SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P05106

- ITB3_HUMAN

UniProt

P05106 - ITB3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Integrin beta-3

Gene
ITGB3, GP3A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. identical protein binding Source: IntAct
  3. platelet-derived growth factor receptor binding Source: BHF-UCL
  4. protein binding Source: UniProtKB
  5. protein disulfide isomerase activity Source: UniProtKB
  6. receptor activity Source: InterPro
  7. vascular endothelial growth factor receptor 2 binding Source: BHF-UCL

GO - Biological processi

  1. activation of protein kinase activity Source: BHF-UCL
  2. angiogenesis involved in wound healing Source: BHF-UCL
  3. axon guidance Source: Reactome
  4. blood coagulation Source: Reactome
  5. cell adhesion Source: ProtInc
  6. cell-matrix adhesion Source: InterPro
  7. cell-substrate junction assembly Source: InterPro
  8. extracellular matrix organization Source: Reactome
  9. integrin-mediated signaling pathway Source: BHF-UCL
  10. leukocyte migration Source: Reactome
  11. negative regulation of lipid storage Source: BHF-UCL
  12. negative regulation of lipid transport Source: BHF-UCL
  13. negative regulation of lipoprotein metabolic process Source: BHF-UCL
  14. negative regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
  15. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  16. platelet activation Source: UniProtKB
  17. platelet aggregation Source: UniProtKB
  18. platelet degranulation Source: Reactome
  19. positive regulation of endothelial cell migration Source: BHF-UCL
  20. positive regulation of endothelial cell proliferation Source: BHF-UCL
  21. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  22. positive regulation of protein phosphorylation Source: BHF-UCL
  23. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  24. protein folding Source: GOC
  25. regulation of bone resorption Source: BHF-UCL
  26. smooth muscle cell migration Source: BHF-UCL
  27. tube development Source: BHF-UCL
  28. viral process Source: UniProtKB-KW
  29. wound healing Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_12519. PECAM1 interactions.
REACT_13552. Integrin cell surface interactions.
REACT_150331. Molecules associated with elastic fibres.
REACT_150366. Elastic fibre formation.
REACT_15381. p130Cas linkage to MAPK signaling for integrins.
REACT_15523. Integrin alphaIIb beta3 signaling.
REACT_163906. ECM proteoglycans.
REACT_163942. Syndecan interactions.
REACT_22272. Signal transduction by L1.
SignaLinkiP05106.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-3
Alternative name(s):
Platelet membrane glycoprotein IIIa
Short name:
GPIIIa
CD_antigen: CD61
Gene namesi
Name:ITGB3
Synonyms:GP3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6156. ITGB3.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Cell projectionlamellipodium membrane. Cell junctionfocal adhesion 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 718692Extracellular Reviewed predictionAdd
BLAST
Transmembranei719 – 74123Helical; Reviewed predictionAdd
BLAST
Topological domaini742 – 78847Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. alphav-beta3 integrin-vitronectin complex Source: BHF-UCL
  2. extracellular vesicular exosome Source: UniProt
  3. focal adhesion Source: UniProtKB-SubCell
  4. integral component of plasma membrane Source: ProtInc
  5. integrin complex Source: BHF-UCL
  6. lamellipodium membrane Source: UniProtKB-SubCell
  7. melanosome Source: UniProtKB
  8. nucleus Source: MGI
  9. plasma membrane Source: UniProtKB
  10. platelet alpha granule membrane Source: Reactome
  11. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Involvement in diseasei

Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability.
Note: The disease is caused by mutations affecting the gene represented in this entry.18 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641C → Y in GT; the mutation prevents normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype. 1 Publication
VAR_069920
Natural varianti119 – 1191R → W in GT. 1 Publication
VAR_030473
Natural varianti141 – 1411Y → C in GT. 1 Publication
VAR_030474
Natural varianti143 – 1431L → W in GT. 1 Publication
VAR_010649
Natural varianti144 – 1441M → R in GT; the mutation prevented normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype. 1 Publication
VAR_069921
Natural varianti145 – 1451D → N in GT. 1 Publication
VAR_030475
Natural varianti145 – 1451D → Y in GT; type B. 1 Publication
VAR_003998
Natural varianti150 – 1501M → V in GT; may confer constitutive activity to the alpha-IIb/(mutated)beta-3 receptor. 1 Publication
VAR_030476
Natural varianti188 – 1881S → L in GT; type II. 1 Publication
VAR_010651
Natural varianti222 – 2221L → P in GT; variant form. 2 Publications
VAR_030478
Natural varianti240 – 2401R → Q in GT; type B. 1 Publication
VAR_003999
Natural varianti240 – 2401R → W in GT; variant Strasbourg-1. 1 Publication
VAR_004000
Natural varianti242 – 2421R → Q in GT. 1 Publication
VAR_030479
Natural varianti243 – 2431D → V in GT. 1 Publication
VAR_030480
Natural varianti247 – 2471G → D in GT; the mutation prevents normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype; the mutation may interfere with correct folding of the protein. 1 Publication
VAR_069922
Natural varianti279 – 2791K → M in GT; the mutation prevents normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype; the mutation interupts the interaction of the ITGA2B/ITGB3 complex. 1 Publication
VAR_069923
Natural varianti288 – 2881L → P in GT. 1 Publication
VAR_030481
Natural varianti306 – 3061H → P in GT. 2 Publications
Corresponds to variant rs13306476 [ dbSNP | Ensembl ].
VAR_004001
Natural varianti321 – 3211M → L in GT. 1 Publication
VAR_030482
Natural varianti330 – 3301I → N in GT; not expressed on the surface and absent inside the transfected cells. 1 Publication
VAR_030483
Natural varianti400 – 4001C → Y in GT. 1 Publication
VAR_004002
Natural varianti532 – 5321C → Y in GT. 1 Publication
VAR_030484
Natural varianti568 – 5681C → R in GT; type I. 1 Publication
VAR_010671
Natural varianti586 – 5861C → F in GT. 1 Publication
VAR_004003
Natural varianti586 – 5861C → R in GT; gain-of-function mutation; constitutively binds ligand-induced binding sites antibodies and the fibrinogen-mimetic antibody PAC-1. 1 Publication
VAR_030485
Natural varianti598 – 5981G → S in GT. 1 Publication
VAR_004004
Natural varianti601 – 6011C → R in GT. 1 Publication
VAR_030486
Natural varianti605 – 6051G → S in GT; type II. 1 Publication
VAR_010672
Natural varianti778 – 7781S → P in GT; variant Strasbourg-1. 1 Publication
VAR_004005
Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti749 – 7491D → H in BDPLT16; the mutant protein is constitutively active. 1 Publication
VAR_069924

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi173470. gene+phenotype.
187800. phenotype.
273800. phenotype.
Orphaneti140957. Autosomal dominant macrothrombocytopenia.
853. Fetal and neonatal alloimmune thrombocytopenia.
849. Glanzmann thrombasthenia.
PharmGKBiPA205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 788762Integrin beta-3PRO_0000016344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 4611 Publication
Disulfide bondi39 ↔ 491 Publication
Disulfide bondi42 ↔ 751 Publication
Disulfide bondi52 ↔ 641 Publication
Glycosylationi125 – 1251N-linked (GlcNAc...)2 Publications
Disulfide bondi203 ↔ 2101 Publication
Disulfide bondi258 ↔ 2991 Publication
Glycosylationi346 – 3461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi397 – 3971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi400 ↔ 4121 Publication
Disulfide bondi432 ↔ 6811 Publication
Disulfide bondi459 ↔ 4631 Publication
Disulfide bondi474 ↔ 486 Inferred
Glycosylationi478 – 4781N-linked (GlcNAc...)
Disulfide bondi483 ↔ 521 Inferred
Disulfide bondi488 ↔ 497 Inferred
Disulfide bondi499 ↔ 512 Inferred
Disulfide bondi527 ↔ 532 Inferred
Disulfide bondi529 ↔ 562 Inferred
Disulfide bondi534 ↔ 547 Inferred
Disulfide bondi549 ↔ 5541 Publication
Disulfide bondi568 ↔ 573 Inferred
Disulfide bondi570 ↔ 601 Inferred
Disulfide bondi575 ↔ 584 Inferred
Glycosylationi585 – 5851N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi586 ↔ 593 Inferred
Disulfide bondi607 ↔ 612 Inferred
Disulfide bondi609 ↔ 657 Inferred
Disulfide bondi614 ↔ 624 Inferred
Disulfide bondi627 ↔ 630 Inferred
Disulfide bondi634 ↔ 643 Inferred
Disulfide bondi640 ↔ 713 Inferred
Disulfide bondi661 ↔ 6891 Publication
Glycosylationi680 – 6801N-linked (GlcNAc...)1 Publication
Modified residuei773 – 7731Phosphotyrosine2 Publications
Modified residuei779 – 7791Phosphothreonine; by PDPK1 and PKB/AKT1; in vitro1 Publication
Modified residuei785 – 7851Phosphotyrosine1 Publication

Post-translational modificationi

Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP05106.
PaxDbiP05106.
PRIDEiP05106.

PTM databases

PhosphoSiteiP05106.

Miscellaneous databases

PMAP-CutDBP05106.

Expressioni

Tissue specificityi

Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Gene expression databases

ArrayExpressiP05106.
BgeeiP05106.
CleanExiHS_ITGB3.
GenevestigatoriP05106.

Organism-specific databases

HPAiCAB002501.
HPA027852.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with HIV-1 Tat. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2. Alpha-V/beta-3 interacts with herpes virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-702847,EBI-702847
P069354EBI-702847,EBI-981051From a different organism.
ACTN1P050942EBI-702847,EBI-5847257From a different organism.
ITGA2BP0851411EBI-702847,EBI-702693
ITGAVP0675611EBI-702847,EBI-298282
ORF8F5HB812EBI-702847,EBI-9027696From a different organism.
Prkd1Q621012EBI-702847,EBI-6903636From a different organism.
PTPN1P180314EBI-702847,EBI-968788
SrcP054805EBI-702847,EBI-298680From a different organism.
TLN1P549392EBI-702847,EBI-1035421From a different organism.
TLN1Q9Y4904EBI-702847,EBI-2462036
Tln1P260393EBI-702847,EBI-1039593From a different organism.

Protein-protein interaction databases

BioGridi109896. 17 interactions.
DIPiDIP-304N.
IntActiP05106. 17 interactions.
MINTiMINT-209501.
STRINGi9606.ENSP00000262017.

Structurei

Secondary structure

1
788
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 334
Helixi35 – 373
Helixi39 – 457
Beta strandi50 – 523
Beta strandi54 – 574
Beta strandi59 – 613
Beta strandi63 – 653
Helixi67 – 726
Helixi77 – 793
Beta strandi86 – 916
Beta strandi99 – 1013
Helixi103 – 1053
Beta strandi109 – 1113
Beta strandi113 – 1186
Beta strandi123 – 1319
Beta strandi138 – 1458
Helixi148 – 1503
Helixi151 – 1566
Turni157 – 1593
Helixi160 – 1689
Turni169 – 1713
Beta strandi175 – 1828
Turni188 – 1903
Helixi196 – 2005
Turni202 – 2076
Beta strandi215 – 22410
Helixi226 – 23510
Beta strandi242 – 2465
Helixi248 – 25710
Helixi259 – 2624
Beta strandi266 – 27813
Helixi285 – 2895
Beta strandi305 – 3073
Turni308 – 3125
Helixi318 – 32710
Beta strandi331 – 3366
Helixi338 – 3403
Helixi341 – 3499
Beta strandi355 – 3584
Turni361 – 3633
Helixi366 – 37712
Beta strandi381 – 3877
Beta strandi392 – 4009
Turni401 – 4033
Beta strandi404 – 4074
Beta strandi411 – 4155
Beta strandi420 – 42910
Beta strandi434 – 44411
Beta strandi451 – 4577
Helixi462 – 4665
Beta strandi468 – 4703
Turni472 – 4787
Beta strandi479 – 4824
Beta strandi485 – 4884
Beta strandi489 – 4913
Turni494 – 4974
Beta strandi500 – 5045
Beta strandi513 – 5186
Helixi520 – 5234
Beta strandi524 – 5274
Beta strandi529 – 5346
Beta strandi538 – 5403
Beta strandi542 – 5443
Beta strandi549 – 5524
Beta strandi556 – 5616
Helixi562 – 5643
Beta strandi565 – 5695
Beta strandi572 – 5754
Beta strandi579 – 5846
Turni591 – 5933
Beta strandi598 – 6003
Beta strandi602 – 6043
Beta strandi606 – 6083
Beta strandi611 – 6133
Turni616 – 6183
Beta strandi620 – 6245
Beta strandi628 – 6303
Turni633 – 6353
Helixi639 – 6413
Turni642 – 6465
Beta strandi649 – 6557
Turni658 – 6603
Beta strandi664 – 6663
Beta strandi669 – 6713
Beta strandi674 – 6785
Beta strandi680 – 6845
Beta strandi688 – 6947
Beta strandi698 – 7003
Beta strandi704 – 7063
Beta strandi707 – 7104
Beta strandi715 – 7173
Turni743 – 75917
Turni761 – 7655
Beta strandi767 – 7704
Helixi771 – 7744
Helixi776 – 7794
Turni782 – 7865

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JV2X-ray3.10B27-718[»]
1KUPNMR-B742-766[»]
1KUZNMR-B742-766[»]
1L5GX-ray3.20B27-718[»]
1M1XX-ray3.30B27-718[»]
1M8ONMR-B742-788[»]
1MIZX-ray1.90A765-769[»]
1MK7X-ray2.20A/C765-775[»]
1MK9X-ray2.80A/C/E/G765-776[»]
1RN0model-B135-378[»]
1S4XNMR-A742-788[»]
1TYEX-ray2.90B/D/F27-466[»]
1U8CX-ray3.10B27-718[»]
2INImodel-B81-460[»]
B558-716[»]
2K9JNMR-B711-753[»]
2KNCNMR-B715-788[»]
2KV9NMR-B739-788[»]
2L1CNMR-B762-788[»]
2L91NMR-A711-753[»]
2LJDNMR-A742-788[»]
2LJENMR-A742-788[»]
2LJFNMR-A742-788[»]
2Q6WX-ray2.25C/F50-61[»]
2RMZNMR-A711-753[»]
2RN0NMR-A711-753[»]
2VC2X-ray3.10B27-487[»]
2VDKX-ray2.80B27-487[»]
2VDLX-ray2.75B27-487[»]
2VDMX-ray2.90B27-487[»]
2VDNX-ray2.90B27-487[»]
2VDOX-ray2.51B27-487[»]
2VDPX-ray2.80B27-487[»]
2VDQX-ray2.59B27-487[»]
2VDRX-ray2.40B27-487[»]
3FCSX-ray2.55B/D27-716[»]
3FCUX-ray2.90B/D/F27-487[»]
3IJEX-ray2.90B27-721[»]
3NIDX-ray2.30B/D27-497[»]
3NIFX-ray2.40B/D27-497[»]
3NIGX-ray2.25B/D27-497[»]
3T3MX-ray2.60B/D27-498[»]
3T3PX-ray2.20B/D27-498[»]
3ZDXX-ray2.45B/D27-498[»]
3ZDYX-ray2.45B/D27-498[»]
3ZDZX-ray2.75B/D27-498[»]
3ZE0X-ray2.95B/D27-498[»]
3ZE1X-ray3.00B/D27-498[»]
3ZE2X-ray2.35B/D27-498[»]
4CAKelectron microscopy20.50B27-716[»]
4G1EX-ray3.00B27-717[»]
4G1MX-ray2.90B27-718[»]
4MMXX-ray3.32B27-718[»]
4MMYX-ray3.18B27-718[»]
4MMZX-ray3.10B27-718[»]
4O02X-ray3.60B27-718[»]
ProteinModelPortaliP05106.
SMRiP05106. Positions 27-788.

Miscellaneous databases

EvolutionaryTraceiP05106.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 377243VWFAAdd
BLAST
Repeati463 – 51149IAdd
BLAST
Repeati512 – 55342IIAdd
BLAST
Repeati554 – 59239IIIAdd
BLAST
Repeati593 – 62937IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni463 – 629167Cysteine-rich tandem repeatsAdd
BLAST

Sequence similaritiesi

Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287997.
HOVERGENiHBG006190.
InParanoidiP05106.
KOiK06493.
OMAiGHGQCSC.
OrthoDBiEOG7T7GSB.
PhylomeDBiP05106.
TreeFamiTF105392.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR027068. Integrin_beta-3.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
PfamiPF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Beta-3A (identifier: P05106-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA    50
WCSDEALPLG SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS 100
GDSSQVTQVS PQRIALRLRP DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM 150
KDDLWSIQNL GTKLATQMRK LTSNLRIGFG AFVDKPVSPY MYISPPEALE 200
NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR NRDAPEGGFD 250
AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH 300
VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL 350
IPGTTVGVLS MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC 400
LNNEVIPGLK SCMGLKIGDT VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS 450
LIVQVTFDCD CACQAQAEPN SHRCNNGNGT FECGVCRCGP GWLGSQCECS 500
EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG KITGKYCECD 550
DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL 600
CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA 650
LHDENTCNRY CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS 700
GKSILYVVEE PECPKGPDIL VVLLSVMGAI LLIGLAALLI WKLLITIHDR 750
KEFAKFEEER ARAKWDTANN PLYKEATSTF TNITYRGT 788
Length:788
Mass (Da):87,058
Last modified:February 6, 2007 - v2
Checksum:iF246623608E05F9E
GO
Isoform Beta-3B (identifier: P05106-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     768-788: ANNPLYKEATSTFTNITYRGT → VRDGAGRFLKSLV

Show »
Length:780
Mass (Da):86,113
Checksum:iC21A1B7814080CD7
GO
Isoform Beta-3C (identifier: P05106-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     768-788: ANNPLYKEATSTFTNITYRGT → HYAQSLRKWNQPVSIDG

Show »
Length:784
Mass (Da):86,694
Checksum:iB8A9F2A7F3C39247
GO

Polymorphismi

Position 59 is associated with platelet-specific alloantigen HPA-1 (ZW or PL(A)). HPA-1A/ZW(A)/PL(A1) has Leu-59 and HPA-1B/ZW(B)/PL(A2) has Pro-59. HPA-1A is involved in fetal-maternal alloimmune thromobocytopenia (FMAIT) as well as in neonatal alloimmune thrombocytopenia (NAIT).
Position 169 is associated with platelet-specific alloantigen HPA-4 (PEN or YUK). HPA-4A/PEN(A)/YUK(A) has Arg-169 and HPA-4B/PEN(B)/YUK(B) has Gln-169. HPA-4B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP).
Position 433 is associated with platelet-specific alloantigen MO. MO- has Pro-433 and MO+ has Ala-433. MO+ is involved in NAIT.
Position 515 is associated with platelet-specific alloantigen CA/TU. CA-/TU- has Arg-515 and CA+/TU+ has Gln-515. CA+ is involved in NAIT.
Position 662 is associated with platelet-specific alloantigen SR(A). SR(A)- has Arg-662 and SR(A)+ has Cys-662.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591L → P in alloantigen HPA-1B. 3 Publications
Corresponds to variant rs5918 [ dbSNP | Ensembl ].
VAR_003993
Natural varianti64 – 641C → Y in GT; the mutation prevents normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype. 1 Publication
VAR_069920
Natural varianti66 – 661L → R.1 Publication
Corresponds to variant rs36080296 [ dbSNP | Ensembl ].
VAR_049633
Natural varianti119 – 1191R → W in GT. 1 Publication
VAR_030473
Natural varianti141 – 1411Y → C in GT. 1 Publication
VAR_030474
Natural varianti143 – 1431L → W in GT. 1 Publication
VAR_010649
Natural varianti144 – 1441M → R in GT; the mutation prevented normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype. 1 Publication
VAR_069921
Natural varianti145 – 1451D → N in GT. 1 Publication
VAR_030475
Natural varianti145 – 1451D → Y in GT; type B. 1 Publication
VAR_003998
Natural varianti150 – 1501M → V in GT; may confer constitutive activity to the alpha-IIb/(mutated)beta-3 receptor. 1 Publication
VAR_030476
Natural varianti166 – 1661T → I Associated with neonatal thrombocytopenia; alloantigen Duv(a+); does not affect significantly the integrin function. 1 Publication
VAR_030477
Natural varianti169 – 1691R → Q in alloantigen HPA-4B. 2 Publications
Corresponds to variant rs5917 [ dbSNP | Ensembl ].
VAR_003994
Natural varianti188 – 1881S → L in GT; type II. 1 Publication
VAR_010651
Natural varianti222 – 2221L → P in GT; variant form. 2 Publications
VAR_030478
Natural varianti240 – 2401R → Q in GT; type B. 1 Publication
VAR_003999
Natural varianti240 – 2401R → W in GT; variant Strasbourg-1. 1 Publication
VAR_004000
Natural varianti242 – 2421R → Q in GT. 1 Publication
VAR_030479
Natural varianti243 – 2431D → V in GT. 1 Publication
VAR_030480
Natural varianti247 – 2471G → D in GT; the mutation prevents normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype; the mutation may interfere with correct folding of the protein. 1 Publication
VAR_069922
Natural varianti279 – 2791K → M in GT; the mutation prevents normal ITGA2B/ITGB3 complex expression on the cell surface consistent with a severe type 1 phenotype; the mutation interupts the interaction of the ITGA2B/ITGB3 complex. 1 Publication
VAR_069923
Natural varianti288 – 2881L → P in GT. 1 Publication
VAR_030481
Natural varianti306 – 3061H → P in GT. 2 Publications
Corresponds to variant rs13306476 [ dbSNP | Ensembl ].
VAR_004001
Natural varianti321 – 3211M → L in GT. 1 Publication
VAR_030482
Natural varianti330 – 3301I → N in GT; not expressed on the surface and absent inside the transfected cells. 1 Publication
VAR_030483
Natural varianti400 – 4001C → Y in GT. 1 Publication
VAR_004002
Natural varianti433 – 4331P → A in alloantigen MO(+); in a case of neonatal alloimmune thrombocytopenia. 1 Publication
Corresponds to variant rs121918448 [ dbSNP | Ensembl ].
VAR_003995
Natural varianti453 – 4531V → I.1 Publication
Corresponds to variant rs5921 [ dbSNP | Ensembl ].
VAR_014178
Natural varianti515 – 5151R → Q in alloantigen CA(+)/TU(+). 1 Publication
Corresponds to variant rs13306487 [ dbSNP | Ensembl ].
VAR_003996
Natural varianti532 – 5321C → Y in GT. 1 Publication
VAR_030484
Natural varianti568 – 5681C → R in GT; type I. 1 Publication
VAR_010671
Natural varianti586 – 5861C → F in GT. 1 Publication
VAR_004003
Natural varianti586 – 5861C → R in GT; gain-of-function mutation; constitutively binds ligand-induced binding sites antibodies and the fibrinogen-mimetic antibody PAC-1. 1 Publication
VAR_030485
Natural varianti598 – 5981G → S in GT. 1 Publication
VAR_004004
Natural varianti601 – 6011C → R in GT. 1 Publication
VAR_030486
Natural varianti605 – 6051G → S in GT; type II. 1 Publication
VAR_010672
Natural varianti662 – 6621R → C in alloantigen SR(A). 1 Publication
Corresponds to variant rs151219882 [ dbSNP | Ensembl ].
VAR_003997
Natural varianti749 – 7491D → H in BDPLT16; the mutant protein is constitutively active. 1 Publication
VAR_069924
Natural varianti778 – 7781S → P in GT; variant Strasbourg-1. 1 Publication
VAR_004005

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei768 – 78821ANNPL…TYRGT → VRDGAGRFLKSLV in isoform Beta-3B. VSP_002745Add
BLAST
Alternative sequencei768 – 78821ANNPL…TYRGT → HYAQSLRKWNQPVSIDG in isoform Beta-3C. VSP_002746Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121A → V in AAA52589. 1 Publication
Sequence conflicti12 – 121A → V in AAA35927. 1 Publication
Sequence conflicti151 – 1511K → P in AAA67537. 1 Publication
Sequence conflicti151 – 1511K → P in AAB23689. 1 Publication
Sequence conflicti205 – 2051D → EY in AAA67537. 1 Publication
Sequence conflicti649 – 6535GALHD → EPYMT in AAA52589. 1 Publication
Sequence conflicti649 – 6535GALHD → EPYMT in AAA60122. 1 Publication
Sequence conflicti649 – 6535GALHD → EPYMT in AAB71380. 1 Publication
Sequence conflicti716 – 7161G → H1 Publication
Sequence conflicti737 – 7415ALLIW → PCSSG in AAA67537. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02703 mRNA. Translation: AAA52589.1.
M20311 mRNA. Translation: AAA60122.1.
M35999 mRNA. Translation: AAA35927.1.
U95204 mRNA. Translation: AAB71380.1.
CH471231 Genomic DNA. Translation: EAW57682.1.
BC127666 mRNA. Translation: AAI27667.1.
BC127667 mRNA. Translation: AAI27668.1.
L28832 Genomic DNA. Translation: AAA20880.2.
M32686
, M32667, M32672, M32673, M32674, M32675, M32680, M32681, M32682, M32685 Genomic DNA. Translation: AAA67537.1.
M57494
, M57481, M57482, M57483, M57484, M57485, M57486, M57487, M57488, M57489, M57490, M57491, M57492, M57493 Genomic DNA. Translation: AAA52600.1.
U03881 Genomic DNA. Translation: AAA16076.1.
S49379 Genomic DNA. Translation: AAB23689.2.
M25108 mRNA. Translation: AAA36121.1.
CCDSiCCDS11511.1. [P05106-1]
PIRiA26547.
A60798.
B36268.
I77349.
S14324.
RefSeqiNP_000203.2. NM_000212.2. [P05106-1]
UniGeneiHs.218040.

Genome annotation databases

EnsembliENST00000559488; ENSP00000452786; ENSG00000259207. [P05106-1]
GeneIDi3690.
KEGGihsa:3690.
UCSCiuc002ilj.3. human. [P05106-1]

Polymorphism databases

DMDMi125987835.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02703 mRNA. Translation: AAA52589.1 .
M20311 mRNA. Translation: AAA60122.1 .
M35999 mRNA. Translation: AAA35927.1 .
U95204 mRNA. Translation: AAB71380.1 .
CH471231 Genomic DNA. Translation: EAW57682.1 .
BC127666 mRNA. Translation: AAI27667.1 .
BC127667 mRNA. Translation: AAI27668.1 .
L28832 Genomic DNA. Translation: AAA20880.2 .
M32686
, M32667 , M32672 , M32673 , M32674 , M32675 , M32680 , M32681 , M32682 , M32685 Genomic DNA. Translation: AAA67537.1 .
M57494
, M57481 , M57482 , M57483 , M57484 , M57485 , M57486 , M57487 , M57488 , M57489 , M57490 , M57491 , M57492 , M57493 Genomic DNA. Translation: AAA52600.1 .
U03881 Genomic DNA. Translation: AAA16076.1 .
S49379 Genomic DNA. Translation: AAB23689.2 .
M25108 mRNA. Translation: AAA36121.1 .
CCDSi CCDS11511.1. [P05106-1 ]
PIRi A26547.
A60798.
B36268.
I77349.
S14324.
RefSeqi NP_000203.2. NM_000212.2. [P05106-1 ]
UniGenei Hs.218040.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JV2 X-ray 3.10 B 27-718 [» ]
1KUP NMR - B 742-766 [» ]
1KUZ NMR - B 742-766 [» ]
1L5G X-ray 3.20 B 27-718 [» ]
1M1X X-ray 3.30 B 27-718 [» ]
1M8O NMR - B 742-788 [» ]
1MIZ X-ray 1.90 A 765-769 [» ]
1MK7 X-ray 2.20 A/C 765-775 [» ]
1MK9 X-ray 2.80 A/C/E/G 765-776 [» ]
1RN0 model - B 135-378 [» ]
1S4X NMR - A 742-788 [» ]
1TYE X-ray 2.90 B/D/F 27-466 [» ]
1U8C X-ray 3.10 B 27-718 [» ]
2INI model - B 81-460 [» ]
B 558-716 [» ]
2K9J NMR - B 711-753 [» ]
2KNC NMR - B 715-788 [» ]
2KV9 NMR - B 739-788 [» ]
2L1C NMR - B 762-788 [» ]
2L91 NMR - A 711-753 [» ]
2LJD NMR - A 742-788 [» ]
2LJE NMR - A 742-788 [» ]
2LJF NMR - A 742-788 [» ]
2Q6W X-ray 2.25 C/F 50-61 [» ]
2RMZ NMR - A 711-753 [» ]
2RN0 NMR - A 711-753 [» ]
2VC2 X-ray 3.10 B 27-487 [» ]
2VDK X-ray 2.80 B 27-487 [» ]
2VDL X-ray 2.75 B 27-487 [» ]
2VDM X-ray 2.90 B 27-487 [» ]
2VDN X-ray 2.90 B 27-487 [» ]
2VDO X-ray 2.51 B 27-487 [» ]
2VDP X-ray 2.80 B 27-487 [» ]
2VDQ X-ray 2.59 B 27-487 [» ]
2VDR X-ray 2.40 B 27-487 [» ]
3FCS X-ray 2.55 B/D 27-716 [» ]
3FCU X-ray 2.90 B/D/F 27-487 [» ]
3IJE X-ray 2.90 B 27-721 [» ]
3NID X-ray 2.30 B/D 27-497 [» ]
3NIF X-ray 2.40 B/D 27-497 [» ]
3NIG X-ray 2.25 B/D 27-497 [» ]
3T3M X-ray 2.60 B/D 27-498 [» ]
3T3P X-ray 2.20 B/D 27-498 [» ]
3ZDX X-ray 2.45 B/D 27-498 [» ]
3ZDY X-ray 2.45 B/D 27-498 [» ]
3ZDZ X-ray 2.75 B/D 27-498 [» ]
3ZE0 X-ray 2.95 B/D 27-498 [» ]
3ZE1 X-ray 3.00 B/D 27-498 [» ]
3ZE2 X-ray 2.35 B/D 27-498 [» ]
4CAK electron microscopy 20.50 B 27-716 [» ]
4G1E X-ray 3.00 B 27-717 [» ]
4G1M X-ray 2.90 B 27-718 [» ]
4MMX X-ray 3.32 B 27-718 [» ]
4MMY X-ray 3.18 B 27-718 [» ]
4MMZ X-ray 3.10 B 27-718 [» ]
4O02 X-ray 3.60 B 27-718 [» ]
ProteinModelPortali P05106.
SMRi P05106. Positions 27-788.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109896. 17 interactions.
DIPi DIP-304N.
IntActi P05106. 17 interactions.
MINTi MINT-209501.
STRINGi 9606.ENSP00000262017.

Chemistry

BindingDBi P05106.
ChEMBLi CHEMBL2111443.
DrugBanki DB00054. Abciximab.
DB00775. Tirofiban.

PTM databases

PhosphoSitei P05106.

Polymorphism databases

DMDMi 125987835.

Proteomic databases

MaxQBi P05106.
PaxDbi P05106.
PRIDEi P05106.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000559488 ; ENSP00000452786 ; ENSG00000259207 . [P05106-1 ]
GeneIDi 3690.
KEGGi hsa:3690.
UCSCi uc002ilj.3. human. [P05106-1 ]

Organism-specific databases

CTDi 3690.
GeneCardsi GC17P045331.
HGNCi HGNC:6156. ITGB3.
HPAi CAB002501.
HPA027852.
MIMi 173470. gene+phenotype.
187800. phenotype.
273800. phenotype.
neXtProti NX_P05106.
Orphaneti 140957. Autosomal dominant macrothrombocytopenia.
853. Fetal and neonatal alloimmune thrombocytopenia.
849. Glanzmann thrombasthenia.
PharmGKBi PA205.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287997.
HOVERGENi HBG006190.
InParanoidi P05106.
KOi K06493.
OMAi GHGQCSC.
OrthoDBi EOG7T7GSB.
PhylomeDBi P05106.
TreeFami TF105392.

Enzyme and pathway databases

Reactomei REACT_12519. PECAM1 interactions.
REACT_13552. Integrin cell surface interactions.
REACT_150331. Molecules associated with elastic fibres.
REACT_150366. Elastic fibre formation.
REACT_15381. p130Cas linkage to MAPK signaling for integrins.
REACT_15523. Integrin alphaIIb beta3 signaling.
REACT_163906. ECM proteoglycans.
REACT_163942. Syndecan interactions.
REACT_22272. Signal transduction by L1.
SignaLinki P05106.

Miscellaneous databases

ChiTaRSi ITGB3. human.
EvolutionaryTracei P05106.
GeneWikii CD61.
GenomeRNAii 3690.
NextBioi 14453.
PMAP-CutDB P05106.
PROi P05106.
SOURCEi Search...

Gene expression databases

ArrayExpressi P05106.
Bgeei P05106.
CleanExi HS_ITGB3.
Genevestigatori P05106.

Family and domain databases

Gene3Di 1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProi IPR027068. Integrin_beta-3.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF25. PTHR10082:SF25. 1 hit.
Pfami PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to 'integrin'."
    Fitzgerald L.A., Steiner B., Rall S.C. Jr., Lo S., Phillips D.R.
    J. Biol. Chem. 262:3936-3939(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A).
  2. "Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors."
    Zimrin A.B., Eisman R., Vilaire G., Schwartz E., Bennett J.S., Poncz M.
    J. Clin. Invest. 81:1470-1475(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A).
  3. "GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs."
    Frachet P., Uzan G., Thevenon D., Denarier E., Prandini M.H., Marguerie G.
    Mol. Biol. Rep. 14:27-33(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3A).
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-3C).
    Tissue: Osteoclastoma.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-3A).
  7. "Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene."
    Villa-Garcia M., Li L., Riely G., Bray P.F.
    Blood 83:668-676(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
    Tissue: Blood.
  8. "Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17."
    Rosa J.P., Bray P.F., Gayet O., Johnston G.I., Cook R.G., Jackson K.W., Shuman M.A., McEver R.P.
    Blood 72:593-600(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-788.
    Tissue: Erythroleukemia.
  9. "Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by F.P.L.C. Characterization by monoclonal antibodies and gas-phase sequencing."
    Catimel B., Parmentier S., Leung L.L., McGregor J.L.
    Biochem. J. 279:419-425(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-37.
    Tissue: Platelet.
  10. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-34.
    Tissue: Platelet.
  11. "The genomic organization of platelet glycoprotein IIIa."
    Zimrin A.B., Gidwitz S., Lord S., Schwartz E., Bennett J.S., White G.C. II, Poncz M.
    J. Biol. Chem. 265:8590-8595(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-788.
  12. "Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene."
    Lanza F., Kieffer N., Phillips D.R., Fitzgerald L.A.
    J. Biol. Chem. 265:18098-18103(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-788.
  13. "A new exon II polymorphism in the platelet glycoprotein IIIa."
    Pascual C., Balas A., Garcia-Sanchez F., Rodriguez de la Rua A., Vicario J.L.
    Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-120, VARIANTS PRO-59 AND ARG-66.
    Tissue: Blood.
  14. "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1."
    Jiang W.-M., Jenkins D., Yuan Q., Leung E., Choo K.H., Watson J.D., Krissansen G.W.
    Int. Immunol. 4:1031-1040(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 122-204.
  15. "Purification and partial amino acid sequence of human platelet membrane glycoproteins IIb and IIIa."
    Hiraiwa A., Matsukage A., Shiku H., Takahashi T., Naito K., Yamada K.
    Blood 69:560-564(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 218-234 AND 439-443.
  16. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 707-788 (ISOFORM BETA-3B).
    Tissue: Placenta.
  17. "Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family."
    Calvete J.J., Henschen A., Gonzalez-Rodriguez J.
    Biochem. J. 274:63-71(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
  18. "Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation."
    Law D.A., Nannizzi-Alaimo L., Phillips D.R.
    J. Biol. Chem. 271:10811-10815(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-773 AND TYR-785 (ISOFORM BETA-3A).
  19. "The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor."
    Barillari G., Sgadari C., Fiorelli V., Samaniego F., Colombini S., Manzari V., Modesti A., Nair B.C., Cafaro A., Stuerzl M., Ensoli B.
    Blood 94:663-672(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIV-1 TAT.
  20. "Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding."
    Kirk R.I., Sanderson M.R., Lerea K.M.
    J. Biol. Chem. 275:30901-30906(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-779.
  21. "Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton."
    Obergfell A., Eto K., Mocsai A., Buensuceso C., Moores S.L., Brugge J.S., Lowell C.A., Shattil S.J.
    J. Cell Biol. 157:265-275(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SYK.
  22. "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
    van Der Flier A., Kuikman I., Kramer D., Geerts D., Kreft M., Takafuta T., Shapiro S.S., Sonnenberg A.
    J. Cell Biol. 156:361-376(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FLNB.
    Tissue: Keratinocyte and Skeletal muscle.
  23. "Myosin-X provides a motor-based link between integrins and the cytoskeleton."
    Zhang H., Berg J.S., Li Z., Wang Y., Lang P., Sousa A.D., Bhaskar A., Cheney R.E., Stromblad S.
    Nat. Cell Biol. 6:523-531(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYO10.
  24. "A role for the thiol isomerase protein ERP5 in platelet function."
    Jordan P.A., Stevens J.M., Hubbard G.P., Barrett N.E., Sage T., Authi K.S., Gibbins J.M.
    Blood 105:1500-1507(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDIA6.
  25. "Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins."
    Chen F.-H., Thomas A.O., Hecht J.T., Goldring M.B., Lawler J.
    J. Biol. Chem. 280:32655-32661(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH COMP.
  26. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125.
    Tissue: Plasma.
  27. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
    Lewandrowski U., Moebius J., Walter U., Sickmann A.
    Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125.
    Tissue: Platelet.
  28. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-773, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  29. "Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor."
    Garrigues H.J., Rubinchikova Y.E., Dipersio C.M., Rose T.M.
    J. Virol. 82:1570-1580(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HHV-8 GLYCOPROTEIN B.
  30. "Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells."
    Anani Sarab G., Moss M., Barker R.N., Urbaniak S.J.
    Blood 114:1954-1957(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF ALLOANTIGEN HPA-1A BY MASS SPECTROMETRY, ASSOCIATION TO ALLELE HLA-DRB3*01:01.
  31. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-680.
    Tissue: Liver.
  32. "Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation."
    Bledzka K., Bialkowska K., Nie H., Qin J., Byzova T., Wu C., Plow E.F., Ma Y.Q.
    J. Biol. Chem. 285:30370-30374(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FERMT2, SUBCELLULAR LOCATION.
  33. "Crystal structure of the extracellular segment of integrin alpha Vbeta3."
    Xiong J.P., Stehle T., Diefenbach B., Zhang R., Dunker R., Scott D.L., Joachimiak A., Goodman S.L., Arnaout M.A.
    Science 294:339-345(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 27-718.
  34. "Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity."
    Parry C.S., Gorski J., Stern L.J.
    J. Mol. Biol. 371:435-446(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 50-61 (ALLOANTIGEN HPA-1A) IN COMPLEX WITH HLA-DRA/HLA-DRB3 HETERODIMER.
  35. "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization."
    Bray P.F.
    Thromb. Haemost. 72:492-502(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON GT VARIANTS.
  36. "The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing."
    Newman P.J., Derbes R.S., Aster R.H.
    J. Clin. Invest. 83:1778-1781(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HPA-1B PRO-59, DESCRIPTION OF ALLOANTIGEN SYSTEM PL(A).
  37. "An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system."
    Wang R., Furihata K., McFarland J.G., Friedman K., Aster R.H., Newman P.J.
    J. Clin. Invest. 90:2038-2043(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HPA-4B GLN-169, DESCRIPTION OF ALLOANTIGEN SYSTEM PEN.
  38. "Single point mutation in human glycoprotein IIIa is associated with a new platelet-specific alloantigen (Mo) involved in neonatal alloimmune thrombocytopenia."
    Kuijpers R.W.A.M., Simsek S., Faber N.M., Goldschmeding R., van Wermerkerken R.K.V., von Dem Borne A.E.G.K.
    Blood 81:70-76(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MO(+) ALA-433.
  39. "Amino acid 489 is encoded by a mutational 'hot spot' on the beta 3 integrin chain: the CA/TU human platelet alloantigen system."
    Wang R., McFarland J.G., Kekomaki R., Newman P.J.
    Blood 82:3386-3391(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CA(+)/TU(+) GLN-515, DESCRIPTION OF ALLOANTIGEN SYSTEM CA/TU.
  40. "A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta 3 integrin subunit. The Sra alloantigen system of GPIIIa."
    Santoso S., Kalb R., Kroll H., Walka M., Kiefel V., Mueller-Eckhardt C., Newman P.J.
    J. Biol. Chem. 269:8439-8444(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SR(A) CYS-662, DESCRIPTION OF ALLOANTIGEN SYSTEM SR(A).
  41. "A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation."
    Loftus J.C., O'Toole T.E., Plow E.F., Glass A., Frelinger A.L. III, Ginsberg M.H.
    Science 249:915-918(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT TYR-145.
  42. "A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site."
    Bajt M.L., Ginsberg M.H., Frelinger A.L. III, Berndt M.C., Loftus J.C.
    J. Biol. Chem. 267:3789-3794(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT GLN-240.
  43. "A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg-->214Trp mutation."
    Lanza F., Stierle A., Fournier D., Morales M., Andre G., Nurden A.T., Cazenave J.-P.
    J. Clin. Invest. 89:1995-2004(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT TRP-240.
  44. "Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia."
    Chen Y.-P., Djaffar I., Pidard D., Steiner B., Cieutat A.-M., Caen J.P., Rosa J.-P.
    Proc. Natl. Acad. Sci. U.S.A. 89:10169-10173(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT PRO-778.
  45. "A Cys374Tyr homozygous mutation of platelet glycoprotein IIIa (beta 3) in a Chinese patient with Glanzmann's thrombasthenia."
    Grimaldi C.M., Chen F., Scudder L.E., Coller B.S., French D.L.
    Blood 88:1666-1675(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT TYR-400.
  46. "A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface."
    Basani R.B., Brown D.L., Vilaire G., Bennett J.S., Poncz M.
    Blood 90:3082-3088(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT TRP-143.
  47. "Hematologically important mutations: Glanzmann thrombasthenia."
    French D.L., Coller B.S.
    Blood Cells Mol. Dis. 23:39-51(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GT ASN-145; GLN-242 AND PRO-288.
  48. "Three novel integrin beta3 subunit missense mutations (H280P, C560F, and G579S) in thrombasthenia, including one (H280P) prevalent in Japanese patients."
    Ambo H., Kamata T., Handa M., Taki M., Kuwajima M., Kawai Y., Oda A., Murata M., Takada Y., Watanabe K., Ikeda Y.
    Biochem. Biophys. Res. Commun. 251:763-768(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GT PRO-306; PHE-586; SER-598 AND SER-605.
  49. "A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia."
    Jackson D.E., White M.M., Jennings L.K., Newman P.J.
    Thromb. Haemost. 80:42-48(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT LEU-188.
  50. "Homozygous Cys542-->Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia."
    Ruan J., Schmugge M., Clemetson K.J., Cazes E., Combrie R., Bourre F., Nurden A.T.
    Br. J. Haematol. 105:523-531(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT ARG-568.
  51. Cited for: VARIANTS PRO-59; GLN-169 AND ILE-453.
  52. "A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype."
    Ruiz C., Liu C.-Y., Sun Q.-H., Sigaud-Fiks M., Fressinaud E., Muller J.-Y., Nurden P., Nurden A.T., Newman P.J., Valentin N.
    Blood 98:2432-2441(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT ARG-586, CHARACTERIZATION OF VARIANT GT ARG-586.
  53. "A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia."
    Jallu V., Meunier M., Brement M., Kaplan C.
    Blood 99:4449-4456(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ILE-166, CHARACTERIZATION OF VARIANT ILE-166.
  54. "A novel 196Leu to Pro substitution in the beta3 subunit of the alphaIIbbeta3 integrin in a patient with a variant form of Glanzmann thrombasthenia."
    Nurden A.T., Ruan J., Pasquet J.-M., Gauthier B., Combrie R., Kunicki T., Nurden P.
    Platelets 13:101-111(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT PRO-222.
  55. "Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients."
    D'Andrea G., Colaizzo D., Vecchione G., Grandone E., Di Minno G., Margaglione M.
    Thromb. Haemost. 87:1034-1042(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GT TRP-119; VAL-243 AND ARG-601.
  56. "Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3."
    Nair S., Li J., Mitchell W.B., Mohanty D., Coller B.S., French D.L.
    Thromb. Haemost. 88:503-509(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT TYR-532.
  57. "A variant thrombasthenic phenotype associated with compound heterozygosity of integrin beta3-subunit: (Met124Val)beta3 alters the subunit dimerization rendering a decreased number of constitutive active alphaIIbbeta3 receptors."
    Gonzalez-Manchon C., Butta N., Larrucea S., Arias-Salgado E.G., Alonso S., Lopez A., Parrilla R.
    Thromb. Haemost. 92:1377-1386(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GT VAL-150, CHARACTERIZATION OF VARIANT GT VAL-150.
  58. "Double heterozygosity for a novel missense mutation of Ile304 to Asn in addition to the missense mutation His280 to Pro in the integrin beta3 gene as a cause of the absence of platelet alphaIIbbeta3 in Glanzmann's thrombasthenia."
    Tanaka S., Hayashi T., Yoshimura K., Nakayama M., Fujita T., Amano T., Tani Y.
    J. Thromb. Haemost. 3:68-73(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GT PRO-306 AND ASN-330, CHARACTERIZATION OF VARIANT GT ASN-330.
  59. "Mutations in GPIIIa molecule as a cause for Glanzmann thrombasthenia in Indian patients."
    Nair S., Ghosh K., Shetty S., Mohanty D.
    J. Thromb. Haemost. 3:482-488(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GT CYS-141 AND LEU-321.
  60. "A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia."
    Ghevaert C., Salsmann A., Watkins N.A., Schaffner-Reckinger E., Rankin A., Garner S.F., Stephens J., Smith G.A., Debili N., Vainchenker W., de Groot P.G., Huntington J.A., Laffan M., Kieffer N., Ouwehand W.H.
    Blood 111:3407-3414(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT BDPLT16 HIS-749, CHARACTERIZATION OF VARIANT BDPLT16 HIS-749.
  61. "AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function."
    Jallu V., Dusseaux M., Panzer S., Torchet M.F., Hezard N., Goudemand J., de Brevern A.G., Kaplan C.
    Hum. Mutat. 31:237-246(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GT TYR-64; ARG-144; PRO-222; ASP-247 AND MET-279, CHARACTERIZATION OF VARIANTS TYR-64; PRO-222; ASP-247 AND MET-279.

Entry informationi

Entry nameiITB3_HUMAN
AccessioniPrimary (citable) accession number: P05106
Secondary accession number(s): A0PJW2
, D3DXJ8, O15495, Q12806, Q13413, Q14648, Q16499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 205 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Metallothioneins
    Classification of metallothioneins and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi