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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.1 Publication

Catalytic activityi

A C(21)-steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 17-alpha-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.1 Publication

Cofactori

heme1 Publication

Enzyme regulationi

Regulated predominantly by intracellular cAMP levels.

Pathwayi: steroid biosynthesis

This protein is involved in the pathway steroid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway steroid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)

GO - Molecular functioni

  • 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB
  • heme binding Source: UniProtKB
  • iron ion binding Source: InterPro
  • oxygen binding Source: ProtInc
  • steroid 17-alpha-monooxygenase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07560-MONOMER.
BRENDAi1.14.99.9. 2681.
ReactomeiR-HSA-193048. Androgen biosynthesis.
R-HSA-194002. Glucocorticoid biosynthesis.
R-HSA-211976. Endogenous sterols.
R-HSA-5579028. Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5).
SABIO-RKP05093.
UniPathwayiUPA00062.

Chemistry

SwissLipidsiSLP:000001611.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.14.191 Publication)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase (EC:4.1.2.301 Publication)
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Steroid 17-alpha-monooxygenase
Gene namesi
Name:CYP17A1
Synonyms:CYP17, S17AH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:2593. CYP17A1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • endoplasmic reticulum Source: ProtInc
  • endoplasmic reticulum membrane Source: Reactome
  • mitochondrion Source: Ensembl
  • neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Adrenal hyperplasia 5 (AH5)19 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late-onset (NC or LOAH)and 'cryptic' (asymptomatic).
See also OMIM:202110
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351P → L in AH5; 38% 17alpha-hydroxylase activity and 33% 17,20-lyase activity. 1 Publication
VAR_022745
Natural varianti53 – 531Missing in AH5; 10% 17alpha-hydroxylase activity and 13% 17,20-lyase activity. 3 Publications
VAR_001270
Natural varianti64 – 641Y → S in AH5. 1 Publication
VAR_001271
Natural varianti93 – 931F → C in AH5. 1 Publication
Corresponds to variant rs104894146 [ dbSNP | Ensembl ].
VAR_013147
Natural varianti96 – 961R → Q in AH5. 1 Publication
Corresponds to variant rs104894153 [ dbSNP | Ensembl ].
VAR_073043
Natural varianti96 – 961R → W in AH5; 25% of both 17alpha-hydroxylase and 17,20-lyase activities. 3 Publications
Corresponds to variant rs104894138 [ dbSNP | Ensembl ].
VAR_022746
Natural varianti106 – 1061S → P in AH5. 1 Publication
Corresponds to variant rs104894135 [ dbSNP | Ensembl ].
VAR_001272
Natural varianti112 – 1121I → II in AH5. 1 Publication
VAR_001273
Natural varianti114 – 1141F → V in AH5. 1 Publication
Corresponds to variant rs104894147 [ dbSNP | Ensembl ].
VAR_022747
Natural varianti116 – 1161D → V in AH5. 1 Publication
Corresponds to variant rs104894148 [ dbSNP | Ensembl ].
VAR_022748
Natural varianti121 – 1211W → R in AH5; partial loss of activity. 1 Publication
VAR_073044
Natural varianti174 – 1741A → E in AH5. 1 Publication
VAR_073045
Natural varianti177 – 1771N → D in AH5; 10% 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication
VAR_022749
Natural varianti329 – 3291Y → D in AH5. 1 Publication
Corresponds to variant rs104894144 [ dbSNP | Ensembl ].
VAR_022750
Natural varianti330 – 3301Missing in AH5; complete loss of both 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication
VAR_022751
Natural varianti342 – 3421P → T in AH5. 1 Publication
Corresponds to variant rs104894137 [ dbSNP | Ensembl ].
VAR_001274
Natural varianti347 – 3471R → C in AH5. 1 Publication
Corresponds to variant rs104894149 [ dbSNP | Ensembl ].
VAR_022752
Natural varianti347 – 3471R → H in AH5; selectively ablates 17,20-lyase activity, while preserving most 17alpha-hydroxylase activity. 3 Publications
Corresponds to variant rs61754278 [ dbSNP | Ensembl ].
VAR_001275
Natural varianti358 – 3581R → Q in AH5; selectively ablates 17,20-lyase activity, while preserving most 17alpha-hydroxylase activity. 2 Publications
Corresponds to variant rs104894139 [ dbSNP | Ensembl ].
VAR_001276
Natural varianti362 – 3621R → C in AH5. 1 Publication
Corresponds to variant rs104894142 [ dbSNP | Ensembl ].
VAR_022753
Natural varianti373 – 3731H → L in AH5. 2 Publications
VAR_001277
Natural varianti373 – 3731H → N in AH5. 1 Publication
VAR_073046
Natural varianti406 – 4061W → L in AH5; complete loss of both 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication
VAR_073047
Natural varianti406 – 4061W → R in AH5. 1 Publication
Corresponds to variant rs104894143 [ dbSNP | Ensembl ].
VAR_022754
Natural varianti417 – 4171F → C in AH5; ablates both 17,20-lyase activity and 17alpha-hydroxylase activity; loss of heme-binding and loss of phosphorylation. 2 Publications
VAR_022755
Natural varianti428 – 4281P → L in AH5. 1 Publication
Corresponds to variant rs104894145 [ dbSNP | Ensembl ].
VAR_022756
Natural varianti440 – 4401R → H in AH5. 1 Publication
Corresponds to variant rs777638364 [ dbSNP | Ensembl ].
VAR_001278
Natural varianti487 – 4893Missing in AH5. 1 Publication
VAR_001279
Natural varianti496 – 4961R → C in AH5. 1 Publication
VAR_001280
Natural varianti496 – 4961R → H in AH5; 30% 17alpha-hydroxylase activity and 29% 17,20-lyase activity. 1 Publication
Corresponds to variant rs763398879 [ dbSNP | Ensembl ].
VAR_022757

Keywords - Diseasei

Congenital adrenal hyperplasia, Disease mutation

Organism-specific databases

MalaCardsiCYP17A1.
MIMi202110. phenotype.
Orphaneti90796. 46,XY disorder of sex development due to isolated 17,20 lyase deficiency.
90793. Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency.
PharmGKBiPA27090.

Chemistry

ChEMBLiCHEMBL3522.
DrugBankiDB05812. Abiraterone.
DB01424. Aminophenazone.
DB01234. Dexamethasone.
DB01233. Metoclopramide.
DB00396. Progesterone.
GuidetoPHARMACOLOGYi1361.

Polymorphism and mutation databases

BioMutaiCYP17A1.
DMDMi117283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051931Add
BLAST

Post-translational modificationi

Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP05093.
PeptideAtlasiP05093.
PRIDEiP05093.

PTM databases

iPTMnetiP05093.
PhosphoSiteiP05093.

Expressioni

Gene expression databases

BgeeiENSG00000148795.
CleanExiHS_CYP17A1.
ExpressionAtlasiP05093. baseline and differential.
GenevisibleiP05093. HS.

Organism-specific databases

HPAiHPA048533.

Interactioni

Protein-protein interaction databases

BioGridi107958. 14 interactions.
IntActiP05093. 13 interactions.
STRINGi9606.ENSP00000358903.

Chemistry

BindingDBiP05093.

Structurei

Secondary structure

1
508
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 427Combined sources
Helixi49 – 557Combined sources
Helixi57 – 604Combined sources
Beta strandi62 – 687Combined sources
Beta strandi71 – 766Combined sources
Helixi79 – 868Combined sources
Turni87 – 937Combined sources
Helixi100 – 1056Combined sources
Turni106 – 1094Combined sources
Beta strandi111 – 1155Combined sources
Helixi119 – 13113Combined sources
Turni132 – 1354Combined sources
Beta strandi136 – 1383Combined sources
Helixi142 – 15918Combined sources
Turni160 – 1623Combined sources
Beta strandi163 – 1653Combined sources
Helixi168 – 18417Combined sources
Helixi194 – 20916Combined sources
Beta strandi211 – 2144Combined sources
Helixi220 – 2223Combined sources
Helixi228 – 25023Combined sources
Turni251 – 2533Combined sources
Helixi262 – 27110Combined sources
Helixi285 – 2873Combined sources
Helixi289 – 32032Combined sources
Helixi322 – 33514Combined sources
Beta strandi338 – 3403Combined sources
Helixi344 – 3485Combined sources
Helixi351 – 36313Combined sources
Beta strandi376 – 3816Combined sources
Beta strandi384 – 3863Combined sources
Beta strandi391 – 3944Combined sources
Helixi396 – 4016Combined sources
Turni403 – 4053Combined sources
Beta strandi406 – 4083Combined sources
Helixi414 – 4174Combined sources
Beta strandi422 – 4254Combined sources
Helixi438 – 4403Combined sources
Helixi445 – 46218Combined sources
Beta strandi463 – 4664Combined sources
Beta strandi479 – 4857Combined sources
Beta strandi491 – 4955Combined sources
Helixi497 – 5015Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C17model-A48-501[»]
3RUKX-ray2.60A/B/C/D24-508[»]
3SWZX-ray2.40A/B/C/D24-508[»]
4NKVX-ray2.65A/B/C/D24-508[»]
4NKWX-ray2.50A/B/C/D24-508[»]
4NKXX-ray2.79A/B/C/D24-508[»]
4NKYX-ray2.55A/B/C/D24-508[»]
4NKZX-ray3.00A/B/C/D24-508[»]
ProteinModelPortaliP05093.
SMRiP05093. Positions 31-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP05093.
KOiK00512.
OMAiLFLIMAW.
OrthoDBiEOG091G0BT8.
PhylomeDBiP05093.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR033282. CYP17A1.
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PANTHERiPTHR24289:SF4. PTHR24289:SF4. 1 hit.
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWELVALLLL TLAYLFWPKR RCPGAKYPKS LLSLPLVGSL PFLPRHGHMH
60 70 80 90 100
NNFFKLQKKY GPIYSVRMGT KTTVIVGHHQ LAKEVLIKKG KDFSGRPQMA
110 120 130 140 150
TLDIASNNRK GIAFADSGAH WQLHRRLAMA TFALFKDGDQ KLEKIICQEI
160 170 180 190 200
STLCDMLATH NGQSIDISFP VFVAVTNVIS LICFNTSYKN GDPELNVIQN
210 220 230 240 250
YNEGIIDNLS KDSLVDLVPW LKIFPNKTLE KLKSHVKIRN DLLNKILENY
260 270 280 290 300
KEKFRSDSIT NMLDTLMQAK MNSDNGNAGP DQDSELLSDN HILTTIGDIF
310 320 330 340 350
GAGVETTTSV VKWTLAFLLH NPQVKKKLYE EIDQNVGFSR TPTISDRNRL
360 370 380 390 400
LLLEATIREV LRLRPVAPML IPHKANVDSS IGEFAVDKGT EVIINLWALH
410 420 430 440 450
HNEKEWHQPD QFMPERFLNP AGTQLISPSV SYLPFGAGPR SCIGEILARQ
460 470 480 490 500
ELFLIMAWLL QRFDLEVPDD GQLPSLEGIP KVVFLIDSFK VKIKVRQAWR

EAQAEGST
Length:508
Mass (Da):57,371
Last modified:August 13, 1987 - v1
Checksum:iE5454E9E18F96B0E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221C → W.
Corresponds to variant rs762563 [ dbSNP | Ensembl ].
VAR_011755
Natural varianti35 – 351P → L in AH5; 38% 17alpha-hydroxylase activity and 33% 17,20-lyase activity. 1 Publication
VAR_022745
Natural varianti53 – 531Missing in AH5; 10% 17alpha-hydroxylase activity and 13% 17,20-lyase activity. 3 Publications
VAR_001270
Natural varianti64 – 641Y → S in AH5. 1 Publication
VAR_001271
Natural varianti93 – 931F → C in AH5. 1 Publication
Corresponds to variant rs104894146 [ dbSNP | Ensembl ].
VAR_013147
Natural varianti96 – 961R → Q in AH5. 1 Publication
Corresponds to variant rs104894153 [ dbSNP | Ensembl ].
VAR_073043
Natural varianti96 – 961R → W in AH5; 25% of both 17alpha-hydroxylase and 17,20-lyase activities. 3 Publications
Corresponds to variant rs104894138 [ dbSNP | Ensembl ].
VAR_022746
Natural varianti106 – 1061S → P in AH5. 1 Publication
Corresponds to variant rs104894135 [ dbSNP | Ensembl ].
VAR_001272
Natural varianti112 – 1121I → II in AH5. 1 Publication
VAR_001273
Natural varianti114 – 1141F → V in AH5. 1 Publication
Corresponds to variant rs104894147 [ dbSNP | Ensembl ].
VAR_022747
Natural varianti116 – 1161D → V in AH5. 1 Publication
Corresponds to variant rs104894148 [ dbSNP | Ensembl ].
VAR_022748
Natural varianti121 – 1211W → R in AH5; partial loss of activity. 1 Publication
VAR_073044
Natural varianti174 – 1741A → E in AH5. 1 Publication
VAR_073045
Natural varianti177 – 1771N → D in AH5; 10% 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication
VAR_022749
Natural varianti329 – 3291Y → D in AH5. 1 Publication
Corresponds to variant rs104894144 [ dbSNP | Ensembl ].
VAR_022750
Natural varianti330 – 3301Missing in AH5; complete loss of both 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication
VAR_022751
Natural varianti342 – 3421P → T in AH5. 1 Publication
Corresponds to variant rs104894137 [ dbSNP | Ensembl ].
VAR_001274
Natural varianti347 – 3471R → C in AH5. 1 Publication
Corresponds to variant rs104894149 [ dbSNP | Ensembl ].
VAR_022752
Natural varianti347 – 3471R → H in AH5; selectively ablates 17,20-lyase activity, while preserving most 17alpha-hydroxylase activity. 3 Publications
Corresponds to variant rs61754278 [ dbSNP | Ensembl ].
VAR_001275
Natural varianti358 – 3581R → Q in AH5; selectively ablates 17,20-lyase activity, while preserving most 17alpha-hydroxylase activity. 2 Publications
Corresponds to variant rs104894139 [ dbSNP | Ensembl ].
VAR_001276
Natural varianti362 – 3621R → C in AH5. 1 Publication
Corresponds to variant rs104894142 [ dbSNP | Ensembl ].
VAR_022753
Natural varianti373 – 3731H → L in AH5. 2 Publications
VAR_001277
Natural varianti373 – 3731H → N in AH5. 1 Publication
VAR_073046
Natural varianti406 – 4061W → L in AH5; complete loss of both 17alpha-hydroxylase and 17,20-lyase activities. 1 Publication
VAR_073047
Natural varianti406 – 4061W → R in AH5. 1 Publication
Corresponds to variant rs104894143 [ dbSNP | Ensembl ].
VAR_022754
Natural varianti417 – 4171F → C in AH5; ablates both 17,20-lyase activity and 17alpha-hydroxylase activity; loss of heme-binding and loss of phosphorylation. 2 Publications
VAR_022755
Natural varianti428 – 4281P → L in AH5. 1 Publication
Corresponds to variant rs104894145 [ dbSNP | Ensembl ].
VAR_022756
Natural varianti440 – 4401R → H in AH5. 1 Publication
Corresponds to variant rs777638364 [ dbSNP | Ensembl ].
VAR_001278
Natural varianti487 – 4893Missing in AH5. 1 Publication
VAR_001279
Natural varianti496 – 4961R → C in AH5. 1 Publication
VAR_001280
Natural varianti496 – 4961R → H in AH5; 30% 17alpha-hydroxylase activity and 29% 17,20-lyase activity. 1 Publication
Corresponds to variant rs763398879 [ dbSNP | Ensembl ].
VAR_022757

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14564 mRNA. Translation: AAA52151.1.
M19489 Genomic DNA. Translation: AAA36405.1.
M63871 Genomic DNA. Translation: AAA59984.1.
M31153
, M31146, M31147, M31148, M31149, M31150, M31151, M31152 Genomic DNA. Translation: AAA52140.1. Sequence problems.
BT020000 mRNA. Translation: AAV38803.1.
AL358790 Genomic DNA. Translation: CAI52498.1.
BC062997 mRNA. Translation: AAH62997.1.
BC063388 mRNA. Translation: AAH63388.1.
CCDSiCCDS7541.1.
PIRiA40921. A26366.
RefSeqiNP_000093.1. NM_000102.3.
UniGeneiHs.438016.

Genome annotation databases

EnsembliENST00000369887; ENSP00000358903; ENSG00000148795.
GeneIDi1586.
KEGGihsa:1586.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14564 mRNA. Translation: AAA52151.1.
M19489 Genomic DNA. Translation: AAA36405.1.
M63871 Genomic DNA. Translation: AAA59984.1.
M31153
, M31146, M31147, M31148, M31149, M31150, M31151, M31152 Genomic DNA. Translation: AAA52140.1. Sequence problems.
BT020000 mRNA. Translation: AAV38803.1.
AL358790 Genomic DNA. Translation: CAI52498.1.
BC062997 mRNA. Translation: AAH62997.1.
BC063388 mRNA. Translation: AAH63388.1.
CCDSiCCDS7541.1.
PIRiA40921. A26366.
RefSeqiNP_000093.1. NM_000102.3.
UniGeneiHs.438016.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C17model-A48-501[»]
3RUKX-ray2.60A/B/C/D24-508[»]
3SWZX-ray2.40A/B/C/D24-508[»]
4NKVX-ray2.65A/B/C/D24-508[»]
4NKWX-ray2.50A/B/C/D24-508[»]
4NKXX-ray2.79A/B/C/D24-508[»]
4NKYX-ray2.55A/B/C/D24-508[»]
4NKZX-ray3.00A/B/C/D24-508[»]
ProteinModelPortaliP05093.
SMRiP05093. Positions 31-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107958. 14 interactions.
IntActiP05093. 13 interactions.
STRINGi9606.ENSP00000358903.

Chemistry

BindingDBiP05093.
ChEMBLiCHEMBL3522.
DrugBankiDB05812. Abiraterone.
DB01424. Aminophenazone.
DB01234. Dexamethasone.
DB01233. Metoclopramide.
DB00396. Progesterone.
GuidetoPHARMACOLOGYi1361.
SwissLipidsiSLP:000001611.

PTM databases

iPTMnetiP05093.
PhosphoSiteiP05093.

Polymorphism and mutation databases

BioMutaiCYP17A1.
DMDMi117283.

Proteomic databases

PaxDbiP05093.
PeptideAtlasiP05093.
PRIDEiP05093.

Protocols and materials databases

DNASUi1586.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369887; ENSP00000358903; ENSG00000148795.
GeneIDi1586.
KEGGihsa:1586.

Organism-specific databases

CTDi1586.
GeneCardsiCYP17A1.
HGNCiHGNC:2593. CYP17A1.
HPAiHPA048533.
MalaCardsiCYP17A1.
MIMi202110. phenotype.
609300. gene.
neXtProtiNX_P05093.
Orphaneti90796. 46,XY disorder of sex development due to isolated 17,20 lyase deficiency.
90793. Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency.
PharmGKBiPA27090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP05093.
KOiK00512.
OMAiLFLIMAW.
OrthoDBiEOG091G0BT8.
PhylomeDBiP05093.
TreeFamiTF105095.

Enzyme and pathway databases

UniPathwayiUPA00062.
BioCyciMetaCyc:HS07560-MONOMER.
BRENDAi1.14.99.9. 2681.
ReactomeiR-HSA-193048. Androgen biosynthesis.
R-HSA-194002. Glucocorticoid biosynthesis.
R-HSA-211976. Endogenous sterols.
R-HSA-5579028. Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5).
SABIO-RKP05093.

Miscellaneous databases

ChiTaRSiCYP17A1. human.
GeneWikiiCYP17A1.
GenomeRNAii1586.
PROiP05093.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148795.
CleanExiHS_CYP17A1.
ExpressionAtlasiP05093. baseline and differential.
GenevisibleiP05093. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR033282. CYP17A1.
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PANTHERiPTHR24289:SF4. PTHR24289:SF4. 1 hit.
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP17A_HUMAN
AccessioniPrimary (citable) accession number: P05093
Secondary accession number(s): Q5TZV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 188 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.