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Protein

1-aminocyclopropane-1-carboxylate oxidase 1

Gene

ACO1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-aminocyclopropane-1-carboxylate + ascorbate + O2 = ethylene + cyanide + dehydroascorbate + CO2 + 2 H2O.

Cofactori

Pathwayi: ethylene biosynthesis via S-adenosyl-L-methionine

This protein is involved in step 2 of the subpathway that synthesizes ethylene from S-adenosyl-L-methionine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1-aminocyclopropane-1-carboxylate synthase 2 (ACS2), 1-aminocyclopropane-1-carboxylate synthase 3 (ACS3), 1-aminocyclopropane-1-carboxylate synthase 4 (ACS4)
  2. 1-aminocyclopropane-1-carboxylate oxidase 1 (ACO1), 1-aminocyclopropane-1-carboxylate oxidase 2 (ACO2), 1-aminocyclopropane-1-carboxylate oxidase 4 (ACO4)
This subpathway is part of the pathway ethylene biosynthesis via S-adenosyl-L-methionine, which is itself part of Alkene biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ethylene from S-adenosyl-L-methionine, the pathway ethylene biosynthesis via S-adenosyl-L-methionine and in Alkene biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi177IronPROSITE-ProRule annotation1
Metal bindingi179IronPROSITE-ProRule annotation1
Metal bindingi234IronPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processEthylene biosynthesis, Fruit ripening
LigandIron, Metal-binding, Vitamin C

Enzyme and pathway databases

BRENDAi1.14.17.4. 3101.
UniPathwayiUPA00384; UER00563.

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate oxidase 1 (EC:1.14.17.4)
Short name:
ACC oxidase 1
Alternative name(s):
Ethylene-forming enzyme
Short name:
EFE
Protein pTOM 13
Gene namesi
Name:ACO1
Synonyms:ETH1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Chromosome 7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000672611 – 3151-aminocyclopropane-1-carboxylate oxidase 1Add BLAST315

Proteomic databases

PaxDbiP05116.

Expressioni

Tissue specificityi

Predominantly expressed in the petals and the stigma and style.

Developmental stagei

Expressed during fruit ripening.

Gene expression databases

ExpressionAtlasiP05116. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc07g049530.2.1.

Structurei

3D structure databases

ProteinModelPortaliP05116.
SMRiP05116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 253Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST101

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0143. Eukaryota.
COG3491. LUCA.
InParanoidiP05116.
KOiK05933.
OMAiDLDDHYR.
OrthoDBiEOG09360IUD.

Family and domain databases

Gene3Di2.60.120.330. 1 hit.
InterProiView protein in InterPro
IPR026992. DIOX_N.
IPR027443. IPNS-like.
IPR005123. Oxoglu/Fe-dep_dioxygenase.
PfamiView protein in Pfam
PF03171. 2OG-FeII_Oxy. 1 hit.
PF14226. DIOX_N. 1 hit.
PROSITEiView protein in PROSITE
PS51471. FE2OG_OXY. 1 hit.

Sequencei

Sequence statusi: Complete.

P05116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFPIINLE KLNGDERANT MEMIKDACEN WGFFELVNHG IPHEVMDTVE
60 70 80 90 100
KMTKGHYKKC MEQRFKELVA SKGLEAVQAE VTDLDWESTF FLRHLPTSNI
110 120 130 140 150
SQVPDLDEEY REVMRDFAKR LEKLAEELLD LLCENLGLEK GYLKNAFYGS
160 170 180 190 200
KGPNFGTKVS NYPPCPKPDL IKGLRAHTDA GGIILLFQDD KVSGLQLLKD
210 220 230 240 250
EQWIDVPPMR HSIVVNLGDQ LEVITNGKYK SVLHRVIAQT DGTRMSLASF
260 270 280 290 300
YNPGSDAVIY PAKTLVEKEA EESTQVYPKF VFDDYMKLYA GLKFQAKEPR
310
FEAMKAMESD PIASA
Length:315
Mass (Da):35,813
Last modified:July 1, 1993 - v2
Checksum:i053E975EC8B5B2E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58273 Genomic DNA. Translation: CAA41212.1.
X04792 mRNA. Translation: CAA28479.1.
PIRiS16591.
RefSeqiNP_001234024.2. NM_001247095.2.
UniGeneiLes.2560.

Genome annotation databases

EnsemblPlantsiSolyc07g049530.2.1; Solyc07g049530.2.1; Solyc07g049530.2.
GeneIDi544052.
GrameneiSolyc07g049530.2.1; Solyc07g049530.2.1; Solyc07g049530.2.
KEGGisly:544052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58273 Genomic DNA. Translation: CAA41212.1.
X04792 mRNA. Translation: CAA28479.1.
PIRiS16591.
RefSeqiNP_001234024.2. NM_001247095.2.
UniGeneiLes.2560.

3D structure databases

ProteinModelPortaliP05116.
SMRiP05116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc07g049530.2.1.

Proteomic databases

PaxDbiP05116.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSolyc07g049530.2.1; Solyc07g049530.2.1; Solyc07g049530.2.
GeneIDi544052.
GrameneiSolyc07g049530.2.1; Solyc07g049530.2.1; Solyc07g049530.2.
KEGGisly:544052.

Phylogenomic databases

eggNOGiKOG0143. Eukaryota.
COG3491. LUCA.
InParanoidiP05116.
KOiK05933.
OMAiDLDDHYR.
OrthoDBiEOG09360IUD.

Enzyme and pathway databases

UniPathwayiUPA00384; UER00563.
BRENDAi1.14.17.4. 3101.

Gene expression databases

ExpressionAtlasiP05116. baseline and differential.

Family and domain databases

Gene3Di2.60.120.330. 1 hit.
InterProiView protein in InterPro
IPR026992. DIOX_N.
IPR027443. IPNS-like.
IPR005123. Oxoglu/Fe-dep_dioxygenase.
PfamiView protein in Pfam
PF03171. 2OG-FeII_Oxy. 1 hit.
PF14226. DIOX_N. 1 hit.
PROSITEiView protein in PROSITE
PS51471. FE2OG_OXY. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACCO1_SOLLC
AccessioniPrimary (citable) accession number: P05116
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: July 1, 1993
Last modified: June 7, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.