ID   IHA_HUMAN      STANDARD;      PRT;   366 AA.
AC   P05111;
DT   13-AUG-1987 (REL. 05, CREATED)
DT   13-AUG-1987 (REL. 05, LAST SEQUENCE UPDATE)
DT   01-AUG-1992 (REL. 23, LAST ANNOTATION UPDATE)
DE   INHIBIN ALPHA CHAIN PRECURSOR.
GN   INHA.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RM   86287350
RA   MAYO K.E., CERELLI G.M., SPIESS J., RIVIER J., ROSENFELD M.G.,
RA   EVANS R.M., VALE W.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 83:5849-5853(1986).
RN   [2]
RP   SEQUENCE FROM N.A.
RM   87005283
RA   STEWART A.G., MILBORROW H.M., RING J.M., CROWTHER C.E., FORAGE R.G.;
RL   FEBS LETT. 206:329-334(1986).
RN   [3]
RP   SEQUENCE OF 16-366 FROM N.A.
RM   86186863
RA   MASON A.J., NIALL H.D., SEEBURG P.H.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 135:957-964(1986).
CC   -!- FUNCTION: INHIBIN IS A GONADAL GLYCOPEPTIDE THAT INHIBITS THE
CC       SECRETION OF FOLLITROPIN BY THE PITUITARY GLAND.
CC   -!- SUBUNIT: DIMERIC, LINKED BY ONE OR MORE DISULFIDE BONDS.
CC       INHIBIN A IS A DIMER OF ALPHA AND BETA-A.
CC       INHIBIN B IS A DIMER OF ALPHA AND BETA-B.
CC   -!- SIMILARITY: TO OTHER GROWTH FACTORS OF THE TGF-BETA FAMILY.
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DR   EMBL; M13981; HSINHA.
DR   EMBL; M13144; HSINHAA.
DR   EMBL; X04445; HSINHAG1.
DR   EMBL; X04446; HSINHAG2.
DR   PIR; A23556; A23556.
DR   PIR; A24248; A24248.
DR   PIR; B25947; B25947.
DR   MIM; 147380; NINTH EDITION.
DR   PROSITE; PS00250; TGF_BETA.
KW   FOLLITROPIN INHIBITOR; CONTRACEPTIVE; HORMONE; GLYCOPROTEIN; SIGNAL.
FT   SIGNAL        1     18
FT   PROPEP       19    232
FT   CHAIN       233    366       INHIBIN ALPHA CHAIN.
FT   DISULFID    262    328       BY SIMILARITY.
FT   DISULFID    291    363       BY SIMILARITY.
FT   DISULFID    295    365       BY SIMILARITY.
FT   DISULFID    327    327       INTERCHAIN (BY SIMILARITY).
FT   CARBOHYD    146    146       POTENTIAL.
FT   CARBOHYD    268    268       POTENTIAL.
FT   CARBOHYD    302    302       POTENTIAL.
SQ   SEQUENCE   366 AA;  39669 MW;  699574 CN;
     MVLHLLLFLL LTPQGGHSCQ GLELARELVL AKVRALFLDA LGPPAVTREG GDPGVRRLPR
     RHALGGFTHR GSEPEEEEDV SQAILFPATD ASCEDKSAAR GLAQEAEEGL FRYMFRPSQH
     TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP LLGLLALSPG GPVAVPMSLG HAPPHWAVLH
     LATSALSLLT HPVLVLLLRC PLCTCSARPE ATPFLVAHTR TRPPSGGERA RRSTPLMSWP
     WSPSALRLLQ RPPEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP
     PNLSLPVPGA PPTPAQPYSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF KYETVPNLLT
     QHCACI
//