ID   IHA$HUMAN      STANDARD;      PRT;   366 AA.
AC   P05111;
DT   13-AUG-1987  (REL. 05, CREATED)
DT   13-AUG-1987  (REL. 05, LAST SEQUENCE UPDATE)
DT   01-APR-1990  (REL. 14, LAST ANNOTATION UPDATE)
DE   INHIBIN ALPHA CHAIN PRECURSOR (GENE NAME: INHA).
OS   HUMAN (HOMO SAPIENS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1] (SEQUENCE FROM N.A.)
RA   MAYO K.E., CERELLI G.M., SPIESS J., RIVIER J., ROSENFELD M.G.,
RA   EVANS R.M., VALE W.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 83:5849-5853(1986).
RN   [2] (SEQUENCE FROM N.A.)
RA   STEWART A.G., MILBORROW H.M., RING J.M., CROWTHER C.E., FORAGE R.G.;
RL   FEBS LETT. 206:329-334(1986).
RN   [3] (SEQUENCE OF 16-366 FROM N.A.)
RA   MASON A.J., NIALL H.D., SEEBURG P.H.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 135:957-964(1986).
CC   -!- FUNCTION: THIS PROTEIN IS SECRETED BY OVARIES OR TESTES AND
CC       INHIBITS THE SECRETION OF FOLLITROPIN BY THE PITUITARY GLAND.
CC   -!- SUBUNIT: DIMER OF ONE BETA AND ONE ALPHA CHAIN, LINKED BY ONE OR
CC       MORE DISULFIDE BONDS.
CC   -!- SIMILARITY: TO TGF-BETA, INHIBIN BETA CHAINS, MIS.
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DR   EMBL; M13981; HSINHA.
DR   EMBL; M13144; HSINHAA.
DR   EMBL; X04445; HSINHAG1.
DR   EMBL; X04446; HSINHAG2.
DR   PROSITE; PS00250; TGF_BETA.
KW   FOLLITROPIN INHIBITOR; CONTRACEPTIVE; GLYCOPROTEIN; SIGNAL.
FT   SIGNAL        1     18
FT   PROPEP       19    232
FT   CHAIN       233    366       INHIBIN ALPHA CHAIN.
FT   CARBOHYD    146    146       POTENTIAL.
FT   CARBOHYD    268    268       POTENTIAL.
FT   CARBOHYD    302    302       POTENTIAL.
SQ   SEQUENCE   366 AA;  39669 MW;  699574 CN;
     MVLHLLLFLL LTPQGGHSCQ GLELARELVL AKVRALFLDA LGPPAVTREG GDPGVRRLPR
     RHALGGFTHR GSEPEEEEDV SQAILFPATD ASCEDKSAAR GLAQEAEEGL FRYMFRPSQH
     TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP LLGLLALSPG GPVAVPMSLG HAPPHWAVLH
     LATSALSLLT HPVLVLLLRC PLCTCSARPE ATPFLVAHTR TRPPSGGERA RRSTPLMSWP
     WSPSALRLLQ RPPEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP
     PNLSLPVPGA PPTPAQPYSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF KYETVPNLLT
     QHCACI
//