ID IHA_HUMAN STANDARD; PRT; 366 AA. AC P05111; DT 13-AUG-1987 (Rel. 05, Created) DT 13-AUG-1987 (Rel. 05, Last sequence update) DT 01-OCT-1996 (Rel. 34, Last annotation update) DE INHIBIN ALPHA CHAIN PRECURSOR. GN INHA. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=86287350; PubMed=3016724; RA Mayo K.E., Cerelli G.M., Spiess J., Rivier J., Rosenfeld M.G., RA Evans R.M., Vale W.; RT "Inhibin A-subunit cDNAs from porcine ovary and human placenta."; RL Proc. Natl. Acad. Sci. U.S.A. 83:5849-5853(1986). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=87005283; PubMed=3758355; RA Stewart A.G., Milborrow H.M., Ring J.M., Crowther C.E., Forage R.G.; RT "Human inhibin genes. Genomic characterisation and sequencing."; RL FEBS Lett. 206:329-334(1986). RN [3] RP SEQUENCE OF 16-366 FROM N.A. RX MEDLINE=86186863; PubMed=3754442; RA Mason A.J., Niall H.D., Seeburg P.H.; RT "Structure of two human ovarian inhibins."; RL Biochem. Biophys. Res. Commun. 135:957-964(1986). CC -!- FUNCTION: INHIBIN IS A GONADAL GLYCOPEPTIDE THAT INHIBITS THE CC SECRETION OF FOLLITROPIN BY THE PITUITARY GLAND. CC -!- SUBUNIT: DIMERIC, LINKED BY ONE OR MORE DISULFIDE BONDS. CC INHIBIN A IS A DIMER OF ALPHA AND BETA-A. CC INHIBIN B IS A DIMER OF ALPHA AND BETA-B. CC -!- SIMILARITY: BELONGS TO THE TGF-BETA FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M13981; AAA59166.1; -. DR EMBL; M13144; AAA59167.1; -. DR EMBL; X04445; CAA28040.1; -. DR EMBL; X04446; CAA28040.1; JOINED. DR EMBL; A14420; CAA01158.1; -. DR PIR; A23556; A23556. DR PIR; A24248; A24248. DR PIR; B25947; B25947. DR MIM; 147380; -. DR InterPro; IPR002405; Inhibin_alpha. DR InterPro; IPR001839; TGF-beta. DR Pfam; PF00019; TGF-beta; 1. DR PRINTS; PR00669; INHIBINA. DR ProDom; PD000357; -; 1. DR SMART; SM00204; TGFB; 1. DR PROSITE; PS00250; TGF_BETA_1; 1. KW Follitropin inhibitor; Contraceptive; Hormone; Glycoprotein; Signal. FT SIGNAL 1 18 POTENTIAL. FT PROPEP 19 232 FT CHAIN 233 366 INHIBIN ALPHA CHAIN. FT DISULFID 262 328 BY SIMILARITY. FT DISULFID 291 363 BY SIMILARITY. FT DISULFID 295 365 BY SIMILARITY. FT DISULFID 327 327 INTERCHAIN (BY SIMILARITY). FT CARBOHYD 146 146 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 268 268 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 302 302 N-LINKED (GLCNAC...) (POTENTIAL). FT CONFLICT 17 17 H -> V (IN REF. 3). FT CONFLICT 19 19 C -> S (IN REF. 3). SQ SEQUENCE 366 AA; 39669 MW; 0E03D2AB12BF8E57 CRC64; MVLHLLLFLL LTPQGGHSCQ GLELARELVL AKVRALFLDA LGPPAVTREG GDPGVRRLPR RHALGGFTHR GSEPEEEEDV SQAILFPATD ASCEDKSAAR GLAQEAEEGL FRYMFRPSQH TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP LLGLLALSPG GPVAVPMSLG HAPPHWAVLH LATSALSLLT HPVLVLLLRC PLCTCSARPE ATPFLVAHTR TRPPSGGERA RRSTPLMSWP WSPSALRLLQ RPPEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP PNLSLPVPGA PPTPAQPYSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF KYETVPNLLT QHCACI //