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Protein

Interleukin-4

Gene

IL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity).By similarity1 Publication

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB
  • interleukin-4 receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

B-cell activation

Enzyme and pathway databases

SignaLinkiP05112.
SIGNORiP05112.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4
Short name:
IL-4
Alternative name(s):
B-cell stimulatory factor 1
Short name:
BSF-1
Binetrakin
Lymphocyte stimulatory factor 1
Pitrakinra
Gene namesi
Name:IL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6014. IL4.

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Ischemic stroke (ISCHSTR)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
See also OMIM:601367

Organism-specific databases

MIMi601367. phenotype.
PharmGKBiPA197.

Polymorphism and mutation databases

BioMutaiIL4.
DMDMi124337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 153129Interleukin-4PRO_0000015532Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 1511 Publication
Disulfide bondi48 ↔ 891 Publication
Glycosylationi62 – 621N-linked (GlcNAc...)1 Publication
Disulfide bondi70 ↔ 123

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05112.
PeptideAtlasiP05112.
PRIDEiP05112.

PTM databases

iPTMnetiP05112.
PhosphoSiteiP05112.

Expressioni

Gene expression databases

BgeeiENSG00000113520.
CleanExiHS_IL4.
ExpressionAtlasiP05112. baseline and differential.
GenevisibleiP05112. HS.

Organism-specific databases

HPAiCAB055509.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IL13RA1P785523EBI-367025,EBI-1391535
IL4RP243947EBI-367025,EBI-367009

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB
  • interleukin-4 receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109779. 2 interactions.
DIPiDIP-3222N.
IntActiP05112. 3 interactions.
MINTiMINT-90320.
STRINGi9606.ENSP00000231449.

Structurei

Secondary structure

1
153
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni26 – 294Combined sources
Helixi30 – 4112Combined sources
Helixi42 – 443Combined sources
Helixi48 – 503Combined sources
Beta strandi51 – 544Combined sources
Helixi56 – 583Combined sources
Turni60 – 623Combined sources
Helixi65 – 8319Combined sources
Turni87 – 893Combined sources
Helixi94 – 11825Combined sources
Beta strandi130 – 1323Combined sources
Helixi133 – 15119Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BBNNMR-A25-153[»]
1BCNNMR-A25-153[»]
1CYLNMR-A25-153[»]
1HIJX-ray3.00A25-153[»]
1HIKX-ray2.60A25-153[»]
1HZIX-ray2.05A25-153[»]
1IARX-ray2.30A25-153[»]
1ILLmodel-425-153[»]
1ITEmodel-A25-153[»]
1ITINMR-A25-153[»]
1ITLNMR-A25-153[»]
1ITMNMR-A25-153[»]
1RCBX-ray2.25A25-153[»]
2B8UX-ray1.80A25-153[»]
2B8XX-ray1.70A25-153[»]
2B8YX-ray1.80A25-153[»]
2B8ZX-ray2.50A25-153[»]
2B90X-ray2.10A25-153[»]
2B91X-ray2.00A25-153[»]
2CYKNMR-A25-153[»]
2D48X-ray1.65A25-153[»]
2INTX-ray2.35A25-153[»]
3BPLX-ray2.93A25-153[»]
3BPNX-ray3.02A25-153[»]
3QB7X-ray3.24A/B25-153[»]
4YDYX-ray2.00I/J25-153[»]
5FHXX-ray2.55A30-153[»]
ProteinModelPortaliP05112.
SMRiP05112. Positions 25-153.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05112.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3886. Eukaryota.
ENOG410XQ0R. LUCA.
GeneTreeiENSGT00390000013108.
HOGENOMiHOG000254781.
HOVERGENiHBG000290.
InParanoidiP05112.
KOiK05430.
OMAiLACTSNF.
OrthoDBiEOG091G0WDE.
PhylomeDBiP05112.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002354. IL-4.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11456. PTHR11456. 1 hit.
PfamiPF00727. IL4. 1 hit.
[Graphical view]
PIRSFiPIRSF001941. Interleukin_4. 1 hit.
PRINTSiPR00431. INTERLEUKIN4.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05112-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKTLCTE
60 70 80 90 100
LTVTDIFAAS KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH
110 120 130 140 150
KQLIRFLKRL DRNLWGLAGL NSCPVKEANQ STLENFLERL KTIMREKYSK

CSS
Length:153
Mass (Da):17,492
Last modified:August 13, 1987 - v1
Checksum:i8725BF64B34D45F7
GO
Isoform 2 (identifier: P05112-2) [UniParc]FASTAAdd to basket
Also known as: Short, IL-4delta2

The sequence of this isoform differs from the canonical sequence as follows:
     46-61: Missing.

Show »
Length:137
Mass (Da):15,797
Checksum:i3B621F60D0F0D261
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271C → R.
Corresponds to variant rs4986964 [ dbSNP | Ensembl ].
VAR_020392

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei46 – 6116Missing in isoform 2. 1 PublicationVSP_002672Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13982 mRNA. Translation: AAA59149.1.
M23442 Genomic DNA. Translation: AAA59150.1.
X81851 mRNA. Translation: CAA57444.1.
AF395008 Genomic DNA. Translation: AAK71324.1.
BC066277 mRNA. Translation: AAH66277.1.
BC067514 mRNA. Translation: AAH67514.1.
BC070123 mRNA. Translation: AAH70123.1.
X06750 Genomic DNA. Translation: CAA29925.1.
CCDSiCCDS4158.1. [P05112-1]
CCDS4159.1. [P05112-2]
PIRiA30546. A25946.
RefSeqiNP_000580.1. NM_000589.3. [P05112-1]
NP_758858.1. NM_172348.2. [P05112-2]
UniGeneiHs.73917.

Genome annotation databases

EnsembliENST00000231449; ENSP00000231449; ENSG00000113520. [P05112-1]
ENST00000350025; ENSP00000325190; ENSG00000113520. [P05112-2]
GeneIDi3565.
KEGGihsa:3565.
UCSCiuc003kxk.3. human. [P05112-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13982 mRNA. Translation: AAA59149.1.
M23442 Genomic DNA. Translation: AAA59150.1.
X81851 mRNA. Translation: CAA57444.1.
AF395008 Genomic DNA. Translation: AAK71324.1.
BC066277 mRNA. Translation: AAH66277.1.
BC067514 mRNA. Translation: AAH67514.1.
BC070123 mRNA. Translation: AAH70123.1.
X06750 Genomic DNA. Translation: CAA29925.1.
CCDSiCCDS4158.1. [P05112-1]
CCDS4159.1. [P05112-2]
PIRiA30546. A25946.
RefSeqiNP_000580.1. NM_000589.3. [P05112-1]
NP_758858.1. NM_172348.2. [P05112-2]
UniGeneiHs.73917.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BBNNMR-A25-153[»]
1BCNNMR-A25-153[»]
1CYLNMR-A25-153[»]
1HIJX-ray3.00A25-153[»]
1HIKX-ray2.60A25-153[»]
1HZIX-ray2.05A25-153[»]
1IARX-ray2.30A25-153[»]
1ILLmodel-425-153[»]
1ITEmodel-A25-153[»]
1ITINMR-A25-153[»]
1ITLNMR-A25-153[»]
1ITMNMR-A25-153[»]
1RCBX-ray2.25A25-153[»]
2B8UX-ray1.80A25-153[»]
2B8XX-ray1.70A25-153[»]
2B8YX-ray1.80A25-153[»]
2B8ZX-ray2.50A25-153[»]
2B90X-ray2.10A25-153[»]
2B91X-ray2.00A25-153[»]
2CYKNMR-A25-153[»]
2D48X-ray1.65A25-153[»]
2INTX-ray2.35A25-153[»]
3BPLX-ray2.93A25-153[»]
3BPNX-ray3.02A25-153[»]
3QB7X-ray3.24A/B25-153[»]
4YDYX-ray2.00I/J25-153[»]
5FHXX-ray2.55A30-153[»]
ProteinModelPortaliP05112.
SMRiP05112. Positions 25-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109779. 2 interactions.
DIPiDIP-3222N.
IntActiP05112. 3 interactions.
MINTiMINT-90320.
STRINGi9606.ENSP00000231449.

PTM databases

iPTMnetiP05112.
PhosphoSiteiP05112.

Polymorphism and mutation databases

BioMutaiIL4.
DMDMi124337.

Proteomic databases

PaxDbiP05112.
PeptideAtlasiP05112.
PRIDEiP05112.

Protocols and materials databases

DNASUi3565.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231449; ENSP00000231449; ENSG00000113520. [P05112-1]
ENST00000350025; ENSP00000325190; ENSG00000113520. [P05112-2]
GeneIDi3565.
KEGGihsa:3565.
UCSCiuc003kxk.3. human. [P05112-1]

Organism-specific databases

CTDi3565.
GeneCardsiIL4.
H-InvDBHIX0164435.
HGNCiHGNC:6014. IL4.
HPAiCAB055509.
MIMi147780. gene.
601367. phenotype.
neXtProtiNX_P05112.
PharmGKBiPA197.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3886. Eukaryota.
ENOG410XQ0R. LUCA.
GeneTreeiENSGT00390000013108.
HOGENOMiHOG000254781.
HOVERGENiHBG000290.
InParanoidiP05112.
KOiK05430.
OMAiLACTSNF.
OrthoDBiEOG091G0WDE.
PhylomeDBiP05112.
TreeFamiTF336383.

Enzyme and pathway databases

SignaLinkiP05112.
SIGNORiP05112.

Miscellaneous databases

EvolutionaryTraceiP05112.
GeneWikiiInterleukin_4.
GenomeRNAii3565.
PROiP05112.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113520.
CleanExiHS_IL4.
ExpressionAtlasiP05112. baseline and differential.
GenevisibleiP05112. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002354. IL-4.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11456. PTHR11456. 1 hit.
PfamiPF00727. IL4. 1 hit.
[Graphical view]
PIRSFiPIRSF001941. Interleukin_4. 1 hit.
PRINTSiPR00431. INTERLEUKIN4.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL4_HUMAN
AccessioniPrimary (citable) accession number: P05112
Secondary accession number(s): Q14630, Q6NZ77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 195 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.