ID   IHA_HUMAN      STANDARD;      PRT;   366 AA.
AC   P05111;
DT   13-AUG-1987 (REL. 05, CREATED)
DT   13-AUG-1987 (REL. 05, LAST SEQUENCE UPDATE)
DT   01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
DE   INHIBIN ALPHA CHAIN PRECURSOR.
GN   INHA.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC   PRIMATES; CATARRHINI; HOMINIDAE; HOMO.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 86287350.
RA   MAYO K.E., CERELLI G.M., SPIESS J., RIVIER J., ROSENFELD M.G.,
RA   EVANS R.M., VALE W.;
RT   "Inhibin A-subunit cDNAs from porcine ovary and human placenta.";
RL   PROC. NATL. ACAD. SCI. U.S.A. 83:5849-5853(1986).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 87005283.
RA   STEWART A.G., MILBORROW H.M., RING J.M., CROWTHER C.E., FORAGE R.G.;
RT   "Human inhibin genes. Genomic characterisation and sequencing.";
RL   FEBS LETT. 206:329-334(1986).
RN   [3]
RP   SEQUENCE OF 16-366 FROM N.A.
RX   MEDLINE; 86186863.
RA   MASON A.J., NIALL H.D., SEEBURG P.H.;
RT   "Structure of two human ovarian inhibins.";
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 135:957-964(1986).
CC   -!- FUNCTION: INHIBIN IS A GONADAL GLYCOPEPTIDE THAT INHIBITS THE
CC       SECRETION OF FOLLITROPIN BY THE PITUITARY GLAND.
CC   -!- SUBUNIT: DIMERIC, LINKED BY ONE OR MORE DISULFIDE BONDS.
CC       INHIBIN A IS A DIMER OF ALPHA AND BETA-A.
CC       INHIBIN B IS A DIMER OF ALPHA AND BETA-B.
CC   -!- SIMILARITY: BELONGS TO THE TGF-BETA FAMILY.
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DR   EMBL; M13981; G307068; -.
DR   EMBL; M13144; G186413; -.
DR   EMBL; X04445; E223561; -.
DR   EMBL; X04446; E223561; JOINED.
DR   EMBL; A14420; G490130; -.
DR   PIR; A23556; A23556.
DR   PIR; A24248; A24248.
DR   PIR; B25947; B25947.
DR   MIM; 147380; -.
DR   PROSITE; PS00250; TGF_BETA; 1.
DR   PFAM; PF00019; TGF-beta; 1.
KW   FOLLITROPIN INHIBITOR; CONTRACEPTIVE; HORMONE; GLYCOPROTEIN; SIGNAL.
FT   SIGNAL        1     18       POTENTIAL.
FT   PROPEP       19    232
FT   CHAIN       233    366       INHIBIN ALPHA CHAIN.
FT   DISULFID    262    328       BY SIMILARITY.
FT   DISULFID    291    363       BY SIMILARITY.
FT   DISULFID    295    365       BY SIMILARITY.
FT   DISULFID    327    327       INTERCHAIN (BY SIMILARITY).
FT   CARBOHYD    146    146       POTENTIAL.
FT   CARBOHYD    268    268       POTENTIAL.
FT   CARBOHYD    302    302       POTENTIAL.
FT   CONFLICT     17     17       H -> V (IN REF. 3).
FT   CONFLICT     19     19       C -> S (IN REF. 3).
SQ   SEQUENCE   366 AA;  39669 MW;  3EFA9EF2 CRC32;
     MVLHLLLFLL LTPQGGHSCQ GLELARELVL AKVRALFLDA LGPPAVTREG GDPGVRRLPR
     RHALGGFTHR GSEPEEEEDV SQAILFPATD ASCEDKSAAR GLAQEAEEGL FRYMFRPSQH
     TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP LLGLLALSPG GPVAVPMSLG HAPPHWAVLH
     LATSALSLLT HPVLVLLLRC PLCTCSARPE ATPFLVAHTR TRPPSGGERA RRSTPLMSWP
     WSPSALRLLQ RPPEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP
     PNLSLPVPGA PPTPAQPYSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF KYETVPNLLT
     QHCACI
//