SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P05120

- PAI2_HUMAN

UniProt

P05120 - PAI2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Plasminogen activator inhibitor 2

Gene
SERPINB2, PAI2, PLANH2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei380 – 3812Reactive bond

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. fibrinolysis Source: Reactome
  3. negative regulation of apoptotic process Source: ProtInc
  4. negative regulation of endopeptidase activity Source: RefGenome
  5. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Plasminogen activation

Enzyme and pathway databases

ReactomeiREACT_641. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 2
Short name:
PAI-2
Alternative name(s):
Monocyte Arg-serpin
Placental plasminogen activator inhibitor
Serpin B2
Urokinase inhibitor
Gene namesi
Synonyms:PAI2, PLANH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:8584. SERPINB2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB-SubCell
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Plasminogen activator inhibitor 2PRO_0000223296Add
BLAST
Signal peptidei1 – ?Not cleaved

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 405
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi115 – 1151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi339 – 3391N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The signal sequence is not cleaved.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP05120.
PaxDbiP05120.
PRIDEiP05120.

PTM databases

PhosphoSiteiP05120.

Expressioni

Gene expression databases

ArrayExpressiP05120.
BgeeiP05120.
CleanExiHS_SERPINB2.
GenevestigatoriP05120.

Organism-specific databases

HPAiHPA015480.

Interactioni

Subunit structurei

Interacts with PSMB1.1 Publication

Protein-protein interaction databases

BioGridi111092. 6 interactions.
IntActiP05120. 1 interaction.
MINTiMINT-270968.
STRINGi9606.ENSP00000299502.

Structurei

Secondary structure

1
415
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 2217
Beta strandi24 – 263
Beta strandi28 – 303
Helixi32 – 4514
Helixi48 – 5710
Turni58 – 625
Helixi100 – 1023
Helixi103 – 11513
Beta strandi122 – 13211
Helixi139 – 14911
Beta strandi154 – 1563
Helixi158 – 17619
Turni177 – 1793
Beta strandi194 – 20512
Beta strandi208 – 2103
Beta strandi220 – 2256
Beta strandi228 – 2325
Beta strandi234 – 24613
Helixi247 – 2493
Beta strandi251 – 26919
Beta strandi275 – 2784
Helixi280 – 2856
Helixi288 – 2958
Turni297 – 2993
Beta strandi301 – 31010
Beta strandi312 – 3198
Helixi321 – 3277
Helixi331 – 3333
Turni335 – 3373
Turni341 – 3433
Beta strandi349 – 36214
Beta strandi368 – 37912
Beta strandi387 – 3893
Beta strandi394 – 4007
Turni401 – 4044
Beta strandi405 – 4128

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BY7X-ray2.00A1-415[»]
1JRRX-ray1.60A1-415[»]
P367-380[»]
2ARQX-ray1.85A1-415[»]
P367-380[»]
2ARRX-ray1.55A1-415[»]
P367-380[»]
ProteinModelPortaliP05120.
SMRiP05120. Positions 3-415.

Miscellaneous databases

EvolutionaryTraceiP05120.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP05120.
KOiK13963.
OMAiLFLIMHK.
PhylomeDBiP05120.
TreeFamiTF352619.

Family and domain databases

InterProiIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF61. PTHR11461:SF61. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05120-1 [UniParc]FASTAAdd to Basket

« Hide

MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST    50
EDQMAKVLQF NEVGANAVTP MTPENFTSCG FMQQIQKGSY PDAILQAQAA 100
DKIHSSFRSL SSAINASTGN YLLESVNKLF GEKSASFREE YIRLCQKYYS 150
SEPQAVDFLE CAEEARKKIN SWVKTQTKGK IPNLLPEGSV DGDTRMVLVN 200
AVYFKGKWKT PFEKKLNGLY PFRVNSAQRT PVQMMYLREK LNIGYIEDLK 250
AQILELPYAG DVSMFLLLPD EIADVSTGLE LLESEITYDK LNKWTSKDKM 300
AEDEVEVYIP QFKLEEHYEL RSILRSMGME DAFNKGRANF SGMSERNDLF 350
LSEVFHQAMV DVNEEGTEAA AGTGGVMTGR TGHGGPQFVA DHPFLFLIMH 400
KITNCILFFG RFSSP 415
Length:415
Mass (Da):46,596
Last modified:February 1, 1996 - v2
Checksum:i10DFAB5A4B1246FF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201N → D.1 Publication
Corresponds to variant rs6098 [ dbSNP | Ensembl ].
VAR_011743
Natural varianti229 – 2291R → H.1 Publication
Corresponds to variant rs6100 [ dbSNP | Ensembl ].
VAR_014173
Natural varianti374 – 3741G → A.
Corresponds to variant rs34066931 [ dbSNP | Ensembl ].
VAR_051946
Natural varianti404 – 4041N → K.1 Publication
Corresponds to variant rs6103 [ dbSNP | Ensembl ].
VAR_011744
Natural varianti413 – 4131S → C.1 Publication
Corresponds to variant rs6104 [ dbSNP | Ensembl ].
VAR_011745

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701N → Y in AAH12609. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02685 mRNA. Translation: AAA36413.1.
M18082 mRNA. Translation: AAA60006.1.
Y00630 mRNA. Translation: CAA68666.1.
J03603 mRNA. Translation: AAA60004.1.
M24657
, M24651, M24652, M24653, M24654, M24655, M24656 Genomic DNA. Translation: AAA60348.1.
M31551
, M31547, M31548, M31549, M31550 Genomic DNA. Translation: AAA36797.1.
BC012609 mRNA. Translation: AAH12609.1.
CCDSiCCDS11989.1.
PIRiA32853.
RefSeqiNP_001137290.1. NM_001143818.1.
NP_002566.1. NM_002575.2.
UniGeneiHs.594481.

Genome annotation databases

EnsembliENST00000299502; ENSP00000299502; ENSG00000197632.
ENST00000457692; ENSP00000401645; ENSG00000197632.
GeneIDi5055.
KEGGihsa:5055.
UCSCiuc002ljo.3. human.

Polymorphism databases

DMDMi1352712.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02685 mRNA. Translation: AAA36413.1 .
M18082 mRNA. Translation: AAA60006.1 .
Y00630 mRNA. Translation: CAA68666.1 .
J03603 mRNA. Translation: AAA60004.1 .
M24657
, M24651 , M24652 , M24653 , M24654 , M24655 , M24656 Genomic DNA. Translation: AAA60348.1 .
M31551
, M31547 , M31548 , M31549 , M31550 Genomic DNA. Translation: AAA36797.1 .
BC012609 mRNA. Translation: AAH12609.1 .
CCDSi CCDS11989.1.
PIRi A32853.
RefSeqi NP_001137290.1. NM_001143818.1.
NP_002566.1. NM_002575.2.
UniGenei Hs.594481.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BY7 X-ray 2.00 A 1-415 [» ]
1JRR X-ray 1.60 A 1-415 [» ]
P 367-380 [» ]
2ARQ X-ray 1.85 A 1-415 [» ]
P 367-380 [» ]
2ARR X-ray 1.55 A 1-415 [» ]
P 367-380 [» ]
ProteinModelPortali P05120.
SMRi P05120. Positions 3-415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111092. 6 interactions.
IntActi P05120. 1 interaction.
MINTi MINT-270968.
STRINGi 9606.ENSP00000299502.

Chemistry

DrugBanki DB00009. Alteplase.
DB00029. Anistreplase.
DB00015. Reteplase.
DB00031. Tenecteplase.
DB00013. Urokinase.

Protein family/group databases

MEROPSi I04.007.

PTM databases

PhosphoSitei P05120.

Polymorphism databases

DMDMi 1352712.

Proteomic databases

MaxQBi P05120.
PaxDbi P05120.
PRIDEi P05120.

Protocols and materials databases

DNASUi 5055.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299502 ; ENSP00000299502 ; ENSG00000197632 .
ENST00000457692 ; ENSP00000401645 ; ENSG00000197632 .
GeneIDi 5055.
KEGGi hsa:5055.
UCSCi uc002ljo.3. human.

Organism-specific databases

CTDi 5055.
GeneCardsi GC18P061528.
H-InvDB HIX0212740.
HGNCi HGNC:8584. SERPINB2.
HPAi HPA015480.
MIMi 173390. gene.
neXtProti NX_P05120.
PharmGKBi PA35500.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi P05120.
KOi K13963.
OMAi LFLIMHK.
PhylomeDBi P05120.
TreeFami TF352619.

Enzyme and pathway databases

Reactomei REACT_641. Dissolution of Fibrin Clot.

Miscellaneous databases

ChiTaRSi SERPINB2. human.
EvolutionaryTracei P05120.
GeneWikii Plasminogen_activator_inhibitor-2.
GenomeRNAii 5055.
NextBioi 19484.
PROi P05120.
SOURCEi Search...

Gene expression databases

ArrayExpressi P05120.
Bgeei P05120.
CleanExi HS_SERPINB2.
Genevestigatori P05120.

Family and domain databases

InterProi IPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
PTHR11461:SF61. PTHR11461:SF61. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 2 hits.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta."
    Ye R.D., Wun T.-Z., Sadler J.E.
    J. Biol. Chem. 262:3718-3725(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells."
    Schleuning W.-D., Medcalf R.L., Hession C., Rothenbuhler R., Shaw A., Kruithof E.K.O.
    Mol. Cell. Biol. 7:4564-4567(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor."
    Webb A.C., Collins K.L., Snyder S.F., Alexander S.J., Rosenwasser L.J., Eddy R.L., Shows T.B., Auron P.E.
    J. Exp. Med. 166:77-94(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Monocyte.
  4. "Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor."
    Antalis T.M., Clark M.A., Barnes T., Lehrbach P.R., Devine P.L., Schevzov G., Goss N.H., Stephens R.W., Tolstoshev P.
    Proc. Natl. Acad. Sci. U.S.A. 85:985-989(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Monocyte.
  5. "Structure of the gene for human plasminogen activator inhibitor-2. The nearest mammalian homologue of chicken ovalbumin."
    Ye R.D., Ahern S.M., le Beau M.M., Lebo R.V., Sadler J.E.
    J. Biol. Chem. 264:5495-5502(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin."
    Samia J.A., Alexander S.J., Horton K.W., Auron P.E., Byers M.G., Shows T.B. Jr., Webb A.C.
    Genomics 6:159-167(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
    Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
    Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 12-17; 103-108 AND 314-321.
  9. "Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1."
    Fan J., Zhang Y.Q., Li P., Hou M., Tan L., Wang X., Zhu Y.S.
    Acta Biochim. Biophys. Sin. 36:42-46(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PSMB1.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "The crystal structure of plasminogen activator inhibitor 2 at 2.0-A resolution: implications for serpin function."
    Harrop S.J., Jankova L., Coles M., Jardine D., Whittaker J.S., Gould A.R., Meister A., King G.C., Mabbutt B.C., Curmi P.M.G.
    Structure 7:43-54(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
  12. Cited for: VARIANTS ASP-120; HIS-229; LYS-404 AND CYS-413.

Entry informationi

Entry nameiPAI2_HUMAN
AccessioniPrimary (citable) accession number: P05120
Secondary accession number(s): Q96E96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi