Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Non-histone chromosomal protein HMG-14

Gene

HMGN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • nucleosomal DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-6781827. Transcription-Coupled Nucleotide Excision Repair (TC-NER).
R-HSA-6782135. Dual incision in TC-NER.
R-HSA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
SIGNORiP05114.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-14
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 1
Gene namesi
Name:HMGN1
Synonyms:HMG14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:4984. HMGN1.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.

GO - Cellular componenti

  • chromatin Source: ProtInc
  • cytoplasm Source: UniProtKB-SubCell
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3150.
OpenTargetsiENSG00000205581.
PharmGKBiPA35088.

Polymorphism and mutation databases

BioMutaiHMGN1.
DMDMi123101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066911 – 100Non-histone chromosomal protein HMG-14Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7ADP-ribosylserine1 Publication1
Modified residuei8PhosphoserineCombined sources1
Modified residuei14N6-acetyllysineCombined sources1
Modified residuei21Phosphoserine; by RPS6KA5Combined sources1 Publication1
Modified residuei25ADP-ribosylserine; alternate1 Publication1
Modified residuei25Phosphoserine; alternate; by RPS6KA5Combined sources1 Publication1
Modified residuei27N6-acetyllysineBy similarity1
Modified residuei81PhosphothreonineBy similarity1
Modified residuei82N6-acetyllysineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.By similarity1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiP05114.
MaxQBiP05114.
PaxDbiP05114.
PeptideAtlasiP05114.
PRIDEiP05114.
TopDownProteomicsiP05114.

PTM databases

iPTMnetiP05114.
PhosphoSitePlusiP05114.

Expressioni

Gene expression databases

BgeeiENSG00000205581.
CleanExiHS_HMGN1.
ExpressionAtlasiP05114. baseline and differential.
GenevisibleiP05114. HS.

Organism-specific databases

HPAiCAB012260.
HPA048694.

Interactioni

Protein-protein interaction databases

BioGridi109393. 26 interactors.
IntActiP05114. 7 interactors.
MINTiMINT-5008059.
STRINGi9606.ENSP00000370125.

Structurei

3D structure databases

ProteinModelPortaliP05114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J491. Eukaryota.
ENOG410ZFVH. LUCA.
GeneTreeiENSGT00730000110877.
HOGENOMiHOG000116394.
HOVERGENiHBG073479.
InParanoidiP05114.
KOiK11299.
PhylomeDBiP05114.
TreeFamiTF105374.

Family and domain databases

InterProiView protein in InterPro
IPR000079. HMGN_fam.
PfamiView protein in Pfam
PF01101. HMG14_17. 1 hit.
PRINTSiPR00925. NONHISHMG17.
SMARTiView protein in SMART
SM00527. HMG17. 1 hit.
PROSITEiView protein in PROSITE
PS00355. HMG14_17. 1 hit.

Sequencei

Sequence statusi: Complete.

P05114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKVSSAE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV
60 70 80 90 100
QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD
Length:100
Mass (Da):10,659
Last modified:January 23, 2007 - v3
Checksum:i8F4CB5374D51FBF3
GO

RNA editingi

Modified position: not applicable.
Partially edited. A new initiator methionine may be created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 45 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 23-31 and 40-48. The RNA edited version is called ET-HMGN1.1 Publication

Mass spectrometryi

Molecular mass is 10527.8±0.7 Da from positions 2 - 100. Determined by ESI. 1 Publication
Molecular mass is 10608 Da from positions 2 - 100. Determined by ESI. 1 Publication
Molecular mass is 10688±1.3 Da from positions 2 - 100. Determined by ESI. 1 Publication
Molecular mass is 10768 Da from positions 2 - 100. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0547901M → MLGRREEWQRQGSPVSRRLS ARRGPQAPGTRLPRRHPARA FPAATM in RNA edited version. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02621 mRNA. Translation: AAA52676.1.
M21339 Genomic DNA. Translation: AAA52677.1.
BT007337 mRNA. Translation: AAP36001.1.
AF064861 Genomic DNA. No translation available.
AL163279 Genomic DNA. Translation: CAB90453.1.
BC000075 mRNA. Translation: AAH00075.1.
BC023984 mRNA. Translation: AAH23984.1.
BC070153 mRNA. Translation: AAH70153.1.
BC106080 mRNA. Translation: AAI06081.1.
CCDSiCCDS33559.1.
PIRiA33310.
RefSeqiNP_004956.5. NM_004965.6.
UniGeneiHs.356285.

Genome annotation databases

EnsembliENST00000380749; ENSP00000370125; ENSG00000205581.
GeneIDi3150.
KEGGihsa:3150.
UCSCiuc002yxo.4. human.

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiHMGN1_HUMAN
AccessioniPrimary (citable) accession number: P05114
Secondary accession number(s): Q3KQR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families