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Protein

ADP/ATP translocase 2

Gene

SLC25A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80NucleotideBy similarity1

GO - Molecular functioni

  • adenine transmembrane transporter activity Source: Reactome
  • poly(A) RNA binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • chromosome segregation Source: UniProtKB-KW
  • negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • regulation of insulin secretion Source: Reactome
  • transport Source: ProtInc
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Chromosome partition, Host-virus interaction, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000005022-MONOMER.
ReactomeiR-HSA-180897. Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.
R-HSA-422356. Regulation of insulin secretion.

Protein family/group databases

TCDBi2.A.29.1.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 2
Alternative name(s):
ADP,ATP carrier protein 2
ADP,ATP carrier protein, fibroblast isoform
Adenine nucleotide translocator 2
Short name:
ANT 2
Solute carrier family 25 member 5
Cleaved into the following chain:
Gene namesi
Name:SLC25A5
Synonyms:ANT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:10991. SLC25A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 39Helical; Name=1By similarityAdd BLAST35
Transmembranei75 – 100Helical; Name=2By similarityAdd BLAST26
Transmembranei109 – 143Helical; Name=3By similarityAdd BLAST35
Transmembranei176 – 202Helical; Name=4By similarityAdd BLAST27
Transmembranei207 – 241Helical; Name=5By similarityAdd BLAST35
Transmembranei273 – 298Helical; Name=6By similarityAdd BLAST26

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • mitochondrial inner membrane Source: Reactome
  • mitochondrial nucleoid Source: BHF-UCL
  • mitochondrion Source: UniProtKB
  • MMXD complex Source: UniProtKB
  • myelin sheath Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi292.
OpenTargetsiENSG00000005022.
PharmGKBiPA35867.

Chemistry databases

DrugBankiDB00720. Clodronate.

Polymorphism and mutation databases

BioMutaiSLC25A5.
DMDMi317373597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232201 – 298ADP/ATP translocase 2Add BLAST298
Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00000905792 – 298ADP/ATP translocase 2, N-terminally processedAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in ADP/ATP translocase 2, N-terminally processedCombined sources2 Publications1
Modified residuei23N6-malonyllysine1 Publication1
Modified residuei43N6-succinyllysineBy similarity1
Modified residuei52N6,N6,N6-trimethyllysine; alternateCombined sources1
Modified residuei52N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei52N6-methyllysine; alternate1 Publication1
Modified residuei92N6-malonyllysine1 Publication1
Modified residuei96N6-malonyllysine1 Publication1
Modified residuei105N6-acetyllysine; alternateCombined sources1
Modified residuei105N6-succinyllysine; alternateBy similarity1
Modified residuei147N6-acetyllysine; alternateBy similarity1
Modified residuei147N6-malonyllysine; alternate1 Publication1
Modified residuei147N6-methyllysine; alternateCombined sources1
Modified residuei147N6-succinyllysine; alternateBy similarity1
Modified residuei163N6-acetyllysineCombined sources1
Modified residuei166N6-acetyllysineBy similarity1
Modified residuei268N6-acetyllysine; alternateBy similarity1
Modified residuei268N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiP05141.
MaxQBiP05141.
PaxDbiP05141.
PeptideAtlasiP05141.
PRIDEiP05141.
TopDownProteomicsiP05141.

PTM databases

iPTMnetiP05141.
PhosphoSitePlusiP05141.
SwissPalmiP05141.

Expressioni

Gene expression databases

BgeeiENSG00000005022.
CleanExiHS_SLC25A5.
GenevisibleiP05141. HS.

Organism-specific databases

HPAiHPA060665.

Interactioni

Subunit structurei

Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with HIV-1 Vpr.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-355133,EBI-5323863
SIRT4Q9Y6E72EBI-355133,EBI-2606540
SLC35F6Q8N3572EBI-355133,EBI-713484

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi106789. 131 interactors.
DIPiDIP-33873N.
IntActiP05141. 81 interactors.
MINTiMINT-1162449.
STRINGi9606.ENSP00000360671.

Structurei

3D structure databases

ProteinModelPortaliP05141.
SMRiP05141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Substrate recognitionBy similarity6

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOVERGENiHBG108348.
InParanoidiP05141.
KOiK05863.
OMAiCFARTYK.
OrthoDBiEOG091G0ULB.
PhylomeDBiP05141.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDKRTQFW LYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKAGA
160 170 180 190 200
EREFRGLGDC LVKIYKSDGI KGLYQGFNVS VQGIIIYRAA YFGIYDTAKG
210 220 230 240 250
MLPDPKNTHI VISWMIAQTV TAVAGLTSYP FDTVRRRMMM QSGRKGTDIM
260 270 280 290
YTGTLDCWRK IARDEGGKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT
Length:298
Mass (Da):32,852
Last modified:January 11, 2011 - v7
Checksum:iDC53D083E7217AFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6V → L in AAA35579 (PubMed:3031073).Curated1
Sequence conflicti43K → M in BAG37698 (PubMed:14702039).Curated1
Sequence conflicti66G → E in AAA35579 (PubMed:3031073).Curated1
Sequence conflicti162V → G in AAA36749 (PubMed:2829183).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030039111L → R.4 PublicationsCorresponds to variant rs371749dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57424 Genomic DNA. Translation: AAA51737.1.
J02683 mRNA. Translation: AAA35579.1.
L78810 Genomic DNA. Translation: AAB39266.1.
AK315292 mRNA. Translation: BAG37698.1.
AC004000 Genomic DNA. Translation: AAB96347.1.
BC056160 mRNA. Translation: AAH56160.1.
J03591 mRNA. Translation: AAA36749.1.
CCDSiCCDS14578.1.
PIRiA29132.
RefSeqiNP_001143.2. NM_001152.4.
UniGeneiHs.632282.

Genome annotation databases

EnsembliENST00000317881; ENSP00000360671; ENSG00000005022.
GeneIDi292.
KEGGihsa:292.
UCSCiuc004erh.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57424 Genomic DNA. Translation: AAA51737.1.
J02683 mRNA. Translation: AAA35579.1.
L78810 Genomic DNA. Translation: AAB39266.1.
AK315292 mRNA. Translation: BAG37698.1.
AC004000 Genomic DNA. Translation: AAB96347.1.
BC056160 mRNA. Translation: AAH56160.1.
J03591 mRNA. Translation: AAA36749.1.
CCDSiCCDS14578.1.
PIRiA29132.
RefSeqiNP_001143.2. NM_001152.4.
UniGeneiHs.632282.

3D structure databases

ProteinModelPortaliP05141.
SMRiP05141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106789. 131 interactors.
DIPiDIP-33873N.
IntActiP05141. 81 interactors.
MINTiMINT-1162449.
STRINGi9606.ENSP00000360671.

Chemistry databases

DrugBankiDB00720. Clodronate.

Protein family/group databases

TCDBi2.A.29.1.1. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiP05141.
PhosphoSitePlusiP05141.
SwissPalmiP05141.

Polymorphism and mutation databases

BioMutaiSLC25A5.
DMDMi317373597.

Proteomic databases

EPDiP05141.
MaxQBiP05141.
PaxDbiP05141.
PeptideAtlasiP05141.
PRIDEiP05141.
TopDownProteomicsiP05141.

Protocols and materials databases

DNASUi292.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317881; ENSP00000360671; ENSG00000005022.
GeneIDi292.
KEGGihsa:292.
UCSCiuc004erh.5. human.

Organism-specific databases

CTDi292.
DisGeNETi292.
GeneCardsiSLC25A5.
H-InvDBHIX0028379.
HGNCiHGNC:10991. SLC25A5.
HPAiHPA060665.
MIMi300150. gene.
neXtProtiNX_P05141.
OpenTargetsiENSG00000005022.
PharmGKBiPA35867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOVERGENiHBG108348.
InParanoidiP05141.
KOiK05863.
OMAiCFARTYK.
OrthoDBiEOG091G0ULB.
PhylomeDBiP05141.
TreeFamiTF300743.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000005022-MONOMER.
ReactomeiR-HSA-180897. Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.
R-HSA-422356. Regulation of insulin secretion.

Miscellaneous databases

ChiTaRSiSLC25A5. human.
GenomeRNAii292.
PROiP05141.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000005022.
CleanExiHS_SLC25A5.
GenevisibleiP05141. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADT2_HUMAN
AccessioniPrimary (citable) accession number: P05141
Secondary accession number(s): B2RCV1, O43350
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 190 of the entry and version 7 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.