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Protein

Non-histone chromosomal protein HMG-14

Gene

HMGN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • nucleosomal DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
SIGNORiP05114

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-14
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 1
Gene namesi
Name:HMGN1
Synonyms:HMG14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000205581.10
HGNCiHGNC:4984 HMGN1
MIMi163920 gene
neXtProtiNX_P05114

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3150
OpenTargetsiENSG00000205581
PharmGKBiPA35088

Polymorphism and mutation databases

BioMutaiHMGN1
DMDMi123101

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066911 – 100Non-histone chromosomal protein HMG-14Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7ADP-ribosylserine1 Publication1
Modified residuei8PhosphoserineCombined sources1
Modified residuei14N6-acetyllysineCombined sources1
Modified residuei21Phosphoserine; by RPS6KA5Combined sources1 Publication1
Modified residuei25ADP-ribosylserine; alternate1 Publication1
Modified residuei25Phosphoserine; alternate; by RPS6KA5Combined sources1 Publication1
Modified residuei27N6-acetyllysineBy similarity1
Modified residuei81PhosphothreonineBy similarity1
Modified residuei82N6-acetyllysineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.By similarity1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiP05114
MaxQBiP05114
PaxDbiP05114
PeptideAtlasiP05114
PRIDEiP05114
ProteomicsDBi51800
TopDownProteomicsiP05114

PTM databases

iPTMnetiP05114
PhosphoSitePlusiP05114

Expressioni

Gene expression databases

BgeeiENSG00000205581
CleanExiHS_HMGN1
ExpressionAtlasiP05114 baseline and differential
GenevisibleiP05114 HS

Organism-specific databases

HPAiCAB012260
HPA048694

Interactioni

Protein-protein interaction databases

BioGridi109393, 27 interactors
IntActiP05114, 7 interactors
MINTiP05114
STRINGi9606.ENSP00000370125

Structurei

3D structure databases

ProteinModelPortaliP05114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J491 Eukaryota
ENOG410ZFVH LUCA
GeneTreeiENSGT00730000110877
HOGENOMiHOG000116394
HOVERGENiHBG073479
InParanoidiP05114
KOiK11299
PhylomeDBiP05114
TreeFamiTF105374

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

Sequencei

Sequence statusi: Complete.

P05114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKVSSAE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV
60 70 80 90 100
QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD
Length:100
Mass (Da):10,659
Last modified:January 23, 2007 - v3
Checksum:i8F4CB5374D51FBF3
GO

RNA editingi

Modified position: not applicable.
Partially edited. A new initiator methionine may be created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 45 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 23-31 and 40-48. The RNA edited version is called ET-HMGN1.1 Publication

Mass spectrometryi

Molecular mass is 10527.8±0.7 Da from positions 2 - 100. Determined by ESI. 1 Publication
Molecular mass is 10608 Da from positions 2 - 100. Determined by ESI. 1 Publication
Molecular mass is 10688±1.3 Da from positions 2 - 100. Determined by ESI. 1 Publication
Molecular mass is 10768 Da from positions 2 - 100. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0547901M → MLGRREEWQRQGSPVSRRLS ARRGPQAPGTRLPRRHPARA FPAATM in RNA edited version. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02621 mRNA Translation: AAA52676.1
M21339 Genomic DNA Translation: AAA52677.1
BT007337 mRNA Translation: AAP36001.1
AF064861 Genomic DNA No translation available.
AL163279 Genomic DNA Translation: CAB90453.1
BC000075 mRNA Translation: AAH00075.1
BC023984 mRNA Translation: AAH23984.1
BC070153 mRNA Translation: AAH70153.1
BC106080 mRNA Translation: AAI06081.1
CCDSiCCDS33559.1
PIRiA33310
RefSeqiNP_004956.5, NM_004965.6
UniGeneiHs.356285

Genome annotation databases

EnsembliENST00000380749; ENSP00000370125; ENSG00000205581
GeneIDi3150
KEGGihsa:3150
UCSCiuc002yxo.4 human

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiHMGN1_HUMAN
AccessioniPrimary (citable) accession number: P05114
Secondary accession number(s): Q3KQR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 180 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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