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P05160 (F13B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 144. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coagulation factor XIII B chain
Alternative name(s):
Fibrin-stabilizing factor B subunit
Protein-glutamine gamma-glutamyltransferase B chain
Transglutaminase B chain
Gene names
Name:F13B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length661 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.

Subunit structure

Tetramer of two A chains and two B chains.

Subcellular location

Secreted.

Involvement in disease

Factor XIII subunit B deficiency (FA13BD) [MIM:613235]: An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8 Ref.11

Sequence similarities

Contains 10 Sushi (CCP/SCR) domains.

Ontologies

Keywords
   Biological processBlood coagulation
Hemostasis
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
   DomainRepeat
Signal
Sushi
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood coagulation

Traceable author statement. Source: Reactome

   Cellular_componentextracellular region

Non-traceable author statement PubMed 14718574. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 661641Coagulation factor XIII B chain
PRO_0000021222

Regions

Domain24 – 8865Sushi 1
Domain89 – 14860Sushi 2
Domain151 – 21060Sushi 3
Domain211 – 26959Sushi 4
Domain272 – 32958Sushi 5
Domain334 – 39158Sushi 6
Domain394 – 45259Sushi 7
Domain453 – 51664Sushi 8
Domain522 – 58059Sushi 9
Domain581 – 64767Sushi 10
Motif617 – 6193Cell attachment site

Amino acid modifications

Glycosylation1621N-linked (GlcNAc...) Ref.10
Glycosylation5451N-linked (GlcNAc...) Ref.9
Disulfide bond25 ↔ 76 By similarity
Disulfide bond59 ↔ 87 By similarity
Disulfide bond91 ↔ 135 By similarity
Disulfide bond118 ↔ 146 By similarity
Disulfide bond153 ↔ 197 By similarity
Disulfide bond180 ↔ 208 By similarity
Disulfide bond213 ↔ 255 By similarity
Disulfide bond241 ↔ 267 By similarity
Disulfide bond274 ↔ 316 By similarity
Disulfide bond302 ↔ 327 By similarity
Disulfide bond336 ↔ 378 By similarity
Disulfide bond364 ↔ 389 By similarity
Disulfide bond396 ↔ 439 By similarity
Disulfide bond425 ↔ 450 By similarity
Disulfide bond454 ↔ 505 By similarity
Disulfide bond486 ↔ 515 By similarity
Disulfide bond524 ↔ 567 By similarity
Disulfide bond553 ↔ 578 By similarity
Disulfide bond582 ↔ 636 By similarity
Disulfide bond616 ↔ 646 By similarity

Natural variations

Natural variant491M → V. Ref.12
Corresponds to variant rs6002 [ dbSNP | Ensembl ].
VAR_013930
Natural variant1151R → H. Ref.1 Ref.2 Ref.5 Ref.12
Corresponds to variant rs6003 [ dbSNP | Ensembl ].
VAR_013931
Natural variant3421I → T. Ref.5
Corresponds to variant rs17514281 [ dbSNP | Ensembl ].
VAR_020612
Natural variant3501H → R. Ref.5 Ref.12
Corresponds to variant rs5999 [ dbSNP | Ensembl ].
VAR_013932
Natural variant3881E → V. Ref.12
Corresponds to variant rs5991 [ dbSNP | Ensembl ].
VAR_013933
Natural variant4501C → F in FA13BD. Ref.11
VAR_007475
Natural variant5291L → P. Ref.5
Corresponds to variant rs17549671 [ dbSNP | Ensembl ].
VAR_020613
Natural variant5431Y → S. Ref.12
Corresponds to variant rs6001 [ dbSNP | Ensembl ].
VAR_013934
Natural variant5691D → E. Ref.4 Ref.5 Ref.12
Corresponds to variant rs6000 [ dbSNP | Ensembl ].
VAR_013935

Sequences

Sequence LengthMass (Da)Tools
P05160 [UniParc].

Last modified April 17, 2007. Version 3.
Checksum: 57A2FD2A0E35B812

FASTA66175,511
        10         20         30         40         50         60 
MRLKNLTFII ILIISGELYA EEKPCGFPHV ENGRIAQYYY TFKSFYFPMS IDKKLSFFCL 

        70         80         90        100        110        120 
AGYTTESGRQ EEQTTCTTEG WSPEPRCFKK CTKPDLSNGY ISDVKLLYKI QENMRYGCAS 

       130        140        150        160        170        180 
GYKTTGGKDE EVVQCLSDGW SSQPTCRKEH ETCLAPELYN GNYSTTQKTF KVKDKVQYEC 

       190        200        210        220        230        240 
ATGYYTAGGK KTEEVECLTY GWSLTPKCTK LKCSSLRLIE NGYFHPVKQT YEEGDVVQFF 

       250        260        270        280        290        300 
CHENYYLSGS DLIQCYNFGW YPESPVCEGR RNRCPPPPLP INSKIQTHST TYRHGEIVHI 

       310        320        330        340        350        360 
ECELNFEIHG SAEIRCEDGK WTEPPKCIEG QEKVACEEPP FIENGAANLH SKIYYNGDKV 

       370        380        390        400        410        420 
TYACKSGYLL HGSNEITCNR GKWTLPPECV ENNENCKHPP VVMNGAVADG ILASYATGSS 

       430        440        450        460        470        480 
VEYRCNEYYL LRGSKISRCE QGKWSSPPVC LEPCTVNVDY MNRNNIEMKW KYEGKVLHGD 

       490        500        510        520        530        540 
LIDFVCKQGY DLSPLTPLSE LSVQCNRGEV KYPLCTRKES KGMCTSPPLI KHGVIISSTV 

       550        560        570        580        590        600 
DTYENGSSVE YRCFDHHFLE GSREAYCLDG MWTTPPLCLE PCTLSFTEME KNNLLLKWDF 

       610        620        630        640        650        660 
DNRPHILHGE YIEFICRGDT YPAELYITGS ILRMQCDRGQ LKYPRCIPRQ STLSYQEPLR 


T 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the gene for the b subunit of human factor XIII."
Bottenus R.E., Ichinose A., Davie E.W.
Biochemistry 29:11195-11209(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-115.
[2]"Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments."
Ichinose A., McMullen B.A., Fujikawa K., Davie E.W.
Biochemistry 25:4633-4638(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-661, VARIANT HIS-115.
[3]Ichinose A.
Submitted (FEB-1987) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-569.
Tissue: Heart.
[5]SeattleSNPs variation discovery resource
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-115; THR-342; ARG-350; PRO-529 AND GLU-569.
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"Complete cDNA sequence encoding the B subunit of human factor XIII."
Grundmann U., Nerlich C., Rein T., Zettlmeissl G.
Nucleic Acids Res. 18:2817-2817(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-20.
Tissue: Liver.
[8]"Truncated mutant B subunit for factor XIII causes its deficiency due to impaired intracellular transportation."
Koseki S., Souri M., Koga S., Yamakawa M., Shichishima T., Maruyama Y., Yanai F., Ichinose A.
Blood 97:2667-2672(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN FA13BD.
[9]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-545.
Tissue: Plasma.
[10]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-162.
Tissue: Liver.
[11]"Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII."
Hashiguchi T., Saito M., Morishita E., Matsuda T., Ichinose A.
Blood 82:145-150(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT FA13BD PHE-450.
[12]"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS VAL-49; HIS-115; ARG-350; VAL-388; SER-543 AND GLU-569.
[13]Erratum
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 23:373-373(1999)
+Additional computationally mapped references.

Web resources

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Factor XIII entry

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64554 Genomic DNA. Translation: AAA51821.1. Sequence problems.
M14057 mRNA. Translation: AAA88042.1.
AK290560 mRNA. Translation: BAF83249.1.
AY692223 Genomic DNA. Translation: AAT85802.1.
AL353809 Genomic DNA. Translation: CAH72549.1.
X51823 mRNA. Translation: CAA36123.1.
PIRKFHU13. A36397.
RefSeqNP_001985.2. NM_001994.2.
UniGeneHs.435782.

3D structure databases

ProteinModelPortalP05160.
SMRP05160. Positions 8-649.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108463. 2 interactions.
STRING9606.ENSP00000356382.

PTM databases

PhosphoSiteP05160.

Polymorphism databases

DMDM145559473.

Proteomic databases

PaxDbP05160.
PeptideAtlasP05160.
PRIDEP05160.

Protocols and materials databases

DNASU2165.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367412; ENSP00000356382; ENSG00000143278.
GeneID2165.
KEGGhsa:2165.
UCSCuc001gtt.1. human.

Organism-specific databases

CTD2165.
GeneCardsGC01M197008.
H-InvDBHIX0028859.
HGNCHGNC:3534. F13B.
HPAHPA003827.
MIM134580. gene+phenotype.
613235. phenotype.
neXtProtNX_P05160.
Orphanet331. Congenital factor XIII deficiency.
PharmGKBPA27944.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146710.
HOGENOMHOG000049250.
HOVERGENHBG005626.
InParanoidP05160.
KOK03906.
OMANFGWYPE.
OrthoDBEOG7CNZF8.
PhylomeDBP05160.
TreeFamTF326157.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.

Gene expression databases

BgeeP05160.
CleanExHS_F13B.
GenevestigatorP05160.

Family and domain databases

InterProIPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00084. Sushi. 8 hits.
[Graphical view]
SMARTSM00032. CCP. 8 hits.
[Graphical view]
SUPFAMSSF57535. SSF57535. 10 hits.
PROSITEPS50923. SUSHI. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiF13B.
GenomeRNAi2165.
NextBio8743.
PROP05160.
SOURCESearch...

Entry information

Entry nameF13B_HUMAN
AccessionPrimary (citable) accession number: P05160
Secondary accession number(s): A8K3E5, Q5VYL5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 17, 2007
Last modified: March 19, 2014
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM