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P05141

- ADT2_HUMAN

UniProt

P05141 - ADT2_HUMAN

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Protein

ADP/ATP translocase 2

Gene

SLC25A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801NucleotideBy similarity

GO - Molecular functioni

  1. adenine transmembrane transporter activity Source: ProtInc
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. adenine transport Source: GOC
  2. chromosome segregation Source: UniProtKB-KW
  3. energy reserve metabolic process Source: Reactome
  4. negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
  5. positive regulation of cell proliferation Source: UniProtKB
  6. regulation of insulin secretion Source: Reactome
  7. small molecule metabolic process Source: Reactome
  8. transport Source: ProtInc
  9. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Chromosome partition, Host-virus interaction, Transport

Enzyme and pathway databases

ReactomeiREACT_18325. Regulation of insulin secretion.
REACT_8016. Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.

Protein family/group databases

TCDBi2.A.29.1.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 2
Alternative name(s):
ADP,ATP carrier protein 2
ADP,ATP carrier protein, fibroblast isoform
Adenine nucleotide translocator 2
Short name:
ANT 2
Solute carrier family 25 member 5
Cleaved into the following chain:
Gene namesi
Name:SLC25A5
Synonyms:ANT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:10991. SLC25A5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: UniProtKB
  4. mitochondrial inner membrane Source: Reactome
  5. mitochondrial nucleoid Source: BHF-UCL
  6. mitochondrion Source: UniProt
  7. MMXD complex Source: UniProtKB
  8. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298ADP/ATP translocase 2PRO_0000423220Add
BLAST
Initiator methioninei1 – 11Removed; alternate3 Publications
Chaini2 – 298297ADP/ATP translocase 2, N-terminally processedPRO_0000090579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei2 – 21N-acetylthreonine; in ADP/ATP translocase 2, N-terminally processed4 Publications
Modified residuei23 – 231N6-malonyllysine1 Publication
Modified residuei43 – 431N6-succinyllysineBy similarity
Modified residuei52 – 521N6,N6-dimethyllysine; alternate1 Publication
Modified residuei52 – 521N6-methyllysine; alternate1 Publication
Modified residuei92 – 921N6-malonyllysine1 Publication
Modified residuei96 – 961N6-malonyllysine1 Publication
Modified residuei105 – 1051N6-acetyllysine; alternate1 Publication
Modified residuei105 – 1051N6-succinyllysine; alternateBy similarity
Modified residuei147 – 1471N6-acetyllysine; alternateBy similarity
Modified residuei147 – 1471N6-malonyllysine; alternate1 Publication
Modified residuei147 – 1471N6-succinyllysine; alternateBy similarity
Modified residuei163 – 1631N6-acetyllysine1 Publication
Modified residuei166 – 1661N6-acetyllysineBy similarity
Modified residuei268 – 2681N6-acetyllysine; alternateBy similarity
Modified residuei268 – 2681N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

MaxQBiP05141.
PaxDbiP05141.
PRIDEiP05141.

PTM databases

PhosphoSiteiP05141.

Expressioni

Gene expression databases

BgeeiP05141.
CleanExiHS_SLC25A5.
ExpressionAtlasiP05141. baseline and differential.
GenevestigatoriP05141.

Interactioni

Subunit structurei

Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with HIV-1 Vpr.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-355133,EBI-5323863
SIRT4Q9Y6E72EBI-355133,EBI-2606540
SLC35F6Q8N3572EBI-355133,EBI-713484

Protein-protein interaction databases

BioGridi106789. 98 interactions.
DIPiDIP-33873N.
IntActiP05141. 63 interactions.
MINTiMINT-1162449.
STRINGi9606.ENSP00000360671.

Structurei

3D structure databases

ProteinModelPortaliP05141.
SMRiP05141. Positions 2-294.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 3935Helical; Name=1By similarityAdd
BLAST
Transmembranei75 – 10026Helical; Name=2By similarityAdd
BLAST
Transmembranei109 – 14335Helical; Name=3By similarityAdd
BLAST
Transmembranei176 – 20227Helical; Name=4By similarityAdd
BLAST
Transmembranei207 – 24135Helical; Name=5By similarityAdd
BLAST
Transmembranei273 – 29826Helical; Name=6By similarityAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 9893Solcar 1Add
BLAST
Repeati111 – 20191Solcar 2Add
BLAST
Repeati212 – 29786Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi235 – 2406Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238123.
GeneTreeiENSGT00390000011543.
HOVERGENiHBG108348.
InParanoidiP05141.
KOiK05863.
OMAiSSYSAMN.
OrthoDBiEOG7T1RBR.
PhylomeDBiP05141.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05141 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDKRTQFW LYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKAGA
160 170 180 190 200
EREFRGLGDC LVKIYKSDGI KGLYQGFNVS VQGIIIYRAA YFGIYDTAKG
210 220 230 240 250
MLPDPKNTHI VISWMIAQTV TAVAGLTSYP FDTVRRRMMM QSGRKGTDIM
260 270 280 290
YTGTLDCWRK IARDEGGKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT
Length:298
Mass (Da):32,852
Last modified:January 11, 2011 - v7
Checksum:iDC53D083E7217AFE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61V → L in AAA35579. (PubMed:3031073)Curated
Sequence conflicti43 – 431K → M in BAG37698. (PubMed:14702039)Curated
Sequence conflicti66 – 661G → E in AAA35579. (PubMed:3031073)Curated
Sequence conflicti162 – 1621V → G in AAA36749. (PubMed:2829183)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111L → R.4 Publications
Corresponds to variant rs371749 [ dbSNP | Ensembl ].
VAR_030039

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57424 Genomic DNA. Translation: AAA51737.1.
J02683 mRNA. Translation: AAA35579.1.
L78810 Genomic DNA. Translation: AAB39266.1.
AK315292 mRNA. Translation: BAG37698.1.
AC004000 Genomic DNA. Translation: AAB96347.1.
BC056160 mRNA. Translation: AAH56160.1.
J03591 mRNA. Translation: AAA36749.1.
CCDSiCCDS14578.1.
PIRiA29132.
RefSeqiNP_001143.2. NM_001152.4.
UniGeneiHs.632282.

Genome annotation databases

EnsembliENST00000317881; ENSP00000360671; ENSG00000005022.
GeneIDi292.
KEGGihsa:292.
UCSCiuc004erh.4. human.

Polymorphism databases

DMDMi317373597.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57424 Genomic DNA. Translation: AAA51737.1 .
J02683 mRNA. Translation: AAA35579.1 .
L78810 Genomic DNA. Translation: AAB39266.1 .
AK315292 mRNA. Translation: BAG37698.1 .
AC004000 Genomic DNA. Translation: AAB96347.1 .
BC056160 mRNA. Translation: AAH56160.1 .
J03591 mRNA. Translation: AAA36749.1 .
CCDSi CCDS14578.1.
PIRi A29132.
RefSeqi NP_001143.2. NM_001152.4.
UniGenei Hs.632282.

3D structure databases

ProteinModelPortali P05141.
SMRi P05141. Positions 2-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106789. 98 interactions.
DIPi DIP-33873N.
IntActi P05141. 63 interactions.
MINTi MINT-1162449.
STRINGi 9606.ENSP00000360671.

Chemistry

DrugBanki DB00720. Clodronate.

Protein family/group databases

TCDBi 2.A.29.1.1. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitei P05141.

Polymorphism databases

DMDMi 317373597.

Proteomic databases

MaxQBi P05141.
PaxDbi P05141.
PRIDEi P05141.

Protocols and materials databases

DNASUi 292.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317881 ; ENSP00000360671 ; ENSG00000005022 .
GeneIDi 292.
KEGGi hsa:292.
UCSCi uc004erh.4. human.

Organism-specific databases

CTDi 292.
GeneCardsi GC0XP118602.
H-InvDB HIX0028379.
HGNCi HGNC:10991. SLC25A5.
MIMi 300150. gene.
neXtProti NX_P05141.
PharmGKBi PA35867.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238123.
GeneTreei ENSGT00390000011543.
HOVERGENi HBG108348.
InParanoidi P05141.
KOi K05863.
OMAi SSYSAMN.
OrthoDBi EOG7T1RBR.
PhylomeDBi P05141.
TreeFami TF300743.

Enzyme and pathway databases

Reactomei REACT_18325. Regulation of insulin secretion.
REACT_8016. Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.

Miscellaneous databases

ChiTaRSi SLC25A5. human.
GenomeRNAii 292.
NextBioi 1191.
PROi P05141.
SOURCEi Search...

Gene expression databases

Bgeei P05141.
CleanExi HS_SLC25A5.
ExpressionAtlasi P05141. baseline and differential.
Genevestigatori P05141.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence."
    Ku D.-H., Kagan J., Chen S.-T., Chang C.-D., Baserga R., Wurzel J.
    J. Biol. Chem. 265:16060-16063(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-111.
    Tissue: Placenta.
  2. "Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated."
    Battini R., Ferrari S., Kaczmarek L., Calabretta B., Chen S.T., Baserga R.
    J. Biol. Chem. 262:4355-4358(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-111.
  3. "Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches."
    Chen C.N., Su Y., Baybayan P., Siruno A., Nagaraja R., Mazzarella R., Schlessinger D., Chen E.
    Nucleic Acids Res. 24:4034-4041(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-111.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-111.
    Tissue: Eye.
  7. Bienvenut W.V.
    Submitted (OCT-2004) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-31; 34-43; 64-92; 141-147; 189-199 AND 273-296, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  8. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-23; 32-43; 50-60; 64-92; 81-92; 97-106; 112-138; 172-199; 207-235; 245-259 AND 281-295, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, METHYLATION AT LYS-52, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic kidney.
  9. "Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver."
    Houldsworth J., Attardi G.
    Proc. Natl. Acad. Sci. U.S.A. 85:377-381(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-297.
    Tissue: Liver.
  10. "Mitochondrial membrane permeabilization by HIV-1 Vpr."
    Deniaud A., Brenner C., Kroemer G.
    Mitochondrion 4:223-233(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIV-1 VPR.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-105 AND LYS-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation."
    Ito S., Tan L.J., Andoh D., Narita T., Seki M., Hirano Y., Narita K., Kuraoka I., Hiraoka Y., Tanaka K.
    Mol. Cell 39:632-640(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN MMXD COMPLEX.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: MALONYLATION AT LYS-23; LYS-92; LYS-96 AND LYS-147.
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADT2_HUMAN
AccessioniPrimary (citable) accession number: P05141
Secondary accession number(s): B2RCV1, O43350
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 169 of the entry and version 7 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3