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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.1 Publication

Catalytic activityi

A C(21)-steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 17-alpha-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication
17-alpha-hydroxyprogesterone + [reduced NADPH--hemoprotein reductase] + O2 = androstenedione + acetate + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication
17-alpha-hydroxypregnenolone + [reduced NADPH--hemoprotein reductase] + O2 = 3-beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

heme1 Publication

Enzyme regulationi

Regulated predominantly by intracellular cAMP levels.

Pathwayi: steroid biosynthesis

This protein is involved in the pathway steroid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway steroid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi442Iron (heme axial ligand)1

GO - Molecular functioni

  • 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB
  • heme binding Source: UniProtKB
  • iron ion binding Source: InterPro
  • oxygen binding Source: ProtInc
  • steroid 17-alpha-monooxygenase activity Source: UniProtKB

GO - Biological processi

  • androgen biosynthetic process Source: Reactome
  • glucocorticoid biosynthetic process Source: Reactome
  • hormone biosynthetic process Source: UniProtKB
  • progesterone metabolic process Source: UniProtKB
  • sex differentiation Source: ProtInc
  • steroid biosynthetic process Source: ProtInc
  • steroid metabolic process Source: UniProtKB
  • sterol metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07560-MONOMER.
ZFISH:HS07560-MONOMER.
BRENDAi1.14.99.9. 2681.
ReactomeiR-HSA-193048. Androgen biosynthesis.
R-HSA-194002. Glucocorticoid biosynthesis.
R-HSA-211976. Endogenous sterols.
SABIO-RKP05093.
SIGNORiP05093.
UniPathwayiUPA00062.

Chemistry databases

SwissLipidsiSLP:000001611.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.14.191 Publication)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase (EC:1.14.14.321 Publication)
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Steroid 17-alpha-monooxygenase
Gene namesi
Name:CYP17A1
Synonyms:CYP17, S17AH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:2593. CYP17A1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • endoplasmic reticulum Source: ProtInc
  • endoplasmic reticulum membrane Source: Reactome
  • mitochondrion Source: Ensembl
  • neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Adrenal hyperplasia 5 (AH5)19 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late-onset (NC or LOAH)and 'cryptic' (asymptomatic).
See also OMIM:202110
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02274535P → L in AH5; 38% 17alpha-hydroxylase activity and 33% 17,20-lyase activity. 1 Publication1
Natural variantiVAR_00127053Missing in AH5; 10% 17alpha-hydroxylase activity and 13% 17,20-lyase activity. 3 Publications1
Natural variantiVAR_00127164Y → S in AH5. 1 Publication1
Natural variantiVAR_01314793F → C in AH5. 1 PublicationCorresponds to variant rs104894146dbSNPEnsembl.1
Natural variantiVAR_07304396R → Q in AH5. 1 PublicationCorresponds to variant rs104894153dbSNPEnsembl.1
Natural variantiVAR_02274696R → W in AH5; 25% of both 17alpha-hydroxylase and 17,20-lyase activities. 3 PublicationsCorresponds to variant rs104894138dbSNPEnsembl.1
Natural variantiVAR_001272106S → P in AH5. 1 PublicationCorresponds to variant rs104894135dbSNPEnsembl.1
Natural variantiVAR_001273112I → II in AH5. 1 Publication1
Natural variantiVAR_022747114F → V in AH5. 1 PublicationCorresponds to variant rs104894147dbSNPEnsembl.1
Natural variantiVAR_022748116D → V in AH5. 1 PublicationCorresponds to variant rs104894148dbSNPEnsembl.1
Natural variantiVAR_073044121W → R in AH5; partial loss of activity. 1 Publication1
Natural variantiVAR_073045174A → E in AH5. 1 Publication1
Natural variantiVAR_022749177N → D in AH5; 10% 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication1
Natural variantiVAR_022750329Y → D in AH5. 1 PublicationCorresponds to variant rs104894144dbSNPEnsembl.1
Natural variantiVAR_022751330Missing in AH5; complete loss of both 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication1
Natural variantiVAR_001274342P → T in AH5. 1 PublicationCorresponds to variant rs104894137dbSNPEnsembl.1
Natural variantiVAR_022752347R → C in AH5. 1 PublicationCorresponds to variant rs104894149dbSNPEnsembl.1
Natural variantiVAR_001275347R → H in AH5; selectively ablates 17,20-lyase activity, while preserving most 17alpha-hydroxylase activity. 3 PublicationsCorresponds to variant rs61754278dbSNPEnsembl.1
Natural variantiVAR_001276358R → Q in AH5; selectively ablates 17,20-lyase activity, while preserving most 17alpha-hydroxylase activity. 2 PublicationsCorresponds to variant rs104894139dbSNPEnsembl.1
Natural variantiVAR_022753362R → C in AH5. 1 PublicationCorresponds to variant rs104894142dbSNPEnsembl.1
Natural variantiVAR_001277373H → L in AH5. 2 PublicationsCorresponds to variant rs760695410dbSNPEnsembl.1
Natural variantiVAR_073046373H → N in AH5. 1 Publication1
Natural variantiVAR_073047406W → L in AH5; complete loss of both 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication1
Natural variantiVAR_022754406W → R in AH5. 1 PublicationCorresponds to variant rs104894143dbSNPEnsembl.1
Natural variantiVAR_022755417F → C in AH5; ablates both 17,20-lyase activity and 17alpha-hydroxylase activity; loss of heme-binding and loss of phosphorylation. 2 PublicationsCorresponds to variant rs104894140dbSNPEnsembl.1
Natural variantiVAR_022756428P → L in AH5. 1 PublicationCorresponds to variant rs104894145dbSNPEnsembl.1
Natural variantiVAR_001278440R → H in AH5. 1 PublicationCorresponds to variant rs777638364dbSNPEnsembl.1
Natural variantiVAR_001279487 – 489Missing in AH5. 1 Publication3
Natural variantiVAR_001280496R → C in AH5. 1 Publication1
Natural variantiVAR_022757496R → H in AH5; 30% 17alpha-hydroxylase activity and 29% 17,20-lyase activity. 1 PublicationCorresponds to variant rs763398879dbSNPEnsembl.1

Keywords - Diseasei

Congenital adrenal hyperplasia, Disease mutation

Organism-specific databases

DisGeNETi1586.
MalaCardsiCYP17A1.
MIMi202110. phenotype.
OpenTargetsiENSG00000148795.
Orphaneti90796. 46,XY disorder of sex development due to isolated 17,20 lyase deficiency.
90793. Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency.
PharmGKBiPA27090.

Chemistry databases

ChEMBLiCHEMBL3522.
DrugBankiDB05812. Abiraterone.
DB01424. Aminophenazone.
DB01234. Dexamethasone.
DB01233. Metoclopramide.
DB00396. Progesterone.
GuidetoPHARMACOLOGYi1361.

Polymorphism and mutation databases

BioMutaiCYP17A1.
DMDMi117283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519311 – 508Steroid 17-alpha-hydroxylase/17,20 lyaseAdd BLAST508

Post-translational modificationi

Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP05093.
PeptideAtlasiP05093.
PRIDEiP05093.

PTM databases

iPTMnetiP05093.
PhosphoSitePlusiP05093.

Expressioni

Gene expression databases

BgeeiENSG00000148795.
CleanExiHS_CYP17A1.
ExpressionAtlasiP05093. baseline and differential.
GenevisibleiP05093. HS.

Organism-specific databases

HPAiHPA048533.

Interactioni

Protein-protein interaction databases

BioGridi107958. 14 interactors.
IntActiP05093. 13 interactors.
STRINGi9606.ENSP00000358903.

Chemistry databases

BindingDBiP05093.

Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 42Combined sources7
Helixi49 – 55Combined sources7
Helixi57 – 60Combined sources4
Beta strandi62 – 68Combined sources7
Beta strandi71 – 76Combined sources6
Helixi79 – 86Combined sources8
Turni87 – 93Combined sources7
Helixi100 – 105Combined sources6
Turni106 – 109Combined sources4
Beta strandi111 – 115Combined sources5
Helixi119 – 131Combined sources13
Turni132 – 135Combined sources4
Beta strandi136 – 138Combined sources3
Helixi142 – 159Combined sources18
Turni160 – 162Combined sources3
Beta strandi163 – 165Combined sources3
Helixi168 – 184Combined sources17
Helixi194 – 209Combined sources16
Beta strandi211 – 214Combined sources4
Helixi220 – 222Combined sources3
Helixi228 – 250Combined sources23
Turni251 – 253Combined sources3
Helixi262 – 271Combined sources10
Helixi285 – 287Combined sources3
Helixi289 – 320Combined sources32
Helixi322 – 335Combined sources14
Beta strandi338 – 340Combined sources3
Helixi344 – 348Combined sources5
Helixi351 – 363Combined sources13
Beta strandi376 – 381Combined sources6
Beta strandi384 – 386Combined sources3
Beta strandi391 – 394Combined sources4
Helixi396 – 401Combined sources6
Turni403 – 405Combined sources3
Beta strandi406 – 408Combined sources3
Helixi414 – 417Combined sources4
Beta strandi422 – 425Combined sources4
Helixi438 – 440Combined sources3
Helixi445 – 462Combined sources18
Beta strandi463 – 466Combined sources4
Beta strandi479 – 485Combined sources7
Beta strandi491 – 495Combined sources5
Helixi497 – 501Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C17model-A48-501[»]
3RUKX-ray2.60A/B/C/D24-508[»]
3SWZX-ray2.40A/B/C/D24-508[»]
4NKVX-ray2.65A/B/C/D24-508[»]
4NKWX-ray2.50A/B/C/D24-508[»]
4NKXX-ray2.79A/B/C/D24-508[»]
4NKYX-ray2.55A/B/C/D24-508[»]
4NKZX-ray3.00A/B/C/D24-508[»]
ProteinModelPortaliP05093.
SMRiP05093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP05093.
KOiK00512.
OMAiLFLIMAW.
OrthoDBiEOG091G0BT8.
PhylomeDBiP05093.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR033282. CYP17A1.
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PANTHERiPTHR24289:SF4. PTHR24289:SF4. 1 hit.
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWELVALLLL TLAYLFWPKR RCPGAKYPKS LLSLPLVGSL PFLPRHGHMH
60 70 80 90 100
NNFFKLQKKY GPIYSVRMGT KTTVIVGHHQ LAKEVLIKKG KDFSGRPQMA
110 120 130 140 150
TLDIASNNRK GIAFADSGAH WQLHRRLAMA TFALFKDGDQ KLEKIICQEI
160 170 180 190 200
STLCDMLATH NGQSIDISFP VFVAVTNVIS LICFNTSYKN GDPELNVIQN
210 220 230 240 250
YNEGIIDNLS KDSLVDLVPW LKIFPNKTLE KLKSHVKIRN DLLNKILENY
260 270 280 290 300
KEKFRSDSIT NMLDTLMQAK MNSDNGNAGP DQDSELLSDN HILTTIGDIF
310 320 330 340 350
GAGVETTTSV VKWTLAFLLH NPQVKKKLYE EIDQNVGFSR TPTISDRNRL
360 370 380 390 400
LLLEATIREV LRLRPVAPML IPHKANVDSS IGEFAVDKGT EVIINLWALH
410 420 430 440 450
HNEKEWHQPD QFMPERFLNP AGTQLISPSV SYLPFGAGPR SCIGEILARQ
460 470 480 490 500
ELFLIMAWLL QRFDLEVPDD GQLPSLEGIP KVVFLIDSFK VKIKVRQAWR

EAQAEGST
Length:508
Mass (Da):57,371
Last modified:August 13, 1987 - v1
Checksum:iE5454E9E18F96B0E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01175522C → W.Corresponds to variant rs762563dbSNPEnsembl.1
Natural variantiVAR_02274535P → L in AH5; 38% 17alpha-hydroxylase activity and 33% 17,20-lyase activity. 1 Publication1
Natural variantiVAR_00127053Missing in AH5; 10% 17alpha-hydroxylase activity and 13% 17,20-lyase activity. 3 Publications1
Natural variantiVAR_00127164Y → S in AH5. 1 Publication1
Natural variantiVAR_01314793F → C in AH5. 1 PublicationCorresponds to variant rs104894146dbSNPEnsembl.1
Natural variantiVAR_07304396R → Q in AH5. 1 PublicationCorresponds to variant rs104894153dbSNPEnsembl.1
Natural variantiVAR_02274696R → W in AH5; 25% of both 17alpha-hydroxylase and 17,20-lyase activities. 3 PublicationsCorresponds to variant rs104894138dbSNPEnsembl.1
Natural variantiVAR_001272106S → P in AH5. 1 PublicationCorresponds to variant rs104894135dbSNPEnsembl.1
Natural variantiVAR_001273112I → II in AH5. 1 Publication1
Natural variantiVAR_022747114F → V in AH5. 1 PublicationCorresponds to variant rs104894147dbSNPEnsembl.1
Natural variantiVAR_022748116D → V in AH5. 1 PublicationCorresponds to variant rs104894148dbSNPEnsembl.1
Natural variantiVAR_073044121W → R in AH5; partial loss of activity. 1 Publication1
Natural variantiVAR_073045174A → E in AH5. 1 Publication1
Natural variantiVAR_022749177N → D in AH5; 10% 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication1
Natural variantiVAR_022750329Y → D in AH5. 1 PublicationCorresponds to variant rs104894144dbSNPEnsembl.1
Natural variantiVAR_022751330Missing in AH5; complete loss of both 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication1
Natural variantiVAR_001274342P → T in AH5. 1 PublicationCorresponds to variant rs104894137dbSNPEnsembl.1
Natural variantiVAR_022752347R → C in AH5. 1 PublicationCorresponds to variant rs104894149dbSNPEnsembl.1
Natural variantiVAR_001275347R → H in AH5; selectively ablates 17,20-lyase activity, while preserving most 17alpha-hydroxylase activity. 3 PublicationsCorresponds to variant rs61754278dbSNPEnsembl.1
Natural variantiVAR_001276358R → Q in AH5; selectively ablates 17,20-lyase activity, while preserving most 17alpha-hydroxylase activity. 2 PublicationsCorresponds to variant rs104894139dbSNPEnsembl.1
Natural variantiVAR_022753362R → C in AH5. 1 PublicationCorresponds to variant rs104894142dbSNPEnsembl.1
Natural variantiVAR_001277373H → L in AH5. 2 PublicationsCorresponds to variant rs760695410dbSNPEnsembl.1
Natural variantiVAR_073046373H → N in AH5. 1 Publication1
Natural variantiVAR_073047406W → L in AH5; complete loss of both 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication1
Natural variantiVAR_022754406W → R in AH5. 1 PublicationCorresponds to variant rs104894143dbSNPEnsembl.1
Natural variantiVAR_022755417F → C in AH5; ablates both 17,20-lyase activity and 17alpha-hydroxylase activity; loss of heme-binding and loss of phosphorylation. 2 PublicationsCorresponds to variant rs104894140dbSNPEnsembl.1
Natural variantiVAR_022756428P → L in AH5. 1 PublicationCorresponds to variant rs104894145dbSNPEnsembl.1
Natural variantiVAR_001278440R → H in AH5. 1 PublicationCorresponds to variant rs777638364dbSNPEnsembl.1
Natural variantiVAR_001279487 – 489Missing in AH5. 1 Publication3
Natural variantiVAR_001280496R → C in AH5. 1 Publication1
Natural variantiVAR_022757496R → H in AH5; 30% 17alpha-hydroxylase activity and 29% 17,20-lyase activity. 1 PublicationCorresponds to variant rs763398879dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14564 mRNA. Translation: AAA52151.1.
M19489 Genomic DNA. Translation: AAA36405.1.
M63871 Genomic DNA. Translation: AAA59984.1.
M31153
, M31146, M31147, M31148, M31149, M31150, M31151, M31152 Genomic DNA. Translation: AAA52140.1. Sequence problems.
BT020000 mRNA. Translation: AAV38803.1.
AL358790 Genomic DNA. Translation: CAI52498.1.
BC062997 mRNA. Translation: AAH62997.1.
BC063388 mRNA. Translation: AAH63388.1.
CCDSiCCDS7541.1.
PIRiA40921. A26366.
RefSeqiNP_000093.1. NM_000102.3.
UniGeneiHs.438016.

Genome annotation databases

EnsembliENST00000369887; ENSP00000358903; ENSG00000148795.
GeneIDi1586.
KEGGihsa:1586.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14564 mRNA. Translation: AAA52151.1.
M19489 Genomic DNA. Translation: AAA36405.1.
M63871 Genomic DNA. Translation: AAA59984.1.
M31153
, M31146, M31147, M31148, M31149, M31150, M31151, M31152 Genomic DNA. Translation: AAA52140.1. Sequence problems.
BT020000 mRNA. Translation: AAV38803.1.
AL358790 Genomic DNA. Translation: CAI52498.1.
BC062997 mRNA. Translation: AAH62997.1.
BC063388 mRNA. Translation: AAH63388.1.
CCDSiCCDS7541.1.
PIRiA40921. A26366.
RefSeqiNP_000093.1. NM_000102.3.
UniGeneiHs.438016.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C17model-A48-501[»]
3RUKX-ray2.60A/B/C/D24-508[»]
3SWZX-ray2.40A/B/C/D24-508[»]
4NKVX-ray2.65A/B/C/D24-508[»]
4NKWX-ray2.50A/B/C/D24-508[»]
4NKXX-ray2.79A/B/C/D24-508[»]
4NKYX-ray2.55A/B/C/D24-508[»]
4NKZX-ray3.00A/B/C/D24-508[»]
ProteinModelPortaliP05093.
SMRiP05093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107958. 14 interactors.
IntActiP05093. 13 interactors.
STRINGi9606.ENSP00000358903.

Chemistry databases

BindingDBiP05093.
ChEMBLiCHEMBL3522.
DrugBankiDB05812. Abiraterone.
DB01424. Aminophenazone.
DB01234. Dexamethasone.
DB01233. Metoclopramide.
DB00396. Progesterone.
GuidetoPHARMACOLOGYi1361.
SwissLipidsiSLP:000001611.

PTM databases

iPTMnetiP05093.
PhosphoSitePlusiP05093.

Polymorphism and mutation databases

BioMutaiCYP17A1.
DMDMi117283.

Proteomic databases

PaxDbiP05093.
PeptideAtlasiP05093.
PRIDEiP05093.

Protocols and materials databases

DNASUi1586.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369887; ENSP00000358903; ENSG00000148795.
GeneIDi1586.
KEGGihsa:1586.

Organism-specific databases

CTDi1586.
DisGeNETi1586.
GeneCardsiCYP17A1.
HGNCiHGNC:2593. CYP17A1.
HPAiHPA048533.
MalaCardsiCYP17A1.
MIMi202110. phenotype.
609300. gene.
neXtProtiNX_P05093.
OpenTargetsiENSG00000148795.
Orphaneti90796. 46,XY disorder of sex development due to isolated 17,20 lyase deficiency.
90793. Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency.
PharmGKBiPA27090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP05093.
KOiK00512.
OMAiLFLIMAW.
OrthoDBiEOG091G0BT8.
PhylomeDBiP05093.
TreeFamiTF105095.

Enzyme and pathway databases

UniPathwayiUPA00062.
BioCyciMetaCyc:HS07560-MONOMER.
ZFISH:HS07560-MONOMER.
BRENDAi1.14.99.9. 2681.
ReactomeiR-HSA-193048. Androgen biosynthesis.
R-HSA-194002. Glucocorticoid biosynthesis.
R-HSA-211976. Endogenous sterols.
SABIO-RKP05093.
SIGNORiP05093.

Miscellaneous databases

ChiTaRSiCYP17A1. human.
GeneWikiiCYP17A1.
GenomeRNAii1586.
PROiP05093.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148795.
CleanExiHS_CYP17A1.
ExpressionAtlasiP05093. baseline and differential.
GenevisibleiP05093. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR033282. CYP17A1.
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PANTHERiPTHR24289:SF4. PTHR24289:SF4. 1 hit.
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP17A_HUMAN
AccessioniPrimary (citable) accession number: P05093
Secondary accession number(s): Q5TZV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 191 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.