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Protein

Plasminogen activator inhibitor 2

Gene

SERPINB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei380 – 381Reactive bond2

GO - Molecular functioni

GO - Biological processi

  • fibrinolysis Source: Reactome
  • negative regulation of apoptotic process Source: ProtInc
  • wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Plasminogen activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166401-MONOMER.
ReactomeiR-HSA-75205. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 2
Short name:
PAI-2
Alternative name(s):
Monocyte Arg-serpin
Placental plasminogen activator inhibitor
Serpin B2
Urokinase inhibitor
Gene namesi
Name:SERPINB2
Synonyms:PAI2, PLANH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:8584. SERPINB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5055.
OpenTargetsiENSG00000197632.
PharmGKBiPA35500.

Chemistry databases

DrugBankiDB00031. Tenecteplase.
DB00013. Urokinase.

Polymorphism and mutation databases

BioMutaiSERPINB2.
DMDMi1352712.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232961 – 415Plasminogen activator inhibitor 2Add BLAST415
Signal peptidei1 – ?Not cleaved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 405
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi339N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The signal sequence is not cleaved.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP05120.
MaxQBiP05120.
PaxDbiP05120.
PeptideAtlasiP05120.
PRIDEiP05120.

PTM databases

iPTMnetiP05120.
PhosphoSitePlusiP05120.
SwissPalmiP05120.

Expressioni

Gene expression databases

BgeeiENSG00000197632.
CleanExiHS_SERPINB2.
ExpressionAtlasiP05120. baseline and differential.
GenevisibleiP05120. HS.

Organism-specific databases

HPAiHPA015480.

Interactioni

Subunit structurei

Interacts with PSMB1.1 Publication

Protein-protein interaction databases

BioGridi111092. 53 interactors.
IntActiP05120. 1 interactor.
MINTiMINT-270968.
STRINGi9606.ENSP00000299502.

Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 22Combined sources17
Beta strandi24 – 26Combined sources3
Beta strandi28 – 30Combined sources3
Helixi32 – 45Combined sources14
Helixi48 – 57Combined sources10
Turni58 – 62Combined sources5
Helixi100 – 102Combined sources3
Helixi103 – 115Combined sources13
Beta strandi122 – 132Combined sources11
Helixi139 – 149Combined sources11
Beta strandi154 – 156Combined sources3
Helixi158 – 176Combined sources19
Turni177 – 179Combined sources3
Beta strandi194 – 205Combined sources12
Beta strandi208 – 210Combined sources3
Beta strandi220 – 225Combined sources6
Beta strandi228 – 232Combined sources5
Beta strandi234 – 246Combined sources13
Helixi247 – 249Combined sources3
Beta strandi251 – 269Combined sources19
Beta strandi275 – 278Combined sources4
Helixi280 – 285Combined sources6
Helixi288 – 295Combined sources8
Turni297 – 299Combined sources3
Beta strandi301 – 310Combined sources10
Beta strandi312 – 319Combined sources8
Helixi321 – 327Combined sources7
Helixi331 – 333Combined sources3
Turni335 – 337Combined sources3
Turni341 – 343Combined sources3
Beta strandi349 – 362Combined sources14
Beta strandi368 – 379Combined sources12
Beta strandi387 – 389Combined sources3
Beta strandi394 – 400Combined sources7
Turni401 – 404Combined sources4
Beta strandi405 – 412Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY7X-ray2.00A1-415[»]
1JRRX-ray1.60A1-415[»]
P367-380[»]
2ARQX-ray1.85A1-415[»]
P367-380[»]
2ARRX-ray1.55A1-415[»]
P367-380[»]
ProteinModelPortaliP05120.
SMRiP05120.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05120.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP05120.
KOiK19821.
OMAiEDLCVAN.
OrthoDBiEOG091G0ION.
PhylomeDBiP05120.
TreeFamiTF352619.

Family and domain databases

InterProiIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 2 hits.
PTHR11461:SF61. PTHR11461:SF61. 2 hits.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST
60 70 80 90 100
EDQMAKVLQF NEVGANAVTP MTPENFTSCG FMQQIQKGSY PDAILQAQAA
110 120 130 140 150
DKIHSSFRSL SSAINASTGN YLLESVNKLF GEKSASFREE YIRLCQKYYS
160 170 180 190 200
SEPQAVDFLE CAEEARKKIN SWVKTQTKGK IPNLLPEGSV DGDTRMVLVN
210 220 230 240 250
AVYFKGKWKT PFEKKLNGLY PFRVNSAQRT PVQMMYLREK LNIGYIEDLK
260 270 280 290 300
AQILELPYAG DVSMFLLLPD EIADVSTGLE LLESEITYDK LNKWTSKDKM
310 320 330 340 350
AEDEVEVYIP QFKLEEHYEL RSILRSMGME DAFNKGRANF SGMSERNDLF
360 370 380 390 400
LSEVFHQAMV DVNEEGTEAA AGTGGVMTGR TGHGGPQFVA DHPFLFLIMH
410
KITNCILFFG RFSSP
Length:415
Mass (Da):46,596
Last modified:February 1, 1996 - v2
Checksum:i10DFAB5A4B1246FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170N → Y in AAH12609 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011743120N → D.1 PublicationCorresponds to variant rs6098dbSNPEnsembl.1
Natural variantiVAR_014173229R → H.1 PublicationCorresponds to variant rs6100dbSNPEnsembl.1
Natural variantiVAR_051946374G → A.Corresponds to variant rs34066931dbSNPEnsembl.1
Natural variantiVAR_011744404N → K.1 PublicationCorresponds to variant rs6103dbSNPEnsembl.1
Natural variantiVAR_011745413S → C.1 PublicationCorresponds to variant rs6104dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02685 mRNA. Translation: AAA36413.1.
M18082 mRNA. Translation: AAA60006.1.
Y00630 mRNA. Translation: CAA68666.1.
J03603 mRNA. Translation: AAA60004.1.
M24657
, M24651, M24652, M24653, M24654, M24655, M24656 Genomic DNA. Translation: AAA60348.1.
M31551
, M31547, M31548, M31549, M31550 Genomic DNA. Translation: AAA36797.1.
BC012609 mRNA. Translation: AAH12609.1.
CCDSiCCDS11989.1.
PIRiA32853.
RefSeqiNP_001137290.1. NM_001143818.1.
NP_002566.1. NM_002575.2.
UniGeneiHs.594481.

Genome annotation databases

EnsembliENST00000299502; ENSP00000299502; ENSG00000197632.
ENST00000457692; ENSP00000401645; ENSG00000197632.
GeneIDi5055.
KEGGihsa:5055.
UCSCiuc002ljo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02685 mRNA. Translation: AAA36413.1.
M18082 mRNA. Translation: AAA60006.1.
Y00630 mRNA. Translation: CAA68666.1.
J03603 mRNA. Translation: AAA60004.1.
M24657
, M24651, M24652, M24653, M24654, M24655, M24656 Genomic DNA. Translation: AAA60348.1.
M31551
, M31547, M31548, M31549, M31550 Genomic DNA. Translation: AAA36797.1.
BC012609 mRNA. Translation: AAH12609.1.
CCDSiCCDS11989.1.
PIRiA32853.
RefSeqiNP_001137290.1. NM_001143818.1.
NP_002566.1. NM_002575.2.
UniGeneiHs.594481.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY7X-ray2.00A1-415[»]
1JRRX-ray1.60A1-415[»]
P367-380[»]
2ARQX-ray1.85A1-415[»]
P367-380[»]
2ARRX-ray1.55A1-415[»]
P367-380[»]
ProteinModelPortaliP05120.
SMRiP05120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111092. 53 interactors.
IntActiP05120. 1 interactor.
MINTiMINT-270968.
STRINGi9606.ENSP00000299502.

Chemistry databases

DrugBankiDB00031. Tenecteplase.
DB00013. Urokinase.

Protein family/group databases

MEROPSiI04.007.

PTM databases

iPTMnetiP05120.
PhosphoSitePlusiP05120.
SwissPalmiP05120.

Polymorphism and mutation databases

BioMutaiSERPINB2.
DMDMi1352712.

Proteomic databases

EPDiP05120.
MaxQBiP05120.
PaxDbiP05120.
PeptideAtlasiP05120.
PRIDEiP05120.

Protocols and materials databases

DNASUi5055.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299502; ENSP00000299502; ENSG00000197632.
ENST00000457692; ENSP00000401645; ENSG00000197632.
GeneIDi5055.
KEGGihsa:5055.
UCSCiuc002ljo.4. human.

Organism-specific databases

CTDi5055.
DisGeNETi5055.
GeneCardsiSERPINB2.
H-InvDBHIX0212740.
HGNCiHGNC:8584. SERPINB2.
HPAiHPA015480.
MIMi173390. gene.
neXtProtiNX_P05120.
OpenTargetsiENSG00000197632.
PharmGKBiPA35500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP05120.
KOiK19821.
OMAiEDLCVAN.
OrthoDBiEOG091G0ION.
PhylomeDBiP05120.
TreeFamiTF352619.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166401-MONOMER.
ReactomeiR-HSA-75205. Dissolution of Fibrin Clot.

Miscellaneous databases

ChiTaRSiSERPINB2. human.
EvolutionaryTraceiP05120.
GeneWikiiPlasminogen_activator_inhibitor-2.
GenomeRNAii5055.
PROiP05120.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197632.
CleanExiHS_SERPINB2.
ExpressionAtlasiP05120. baseline and differential.
GenevisibleiP05120. HS.

Family and domain databases

InterProiIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 2 hits.
PTHR11461:SF61. PTHR11461:SF61. 2 hits.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAI2_HUMAN
AccessioniPrimary (citable) accession number: P05120
Secondary accession number(s): Q96E96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 181 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.