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Protein

Aldehyde dehydrogenase, mitochondrial

Gene

ALDH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase, mitochondrial (ALDH2), Aldehyde dehydrogenase X, mitochondrial (ALDH1B1), Aldehyde dehydrogenase family 3 member B1 (ALDH3B1), Aldehyde dehydrogenase family 3 member B2 (ALDH3B2)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei186Transition state stabilizerBy similarity1
Active sitei285Proton acceptor1
Active sitei319Nucleophile1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi262 – 267NADBy similarity6

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: CACAO
  • aldehyde dehydrogenase [NAD(P)+] activity Source: ProtInc
  • electron carrier activity Source: UniProtKB

GO - Biological processi

  • alcohol metabolic process Source: ProtInc
  • carbohydrate metabolic process Source: ProtInc
  • ethanol catabolic process Source: UniProtKB-UniPathway
  • ethanol oxidation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER66-302.
ZFISH:MONOMER66-302.
BRENDAi1.2.1.3. 2681.
ReactomeiR-HSA-380612. Metabolism of serotonin.
R-HSA-71384. Ethanol oxidation.
SABIO-RKP05091.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, mitochondrial (EC:1.2.1.3)
Alternative name(s):
ALDH class 2
ALDH-E2
ALDHI
Gene namesi
Name:ALDH2
Synonyms:ALDM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:404. ALDH2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrial matrix Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi217.
MalaCardsiALDH2.
MIMi100650. gene+phenotype.
610251. phenotype.
OpenTargetsiENSG00000111275.
PharmGKBiPA24696.

Chemistry databases

ChEMBLiCHEMBL1935.
DrugBankiDB01612. Amyl Nitrite.
DB06770. Benzyl alcohol.
DB00822. Disulfiram.
DB00536. Guanidine.
DB00435. Nitric Oxide.
DB00727. Nitroglycerin.
GuidetoPHARMACOLOGYi2595.

Polymorphism and mutation databases

BioMutaiALDH2.
DMDMi118504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionAdd BLAST17
ChainiPRO_000000716818 – 517Aldehyde dehydrogenase, mitochondrialAdd BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52N6-acetyllysineBy similarity1
Modified residuei73N6-acetyllysineBy similarity1
Modified residuei78N6-acetyllysineBy similarity1
Modified residuei159N6-acetyllysineBy similarity1
Modified residuei368N6-acetyllysineBy similarity1
Modified residuei383N6-acetyllysineBy similarity1
Modified residuei426N6-acetyllysineBy similarity1
Modified residuei428N6-acetyllysineBy similarity1
Modified residuei451N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP05091.
MaxQBiP05091.
PaxDbiP05091.
PeptideAtlasiP05091.
PRIDEiP05091.

2D gel databases

REPRODUCTION-2DPAGEIPI00006663.
P05091.
UCD-2DPAGEP05091.

PTM databases

iPTMnetiP05091.
PhosphoSitePlusiP05091.
SwissPalmiP05091.

Expressioni

Gene expression databases

BgeeiENSG00000111275.
CleanExiHS_ALDH2.
ExpressionAtlasiP05091. baseline and differential.
GenevisibleiP05091. HS.

Organism-specific databases

HPAiHPA051065.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi106719. 41 interactors.
DIPiDIP-40262N.
IntActiP05091. 17 interactors.
MINTiMINT-1368102.
STRINGi9606.ENSP00000261733.

Chemistry databases

BindingDBiP05091.

Structurei

Secondary structure

1517
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 41Combined sources4
Beta strandi44 – 46Combined sources3
Beta strandi53 – 57Combined sources5
Turni59 – 61Combined sources3
Beta strandi64 – 69Combined sources6
Helixi73 – 86Combined sources14
Helixi92 – 95Combined sources4
Helixi98 – 114Combined sources17
Helixi116 – 127Combined sources12
Helixi131 – 136Combined sources6
Helixi138 – 152Combined sources15
Turni153 – 155Combined sources3
Beta strandi158 – 161Combined sources4
Beta strandi164 – 175Combined sources12
Beta strandi178 – 182Combined sources5
Beta strandi185 – 187Combined sources3
Helixi188 – 201Combined sources14
Beta strandi205 – 209Combined sources5
Beta strandi212 – 214Combined sources3
Helixi216 – 228Combined sources13
Beta strandi234 – 237Combined sources4
Turni242 – 244Combined sources3
Helixi245 – 250Combined sources6
Beta strandi257 – 262Combined sources6
Helixi264 – 276Combined sources13
Beta strandi281 – 285Combined sources5
Beta strandi290 – 294Combined sources5
Helixi300 – 312Combined sources13
Helixi313 – 316Combined sources4
Beta strandi322 – 328Combined sources7
Helixi329 – 345Combined sources17
Helixi364 – 379Combined sources16
Beta strandi383 – 386Combined sources4
Beta strandi389 – 391Combined sources3
Beta strandi393 – 396Combined sources4
Beta strandi401 – 405Combined sources5
Helixi411 – 414Combined sources4
Beta strandi419 – 427Combined sources9
Helixi430 – 438Combined sources9
Beta strandi439 – 441Combined sources3
Beta strandi444 – 449Combined sources6
Helixi453 – 462Combined sources10
Beta strandi465 – 471Combined sources7
Beta strandi478 – 480Combined sources3
Helixi486 – 488Combined sources3
Beta strandi489 – 491Combined sources3
Helixi496 – 502Combined sources7
Beta strandi503 – 511Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CW3X-ray2.58A/B/C/D/E/F/G/H24-517[»]
1NZWX-ray2.65A/B/C/D/E/F/G/H18-517[»]
1NZXX-ray2.45A/B/C/D/E/F/G/H18-517[»]
1NZZX-ray2.45A/B/C/D/E/F/G/H18-517[»]
1O00X-ray2.60A/B/C/D/E/F/G/H18-517[»]
1O01X-ray2.15A/B/C/D/E/F/G/H18-517[»]
1O02X-ray1.90A/B/C/D/E/F/G/H18-517[»]
1O04X-ray1.42A/B/C/D/E/F/G/H18-517[»]
1O05X-ray2.25A/B/C/D/E/F/G/H18-517[»]
1ZUMX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L18-517[»]
2ONMX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L18-517[»]
2ONNX-ray2.75A/B/C/D/E/F/G/H18-517[»]
2ONOX-ray2.15A/B/C/D/E/F/G/H18-517[»]
2ONPX-ray2.00A/B/C/D/E/F/G/H18-517[»]
2VLEX-ray2.40A/B/C/D/E/F/G/H24-517[»]
3INJX-ray1.69A/B/C/D/E/F/G/H18-517[»]
3INLX-ray1.86A/B/C/D/E/F/G/H18-517[»]
3N80X-ray1.50A/B/C/D/E/F/G/H18-517[»]
3N81X-ray1.70A/B/C/D/E/F/G/H18-517[»]
3N82X-ray2.25A/B/C/D/E/F/G/H18-517[»]
3N83X-ray1.90A/B/C/D/E/F/G/H18-517[»]
3SZ9X-ray2.10A/B/C/D/E/F/G/H18-517[»]
4FQFX-ray2.28A/B/C/D18-517[»]
4FR8X-ray2.20A/B/C/D/E/F/G/H18-517[»]
4KWFX-ray2.31A/B/C/D/E/F/G/H24-517[»]
4KWGX-ray2.10A/B/C/D/E/F/G/H24-517[»]
DisProtiDP00383.
ProteinModelPortaliP05091.
SMRiP05091.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05091.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP05091.
KOiK00128.
OMAiHLIMEAA.
OrthoDBiEOG091G05E8.
PhylomeDBiP05091.
TreeFamiTF300455.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05091-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRAAARFGP RLGRRLLSAA ATQAVPAPNQ QPEVFCNQIF INNEWHDAVS
60 70 80 90 100
RKTFPTVNPS TGEVICQVAE GDKEDVDKAV KAARAAFQLG SPWRRMDASH
110 120 130 140 150
RGRLLNRLAD LIERDRTYLA ALETLDNGKP YVISYLVDLD MVLKCLRYYA
160 170 180 190 200
GWADKYHGKT IPIDGDFFSY TRHEPVGVCG QIIPWNFPLL MQAWKLGPAL
210 220 230 240 250
ATGNVVVMKV AEQTPLTALY VANLIKEAGF PPGVVNIVPG FGPTAGAAIA
260 270 280 290 300
SHEDVDKVAF TGSTEIGRVI QVAAGSSNLK RVTLELGGKS PNIIMSDADM
310 320 330 340 350
DWAVEQAHFA LFFNQGQCCC AGSRTFVQED IYDEFVERSV ARAKSRVVGN
360 370 380 390 400
PFDSKTEQGP QVDETQFKKI LGYINTGKQE GAKLLCGGGI AADRGYFIQP
410 420 430 440 450
TVFGDVQDGM TIAKEEIFGP VMQILKFKTI EEVVGRANNS TYGLAAAVFT
460 470 480 490 500
KDLDKANYLS QALQAGTVWV NCYDVFGAQS PFGGYKMSGS GRELGEYGLQ
510
AYTEVKTVTV KVPQKNS
Length:517
Mass (Da):56,381
Last modified:January 1, 1990 - v2
Checksum:iE8F74D44D285A00E
GO
Isoform 2 (identifier: P05091-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-120: Missing.

Note: No experimental confirmation available.
Show »
Length:470
Mass (Da):50,989
Checksum:i5D232BE0405A5F2E
GO

Sequence cautioni

The sequence AAA62825 differs from that shown. Reason: Frameshift at positions 424, 444, 448 and 461.Curated
The sequence CAA68290 differs from that shown.Curated
The sequence CAA68290 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 12RFGPRL → ARAPP in CAA28990 (PubMed:3582651).Curated6
Sequence conflicti18S → A AA sequence (PubMed:4065146).Curated1
Sequence conflicti60S → F in CAG33272 (Ref. 6) Curated1
Sequence conflicti80 – 85VKAARA → REGRPG in CAA28990 (PubMed:3582651).Curated6
Sequence conflicti101R → S in CAA28990 (PubMed:3582651).Curated1
Sequence conflicti116R → Q in AAT41621 (Ref. 5) Curated1
Sequence conflicti216L → S in AAA62825 (PubMed:3610592).Curated1
Sequence conflicti218A → R in AAA62825 (PubMed:3610592).Curated1
Sequence conflicti247A → P in AAA62825 (PubMed:3610592).Curated1
Sequence conflicti332Y → C in BAG62916 (PubMed:14702039).Curated1
Sequence conflicti362V → L in CAG33272 (Ref. 6) Curated1
Sequence conflicti380E → Q in AAA51693 (PubMed:2838413).Curated1

Polymorphismi

Genetic variation in ALDH2 is responsible for individual differences in responses to drinking alcohol [MIMi:610251]. Allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication in Orientals and South American Indians, as compared to Caucasians.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011869337E → V.1 PublicationCorresponds to variant rs1062136dbSNPEnsembl.1
Natural variantiVAR_011302496E → K in allele ALDH2*3. 1 PublicationCorresponds to variant rs769724893dbSNPEnsembl.1
Natural variantiVAR_002248504E → K in allele ALDH2*2; drastic reduction of enzyme activity. 1 PublicationCorresponds to variant rs671dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04671574 – 120Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05409 mRNA. Translation: CAA28990.1.
Y00109 mRNA. Translation: CAA68290.1. Sequence problems.
M20456
, M20444, M20445, M20446, M20447, M20448, M20449, M20450, M20451, M20452, M20453, M20454 Genomic DNA. Translation: AAA51693.1.
AY621070 mRNA. Translation: AAT41621.1.
CR456991 mRNA. Translation: CAG33272.1.
AK301375 mRNA. Translation: BAG62916.1.
AC002996 Genomic DNA. No translation available.
AC003029 Genomic DNA. No translation available.
BC002967 mRNA. Translation: AAH02967.1.
BC071839 mRNA. Translation: AAH71839.1.
K03001 mRNA. Translation: AAB59500.1.
M26760 mRNA. Translation: AAA51694.1.
M54931 mRNA. Translation: AAA62825.1. Frameshift.
CCDSiCCDS55885.1. [P05091-2]
CCDS9155.1. [P05091-1]
PIRiA29975. DEHUE2.
RefSeqiNP_000681.2. NM_000690.3. [P05091-1]
NP_001191818.1. NM_001204889.1. [P05091-2]
UniGeneiHs.604551.

Genome annotation databases

EnsembliENST00000261733; ENSP00000261733; ENSG00000111275. [P05091-1]
ENST00000416293; ENSP00000403349; ENSG00000111275. [P05091-2]
GeneIDi217.
KEGGihsa:217.
UCSCiuc001tst.4. human. [P05091-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05409 mRNA. Translation: CAA28990.1.
Y00109 mRNA. Translation: CAA68290.1. Sequence problems.
M20456
, M20444, M20445, M20446, M20447, M20448, M20449, M20450, M20451, M20452, M20453, M20454 Genomic DNA. Translation: AAA51693.1.
AY621070 mRNA. Translation: AAT41621.1.
CR456991 mRNA. Translation: CAG33272.1.
AK301375 mRNA. Translation: BAG62916.1.
AC002996 Genomic DNA. No translation available.
AC003029 Genomic DNA. No translation available.
BC002967 mRNA. Translation: AAH02967.1.
BC071839 mRNA. Translation: AAH71839.1.
K03001 mRNA. Translation: AAB59500.1.
M26760 mRNA. Translation: AAA51694.1.
M54931 mRNA. Translation: AAA62825.1. Frameshift.
CCDSiCCDS55885.1. [P05091-2]
CCDS9155.1. [P05091-1]
PIRiA29975. DEHUE2.
RefSeqiNP_000681.2. NM_000690.3. [P05091-1]
NP_001191818.1. NM_001204889.1. [P05091-2]
UniGeneiHs.604551.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CW3X-ray2.58A/B/C/D/E/F/G/H24-517[»]
1NZWX-ray2.65A/B/C/D/E/F/G/H18-517[»]
1NZXX-ray2.45A/B/C/D/E/F/G/H18-517[»]
1NZZX-ray2.45A/B/C/D/E/F/G/H18-517[»]
1O00X-ray2.60A/B/C/D/E/F/G/H18-517[»]
1O01X-ray2.15A/B/C/D/E/F/G/H18-517[»]
1O02X-ray1.90A/B/C/D/E/F/G/H18-517[»]
1O04X-ray1.42A/B/C/D/E/F/G/H18-517[»]
1O05X-ray2.25A/B/C/D/E/F/G/H18-517[»]
1ZUMX-ray2.10A/B/C/D/E/F/G/H/I/J/K/L18-517[»]
2ONMX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L18-517[»]
2ONNX-ray2.75A/B/C/D/E/F/G/H18-517[»]
2ONOX-ray2.15A/B/C/D/E/F/G/H18-517[»]
2ONPX-ray2.00A/B/C/D/E/F/G/H18-517[»]
2VLEX-ray2.40A/B/C/D/E/F/G/H24-517[»]
3INJX-ray1.69A/B/C/D/E/F/G/H18-517[»]
3INLX-ray1.86A/B/C/D/E/F/G/H18-517[»]
3N80X-ray1.50A/B/C/D/E/F/G/H18-517[»]
3N81X-ray1.70A/B/C/D/E/F/G/H18-517[»]
3N82X-ray2.25A/B/C/D/E/F/G/H18-517[»]
3N83X-ray1.90A/B/C/D/E/F/G/H18-517[»]
3SZ9X-ray2.10A/B/C/D/E/F/G/H18-517[»]
4FQFX-ray2.28A/B/C/D18-517[»]
4FR8X-ray2.20A/B/C/D/E/F/G/H18-517[»]
4KWFX-ray2.31A/B/C/D/E/F/G/H24-517[»]
4KWGX-ray2.10A/B/C/D/E/F/G/H24-517[»]
DisProtiDP00383.
ProteinModelPortaliP05091.
SMRiP05091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106719. 41 interactors.
DIPiDIP-40262N.
IntActiP05091. 17 interactors.
MINTiMINT-1368102.
STRINGi9606.ENSP00000261733.

Chemistry databases

BindingDBiP05091.
ChEMBLiCHEMBL1935.
DrugBankiDB01612. Amyl Nitrite.
DB06770. Benzyl alcohol.
DB00822. Disulfiram.
DB00536. Guanidine.
DB00435. Nitric Oxide.
DB00727. Nitroglycerin.
GuidetoPHARMACOLOGYi2595.

PTM databases

iPTMnetiP05091.
PhosphoSitePlusiP05091.
SwissPalmiP05091.

Polymorphism and mutation databases

BioMutaiALDH2.
DMDMi118504.

2D gel databases

REPRODUCTION-2DPAGEIPI00006663.
P05091.
UCD-2DPAGEP05091.

Proteomic databases

EPDiP05091.
MaxQBiP05091.
PaxDbiP05091.
PeptideAtlasiP05091.
PRIDEiP05091.

Protocols and materials databases

DNASUi217.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261733; ENSP00000261733; ENSG00000111275. [P05091-1]
ENST00000416293; ENSP00000403349; ENSG00000111275. [P05091-2]
GeneIDi217.
KEGGihsa:217.
UCSCiuc001tst.4. human. [P05091-1]

Organism-specific databases

CTDi217.
DisGeNETi217.
GeneCardsiALDH2.
HGNCiHGNC:404. ALDH2.
HPAiHPA051065.
MalaCardsiALDH2.
MIMi100650. gene+phenotype.
610251. phenotype.
neXtProtiNX_P05091.
OpenTargetsiENSG00000111275.
PharmGKBiPA24696.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP05091.
KOiK00128.
OMAiHLIMEAA.
OrthoDBiEOG091G05E8.
PhylomeDBiP05091.
TreeFamiTF300455.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
BioCyciMetaCyc:MONOMER66-302.
ZFISH:MONOMER66-302.
BRENDAi1.2.1.3. 2681.
ReactomeiR-HSA-380612. Metabolism of serotonin.
R-HSA-71384. Ethanol oxidation.
SABIO-RKP05091.

Miscellaneous databases

ChiTaRSiALDH2. human.
EvolutionaryTraceiP05091.
GeneWikiiALDH2.
GenomeRNAii217.
PROiP05091.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111275.
CleanExiHS_ALDH2.
ExpressionAtlasiP05091. baseline and differential.
GenevisibleiP05091. HS.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALDH2_HUMAN
AccessioniPrimary (citable) accession number: P05091
Secondary accession number(s): B4DW54
, E7EUE5, Q03639, Q6IB13, Q6IV71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 1, 1990
Last modified: November 30, 2016
This is version 210 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.