Reviewed, UniProtKB/Swiss-Prot P05107 (ITB2_HUMAN)

Names and origin

Protein names

Recommended name:
    Integrin beta-2
Alternative name(s):
    Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
    Complement receptor C3 subunit beta
    CD_antigen=CD18

Gene names

Name:	ITGB2
Synonyms:	CD18, MFI7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	769 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
Subunit structure	Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9. Ref.7 Ref.9
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins. Ref.8
Involvement in disease	Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. Ref.6 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18
Sequence similarities	Belongs to the integrin beta chain family. Contains 1 VWFA domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Disease	Disease mutation
Domain	Repeat Signal Transmembrane
Molecular function	Integrin Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein Pyrrolidone carboxylic acid
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	apoptosis Non-traceable author statement. Source: UniProtKB cell-cell signaling Non-traceable author statement. Source: UniProtKB cell-matrix adhesion Inferred from electronic annotation. Source: InterPro inflammatory response Non-traceable author statement. Source: UniProtKB integrin-mediated signaling pathway Non-traceable author statement. Source: UniProtKB leukocyte adhesion Inferred from direct assay. Source: UniProtKB neutrophil chemotaxis Inferred from direct assay. Source: UniProtKB regulation of cell shape Non-traceable author statement. Source: UniProtKB regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay. Source: UniProtKB
Cellular component	cytoplasm Inferred from direct assay. Source: HPA integrin complex Ref.2 Non-traceable author statement. Source: UniProtKB
Molecular function	glycoprotein binding Inferred from physical interaction. Source: UniProtKB protein kinase binding Inferred from physical interaction. Source: UniProtKB receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SYK	P43405	1	EBI-300173,EBI-78302

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

22

Chain

23 – 769

747

Integrin beta-2

PRO_0000016341

Regions

Topological domain

23 – 700

678

Extracellular Potential

Transmembrane

701 – 723

23

Potential

Topological domain

724 – 769

46

Cytoplasmic Potential

Domain

124 – 363

240

VWFA

Repeat

449 – 496

48

I

Repeat

497 – 540

44

II

Repeat

541 – 581

41

III

Repeat

582 – 617

36

IV

Region

449 – 617

169

Cysteine-rich tandem repeats

Motif

397 – 399

3

Cell attachment site Potential

Amino acid modifications

Modified residue

23

1

Pyrrolidone carboxylic acid

Modified residue

745

1

Phosphoserine; by PKC Ref.8

Modified residue

756

1

Phosphoserine Ref.8

Modified residue

758

1

Phosphothreonine; by PKC; in vitro Ref.8

Modified residue

759

1

Phosphothreonine Potential

Modified residue

760

1

Phosphothreonine; by PKC/PRKCA; in vitro Ref.8

Glycosylation

50

1

N-linked (GlcNAc...)

Glycosylation

116

1

N-linked (GlcNAc...) Potential

Glycosylation

212

1

N-linked (GlcNAc...) Ref.10

Glycosylation

254

1

N-linked (GlcNAc...) Potential

Glycosylation

501

1

N-linked (GlcNAc...) Potential

Glycosylation

642

1

N-linked (GlcNAc...) Potential

Disulfide bond

25 ↔ 447

By similarity

Disulfide bond

33 ↔ 43

By similarity

Disulfide bond

36 ↔ 73

By similarity

Disulfide bond

46 ↔ 62

By similarity

Disulfide bond

191 ↔ 198

By similarity

Disulfide bond

246 ↔ 286

By similarity

Disulfide bond

386 ↔ 400

By similarity

Disulfide bond

420 ↔ 662

By similarity

Disulfide bond

445 ↔ 449

By similarity

Disulfide bond

459 ↔ 470

By similarity

Disulfide bond

467 ↔ 506

By similarity

Disulfide bond

472 ↔ 481

By similarity

Disulfide bond

483 ↔ 497

By similarity

Disulfide bond

512 ↔ 517

By similarity

Disulfide bond

514 ↔ 549

By similarity

Disulfide bond

519 ↔ 534

By similarity

Disulfide bond

536 ↔ 541

By similarity

Disulfide bond

557 ↔ 562

By similarity

Disulfide bond

559 ↔ 590

By similarity

Disulfide bond

564 ↔ 573

By similarity

Disulfide bond

575 ↔ 582

By similarity

Disulfide bond

596 ↔ 601

By similarity

Disulfide bond

598 ↔ 643

By similarity

Disulfide bond

603 ↔ 612

By similarity

Disulfide bond

615 ↔ 618

By similarity

Disulfide bond

622 ↔ 631

By similarity

Disulfide bond

628 ↔ 695

By similarity

Disulfide bond

647 ↔ 670

By similarity

Natural variations

Natural variant

128

1

D → N in LAD1. Ref.16

VAR_003984

Natural variant

138

1

S → P in LAD1. Ref.18

VAR_013402

Natural variant

149

1

L → P in LAD1. Ref.12

VAR_003985

Natural variant

169

1

G → R in LAD1. Ref.12 Ref.13

VAR_003986

Natural variant

178

1

P → L in LAD1. Ref.15

VAR_003987

Natural variant

196

1

K → T in LAD1. Ref.14

VAR_003988

Natural variant

273

1

G → R in LAD1. Ref.18

VAR_013403

Natural variant

284

1

G → S in LAD1. Ref.17

VAR_003989

Natural variant

351

1

N → S in LAD1. Ref.6

VAR_003990

Natural variant

354

1

Q → H: dbSNP rs235330. Ref.6 Ref.1 Ref.2 Ref.4 Ref.5

VAR_030035

Natural variant

586

1

R → W in LAD1. dbSNP rs5030672. Ref.6

VAR_003991

Natural variant

593

1

R → C in LAD1. Ref.14

VAR_003992

Experimental info

Sequence conflict

199

1

Q → P in CAA68266. Ref.5

Secondary structure

1

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769

Helix Strand Turn

Details...

Helix

33 – 37

5

Beta strand

44 – 46

3

Helix

58 – 61

4

Helix

65 – 70

6

Helix

75 – 77

3

Beta strand

84 – 88

5

Beta strand

97 – 99

3

Beta strand

101 – 107

7

Beta strand

113 – 119

7

Helix

297 – 300

4

Helix

304 – 309

6

Helix

314 – 316

3

Beta strand

323 – 327

5

Beta strand

330 – 333

4

Beta strand

335 – 338

4

Beta strand

340 – 346

7

Beta strand

352 – 358

7

Beta strand

360 – 362

3

Beta strand

366 – 371

6

Beta strand

378 – 385

8

Helix

387 – 389

3

Beta strand

391 – 401

11

Beta strand

409 – 419

11

Beta strand

424 – 430

7

Beta strand

437 – 443

7

Helix

458 – 461

4

Beta strand

462 – 466

5

Beta strand

469 – 472

4

Helix

490 – 495

6

Helix

505 – 508

4

Beta strand

509 – 513

5

Beta strand

516 – 519

4

Beta strand

528 – 531

4

Beta strand

536 – 539

4

Turn

552 – 554

3

Beta strand

555 – 558

4

Beta strand

561 – 564

4

Beta strand

568 – 570

3

Beta strand

754 – 762

9

Sequences

	Sequence		Length	Mass (Da)
	P05107-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: EB9F3C3DF338B4E1	FASTA	769	84,782
	10 20 30 40 50 60 MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN FTGPGDPDSI 70 80 90 100 110 120 RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP QKVTLYLRPG QAAAFNVTFR 130 140 150 160 170 180 RAKGYPIDLY YLMDLSYSML DDLRNVKKLG GDLLRALNEI TESGRIGFGS FVDKTVLPFV 190 200 210 220 230 240 NTHPDKLRNP CPNKEKECQP PFAFRHVLKL TNNSNQFQTE VGKQLISGNL DAPEGGLDAM 250 260 270 280 290 300 MQVAACPEEI GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGRCHLED NLYKRSNEFD 310 320 330 340 350 360 YPSVGQLAHK LAENNIQPIF AVTSRMVKTY EKLTEIIPKS AVGELSEDSS NVVQLIKNAY 370 380 390 400 410 420 NKLSSRVFLD HNALPDTLKV TYDSFCSNGV THRNQPRGDC DGVQINVPIT FQVKVTATEC 430 440 450 460 470 480 IQEQSFVIRA LGFTDIVTVQ VLPQCECRCR DQSRDRSLCH GKGFLECGIC RCDTGYIGKN 490 500 510 520 530 540 CECQTQGRSS QELEGSCRKD NNSIICSGLG DCVCGQCLCH TSDVPGKLIY GQYCECDTIN 550 560 570 580 590 600 CERYNGQVCG GPGRGLCFCG KCRCHPGFEG SACQCERTTE GCLNPRRVEC SGRGRCRCNV 610 620 630 640 650 660 CECHSGYQLP LCQECPGCPS PCGKYISCAE CLKFEKGPFG KNCSAACPGL QLSNNPVKGR 670 680 690 700 710 720 TCKERDSEGC WVAYTLEQQD GMDRYLIYVD ESRECVAGPN IAAIVGGTVA GIVLIGILLL 730 740 750 760 VIWKALIHLS DLREYRRFEK EKLKSQWNND NPLFKSATTT VMNPKFAES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family." Kishimoto T.K., O'Connor K., Lee A., Roberts T.M., Springer T.A. Cell 48:681-690(1987) [PubMed: 3028646] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-354.
[2]	"The gene organisation of the human beta 2 integrin subunit (CD18)." Weitzman J.B., Wells C.E., Wright A.H., Clark P.A., Law S.K.A. FEBS Lett. 294:97-103(1991) [PubMed: 1683838] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-354.
[3]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-354. Tissue: Muscle.
[5]	"The primary structure of the beta-subunit of the cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship to the fibronectin receptor." Law S.K.A., Gagnon J., Hildreth J.E., Wells C.E., Willis A.C., Wong A.J. EMBO J. 6:915-919(1987) [PubMed: 2954816] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-769, PARTIAL PROTEIN SEQUENCE, VARIANT HIS-354. Tissue: Spleen.
[6]	"Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins." Nelson C., Rabb H., Arnaout M.A. J. Biol. Chem. 267:3351-3357(1992) [PubMed: 1346613] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 347-355, VARIANTS LAD1 SER-351 AND TRP-586, VARIANT HIS-354.
[7]	"Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity." Bianchi E., Denti S., Granata A., Bossi G., Geginat J., Villa A., Rogge L., Pardi R. Nature 404:617-621(2000) [PubMed: 10766246] [Abstract] Cited for: INTERACTION WITH COPS5.
[8]	"Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes." Fagerholm S., Morrice N., Gahmberg C.G., Cohen P. J. Biol. Chem. 277:1728-1738(2002) [PubMed: 11700305] [Abstract] Cited for: PHOSPHORYLATION AT SER-745; SER-756; THR-758 AND THR-760.
[9]	"RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1." Denti S., Sirri A., Cheli A., Rogge L., Innamorati G., Putignano S., Fabbri M., Pardi R., Bianchi E. J. Biol. Chem. 279:13027-13034(2004) [PubMed: 14722085] [Abstract] Cited for: INTERACTION WITH RANBP9.
[10]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-212, MASS SPECTROMETRY. Tissue: Plasma.
[11]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-50 AND ASN-212, MASS SPECTROMETRY. Tissue: Liver.
[12]	"Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates." Wardlaw A.J., Hibbs M.L., Stacker S.A., Springer T.A. J. Exp. Med. 172:335-345(1990) [PubMed: 1694220] [Abstract] Cited for: VARIANTS LAD1 PRO-149 AND ARG-169.
[13]	"Molecular basis for a severe case of leukocyte adhesion deficiency." Corbi A., Vara A., Ursa A., Rodriguez M.C.G., Fontan G., Sanchez-Madrid F. Eur. J. Immunol. 22:1877-1881(1992) [PubMed: 1352501] [Abstract] Cited for: VARIANT LAD1 ARG-169.
[14]	"Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency." Arnaout M.A., Dana N., Gupta S.K., Tenen D.G., Fathallah D.M. J. Clin. Invest. 85:977-981(1990) [PubMed: 1968911] [Abstract] Cited for: VARIANTS LAD1 THR-196 AND CYS-593.
[15]	"Identification of two molecular defects in a child with leukocyte adherence deficiency." Back L.L., Kwok W.W., Hickstein D.D. J. Biol. Chem. 267:5482-5487(1992) [PubMed: 1347532] [Abstract] Cited for: VARIANT LAD1 LEU-178.
[16]	"Leukocyte adhesion deficiency: identification of novel mutations in two Japanese patients with a severe form." Matsuura S., Kishi F., Tsukahara M., Nunoi H., Matsuda I., Kobayashi K., Kajii T. Biochem. Biophys. Res. Commun. 184:1460-1467(1992) [PubMed: 1590804] [Abstract] Cited for: VARIANT LAD1 ASN-128.
[17]	"A point mutation associated with leukocyte adhesion deficiency type 1 of moderate severity." Back L.A., Kerkering M., Baker D., Bauer T.R., Embree L.J., Hickstein D.D. Biochem. Biophys. Res. Commun. 193:912-918(1993) [PubMed: 7686755] [Abstract] Cited for: VARIANT LAD1 SER-284.
[18]	"A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1." Hogg N., Stewart M.P., Scarth S.L., Newton R., Shaw J.M., Law S.K.A., Klein N. J. Clin. Invest. 103:97-106(1999) [PubMed: 9884339] [Abstract] Cited for: VARIANTS LAD1 PRO-138 AND ARG-273.
+	Additional computationally mapped references.

Web resources

ITGB2base

ITGB2 mutation db

GeneReviews

Cross-references

Sequence databases

EMBLGenBankDDBJ

M15395 mRNA. Translation: AAA59490.1.
X64072 , X64073, X64074, X64075, X64076, X64077, X64078, X64079, X64080, X64081, X64082, X64083, X63924, X63925, X63926 Genomic DNA. Translation: CAA45427.1.
AL163300 Genomic DNA. Translation: CAB90553.1.
BC005861 mRNA. Translation: AAH05861.1.
Y00057 mRNA. Translation: CAA68266.1.
S81234 mRNA. Translation: AAB21404.1.

IPI

IPI00291792.

PIR

IJHULM. A25967.

RefSeq

NP_000202.2.
NP_001120963.1.

UniGene

Hs.375957

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JX3	model	-	A	126-364	[»]
1L3Y	NMR	-	A	535-574	[»]
1YUK	X-ray	1.80	A	23-125	[»]
			B	365-482	[»]
2JF1	X-ray	2.20	T	735-769	[»]
2P26	X-ray	1.75	A	23-535	[»]
2P28	X-ray	2.20	A	23-122	[»]
			B	362-574	[»]
2V7D	X-ray	2.50	P/Q/R/S	755-764	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:478N.

IntAct

P05107. 1 interaction.

PTM databases

PhosphoSite

P05107.

Proteomic databases

PRIDE

P05107.

Genome annotation databases

Ensembl

ENSG00000160255. Homo sapiens. [Contig view]

GeneID

3689.

KEGG

hsa:3689.

Organism-specific databases

GeneCards

GC21M045130.

H-InvDB

HIX0016175.

HGNC

HGNC:6155. ITGB2.

HPA

HPA008877.
HPA016894.

MIM

116920. phenotype.
600065. gene.

Orphanet

2968. Leukocyte adhesion deficiency.

PharmGKB

PA29955.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P05107.

HOVERGEN

P05107.

OMA

P05107. CHTSDVP.

Enzyme and pathway databases

Pathway_Interaction_DB

amb2_neutrophils_pathway. amb2 Integrin signaling.
hif1_tfpathway. HIF-1-alpha transcription factor network.
a4b1_paxdep_pathway. Paxillin-dependent events mediated by a4b1.

Reactome

REACT_13552. Integrin cell surface interactions.
REACT_604. Hemostasis.
REACT_6900. Signaling in Immune system.

Gene expression databases

ArrayExpress

P05107.

Bgee

P05107.

CleanEx

HS_ITGB2.

GermOnline

ENSG00000160255. Homo sapiens.

Family and domain databases

InterPro

IPR013032. EGF-like_reg_CS.
IPR013111. EGF_extracell.
IPR015812. Integrin_bsu.
IPR015439. Integrin_bsu-2_C.
IPR001169. Integrin_bsu_C.
IPR014836. Integrin_bsu_cyt.
IPR002369. Integrin_bsu_N.
IPR012012. Integrin_bsu_subgr.
IPR012896. Integrin_bsu_tail.
IPR003659. Plexin-like.
IPR002035. VWF_A.
[Graphical view]

Gene3D

G3DSA:1.20.5.630. Integrin_bsu_cyt. 1 hit.

PANTHER

PTHR10082. Integrin_beta_C. 1 hit.
PTHR10082:SF15. Integrin_bsu-2_C. 1 hit.

Pfam

PF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]

PIRSF

PIRSF002512. Integrin_B. 1 hit.

PRINTS

PR01186. INTEGRINB.

SMART

SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]

PROSITE

PS00022. EGF_1. 2 hits. Uncertain.
PS01186. EGF_2. 3 hits. Uncertain.
PS00243. INTEGRIN_BETA. 3 hits.
PS50234. VWFA. False negative.
[Graphical view]

ProtoNet

Search...

Other Resources

DrugBank

DB00641. Simvastatin.

NextBio

14449.

PMAP-CutDB

P05107.

SOURCE

Search...

Entry information

Entry name

ITB2_HUMAN

Accession

Primary (citable) accession number: P05107
Secondary accession number(s): Q16418

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 134 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)