P05130 (KPC1_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 129.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein kinase C, brain isozyme Short name=PKC EC=2.7.11.13 Alternative name(s): dPKC53E(BR) | ||||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 679 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Tissue specificity | Head neural tissue. |
| Miscellaneous | This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. The sequence shown is that of Oregon-R. |
| Sequence similarities | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 C2 domain. Contains 2 phorbol-ester/DAG-type zinc fingers. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Domain | Repeat Zinc-finger |
| Ligand | ATP-binding Calcium Metal-binding Nucleotide-binding Zinc |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | intracellular signal transduction Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase C activityInferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform Long (identifier: P05130-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Short (identifier: P05130-2) The sequence of this isoform differs from the canonical sequence as follows: 67-77: CGYQSGYAWMG → WG | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 679 | 679 | Protein kinase C, brain isozyme | PRO_0000055730 | |||||
Regions | |||||||||
| Domain | 191 – 278 | 88 | C2 | ||||||
| Domain | 350 – 608 | 259 | Protein kinase | ||||||
| Domain | 609 – 679 | 71 | AGC-kinase C-terminal | ||||||
| Zinc finger | 45 – 104 | 60 | Phorbol-ester/DAG-type 1 | ||||||
| Zinc finger | 119 – 169 | 51 | Phorbol-ester/DAG-type 2 | ||||||
| Nucleotide binding | 356 – 364 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 474 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 379 | 1 | ATP By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 67 – 77 | 11 | CGYQSGYAWMG → WG in isoform Short. | VSP_004743 | |||||
| Natural variant | 437 | 1 | M → I. | ||||||
Experimental info | |||||||||
| Sequence conflict | 608 | 1 | F → S in CAA28736. Ref.1 | ||||||
| Sequence conflict | 608 | 1 | F → S in CAA28890. Ref.1 | ||||||
| Sequence conflict | 634 – 648 | 15 | DVSNF…SEKTD → MCPTLTSSSHQRKQT Ref.1 | ||||||
| Sequence conflict | 649 – 679 | 31 | Missing Ref.1 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X05076 mRNA. Translation: CAA28736.1. X05279 X05283 Genomic DNA. Translation: CAA28890.2.AE013599 Genomic DNA. Translation: AAF57932.1. AE013599 Genomic DNA. Translation: AAF57933.1. AY095003 mRNA. Translation: AAM11331.1. |
| PIR | A32545. |
| RefSeq | NP_476682.1. NM_057334.2. NP_725626.1. NM_166201.1. |
| UniGene | Dm.3632. |
3D structure databases | |
| ProteinModelPortal | P05130. |
| SMR | P05130. Positions 46-676. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P05130. 1 interaction. |
| STRING | P05130. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0087048; FBpp0086197; FBgn0003091. |
| GeneID | 48311. |
| KEGG | dme:Dmel_CG6622. |
Organism-specific databases | |
| CTD | 48311. |
| FlyBase | FBgn0003091. Pkc53E. |
Phylogenomic databases | |
| eggNOG | inNOG09369. |
| GeneTree | EMGT00050000001097. |
| InParanoid | P05130. |
| OMA | YNINITP. |
| OrthoDB | EOG4H189V. |
| PhylomeDB | P05130. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.13. 1994. |
Gene expression databases | |
| Bgee | P05130. |
| GermOnline | CG6622. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR000961. AGC-kinase_C. IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR020477. C2_dom. IPR018029. C2_membr_targeting. IPR020454. DAG/PE-bd. IPR011009. Kinase-like_dom. IPR017892. Pkinase_C. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR014375. Protein_kinase_C_a/b/g. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view] |
| KO | K02677. |
| Pfam | PF00130. C1_1. 2 hits. PF00168. C2. 1 hit. PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view] |
| PIRSF | PIRSF000550. PKC_alpha. 1 hit. |
| PRINTS | PR00360. C2DOMAIN. PR00008. DAGPEDOMAIN. |
| SMART | SM00109. C1. 2 hits. SM00239. C2. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view] |
| SUPFAM | SSF49562. C2_CaLB. 1 hit. SSF56112. Kinase_like. 1 hit. |
| PROSITE | PS51285. AGC_KINASE_CTER. 1 hit. PS50004. C2. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 839293. |
Entry information
| Entry name | KPC1_DROME | ||||||||
| Accession | Primary (citable) accession number: P05130 Secondary accession number(s): Q9V7V6, Q9V7V7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with