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P05106 (ITB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 201. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin beta-3
Alternative name(s):
Platelet membrane glycoprotein IIIa
Short name=GPIIIa
CD_antigen=CD61
Gene names
Name:ITGB3
Synonyms:GP3A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length788 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Subunit structure

Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with HIV-1 Tat. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2. Alpha-V/beta-3 interacts with herpes virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus. Ref.19 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.29 Ref.32

Subcellular location

Cell membrane; Single-pass type I membrane protein. Cell projectionlamellipodium membrane. Cell junctionfocal adhesion Ref.32.

Tissue specificity

Isoform beta-3Aand isoform beta-3Care widely expressed. Isoform beta-3Ais specifically expressed in osteoblast cells; isoform beta-3Cis specifically expressed in prostate and testis.

Post-translational modification

Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding. Ref.18 Ref.20

Polymorphism

Position 59 is associated with platelet-specific alloantigen HPA-1 (ZW or PL(A)). HPA-1A/ZW(A)/PL(A1) has Leu-59 and HPA-1B/ZW(B)/PL(A2) has Pro-59. HPA-1A is involved in fetal-maternal alloimmune thromobocytopenia (FMAIT) as well as in neonatal alloimmune thrombocytopenia (NAIT).

Position 169 is associated with platelet-specific alloantigen HPA-4 (PEN or YUK). HPA-4A/PEN(A)/YUK(A) has Arg-169 and HPA-4B/PEN(B)/YUK(B) has Gln-169. HPA-4B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP).

Position 433 is associated with platelet-specific alloantigen MO. MO- has Pro-433 and MO+ has Ala-433. MO+ is involved in NAIT.

Position 515 is associated with platelet-specific alloantigen CA/TU. CA-/TU- has Arg-515 and CA+/TU+ has Gln-515. CA+ is involved in NAIT.

Position 662 is associated with platelet-specific alloantigen SR(A). SR(A)- has Arg-662 and SR(A)+ has Cys-662.

Involvement in disease

Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.41 Ref.42 Ref.43 Ref.44 Ref.45 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.53 Ref.55 Ref.56 Ref.57 Ref.58 Ref.59 Ref.60 Ref.62

Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.61

Sequence similarities

Belongs to the integrin beta chain family.

Contains 1 VWFA domain.

Ontologies

Keywords
   Biological processCell adhesion
Host-virus interaction
   Cellular componentCell junction
Cell membrane
Cell projection
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionIntegrin
Receptor
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of protein kinase activity

Inferred from mutant phenotype PubMed 10022831. Source: BHF-UCL

angiogenesis involved in wound healing

Traceable author statement PubMed 19267251. Source: BHF-UCL

axon guidance

Traceable author statement. Source: Reactome

blood coagulation

Traceable author statement. Source: Reactome

cell adhesion

Traceable author statement PubMed 10429193Ref.2. Source: ProtInc

cell-matrix adhesion

Inferred from electronic annotation. Source: InterPro

cell-substrate junction assembly

Inferred from electronic annotation. Source: InterPro

extracellular matrix organization

Traceable author statement. Source: Reactome

integrin-mediated signaling pathway

Traceable author statement PubMed 21488147. Source: BHF-UCL

leukocyte migration

Traceable author statement. Source: Reactome

negative regulation of lipid storage

Inferred from mutant phenotype PubMed 15215180. Source: BHF-UCL

negative regulation of lipid transport

Inferred from mutant phenotype PubMed 15215180. Source: BHF-UCL

negative regulation of lipoprotein metabolic process

Inferred from mutant phenotype PubMed 15215180. Source: BHF-UCL

negative regulation of low-density lipoprotein particle receptor biosynthetic process

Inferred from mutant phenotype PubMed 15215180. Source: BHF-UCL

negative regulation of macrophage derived foam cell differentiation

Inferred from mutant phenotype PubMed 15215180. Source: BHF-UCL

platelet activation

Inferred from mutant phenotype Ref.24. Source: UniProtKB

platelet aggregation

Inferred from mutant phenotype Ref.24. Source: UniProtKB

platelet degranulation

Traceable author statement. Source: Reactome

positive regulation of endothelial cell migration

Inferred from mutant phenotype PubMed 10022831. Source: BHF-UCL

positive regulation of endothelial cell proliferation

Inferred from mutant phenotype PubMed 10022831. Source: BHF-UCL

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from mutant phenotype PubMed 10022831. Source: BHF-UCL

positive regulation of protein phosphorylation

Traceable author statement PubMed 19267251. Source: BHF-UCL

positive regulation of vascular endothelial growth factor receptor signaling pathway

Traceable author statement PubMed 19267251. Source: BHF-UCL

protein folding

Inferred from direct assay PubMed 12204115Ref.24. Source: GOC

regulation of bone resorption

Traceable author statement PubMed 19267251. Source: BHF-UCL

smooth muscle cell migration

Inferred from mutant phenotype PubMed 8837777. Source: BHF-UCL

tube development

Traceable author statement PubMed 19267251. Source: BHF-UCL

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

wound healing

Inferred by curator PubMed 8837777. Source: BHF-UCL

   Cellular_componentalphav-beta3 integrin-vitronectin complex

Traceable author statement PubMed 19267251. Source: BHF-UCL

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337. Source: UniProt

focal adhesion

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of plasma membrane

Traceable author statement Ref.2. Source: ProtInc

integrin complex

Inferred from direct assay PubMed 15215180. Source: BHF-UCL

lamellipodium membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

melanosome

Inferred from direct assay Ref.24. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 22027834. Source: MGI

plasma membrane

Inferred from direct assay Ref.24. Source: UniProtKB

platelet alpha granule membrane

Traceable author statement. Source: Reactome

receptor complex

Inferred from direct assay PubMed 23382219. Source: MGI

   Molecular_functioncell adhesion molecule binding

Inferred from physical interaction PubMed 8837777. Source: BHF-UCL

identical protein binding

Inferred from physical interaction PubMed 11606749PubMed 14681217. Source: IntAct

platelet-derived growth factor receptor binding

Traceable author statement PubMed 19267251. Source: BHF-UCL

protein disulfide isomerase activity

Inferred from direct assay PubMed 12204115Ref.24. Source: UniProtKB

receptor activity

Inferred from electronic annotation. Source: InterPro

vascular endothelial growth factor receptor 2 binding

Inferred from physical interaction PubMed 10022831. Source: BHF-UCL

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself4EBI-702847,EBI-702847
P069354EBI-702847,EBI-981051From a different organism.
ACTN1P050942EBI-702847,EBI-5847257From a different organism.
ITGA2BP0851411EBI-702847,EBI-702693
ITGAVP0675611EBI-702847,EBI-298282
ORF8F5HB812EBI-702847,EBI-9027696From a different organism.
Prkd1Q621012EBI-702847,EBI-6903636From a different organism.
PTPN1P180314EBI-702847,EBI-968788
SrcP054805EBI-702847,EBI-298680From a different organism.
TLN1P549392EBI-702847,EBI-1035421From a different organism.
TLN1Q9Y4904EBI-702847,EBI-2462036
Tln1P260393EBI-702847,EBI-1039593From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform Beta-3A (identifier: P05106-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta-3B (identifier: P05106-2)

The sequence of this isoform differs from the canonical sequence as follows:
     768-788: ANNPLYKEATSTFTNITYRGT → VRDGAGRFLKSLV
Isoform Beta-3C (identifier: P05106-3)

The sequence of this isoform differs from the canonical sequence as follows:
     768-788: ANNPLYKEATSTFTNITYRGT → HYAQSLRKWNQPVSIDG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 788762Integrin beta-3
PRO_0000016344

Regions

Topological domain27 – 718692Extracellular Potential
Transmembrane719 – 74123Helical; Potential
Topological domain742 – 78847Cytoplasmic Potential
Domain135 – 377243VWFA
Repeat463 – 51149I
Repeat512 – 55342II
Repeat554 – 59239III
Repeat593 – 62937IV
Region463 – 629167Cysteine-rich tandem repeats

Amino acid modifications

Modified residue7731Phosphotyrosine Ref.18 Ref.28
Modified residue7791Phosphothreonine; by PDPK1 and PKB/AKT1; in vitro Ref.20
Modified residue7851Phosphotyrosine Ref.18
Glycosylation1251N-linked (GlcNAc...) Ref.26 Ref.27
Glycosylation3461N-linked (GlcNAc...) Potential
Glycosylation3971N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...)
Glycosylation5851N-linked (GlcNAc...) Potential
Glycosylation6801N-linked (GlcNAc...) Ref.31
Disulfide bond31 ↔ 461 Ref.17
Disulfide bond39 ↔ 49 Ref.17
Disulfide bond42 ↔ 75 Ref.17
Disulfide bond52 ↔ 64 Ref.17
Disulfide bond203 ↔ 210 Ref.17
Disulfide bond258 ↔ 299 Ref.17
Disulfide bond400 ↔ 412 Ref.17
Disulfide bond432 ↔ 681 Ref.17
Disulfide bond459 ↔ 463 Ref.17
Disulfide bond474 ↔ 486 Probable
Disulfide bond483 ↔ 521 Probable
Disulfide bond488 ↔ 497 Probable
Disulfide bond499 ↔ 512 Probable
Disulfide bond527 ↔ 532 Probable
Disulfide bond529 ↔ 562 Probable
Disulfide bond534 ↔ 547 Probable
Disulfide bond549 ↔ 554 Ref.17
Disulfide bond568 ↔ 573 Probable
Disulfide bond570 ↔ 601 Probable
Disulfide bond575 ↔ 584 Probable
Disulfide bond586 ↔ 593 Probable
Disulfide bond607 ↔ 612 Probable
Disulfide bond609 ↔ 657 Probable
Disulfide bond614 ↔ 624 Probable
Disulfide bond627 ↔ 630 Probable
Disulfide bond634 ↔ 643 Probable
Disulfide bond640 ↔ 713 Probable
Disulfide bond661 ↔ 689 Ref.17

Natural variations

Alternative sequence768 – 78821ANNPL…TYRGT → VRDGAGRFLKSLV in isoform Beta-3B.
VSP_002745
Alternative sequence768 – 78821ANNPL…TYRGT → HYAQSLRKWNQPVSIDG in isoform Beta-3C.
VSP_002746
Natural variant591L → P in alloantigen HPA-1B. Ref.13 Ref.36 Ref.51
Corresponds to variant rs5918 [ dbSNP | Ensembl ].
VAR_003993
Natural variant641C → Y in GT; the mutation prevents normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype. Ref.62
VAR_069920
Natural variant661L → R. Ref.13
Corresponds to variant rs36080296 [ dbSNP | Ensembl ].
VAR_049633
Natural variant1191R → W in GT. Ref.56
VAR_030473
Natural variant1411Y → C in GT. Ref.60
VAR_030474
Natural variant1431L → W in GT. Ref.46
VAR_010649
Natural variant1441M → R in GT; the mutation prevented normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype. Ref.62
VAR_069921
Natural variant1451D → N in GT. Ref.47
VAR_030475
Natural variant1451D → Y in GT; type B. Ref.41
VAR_003998
Natural variant1501M → V in GT; may confer constitutive activity to the alpha-IIb/(mutated)beta-3 receptor. Ref.58
VAR_030476
Natural variant1661T → I Associated with neonatal thrombocytopenia; alloantigen Duv(a+); does not affect significantly the integrin function. Ref.54
VAR_030477
Natural variant1691R → Q in alloantigen HPA-4B. Ref.37 Ref.51
Corresponds to variant rs5917 [ dbSNP | Ensembl ].
VAR_003994
Natural variant1881S → L in GT; type II. Ref.49
VAR_010651
Natural variant2221L → P in GT; variant form. Ref.55 Ref.62
VAR_030478
Natural variant2401R → Q in GT; type B. Ref.42
VAR_003999
Natural variant2401R → W in GT; variant Strasbourg-1. Ref.43
VAR_004000
Natural variant2421R → Q in GT. Ref.47
VAR_030479
Natural variant2431D → V in GT. Ref.56
VAR_030480
Natural variant2471G → D in GT; the mutation prevents normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype; the mutation may interfere with correct folding of the protein. Ref.62
VAR_069922
Natural variant2791K → M in GT; the mutation prevents normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype; the mutation interupts the interaction of the ITGA2B/ITGB3 complex. Ref.62
VAR_069923
Natural variant2881L → P in GT. Ref.47
VAR_030481
Natural variant3061H → P in GT. Ref.48 Ref.59
Corresponds to variant rs13306476 [ dbSNP | Ensembl ].
VAR_004001
Natural variant3211M → L in GT. Ref.60
VAR_030482
Natural variant3301I → N in GT; not expressed on the surface and absent inside the transfected cells. Ref.59
VAR_030483
Natural variant4001C → Y in GT. Ref.45
VAR_004002
Natural variant4331P → A in alloantigen MO(+); in a case of neonatal alloimmune thrombocytopenia. Ref.38
Corresponds to variant rs121918448 [ dbSNP | Ensembl ].
VAR_003995
Natural variant4531V → I. Ref.51
Corresponds to variant rs5921 [ dbSNP | Ensembl ].
VAR_014178
Natural variant5151R → Q in alloantigen CA(+)/TU(+). Ref.39
Corresponds to variant rs13306487 [ dbSNP | Ensembl ].
VAR_003996
Natural variant5321C → Y in GT. Ref.57
VAR_030484
Natural variant5681C → R in GT; type I. Ref.50
VAR_010671
Natural variant5861C → F in GT. Ref.48
VAR_004003
Natural variant5861C → R in GT; gain-of-function mutation; constitutively binds ligand-induced binding sites antibodies and the fibrinogen-mimetic antibody PAC-1. Ref.53
VAR_030485
Natural variant5981G → S in GT. Ref.48
VAR_004004
Natural variant6011C → R in GT. Ref.56
VAR_030486
Natural variant6051G → S in GT; type II. Ref.48
VAR_010672
Natural variant6621R → C in alloantigen SR(A). Ref.40
Corresponds to variant rs151219882 [ dbSNP | Ensembl ].
VAR_003997
Natural variant7491D → H in BDPLT16; the mutant protein is constitutively active. Ref.61
VAR_069924
Natural variant7781S → P in GT; variant Strasbourg-1. Ref.44
VAR_004005

Experimental info

Sequence conflict121A → V in AAA52589. Ref.1
Sequence conflict121A → V in AAA35927. Ref.3
Sequence conflict1511K → P in AAA67537. Ref.11
Sequence conflict1511K → P in AAB23689. Ref.14
Sequence conflict2051D → EY in AAA67537. Ref.11
Sequence conflict649 – 6535GALHD → EPYMT in AAA52589. Ref.1
Sequence conflict649 – 6535GALHD → EPYMT in AAA60122. Ref.2
Sequence conflict649 – 6535GALHD → EPYMT in AAB71380. Ref.4
Sequence conflict7161G → H Ref.8
Sequence conflict737 – 7415ALLIW → PCSSG in AAA67537. Ref.11

Secondary structure

................................................................................................................................................................................. 788
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform Beta-3A [UniParc].

Last modified February 6, 2007. Version 2.
Checksum: F246623608E05F9E

FASTA78887,058
        10         20         30         40         50         60 
MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPLG 

        70         80         90        100        110        120 
SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP 

       130        140        150        160        170        180 
DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG 

       190        200        210        220        230        240 
AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR 

       250        260        270        280        290        300 
NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH 

       310        320        330        340        350        360 
VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS 

       370        380        390        400        410        420 
MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT 

       430        440        450        460        470        480 
VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS LIVQVTFDCD CACQAQAEPN SHRCNNGNGT 

       490        500        510        520        530        540 
FECGVCRCGP GWLGSQCECS EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG 

       550        560        570        580        590        600 
KITGKYCECD DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL 

       610        620        630        640        650        660 
CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA LHDENTCNRY 

       670        680        690        700        710        720 
CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS GKSILYVVEE PECPKGPDIL 

       730        740        750        760        770        780 
VVLLSVMGAI LLIGLAALLI WKLLITIHDR KEFAKFEEER ARAKWDTANN PLYKEATSTF 


TNITYRGT 

« Hide

Isoform Beta-3B [UniParc].

Checksum: C21A1B7814080CD7
Show »

FASTA78086,113
Isoform Beta-3C [UniParc].

Checksum: B8A9F2A7F3C39247
Show »

FASTA78486,694

References

« Hide 'large scale' references
[1]"Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to 'integrin'."
Fitzgerald L.A., Steiner B., Rall S.C. Jr., Lo S., Phillips D.R.
J. Biol. Chem. 262:3936-3939(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A).
[2]"Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors."
Zimrin A.B., Eisman R., Vilaire G., Schwartz E., Bennett J.S., Poncz M.
J. Clin. Invest. 81:1470-1475(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A).
[3]"GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs."
Frachet P., Uzan G., Thevenon D., Denarier E., Prandini M.H., Marguerie G.
Mol. Biol. Rep. 14:27-33(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A).
[4]"Cloning and characterization of a novel integrin beta3 subunit."
Kumar C.S., James I.E., Wong A., Mwangi V., Feild J.A., Nuthulaganti P., Connor J.R., Eichman C., Ali F., Hwang S.M., Rieman D.J., Drake F.H., Gowen M.
J. Biol. Chem. 272:16390-16397(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3C).
Tissue: Osteoclastoma.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-3A).
[7]"Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene."
Villa-Garcia M., Li L., Riely G., Bray P.F.
Blood 83:668-676(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
Tissue: Blood.
[8]"Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17."
Rosa J.P., Bray P.F., Gayet O., Johnston G.I., Cook R.G., Jackson K.W., Shuman M.A., McEver R.P.
Blood 72:593-600(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-788.
Tissue: Erythroleukemia.
[9]"Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing."
Catimel B., Parmentier S., Leung L.L., McGregor J.L.
Biochem. J. 279:419-425(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-37.
Tissue: Platelet.
[10]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-34.
Tissue: Platelet.
[11]"The genomic organization of platelet glycoprotein IIIa."
Zimrin A.B., Gidwitz S., Lord S., Schwartz E., Bennett J.S., White G.C. II, Poncz M.
J. Biol. Chem. 265:8590-8595(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-788.
[12]"Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene."
Lanza F., Kieffer N., Phillips D.R., Fitzgerald L.A.
J. Biol. Chem. 265:18098-18103(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-788.
[13]"A new exon II polymorphism in the platelet glycoprotein IIIa."
Pascual C., Balas A., Garcia-Sanchez F., Rodriguez de la Rua A., Vicario J.L.
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-120, VARIANTS PRO-59 AND ARG-66.
Tissue: Blood.
[14]"The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1."
Jiang W.-M., Jenkins D., Yuan Q., Leung E., Choo K.H., Watson J.D., Krissansen G.W.
Int. Immunol. 4:1031-1040(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 122-204.
[15]"Purification and partial amino acid sequence of human platelet membrane glycoproteins IIb and IIIa."
Hiraiwa A., Matsukage A., Shiku H., Takahashi T., Naito K., Yamada K.
Blood 69:560-564(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 218-234 AND 439-443.
[16]"An alternative cytoplasmic domain of the integrin beta 3 subunit."
Van Kuppevelt T.H.M.S.M., Languino L.R., Gailit J.O., Suzuki S., Ruoslahti E.
Proc. Natl. Acad. Sci. U.S.A. 86:5415-5418(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 707-788 (ISOFORM BETA-3B).
Tissue: Placenta.
[17]"Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family."
Calvete J.J., Henschen A., Gonzalez-Rodriguez J.
Biochem. J. 274:63-71(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
[18]"Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation."
Law D.A., Nannizzi-Alaimo L., Phillips D.R.
J. Biol. Chem. 271:10811-10815(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT TYR-773 AND TYR-785 (ISOFORM BETA-3A).
[19]"The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor."
Barillari G., Sgadari C., Fiorelli V., Samaniego F., Colombini S., Manzari V., Modesti A., Nair B.C., Cafaro A., Stuerzl M., Ensoli B.
Blood 94:663-672(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HIV-1 TAT.
[20]"Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding."
Kirk R.I., Sanderson M.R., Lerea K.M.
J. Biol. Chem. 275:30901-30906(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT THR-779.
[21]"Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton."
Obergfell A., Eto K., Mocsai A., Buensuceso C., Moores S.L., Brugge J.S., Lowell C.A., Shattil S.J.
J. Cell Biol. 157:265-275(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SYK.
[22]"Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
van Der Flier A., Kuikman I., Kramer D., Geerts D., Kreft M., Takafuta T., Shapiro S.S., Sonnenberg A.
J. Cell Biol. 156:361-376(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FLNB.
Tissue: Keratinocyte and Skeletal muscle.
[23]"Myosin-X provides a motor-based link between integrins and the cytoskeleton."
Zhang H., Berg J.S., Li Z., Wang Y., Lang P., Sousa A.D., Bhaskar A., Cheney R.E., Stromblad S.
Nat. Cell Biol. 6:523-531(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MYO10.
[24]"A role for the thiol isomerase protein ERP5 in platelet function."
Jordan P.A., Stevens J.M., Hubbard G.P., Barrett N.E., Sage T., Authi K.S., Gibbins J.M.
Blood 105:1500-1507(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PDIA6.
[25]"Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins."
Chen F.-H., Thomas A.O., Hecht J.T., Goldring M.B., Lawler J.
J. Biol. Chem. 280:32655-32661(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH COMP.
[26]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125.
Tissue: Plasma.
[27]"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U., Moebius J., Walter U., Sickmann A.
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125.
Tissue: Platelet.
[28]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-773, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[29]"Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor."
Garrigues H.J., Rubinchikova Y.E., Dipersio C.M., Rose T.M.
J. Virol. 82:1570-1580(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HHV-8 GLYCOPROTEIN B.
[30]"Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells."
Anani Sarab G., Moss M., Barker R.N., Urbaniak S.J.
Blood 114:1954-1957(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF ALLOANTIGEN HPA-1A BY MASS SPECTROMETRY, ASSOCIATION TO ALLELE HLA-DRB3*01:01.
[31]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-680.
Tissue: Liver.
[32]"Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation."
Bledzka K., Bialkowska K., Nie H., Qin J., Byzova T., Wu C., Plow E.F., Ma Y.Q.
J. Biol. Chem. 285:30370-30374(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FERMT2, SUBCELLULAR LOCATION.
[33]"Crystal structure of the extracellular segment of integrin alpha Vbeta3."
Xiong J.P., Stehle T., Diefenbach B., Zhang R., Dunker R., Scott D.L., Joachimiak A., Goodman S.L., Arnaout M.A.
Science 294:339-345(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 27-718.
[34]"Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity."
Parry C.S., Gorski J., Stern L.J.
J. Mol. Biol. 371:435-446(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 50-61 (ALLOANTIGEN HPA-1A) IN COMPLEX WITH HLA-DRA/HLA-DRB3 HETERODIMER.
[35]"Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization."
Bray P.F.
Thromb. Haemost. 72:492-502(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW ON GT VARIANTS.
[36]"The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing."
Newman P.J., Derbes R.S., Aster R.H.
J. Clin. Invest. 83:1778-1781(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HPA-1B PRO-59, DESCRIPTION OF ALLOANTIGEN SYSTEM PL(A).
[37]"An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system."
Wang R., Furihata K., McFarland J.G., Friedman K., Aster R.H., Newman P.J.
J. Clin. Invest. 90:2038-2043(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HPA-4B GLN-169, DESCRIPTION OF ALLOANTIGEN SYSTEM PEN.
[38]"Single point mutation in human glycoprotein IIIa is associated with a new platelet-specific alloantigen (Mo) involved in neonatal alloimmune thrombocytopenia."
Kuijpers R.W.A.M., Simsek S., Faber N.M., Goldschmeding R., van Wermerkerken R.K.V., von Dem Borne A.E.G.K.
Blood 81:70-76(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MO(+) ALA-433.
[39]"Amino acid 489 is encoded by a mutational 'hot spot' on the beta 3 integrin chain: the CA/TU human platelet alloantigen system."
Wang R., McFarland J.G., Kekomaki R., Newman P.J.
Blood 82:3386-3391(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT CA(+)/TU(+) GLN-515, DESCRIPTION OF ALLOANTIGEN SYSTEM CA/TU.
[40]"A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa."
Santoso S., Kalb R., Kroll H., Walka M., Kiefel V., Mueller-Eckhardt C., Newman P.J.
J. Biol. Chem. 269:8439-8444(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SR(A) CYS-662, DESCRIPTION OF ALLOANTIGEN SYSTEM SR(A).
[41]"A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation."
Loftus J.C., O'Toole T.E., Plow E.F., Glass A., Frelinger A.L. III, Ginsberg M.H.
Science 249:915-918(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT TYR-145.
[42]"A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site."
Bajt M.L., Ginsberg M.H., Frelinger A.L. III, Berndt M.C., Loftus J.C.
J. Biol. Chem. 267:3789-3794(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT GLN-240.
[43]"A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg-->214Trp mutation."
Lanza F., Stierle A., Fournier D., Morales M., Andre G., Nurden A.T., Cazenave J.-P.
J. Clin. Invest. 89:1995-2004(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT TRP-240.
[44]"Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia."
Chen Y.-P., Djaffar I., Pidard D., Steiner B., Cieutat A.-M., Caen J.P., Rosa J.-P.
Proc. Natl. Acad. Sci. U.S.A. 89:10169-10173(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT PRO-778.
[45]"A Cys374Tyr homozygous mutation of platelet glycoprotein IIIa (beta 3) in a Chinese patient with Glanzmann's thrombasthenia."
Grimaldi C.M., Chen F., Scudder L.E., Coller B.S., French D.L.
Blood 88:1666-1675(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT TYR-400.
[46]"A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface."
Basani R.B., Brown D.L., Vilaire G., Bennett J.S., Poncz M.
Blood 90:3082-3088(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT TRP-143.
[47]"Hematologically important mutations: Glanzmann thrombasthenia."
French D.L., Coller B.S.
Blood Cells Mol. Dis. 23:39-51(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS GT ASN-145; GLN-242 AND PRO-288.
[48]"Three novel integrin beta3 subunit missense mutations (H280P, C560F, and G579S) in thrombasthenia, including one (H280P) prevalent in Japanese patients."
Ambo H., Kamata T., Handa M., Taki M., Kuwajima M., Kawai Y., Oda A., Murata M., Takada Y., Watanabe K., Ikeda Y.
Biochem. Biophys. Res. Commun. 251:763-768(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS GT PRO-306; PHE-586; SER-598 AND SER-605.
[49]"A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia."
Jackson D.E., White M.M., Jennings L.K., Newman P.J.
Thromb. Haemost. 80:42-48(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT LEU-188.
[50]"Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia."
Ruan J., Schmugge M., Clemetson K.J., Cazes E., Combrie R., Bourre F., Nurden A.T.
Br. J. Haematol. 105:523-531(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT ARG-568.
[51]"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PRO-59; GLN-169 AND ILE-453.
[52]Erratum
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 23:373-373(1999)
[53]"A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype."
Ruiz C., Liu C.-Y., Sun Q.-H., Sigaud-Fiks M., Fressinaud E., Muller J.-Y., Nurden P., Nurden A.T., Newman P.J., Valentin N.
Blood 98:2432-2441(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT ARG-586, CHARACTERIZATION OF VARIANT GT ARG-586.
[54]"A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia."
Jallu V., Meunier M., Brement M., Kaplan C.
Blood 99:4449-4456(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ILE-166, CHARACTERIZATION OF VARIANT ILE-166.
[55]"A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia."
Nurden A.T., Ruan J., Pasquet J.-M., Gauthier B., Combrie R., Kunicki T., Nurden P.
Platelets 13:101-111(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT PRO-222.
[56]"Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients."
D'Andrea G., Colaizzo D., Vecchione G., Grandone E., Di Minno G., Margaglione M.
Thromb. Haemost. 87:1034-1042(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS GT TRP-119; VAL-243 AND ARG-601.
[57]"Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3."
Nair S., Li J., Mitchell W.B., Mohanty D., Coller B.S., French D.L.
Thromb. Haemost. 88:503-509(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT TYR-532.
[58]"A variant thrombasthenic phenotype associated with compound heterozygosity of integrin beta3-subunit: (Met124Val)beta3 alters the subunit dimerization rendering a decreased number of constitutive active alphaIIbbeta3 receptors."
Gonzalez-Manchon C., Butta N., Larrucea S., Arias-Salgado E.G., Alonso S., Lopez A., Parrilla R.
Thromb. Haemost. 92:1377-1386(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GT VAL-150, CHARACTERIZATION OF VARIANT GT VAL-150.
[59]"Double heterozygosity for a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia."
Tanaka S., Hayashi T., Yoshimura K., Nakayama M., Fujita T., Amano T., Tani Y.
J. Thromb. Haemost. 3:68-73(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS GT PRO-306 AND ASN-330, CHARACTERIZATION OF VARIANT GT ASN-330.
[60]"Mutations in GPIIIa molecule as a cause for Glanzmann thrombasthenia in Indian patients."
Nair S., Ghosh K., Shetty S., Mohanty D.
J. Thromb. Haemost. 3:482-488(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS GT CYS-141 AND LEU-321.
[61]"A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia."
Ghevaert C., Salsmann A., Watkins N.A., Schaffner-Reckinger E., Rankin A., Garner S.F., Stephens J., Smith G.A., Debili N., Vainchenker W., de Groot P.G., Huntington J.A., Laffan M., Kieffer N., Ouwehand W.H.
Blood 111:3407-3414(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT BDPLT16 HIS-749, CHARACTERIZATION OF VARIANT BDPLT16 HIS-749.
[62]"AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function."
Jallu V., Dusseaux M., Panzer S., Torchet M.F., Hezard N., Goudemand J., de Brevern A.G., Kaplan C.
Hum. Mutat. 31:237-246(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS GT TYR-64; ARG-144; PRO-222; ASP-247 AND MET-279, CHARACTERIZATION OF VARIANTS TYR-64; PRO-222; ASP-247 AND MET-279.
+Additional computationally mapped references.

Web resources

GeneReviews
SHMPD

The Singapore human mutation and polymorphism database

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02703 mRNA. Translation: AAA52589.1.
M20311 mRNA. Translation: AAA60122.1.
M35999 mRNA. Translation: AAA35927.1.
U95204 mRNA. Translation: AAB71380.1.
CH471231 Genomic DNA. Translation: EAW57682.1.
BC127666 mRNA. Translation: AAI27667.1.
BC127667 mRNA. Translation: AAI27668.1.
L28832 Genomic DNA. Translation: AAA20880.2.
M32686 expand/collapse EMBL AC list , M32667, M32672, M32673, M32674, M32675, M32680, M32681, M32682, M32685 Genomic DNA. Translation: AAA67537.1.
M57494 expand/collapse EMBL AC list , M57481, M57482, M57483, M57484, M57485, M57486, M57487, M57488, M57489, M57490, M57491, M57492, M57493 Genomic DNA. Translation: AAA52600.1.
U03881 Genomic DNA. Translation: AAA16076.1.
S49379 Genomic DNA. Translation: AAB23689.2.
M25108 mRNA. Translation: AAA36121.1.
PIRA26547.
A60798.
B36268.
I77349.
S14324.
RefSeqNP_000203.2. NM_000212.2.
UniGeneHs.218040.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JV2X-ray3.10B27-718[»]
1KUPNMR-B742-766[»]
1KUZNMR-B742-766[»]
1L5GX-ray3.20B27-718[»]
1M1XX-ray3.30B27-718[»]
1M8ONMR-B742-788[»]
1MIZX-ray1.90A761-769[»]
1MK7X-ray2.20A/C765-775[»]
1MK9X-ray2.80A/C/E/G765-776[»]
1RN0model-B135-378[»]
1S4XNMR-A742-788[»]
1TYEX-ray2.90B/D/F27-466[»]
1U8CX-ray3.10B27-718[»]
2INImodel-B81-460[»]
B558-716[»]
2K9JNMR-B711-753[»]
2KNCNMR-B715-788[»]
2KV9NMR-B739-788[»]
2L1CNMR-B762-788[»]
2L91NMR-A711-753[»]
2LJDNMR-A742-788[»]
2LJENMR-A742-788[»]
2LJFNMR-A742-788[»]
2Q6WX-ray2.25C/F50-61[»]
2RMZNMR-A711-753[»]
2RN0NMR-A711-753[»]
2VC2X-ray3.10B27-487[»]
2VDKX-ray2.80B27-487[»]
2VDLX-ray2.75B27-487[»]
2VDMX-ray2.90B27-487[»]
2VDNX-ray2.90B27-487[»]
2VDOX-ray2.51B27-487[»]
2VDPX-ray2.80B27-487[»]
2VDQX-ray2.59B27-487[»]
2VDRX-ray2.40B27-487[»]
3FCSX-ray2.55B/D27-716[»]
3FCUX-ray2.90B/D/F27-487[»]
3IJEX-ray2.90B27-721[»]
3NIDX-ray2.30B/D27-497[»]
3NIFX-ray2.40B/D27-497[»]
3NIGX-ray2.25B/D27-497[»]
3T3MX-ray2.60B/D27-498[»]
3T3PX-ray2.20B/D27-498[»]
3ZDXX-ray2.45B/D27-498[»]
3ZDYX-ray2.45B/D27-498[»]
3ZDZX-ray2.75B/D27-498[»]
3ZE0X-ray2.95B/D27-498[»]
3ZE1X-ray3.00B/D27-498[»]
3ZE2X-ray2.35B/D27-498[»]
4CAKelectron microscopy20.50B27-716[»]
4G1EX-ray3.00B27-717[»]
4G1MX-ray2.90B27-718[»]
ProteinModelPortalP05106.
SMRP05106. Positions 27-788.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109896. 16 interactions.
DIPDIP-304N.
IntActP05106. 17 interactions.
MINTMINT-209501.
STRING9606.ENSP00000262017.

Chemistry

BindingDBP05106.
ChEMBLCHEMBL2111443.
DrugBankDB00054. Abciximab.
DB00775. Tirofiban.

PTM databases

PhosphoSiteP05106.

Polymorphism databases

DMDM125987835.

Proteomic databases

PaxDbP05106.
PRIDEP05106.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000559488; ENSP00000452786; ENSG00000259207. [P05106-1]
GeneID3690.
KEGGhsa:3690.
UCSCuc002ilj.3. human. [P05106-1]

Organism-specific databases

CTD3690.
GeneCardsGC17P045331.
HGNCHGNC:6156. ITGB3.
HPACAB002501.
HPA027852.
MIM173470. gene+phenotype.
187800. phenotype.
273800. phenotype.
neXtProtNX_P05106.
Orphanet140957. Autosomal dominant macrothrombocytopenia.
853. Fetal and neonatal alloimmune thrombocytopenia.
849. Glanzmann thrombasthenia.
PharmGKBPA205.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG287997.
HOVERGENHBG006190.
InParanoidP05106.
KOK06493.
OMAGHGQCSC.
OrthoDBEOG7T7GSB.
PhylomeDBP05106.
TreeFamTF105392.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_111102. Signal Transduction.
REACT_118779. Extracellular matrix organization.
REACT_604. Hemostasis.
SignaLinkP05106.

Gene expression databases

ArrayExpressP05106.
BgeeP05106.
CleanExHS_ITGB3.
GenevestigatorP05106.

Family and domain databases

Gene3D1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProIPR027068. Integrin_beta-3.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
PfamPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFPIRSF002512. Integrin_B. 1 hit.
PRINTSPR01186. INTEGRINB.
SMARTSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSITGB3. human.
EvolutionaryTraceP05106.
GeneWikiCD61.
GenomeRNAi3690.
NextBio14453.
PMAP-CutDBP05106.
PROP05106.
SOURCESearch...

Entry information

Entry nameITB3_HUMAN
AccessionPrimary (citable) accession number: P05106
Secondary accession number(s): A0PJW2 expand/collapse secondary AC list , D3DXJ8, O15495, Q12806, Q13413, Q14648, Q16499
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 201 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Metallothioneins

Classification of metallothioneins and list of entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries