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Protein

Interleukin-5

Gene

IL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113525-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP05113.
SIGNORiP05113.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5
Short name:
IL-5
Alternative name(s):
B-cell differentiation factor I
Eosinophil differentiation factor
T-cell replacing factor
Short name:
TRF
Gene namesi
Name:IL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6016. IL5.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: BHF-UCL
  • extracellular space Source: UniProtKB
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3567.
OpenTargetsiENSG00000113525.
PharmGKBiPA29833.

Chemistry databases

ChEMBLiCHEMBL1169600.
DrugBankiDB06612. Mepolizumab.
DB01411. Pranlukast.

Polymorphism and mutation databases

BioMutaiIL5.
DMDMi124341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001556020 – 134Interleukin-5Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22O-linked (GalNAc...)1 Publication1
Glycosylationi47N-linked (GlcNAc...)1 Publication1
Disulfide bondi63Interchain (with C-105)1 Publication
Disulfide bondi105Interchain (with C-63)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei90Not glycosylated1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP05113.
PaxDbiP05113.
PeptideAtlasiP05113.
PRIDEiP05113.

PTM databases

iPTMnetiP05113.
PhosphoSitePlusiP05113.

Expressioni

Gene expression databases

BgeeiENSG00000113525.
CleanExiHS_IL5.
ExpressionAtlasiP05113. baseline and differential.
GenevisibleiP05113. HS.

Organism-specific databases

HPAiCAB010304.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CSF2RBP329272EBI-2435811,EBI-1809771
IL5RAQ013442EBI-2435811,EBI-1759442

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-5 receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi109781. 2 interactors.
DIPiDIP-28N.
IntActiP05113. 2 interactors.
STRINGi9606.ENSP00000231454.

Chemistry databases

BindingDBiP05113.

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 39Combined sources14
Helixi41 – 45Combined sources5
Beta strandi51 – 54Combined sources4
Beta strandi56 – 58Combined sources3
Helixi60 – 62Combined sources3
Helixi64 – 75Combined sources12
Helixi84 – 103Combined sources20
Beta strandi106 – 111Combined sources6
Helixi112 – 128Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HULX-ray2.40A/B24-131[»]
3QT2X-ray2.55C/D/E/F19-134[»]
3VA2X-ray2.70A/B23-134[»]
ProteinModelPortaliP05113.
SMRiP05113.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05113.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-5 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYJN. Eukaryota.
ENOG41117ER. LUCA.
GeneTreeiENSGT00390000016991.
HOGENOMiHOG000074049.
HOVERGENiHBG003865.
InParanoidiP05113.
KOiK05428.
OMAiGVINTEW.
OrthoDBiEOG091G0XPD.
PhylomeDBiP05113.
TreeFamiTF338422.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
[Graphical view]
PANTHERiPTHR10525. PTHR10525. 1 hit.
PfamiPF02025. IL5. 1 hit.
[Graphical view]
PRINTSiPR00432. INTERLEUKIN5.
ProDomiPD006721. Interleukin_5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMLLHLSLL ALGAAYVYAI PTEIPTSALV KETLALLSTH RTLLIANETL
60 70 80 90 100
RIPVPVHKNH QLCTEEIFQG IGTLESQTVQ GGTVERLFKN LSLIKKYIDG
110 120 130
QKKKCGEERR RVNQFLDYLQ EFLGVMNTEW IIES
Length:134
Mass (Da):15,238
Last modified:August 13, 1987 - v1
Checksum:iDC984467179556A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88F → L in CAA31210 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04688 mRNA. Translation: CAA28390.1.
J03478 Genomic DNA. Translation: AAA74469.1.
J02971 Genomic DNA. Translation: AAA98620.1.
X12705 mRNA. Translation: CAA31210.1.
X12706 Genomic DNA. Translation: CAA31211.1.
AF353265 Genomic DNA. Translation: AAK19759.1.
BC066282 mRNA. Translation: AAH66282.1.
CCDSiCCDS4156.1.
PIRiA28477.
RefSeqiNP_000870.1. NM_000879.2.
XP_011541675.1. XM_011543373.2.
XP_011541676.1. XM_011543374.2.
UniGeneiHs.2247.

Genome annotation databases

EnsembliENST00000231454; ENSP00000231454; ENSG00000113525.
GeneIDi3567.
KEGGihsa:3567.
UCSCiuc003kxe.1. human.

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-5 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04688 mRNA. Translation: CAA28390.1.
J03478 Genomic DNA. Translation: AAA74469.1.
J02971 Genomic DNA. Translation: AAA98620.1.
X12705 mRNA. Translation: CAA31210.1.
X12706 Genomic DNA. Translation: CAA31211.1.
AF353265 Genomic DNA. Translation: AAK19759.1.
BC066282 mRNA. Translation: AAH66282.1.
CCDSiCCDS4156.1.
PIRiA28477.
RefSeqiNP_000870.1. NM_000879.2.
XP_011541675.1. XM_011543373.2.
XP_011541676.1. XM_011543374.2.
UniGeneiHs.2247.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HULX-ray2.40A/B24-131[»]
3QT2X-ray2.55C/D/E/F19-134[»]
3VA2X-ray2.70A/B23-134[»]
ProteinModelPortaliP05113.
SMRiP05113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109781. 2 interactors.
DIPiDIP-28N.
IntActiP05113. 2 interactors.
STRINGi9606.ENSP00000231454.

Chemistry databases

BindingDBiP05113.
ChEMBLiCHEMBL1169600.
DrugBankiDB06612. Mepolizumab.
DB01411. Pranlukast.

PTM databases

iPTMnetiP05113.
PhosphoSitePlusiP05113.

Polymorphism and mutation databases

BioMutaiIL5.
DMDMi124341.

Proteomic databases

EPDiP05113.
PaxDbiP05113.
PeptideAtlasiP05113.
PRIDEiP05113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231454; ENSP00000231454; ENSG00000113525.
GeneIDi3567.
KEGGihsa:3567.
UCSCiuc003kxe.1. human.

Organism-specific databases

CTDi3567.
DisGeNETi3567.
GeneCardsiIL5.
HGNCiHGNC:6016. IL5.
HPAiCAB010304.
MIMi147850. gene.
neXtProtiNX_P05113.
OpenTargetsiENSG00000113525.
PharmGKBiPA29833.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYJN. Eukaryota.
ENOG41117ER. LUCA.
GeneTreeiENSGT00390000016991.
HOGENOMiHOG000074049.
HOVERGENiHBG003865.
InParanoidiP05113.
KOiK05428.
OMAiGVINTEW.
OrthoDBiEOG091G0XPD.
PhylomeDBiP05113.
TreeFamiTF338422.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113525-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP05113.
SIGNORiP05113.

Miscellaneous databases

ChiTaRSiIL5. human.
EvolutionaryTraceiP05113.
GeneWikiiInterleukin_5.
GenomeRNAii3567.
PROiP05113.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113525.
CleanExiHS_IL5.
ExpressionAtlasiP05113. baseline and differential.
GenevisibleiP05113. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
[Graphical view]
PANTHERiPTHR10525. PTHR10525. 1 hit.
PfamiPF02025. IL5. 1 hit.
[Graphical view]
PRINTSiPR00432. INTERLEUKIN5.
ProDomiPD006721. Interleukin_5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL5_HUMAN
AccessioniPrimary (citable) accession number: P05113
Secondary accession number(s): Q13840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 2, 2016
This is version 180 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.