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Protein

Coagulation factor XIII B chain

Gene

F13B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.

GO - Biological processi

  1. blood coagulation Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_1439. Common Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII B chain
Alternative name(s):
Fibrin-stabilizing factor B subunit
Protein-glutamine gamma-glutamyltransferase B chain
Transglutaminase B chain
Gene namesi
Name:F13B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3534. F13B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Factor XIII subunit B deficiency (FA13BD)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.

See also OMIM:613235
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti450 – 4501C → F in FA13BD. 1 Publication
VAR_007475

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi134580. gene+phenotype.
613235. phenotype.
Orphaneti331. Congenital factor XIII deficiency.
PharmGKBiPA27944.

Polymorphism and mutation databases

BioMutaiF13B.
DMDMi145559473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 661641Coagulation factor XIII B chainPRO_0000021222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 76PROSITE-ProRule annotation
Disulfide bondi59 ↔ 87PROSITE-ProRule annotation
Disulfide bondi91 ↔ 135PROSITE-ProRule annotation
Disulfide bondi118 ↔ 146PROSITE-ProRule annotation
Disulfide bondi153 ↔ 197PROSITE-ProRule annotation
Glycosylationi162 – 1621N-linked (GlcNAc...)1 Publication
Disulfide bondi180 ↔ 208PROSITE-ProRule annotation
Disulfide bondi213 ↔ 255PROSITE-ProRule annotation
Disulfide bondi241 ↔ 267PROSITE-ProRule annotation
Disulfide bondi274 ↔ 316PROSITE-ProRule annotation
Disulfide bondi302 ↔ 327PROSITE-ProRule annotation
Disulfide bondi336 ↔ 378PROSITE-ProRule annotation
Disulfide bondi364 ↔ 389PROSITE-ProRule annotation
Disulfide bondi396 ↔ 439PROSITE-ProRule annotation
Disulfide bondi425 ↔ 450PROSITE-ProRule annotation
Disulfide bondi454 ↔ 505PROSITE-ProRule annotation
Disulfide bondi486 ↔ 515PROSITE-ProRule annotation
Disulfide bondi524 ↔ 567PROSITE-ProRule annotation
Glycosylationi545 – 5451N-linked (GlcNAc...)1 Publication
Disulfide bondi553 ↔ 578PROSITE-ProRule annotation
Disulfide bondi582 ↔ 636PROSITE-ProRule annotation
Disulfide bondi616 ↔ 646PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05160.
PeptideAtlasiP05160.
PRIDEiP05160.

PTM databases

PhosphoSiteiP05160.

Expressioni

Gene expression databases

BgeeiP05160.
CleanExiHS_F13B.
GenevestigatoriP05160.

Organism-specific databases

HPAiHPA003827.
HPA052139.

Interactioni

Subunit structurei

Tetramer of two A chains and two B chains.

Protein-protein interaction databases

BioGridi108463. 2 interactions.
STRINGi9606.ENSP00000356382.

Structurei

3D structure databases

ProteinModelPortaliP05160.
SMRiP05160. Positions 23-649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8865Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini89 – 14860Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 21060Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini211 – 26959Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini272 – 32958Sushi 5PROSITE-ProRule annotationAdd
BLAST
Domaini334 – 39158Sushi 6PROSITE-ProRule annotationAdd
BLAST
Domaini394 – 45259Sushi 7PROSITE-ProRule annotationAdd
BLAST
Domaini453 – 51664Sushi 8PROSITE-ProRule annotationAdd
BLAST
Domaini522 – 58059Sushi 9PROSITE-ProRule annotationAdd
BLAST
Domaini581 – 64767Sushi 10PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi617 – 6193Cell attachment site

Sequence similaritiesi

Contains 10 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG146710.
GeneTreeiENSGT00780000121907.
HOGENOMiHOG000049250.
HOVERGENiHBG005626.
InParanoidiP05160.
KOiK03906.
OMAiNFGWYPE.
OrthoDBiEOG7CNZF8.
PhylomeDBiP05160.
TreeFamiTF326157.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 8 hits.
[Graphical view]
SMARTiSM00032. CCP. 8 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 10 hits.
PROSITEiPS50923. SUSHI. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLKNLTFII ILIISGELYA EEKPCGFPHV ENGRIAQYYY TFKSFYFPMS
60 70 80 90 100
IDKKLSFFCL AGYTTESGRQ EEQTTCTTEG WSPEPRCFKK CTKPDLSNGY
110 120 130 140 150
ISDVKLLYKI QENMRYGCAS GYKTTGGKDE EVVQCLSDGW SSQPTCRKEH
160 170 180 190 200
ETCLAPELYN GNYSTTQKTF KVKDKVQYEC ATGYYTAGGK KTEEVECLTY
210 220 230 240 250
GWSLTPKCTK LKCSSLRLIE NGYFHPVKQT YEEGDVVQFF CHENYYLSGS
260 270 280 290 300
DLIQCYNFGW YPESPVCEGR RNRCPPPPLP INSKIQTHST TYRHGEIVHI
310 320 330 340 350
ECELNFEIHG SAEIRCEDGK WTEPPKCIEG QEKVACEEPP FIENGAANLH
360 370 380 390 400
SKIYYNGDKV TYACKSGYLL HGSNEITCNR GKWTLPPECV ENNENCKHPP
410 420 430 440 450
VVMNGAVADG ILASYATGSS VEYRCNEYYL LRGSKISRCE QGKWSSPPVC
460 470 480 490 500
LEPCTVNVDY MNRNNIEMKW KYEGKVLHGD LIDFVCKQGY DLSPLTPLSE
510 520 530 540 550
LSVQCNRGEV KYPLCTRKES KGMCTSPPLI KHGVIISSTV DTYENGSSVE
560 570 580 590 600
YRCFDHHFLE GSREAYCLDG MWTTPPLCLE PCTLSFTEME KNNLLLKWDF
610 620 630 640 650
DNRPHILHGE YIEFICRGDT YPAELYITGS ILRMQCDRGQ LKYPRCIPRQ
660
STLSYQEPLR T
Length:661
Mass (Da):75,511
Last modified:April 17, 2007 - v3
Checksum:i57A2FD2A0E35B812
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491M → V.1 Publication
Corresponds to variant rs6002 [ dbSNP | Ensembl ].
VAR_013930
Natural varianti115 – 1151R → H.4 Publications
Corresponds to variant rs6003 [ dbSNP | Ensembl ].
VAR_013931
Natural varianti342 – 3421I → T.1 Publication
Corresponds to variant rs17514281 [ dbSNP | Ensembl ].
VAR_020612
Natural varianti350 – 3501H → R.2 Publications
Corresponds to variant rs5999 [ dbSNP | Ensembl ].
VAR_013932
Natural varianti388 – 3881E → V.1 Publication
Corresponds to variant rs5991 [ dbSNP | Ensembl ].
VAR_013933
Natural varianti450 – 4501C → F in FA13BD. 1 Publication
VAR_007475
Natural varianti529 – 5291L → P.1 Publication
Corresponds to variant rs17549671 [ dbSNP | Ensembl ].
VAR_020613
Natural varianti543 – 5431Y → S.1 Publication
Corresponds to variant rs6001 [ dbSNP | Ensembl ].
VAR_013934
Natural varianti569 – 5691D → E.3 Publications
Corresponds to variant rs6000 [ dbSNP | Ensembl ].
VAR_013935

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64554 Genomic DNA. Translation: AAA51821.1. Sequence problems.
M14057 mRNA. Translation: AAA88042.1.
AK290560 mRNA. Translation: BAF83249.1.
AY692223 Genomic DNA. Translation: AAT85802.1.
AL353809 Genomic DNA. Translation: CAH72549.1.
X51823 mRNA. Translation: CAA36123.1.
CCDSiCCDS1388.1.
PIRiA36397. KFHU13.
RefSeqiNP_001985.2. NM_001994.2.
UniGeneiHs.435782.

Genome annotation databases

EnsembliENST00000367412; ENSP00000356382; ENSG00000143278.
GeneIDi2165.
KEGGihsa:2165.
UCSCiuc001gtt.1. human.

Polymorphism and mutation databases

BioMutaiF13B.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Factor XIII entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64554 Genomic DNA. Translation: AAA51821.1. Sequence problems.
M14057 mRNA. Translation: AAA88042.1.
AK290560 mRNA. Translation: BAF83249.1.
AY692223 Genomic DNA. Translation: AAT85802.1.
AL353809 Genomic DNA. Translation: CAH72549.1.
X51823 mRNA. Translation: CAA36123.1.
CCDSiCCDS1388.1.
PIRiA36397. KFHU13.
RefSeqiNP_001985.2. NM_001994.2.
UniGeneiHs.435782.

3D structure databases

ProteinModelPortaliP05160.
SMRiP05160. Positions 23-649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108463. 2 interactions.
STRINGi9606.ENSP00000356382.

PTM databases

PhosphoSiteiP05160.

Polymorphism and mutation databases

BioMutaiF13B.
DMDMi145559473.

Proteomic databases

PaxDbiP05160.
PeptideAtlasiP05160.
PRIDEiP05160.

Protocols and materials databases

DNASUi2165.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367412; ENSP00000356382; ENSG00000143278.
GeneIDi2165.
KEGGihsa:2165.
UCSCiuc001gtt.1. human.

Organism-specific databases

CTDi2165.
GeneCardsiGC01M197008.
H-InvDBHIX0028859.
HGNCiHGNC:3534. F13B.
HPAiHPA003827.
HPA052139.
MIMi134580. gene+phenotype.
613235. phenotype.
neXtProtiNX_P05160.
Orphaneti331. Congenital factor XIII deficiency.
PharmGKBiPA27944.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146710.
GeneTreeiENSGT00780000121907.
HOGENOMiHOG000049250.
HOVERGENiHBG005626.
InParanoidiP05160.
KOiK03906.
OMAiNFGWYPE.
OrthoDBiEOG7CNZF8.
PhylomeDBiP05160.
TreeFamiTF326157.

Enzyme and pathway databases

ReactomeiREACT_1439. Common Pathway.

Miscellaneous databases

GeneWikiiF13B.
GenomeRNAii2165.
NextBioi8743.
PROiP05160.
SOURCEiSearch...

Gene expression databases

BgeeiP05160.
CleanExiHS_F13B.
GenevestigatoriP05160.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 8 hits.
[Graphical view]
SMARTiSM00032. CCP. 8 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 10 hits.
PROSITEiPS50923. SUSHI. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the gene for the b subunit of human factor XIII."
    Bottenus R.E., Ichinose A., Davie E.W.
    Biochemistry 29:11195-11209(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-115.
  2. "Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments."
    Ichinose A., McMullen B.A., Fujikawa K., Davie E.W.
    Biochemistry 25:4633-4638(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-661, VARIANT HIS-115.
  3. Ichinose A.
    Submitted (FEB-1987) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-569.
    Tissue: Heart.
  5. SeattleSNPs variation discovery resource
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-115; THR-342; ARG-350; PRO-529 AND GLU-569.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Complete cDNA sequence encoding the B subunit of human factor XIII."
    Grundmann U., Nerlich C., Rein T., Zettlmeissl G.
    Nucleic Acids Res. 18:2817-2817(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-20.
    Tissue: Liver.
  8. "Truncated mutant B subunit for factor XIII causes its deficiency due to impaired intracellular transportation."
    Koseki S., Souri M., Koga S., Yamakawa M., Shichishima T., Maruyama Y., Yanai F., Ichinose A.
    Blood 97:2667-2672(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN FA13BD.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-545.
    Tissue: Plasma.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-162.
    Tissue: Liver.
  11. "Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII."
    Hashiguchi T., Saito M., Morishita E., Matsuda T., Ichinose A.
    Blood 82:145-150(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT FA13BD PHE-450.
  12. Cited for: VARIANTS VAL-49; HIS-115; ARG-350; VAL-388; SER-543 AND GLU-569.

Entry informationi

Entry nameiF13B_HUMAN
AccessioniPrimary (citable) accession number: P05160
Secondary accession number(s): A8K3E5, Q5VYL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 17, 2007
Last modified: April 29, 2015
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.