Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inhibin alpha chain

Gene

INHA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • hormone activity Source: UniProtKB
  • receptor binding Source: HGNC
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  • cell-cell signaling Source: UniProtKB
  • cell cycle arrest Source: UniProtKB
  • cell development Source: GO_Central
  • cell differentiation Source: UniProtKB
  • cell surface receptor signaling pathway Source: UniProtKB
  • erythrocyte differentiation Source: UniProtKB
  • hemoglobin biosynthetic process Source: UniProtKB
  • male gonad development Source: Ensembl
  • negative regulation of B cell differentiation Source: UniProtKB
  • negative regulation of cell cycle Source: UniProtKB
  • negative regulation of follicle-stimulating hormone secretion Source: UniProtKB
  • negative regulation of interferon-gamma biosynthetic process Source: UniProtKB
  • negative regulation of macrophage differentiation Source: UniProtKB
  • negative regulation of phosphorylation Source: UniProtKB
  • nervous system development Source: UniProtKB
  • ovarian follicle development Source: UniProtKB
  • positive regulation of follicle-stimulating hormone secretion Source: UniProtKB
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  • regulation of apoptotic process Source: GO_Central
  • regulation of cell cycle Source: HGNC
  • regulation of cell proliferation Source: HGNC
  • regulation of MAPK cascade Source: GO_Central
  • response to external stimulus Source: UniProtKB
  • signal transduction Source: ProtInc
  • skeletal system development Source: ProtInc
  • SMAD protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123999-MONOMER.
ReactomeiR-HSA-209822. Glycoprotein hormones.
SIGNORiP05111.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin alpha chain
Gene namesi
Name:INHA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6065. INHA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • extracellular region Source: UniProtKB
  • inhibin A complex Source: HGNC
  • inhibin B complex Source: Ensembl
  • inhibin-betaglycan-ActRII complex Source: BHF-UCL
  • neuronal cell body Source: Ensembl
  • photoreceptor inner segment Source: Ensembl
  • photoreceptor outer segment Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56 – 57RR → AA: Loss of cleavage; when associated with 60-AA-61. 1 Publication2
Mutagenesisi60 – 61RR → AA: Loss of cleavage; when associated with 55-AA-56. 1 Publication2
Mutagenesisi231 – 232RR → EA: Loss of cleavage. 1 Publication2
Mutagenesisi268N → Q: Loss of glycosylation. 1 Publication1
Mutagenesisi302N → Q: Loss of glycosylation. 1 Publication1

Organism-specific databases

DisGeNETi3623.
OpenTargetsiENSG00000123999.
PharmGKBiPA29876.

Polymorphism and mutation databases

BioMutaiINHA.
DMDMi124274.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
PropeptideiPRO_000003368519 – 61Add BLAST43
PropeptideiPRO_000003368662 – 232Inhibin alpha N-terminal regionAdd BLAST171
ChainiPRO_0000033687233 – 366Inhibin alpha chainAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi262 ↔ 328By similarity
Glycosylationi268N-linked (GlcNAc...)1 Publication1
Disulfide bondi291 ↔ 363By similarity
Disulfide bondi295 ↔ 365By similarity
Glycosylationi302N-linked (GlcNAc...); partial1 Publication1
Disulfide bondi327InterchainBy similarity

Post-translational modificationi

Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei61 – 62Cleavage2
Sitei232 – 233Cleavage2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05111.
PeptideAtlasiP05111.
PRIDEiP05111.

PTM databases

iPTMnetiP05111.
PhosphoSitePlusiP05111.

Expressioni

Tissue specificityi

Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.1 Publication

Gene expression databases

BgeeiENSG00000123999.
CleanExiHS_INHA.
GenevisibleiP05111. HS.

Organism-specific databases

HPAiCAB000047.
HPA019141.
HPA048834.

Interactioni

Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.

Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-10194422,EBI-747107

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • hormone activity Source: UniProtKB
  • receptor binding Source: HGNC
  • transforming growth factor beta receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109835. 6 interactors.
DIPiDIP-5826N.
IntActiP05111. 1 interactor.
STRINGi9606.ENSP00000243786.

Structurei

3D structure databases

ProteinModelPortaliP05111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00390000005935.
HOGENOMiHOG000013165.
HOVERGENiHBG052131.
InParanoidiP05111.
KOiK05500.
OMAiFIFHYCH.
OrthoDBiEOG091G0CTF.
PhylomeDBiP05111.
TreeFamiTF331531.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR017175. Inhibin_asu_subgr.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037328. Inhibin_alpha_subunit. 1 hit.
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLHLLLFLL LTPQGGHSCQ GLELARELVL AKVRALFLDA LGPPAVTREG
60 70 80 90 100
GDPGVRRLPR RHALGGFTHR GSEPEEEEDV SQAILFPATD ASCEDKSAAR
110 120 130 140 150
GLAQEAEEGL FRYMFRPSQH TRSRQVTSAQ LWFHTGLDRQ GTAASNSSEP
160 170 180 190 200
LLGLLALSPG GPVAVPMSLG HAPPHWAVLH LATSALSLLT HPVLVLLLRC
210 220 230 240 250
PLCTCSARPE ATPFLVAHTR TRPPSGGERA RRSTPLMSWP WSPSALRLLQ
260 270 280 290 300
RPPEEPAAHA NCHRVALNIS FQELGWERWI VYPPSFIFHY CHGGCGLHIP
310 320 330 340 350
PNLSLPVPGA PPTPAQPYSL LPGAQPCCAA LPGTMRPLHV RTTSDGGYSF
360
KYETVPNLLT QHCACI
Length:366
Mass (Da):39,670
Last modified:August 13, 1987 - v1
Checksum:i0E03D2AB12BF8E57
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17H → V (PubMed:3754442).Curated1
Sequence conflicti19C → S (PubMed:3754442).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07263960R → L Found in a patient with early-onset epithelial ovarian tumor; unknown pathological significance; alters the ratio of secreted activins and ihibins. 1 Publication1
Natural variantiVAR_034016227G → R.Corresponds to variant rs12720061dbSNPEnsembl.1
Natural variantiVAR_015110257A → T Polymorphism; may play a role in premature ovarian failure. 1 PublicationCorresponds to variant rs12720062dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13981 mRNA. Translation: AAA59166.1.
X04445, X04446 Genomic DNA. Translation: CAA28040.1.
BT006954 mRNA. Translation: AAP35600.1.
AK292340 mRNA. Translation: BAF85029.1.
CH471063 Genomic DNA. Translation: EAW70774.1.
BC006391 mRNA. Translation: AAH06391.1.
M13144 mRNA. Translation: AAA59167.1.
CCDSiCCDS2444.1.
PIRiA23556. A24248.
RefSeqiNP_002182.1. NM_002191.3.
UniGeneiHs.407506.

Genome annotation databases

EnsembliENST00000243786; ENSP00000243786; ENSG00000123999.
GeneIDi3623.
KEGGihsa:3623.
UCSCiuc002vmk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Inhibin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13981 mRNA. Translation: AAA59166.1.
X04445, X04446 Genomic DNA. Translation: CAA28040.1.
BT006954 mRNA. Translation: AAP35600.1.
AK292340 mRNA. Translation: BAF85029.1.
CH471063 Genomic DNA. Translation: EAW70774.1.
BC006391 mRNA. Translation: AAH06391.1.
M13144 mRNA. Translation: AAA59167.1.
CCDSiCCDS2444.1.
PIRiA23556. A24248.
RefSeqiNP_002182.1. NM_002191.3.
UniGeneiHs.407506.

3D structure databases

ProteinModelPortaliP05111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109835. 6 interactors.
DIPiDIP-5826N.
IntActiP05111. 1 interactor.
STRINGi9606.ENSP00000243786.

PTM databases

iPTMnetiP05111.
PhosphoSitePlusiP05111.

Polymorphism and mutation databases

BioMutaiINHA.
DMDMi124274.

Proteomic databases

PaxDbiP05111.
PeptideAtlasiP05111.
PRIDEiP05111.

Protocols and materials databases

DNASUi3623.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243786; ENSP00000243786; ENSG00000123999.
GeneIDi3623.
KEGGihsa:3623.
UCSCiuc002vmk.3. human.

Organism-specific databases

CTDi3623.
DisGeNETi3623.
GeneCardsiINHA.
HGNCiHGNC:6065. INHA.
HPAiCAB000047.
HPA019141.
HPA048834.
MIMi147380. gene.
neXtProtiNX_P05111.
OpenTargetsiENSG00000123999.
PharmGKBiPA29876.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00390000005935.
HOGENOMiHOG000013165.
HOVERGENiHBG052131.
InParanoidiP05111.
KOiK05500.
OMAiFIFHYCH.
OrthoDBiEOG091G0CTF.
PhylomeDBiP05111.
TreeFamiTF331531.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123999-MONOMER.
ReactomeiR-HSA-209822. Glycoprotein hormones.
SIGNORiP05111.

Miscellaneous databases

GeneWikiiINHA.
GenomeRNAii3623.
PROiP05111.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123999.
CleanExiHS_INHA.
GenevisibleiP05111. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR017175. Inhibin_asu_subgr.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037328. Inhibin_alpha_subunit. 1 hit.
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINHA_HUMAN
AccessioniPrimary (citable) accession number: P05111
Secondary accession number(s): A8K8H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 2, 2016
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.