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P05090

- APOD_HUMAN

UniProt

P05090 - APOD_HUMAN

Protein

Apolipoprotein D

Gene

APOD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 167 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

    GO - Molecular functioni

    1. cholesterol binding Source: UniProtKB
    2. lipid transporter activity Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. aging Source: UniProtKB
    2. angiogenesis Source: UniProtKB
    3. brain development Source: UniProtKB
    4. glucose metabolic process Source: UniProtKB
    5. lipid metabolic process Source: UniProtKB
    6. lipid transport Source: GOC
    7. negative regulation of cytokine production involved in inflammatory response Source: UniProtKB
    8. negative regulation of focal adhesion assembly Source: UniProtKB
    9. negative regulation of lipoprotein lipid oxidation Source: UniProtKB
    10. negative regulation of monocyte chemotactic protein-1 production Source: UniProtKB
    11. negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKB
    12. negative regulation of protein import into nucleus Source: UniProtKB
    13. negative regulation of smooth muscle cell-matrix adhesion Source: UniProtKB
    14. negative regulation of smooth muscle cell proliferation Source: UniProtKB
    15. negative regulation of T cell migration Source: UniProtKB
    16. peripheral nervous system axon regeneration Source: UniProtKB
    17. response to axon injury Source: UniProtKB
    18. response to drug Source: UniProtKB
    19. response to reactive oxygen species Source: UniProtKB
    20. tissue regeneration Source: UniProtKB

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein D
    Short name:
    Apo-D
    Short name:
    ApoD
    Gene namesi
    Name:APOD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:612. APOD.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosolic ribosome Source: UniProtKB
    2. dendrite Source: UniProtKB
    3. endoplasmic reticulum Source: UniProtKB
    4. extracellular region Source: UniProtKB
    5. extracellular space Source: UniProtKB
    6. extracellular vesicular exosome Source: UniProt
    7. neuronal cell body Source: UniProtKB
    8. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24900.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 189169Apolipoprotein DPRO_0000017872Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211Pyrrolidone carboxylic acid2 Publications
    Disulfide bondi28 ↔ 1341 Publication
    Disulfide bondi61 ↔ 1851 Publication
    Glycosylationi65 – 651N-linked (GlcNAc...) (complex)4 Publications
    Glycosylationi98 – 981N-linked (GlcNAc...) (complex)8 Publications
    Disulfide bondi136 – 136Interchain (with C-29 in APOA2)1 Publication

    Post-translational modificationi

    N-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor).8 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiP05090.
    PaxDbiP05090.
    PeptideAtlasiP05090.
    PRIDEiP05090.

    2D gel databases

    SWISS-2DPAGEP05090.

    PTM databases

    PhosphoSiteiP05090.

    Expressioni

    Tissue specificityi

    Expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue and tears.

    Gene expression databases

    ArrayExpressiP05090.
    BgeeiP05090.
    CleanExiHS_APOD.
    GenevestigatoriP05090.

    Interactioni

    Subunit structurei

    Homodimer. In plasma, also exists as a disulfide-linked heterodimer with APOA2.1 Publication

    Protein-protein interaction databases

    BioGridi106844. 10 interactions.
    IntActiP05090. 5 interactions.
    MINTiMINT-1396020.
    STRINGi9606.ENSP00000345179.

    Structurei

    Secondary structure

    1
    189
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi24 – 274
    Helixi39 – 413
    Beta strandi44 – 518
    Beta strandi60 – 689
    Beta strandi74 – 818
    Beta strandi87 – 9711
    Beta strandi104 – 1085
    Beta strandi116 – 1238
    Beta strandi125 – 13814
    Beta strandi141 – 15313
    Helixi157 – 16913
    Beta strandi183 – 1853

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2APDmodel-A21-189[»]
    2HZQX-ray1.80A23-189[»]
    2HZRX-ray1.80A23-189[»]
    ProteinModelPortaliP05090.
    SMRiP05090. Positions 23-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP05090.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calycin superfamily. Lipocalin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3040.
    HOGENOMiHOG000061525.
    HOVERGENiHBG018734.
    InParanoidiP05090.
    KOiK03098.
    PhylomeDBiP05090.
    TreeFamiTF324836.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR026222. ApoD_vertbrte.
    IPR002969. ApolipopD.
    IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR002345. Lipocalin.
    IPR022271. Lipocalin_ApoD.
    IPR022272. Lipocalin_CS.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
    PRINTSiPR02058. APODVERTBRTE.
    PR01219. APOLIPOPROTD.
    PR00179. LIPOCALIN.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00213. LIPOCALIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05090-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVMLLLLLSA LAGLFGAAEG QAFHLGKCPN PPVQENFDVN KYLGRWYEIE    50
    KIPTTFENGR CIQANYSLME NGKIKVLNQE LRADGTVNQI EGEATPVNLT 100
    EPAKLEVKFS WFMPSAPYWI LATDYENYAL VYSCTCIIQL FHVDFAWILA 150
    RNPNLPPETV DSLKNILTSN NIDVKKMTVT DQVNCPKLS 189
    Length:189
    Mass (Da):21,276
    Last modified:August 13, 1987 - v1
    Checksum:i0EAA6DE03D5E71A8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151F → S.1 Publication
    Corresponds to variant rs5952 [ dbSNP | Ensembl ].
    VAR_011931
    Natural varianti115 – 1151S → L.1 Publication
    Corresponds to variant rs5954 [ dbSNP | Ensembl ].
    VAR_011932
    Natural varianti178 – 1781T → K.1 Publication
    Corresponds to variant rs5955 [ dbSNP | Ensembl ].
    VAR_011933

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02611 mRNA. Translation: AAB59517.1.
    M16696 Genomic DNA. Translation: AAA51764.1.
    BT019860 mRNA. Translation: AAV38663.1.
    BT019861 mRNA. Translation: AAV38664.1.
    CR456838 mRNA. Translation: CAG33119.1.
    CR541773 mRNA. Translation: CAG46572.1.
    AK312090 mRNA. Translation: BAG35026.1.
    CH471052 Genomic DNA. Translation: EAW78023.1.
    CH471052 Genomic DNA. Translation: EAW78024.1.
    BC007402 mRNA. Translation: AAH07402.1.
    S80440 mRNA. Translation: AAB35919.1.
    CCDSiCCDS33925.1.
    PIRiA26958. LPHUD.
    RefSeqiNP_001638.1. NM_001647.3.
    UniGeneiHs.522555.

    Genome annotation databases

    EnsembliENST00000343267; ENSP00000345179; ENSG00000189058.
    GeneIDi347.
    KEGGihsa:347.
    UCSCiuc003fur.2. human.

    Polymorphism databases

    DMDMi114034.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02611 mRNA. Translation: AAB59517.1 .
    M16696 Genomic DNA. Translation: AAA51764.1 .
    BT019860 mRNA. Translation: AAV38663.1 .
    BT019861 mRNA. Translation: AAV38664.1 .
    CR456838 mRNA. Translation: CAG33119.1 .
    CR541773 mRNA. Translation: CAG46572.1 .
    AK312090 mRNA. Translation: BAG35026.1 .
    CH471052 Genomic DNA. Translation: EAW78023.1 .
    CH471052 Genomic DNA. Translation: EAW78024.1 .
    BC007402 mRNA. Translation: AAH07402.1 .
    S80440 mRNA. Translation: AAB35919.1 .
    CCDSi CCDS33925.1.
    PIRi A26958. LPHUD.
    RefSeqi NP_001638.1. NM_001647.3.
    UniGenei Hs.522555.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2APD model - A 21-189 [» ]
    2HZQ X-ray 1.80 A 23-189 [» ]
    2HZR X-ray 1.80 A 23-189 [» ]
    ProteinModelPortali P05090.
    SMRi P05090. Positions 23-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106844. 10 interactions.
    IntActi P05090. 5 interactions.
    MINTi MINT-1396020.
    STRINGi 9606.ENSP00000345179.

    PTM databases

    PhosphoSitei P05090.

    Polymorphism databases

    DMDMi 114034.

    2D gel databases

    SWISS-2DPAGE P05090.

    Proteomic databases

    MaxQBi P05090.
    PaxDbi P05090.
    PeptideAtlasi P05090.
    PRIDEi P05090.

    Protocols and materials databases

    DNASUi 347.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343267 ; ENSP00000345179 ; ENSG00000189058 .
    GeneIDi 347.
    KEGGi hsa:347.
    UCSCi uc003fur.2. human.

    Organism-specific databases

    CTDi 347.
    GeneCardsi GC03M195295.
    HGNCi HGNC:612. APOD.
    MIMi 107740. gene.
    neXtProti NX_P05090.
    PharmGKBi PA24900.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3040.
    HOGENOMi HOG000061525.
    HOVERGENi HBG018734.
    InParanoidi P05090.
    KOi K03098.
    PhylomeDBi P05090.
    TreeFami TF324836.

    Miscellaneous databases

    ChiTaRSi APOD. human.
    EvolutionaryTracei P05090.
    GeneWikii Apolipoprotein_D.
    GenomeRNAii 347.
    NextBioi 1431.
    PROi P05090.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P05090.
    Bgeei P05090.
    CleanExi HS_APOD.
    Genevestigatori P05090.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR026222. ApoD_vertbrte.
    IPR002969. ApolipopD.
    IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR002345. Lipocalin.
    IPR022271. Lipocalin_ApoD.
    IPR022272. Lipocalin_CS.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036893. Lipocalin_ApoD. 1 hit.
    PRINTSi PR02058. APODVERTBRTE.
    PR01219. APOLIPOPROTD.
    PR00179. LIPOCALIN.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00213. LIPOCALIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of human apolipoprotein D cDNA."
      Drayna D.T., Fielding C., McLean J.W., Baer B., Castro G., Chen E., Comstock L., Henzel W., Kohr W., Rhee L., Wion K.L., Lawn R.M.
      J. Biol. Chem. 261:16535-16539(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily."
      Drayna D.T., McLean J.W., Wion K.L., Trent J.M., Drabkin H.A., Lawn R.M.
      DNA 6:199-204(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    9. "Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links."
      Yang C.-Y., Gu Z.-W., Blanco-Vaca F., Gaskell S.J., Yang M., Massey J.B., Gotto A.M. Jr., Pownall H.J.
      Biochemistry 33:12451-12455(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-189, DISULFIDE BONDS, PYROGLUTAMATE FORMATION AT GLN-21, GLYCOSYLATION AT ASN-65 AND ASN-98.
      Tissue: Plasma.
    10. "The human lacrimal gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members of the lipocalin superfamily."
      Holzfeind P., Merschak P., Dieplinger H., Redl B.
      Exp. Eye Res. 61:495-500(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-189.
      Tissue: Lacrimal gland.
    11. "Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease."
      Balbin M., Freije J.M.P., Fueyo A., Sanchez L.M., Lopez-Otin C.
      Biochem. J. 271:803-807(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 128-187.
    12. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
      Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-98.
      Tissue: Plasma.
    13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-98.
      Tissue: Plasma.
    14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-65 AND ASN-98.
      Tissue: Liver.
    15. Cited for: GLYCOSYLATION AT ASN-98.
    16. "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
      Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-98, STRUCTURE OF CARBOHYDRATES.
      Tissue: Cerebrospinal fluid.
    17. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
      Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
      Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-65 AND ASN-98, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
    18. "Is apolipoprotein D a mammalian bilin-binding protein?"
      Peitsch M.C., Boguski M.S.
      New Biol. 2:197-206(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, BILIN-BINDING.
    19. "Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion."
      Schindler P.A., Settineri C.A., Collet X., Fielding C.J., Burlingame A.L.
      Protein Sci. 4:791-803(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-65 AND ASN-98.
    20. Cited for: VARIANTS SER-15; LEU-115 AND LYS-178.

    Entry informationi

    Entry nameiAPOD_HUMAN
    AccessioniPrimary (citable) accession number: P05090
    Secondary accession number(s): B2R579, D3DNW6, Q6IBG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 167 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    APOD is primarily localized in HDL (60-65%), with most of the remainder in VHDL and only trace amounts in VLDL and LDL.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3