII ILIISGELYA EEKPCGFPHV ENGRIAQYYY TFKSFYFPMS    50
IDKKLSFFCL AGYTTESGRQ EEQTTCTTEG WSPEPRCFKK CTKPDLSNGY 100
ISDVKLLYKI QENMRYGCAS GYKTTGGKDE EVVQCLSDGW SSQPTCRKEH 150
ETCLAPELYN GNYSTTQKTF KVKDKVQYEC ATGYYTAGGK KTEEVECLTY 200
GWSLTPKCTK LKCSSLRLIE NGYFHPVKQT YEEGDVVQFF CHENYYLSGS 250
DLIQCYNFGW YPESPVCEGR RNRCPPPPLP INSKIQTHST TYRHGEIVHI 300
ECELNFEIHG SAEIRCEDGK WTEPPKCIEG QEKVACEEPP FIENGAANLH 350
SKIYYNGDKV TYACKSGYLL HGSNEITCNR GKWTLPPECV ENNENCKHPP 400
VVMNGAVADG ILASYATGSS VEYRCNEYYL LRGSKISRCE QGKWSSPPVC 450
LEPCTVNVDY MNRNNIEMKW KYEGKVLHGD LIDFVCKQGY DLSPLTPLSE 500
LSVQCNRGEV KYPLCTRKES KGMCTSPPLI KHGVIISSTV DTYENGSSVE 550
YRCFDHHFLE GSREAYCLDG MWTTPPLCLE PCTLSFTEME KNNLLLKWDF 600
DNRPHILHGE YIEFICRGDT YPAELYITGS ILRMQCDRGQ LKYPRCIPRQ 650
STLSYQEPLR T 661
Length:661
Mass (Da):75,511
Last modified:April 17, 2007 - v3
Checksum:i57A2FD2A0E35B812
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491M → V.1 Publication
Corresponds to variant rs6002 [ dbSNP | Ensembl ].
VAR_013930
Natural varianti115 – 1151R → H.4 Publications
Corresponds to variant rs6003 [ dbSNP | Ensembl ].
VAR_013931
Natural varianti342 – 3421I → T.1 Publication
Corresponds to variant rs17514281 [ dbSNP | Ensembl ].
VAR_020612
Natural varianti350 – 3501H → R.2 Publications
Corresponds to variant rs5999 [ dbSNP | Ensembl ].
VAR_013932
Natural varianti388 – 3881E → V.1 Publication
Corresponds to variant rs5991 [ dbSNP | Ensembl ].
VAR_013933
Natural varianti450 – 4501C → F in FA13BD. 1 Publication
VAR_007475
Natural varianti529 – 5291L → P.1 Publication
Corresponds to variant rs17549671 [ dbSNP | Ensembl ].
VAR_020613
Natural varianti543 – 5431Y → S.1 Publication
Corresponds to variant rs6001 [ dbSNP | Ensembl ].
VAR_013934
Natural varianti569 – 5691D → E.3 Publications
Corresponds to variant rs6000 [ dbSNP | Ensembl ].
VAR_013935

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64554 Genomic DNA. Translation: AAA51821.1. Sequence problems.
M14057 mRNA. Translation: AAA88042.1.
AK290560 mRNA. Translation: BAF83249.1.
AY692223 Genomic DNA. Translation: AAT85802.1.
AL353809 Genomic DNA. Translation: CAH72549.1.
X51823 mRNA. Translation: CAA36123.1.
CCDSiCCDS1388.1.
PIRiA36397. KFHU13.
RefSeqiNP_001985.2. NM_001994.2.
UniGeneiHs.435782.

Genome annotation databases

EnsembliENST00000367412; ENSP00000356382; ENSG00000143278.
GeneIDi2165.
KEGGihsa:2165.
UCSCiuc001gtt.1. human.

Polymorphism databases

DMDMi145559473.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Factor XIII entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64554 Genomic DNA. Translation: AAA51821.1 . Sequence problems.
M14057 mRNA. Translation: AAA88042.1 .
AK290560 mRNA. Translation: BAF83249.1 .
AY692223 Genomic DNA. Translation: AAT85802.1 .
AL353809 Genomic DNA. Translation: CAH72549.1 .
X51823 mRNA. Translation: CAA36123.1 .
CCDSi CCDS1388.1.
PIRi A36397. KFHU13.
RefSeqi NP_001985.2. NM_001994.2.
UniGenei Hs.435782.

3D structure databases

ProteinModelPortali P05160.
SMRi P05160. Positions 23-649.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108463. 2 interactions.
STRINGi 9606.ENSP00000356382.

PTM databases

PhosphoSitei P05160.

Polymorphism databases

DMDMi 145559473.

Proteomic databases

PaxDbi P05160.
PeptideAtlasi P05160.
PRIDEi P05160.

Protocols and materials databases

DNASUi 2165.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367412 ; ENSP00000356382 ; ENSG00000143278 .
GeneIDi 2165.
KEGGi hsa:2165.
UCSCi uc001gtt.1. human.

Organism-specific databases

CTDi 2165.
GeneCardsi GC01M197008.
H-InvDB HIX0028859.
HGNCi HGNC:3534. F13B.
HPAi HPA003827.
MIMi 134580. gene+phenotype.
613235. phenotype.
neXtProti NX_P05160.
Orphaneti 331. Congenital factor XIII deficiency.
PharmGKBi PA27944.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146710.
HOGENOMi HOG000049250.
HOVERGENi HBG005626.
InParanoidi P05160.
KOi K03906.
OMAi NFGWYPE.
OrthoDBi EOG7CNZF8.
PhylomeDBi P05160.
TreeFami TF326157.

Enzyme and pathway databases

Reactomei REACT_1439. Common Pathway.

Miscellaneous databases

GeneWikii F13B.
GenomeRNAii 2165.
NextBioi 8743.
PROi P05160.
SOURCEi Search...

Gene expression databases

Bgeei P05160.
CleanExi HS_F13B.
Genevestigatori P05160.

Family and domain databases

InterProi IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00084. Sushi. 8 hits.
[Graphical view ]
SMARTi SM00032. CCP. 8 hits.
[Graphical view ]
SUPFAMi SSF57535. SSF57535. 10 hits.
PROSITEi PS50923. SUSHI. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the gene for the b subunit of human factor XIII."
    Bottenus R.E., Ichinose A., Davie E.W.
    Biochemistry 29:11195-11209(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-115.
  2. "Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments."
    Ichinose A., McMullen B.A., Fujikawa K., Davie E.W.
    Biochemistry 25:4633-4638(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-661, VARIANT HIS-115.
  3. Ichinose A.
    Submitted (FEB-1987) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-569.
    Tissue: Heart.
  5. SeattleSNPs variation discovery resource
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-115; THR-342; ARG-350; PRO-529 AND GLU-569.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Complete cDNA sequence encoding the B subunit of human factor XIII."
    Grundmann U., Nerlich C., Rein T., Zettlmeissl G.
    Nucleic Acids Res. 18:2817-2817(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-20.
    Tissue: Liver.
  8. "Truncated mutant B subunit for factor XIII causes its deficiency due to impaired intracellular transportation."
    Koseki S., Souri M., Koga S., Yamakawa M., Shichishima T., Maruyama Y., Yanai F., Ichinose A.
    Blood 97:2667-2672(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN FA13BD.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-545.
    Tissue: Plasma.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-162.
    Tissue: Liver.
  11. "Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII."
    Hashiguchi T., Saito M., Morishita E., Matsuda T., Ichinose A.
    Blood 82:145-150(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT FA13BD PHE-450.
  12. Cited for: VARIANTS VAL-49; HIS-115; ARG-350; VAL-388; SER-543 AND GLU-569.

Entry informationi

Entry nameiF13B_HUMAN
AccessioniPrimary (citable) accession number: P05160
Secondary accession number(s): A8K3E5, Q5VYL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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