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Protein

Arginine metabolism regulation protein II

Gene

ARG81

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

With ARG80, ARG82 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi21 – 4828Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • arginine metabolic process Source: UniProtKB-KW
  • regulation of arginine metabolic process Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Arginine metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32684-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine metabolism regulation protein II
Alternative name(s):
Arginine-requiring protein 81
Gene namesi
Name:ARG81
Synonyms:ARGR2
Ordered Locus Names:YML099C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML099C.
SGDiS000004565. ARG81.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Arginine metabolism regulation protein IIPRO_0000114937Add
BLAST

Proteomic databases

MaxQBiP05085.

Interactioni

Subunit structurei

Interacts with ARG80 and MCM1.1 Publication

Protein-protein interaction databases

BioGridi35044. 35 interactions.
DIPiDIP-1346N.
IntActiP05085. 14 interactions.
MINTiMINT-412052.

Structurei

3D structure databases

ProteinModelPortaliP05085.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000247977.
InParanoidiP05085.
KOiK09246.
OMAiVQPLTRY.
OrthoDBiEOG092C0UHI.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR021858. Fun_TF.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF11951. Fungal_trans_2. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISSKNGPK KMGRAKTFTG CWTCRGRKVK CDLRHPHCQR CEKSNLPCGG
60 70 80 90 100
YDIKLRWSKP MQFDPYGVPI PQNSPATTTN LSGSVDEPQY QRRNIDFVRY
110 120 130 140 150
DEEYVYHEDM DDELTMLHTP PIEKISDNKT WIIKKFGVFK GTDKIDKQYA
160 170 180 190 200
PRKKRNRKRV AKSLESSASI SLSSLPSSST ISFPIRHIED KLRNKGHVKT
210 220 230 240 250
GILSANDGVP PTPNLLDYDW NNLNITGYEW ISSELRDDAL LSAVTLQGHH
260 270 280 290 300
LGHTQPQEIS LEENSNVVSG EEHVNAKEHG CAFEADNQGS STLPNKAASA
310 320 330 340 350
NDKLYQQNLK LLFQKNSSNS EEPDPQALID DVFVNIEPRS LPASDLNKIT
360 370 380 390 400
LAPPNEESRM PKSMLELTSY SSDLPPELVD IIPKTDLTVH GLARFLLNHY
410 420 430 440 450
FNNVADKMTV VVLEKNPWKT LYFPRALMAL GDLAGLGQSS NSRNALLNAL
460 470 480 490 500
LAVSCFHLQS KYPRNYKLQK YFLGLGIELR NQASNFLRLC LNTKSSIPEK
510 520 530 540 550
YKDVLTAILS MNSIDVVWGT MADCQDHLAL CEDFVESRMK LRPNISEKTK
560 570 580 590 600
TLHRIFSFLK LIQDSTALDK VRAKEIVILP SEEDDNYKPL DTSNATTSSS
610 620 630 640 650
EPRVDVVQEG LFREALNEND GKIHIEFVKE PITNVSADST PSSTTPPIFT
660 670 680 690 700
NIATESYYNK SDISKLVSKT DENIIGTDSL YGLPNSLILL FSDCVRIVRH
710 720 730 740 750
NEYYNLTYLP VPRKFNELSL NFEKRLLKWK SEWNFHQENS EGKSFINSTA
760 770 780 790 800
EALYHHTMSF YFSLIIYYFT MARSLNCQFL QNYVAKVLDH LNAMEELVDQ
810 820 830 840 850
KKVKIVPLIW QGFMAGCACT DENRQQEFRR WAAKLAESGV GSYWGARQVM
860 870 880
LEVWRRRKED EPGDNWYSVY KDWEMNLMLS
Length:880
Mass (Da):100,282
Last modified:February 1, 1996 - v3
Checksum:iDA033AB2B373F415
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41S → F in CAA27577 (PubMed:3709534).Curated
Sequence conflicti129 – 1291Missing in CAA27577 (PubMed:3709534).Curated
Sequence conflicti283 – 2831F → V in CAA27577 (PubMed:3709534).Curated
Sequence conflicti345 – 3451D → V in CAA27577 (PubMed:3709534).Curated
Sequence conflicti366 – 3661E → Q in CAA27577 (PubMed:3709534).Curated
Sequence conflicti549 – 5491T → A in CAA27577 (PubMed:3709534).Curated
Sequence conflicti597 – 5971T → S in CAA27577 (PubMed:3709534).Curated
Sequence conflicti665 – 6651K → N in CAA27577 (PubMed:3709534).Curated
Sequence conflicti869 – 8691V → I in CAA27577 (PubMed:3709534).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03940 Genomic DNA. Translation: CAA27577.1.
Z46660 Genomic DNA. Translation: CAA86638.1.
BK006946 Genomic DNA. Translation: DAA09800.1.
PIRiS49627.
RefSeqiNP_013610.1. NM_001182459.1.

Genome annotation databases

EnsemblFungiiYML099C; YML099C; YML099C.
GeneIDi854874.
KEGGisce:YML099C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03940 Genomic DNA. Translation: CAA27577.1.
Z46660 Genomic DNA. Translation: CAA86638.1.
BK006946 Genomic DNA. Translation: DAA09800.1.
PIRiS49627.
RefSeqiNP_013610.1. NM_001182459.1.

3D structure databases

ProteinModelPortaliP05085.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35044. 35 interactions.
DIPiDIP-1346N.
IntActiP05085. 14 interactions.
MINTiMINT-412052.

Proteomic databases

MaxQBiP05085.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML099C; YML099C; YML099C.
GeneIDi854874.
KEGGisce:YML099C.

Organism-specific databases

EuPathDBiFungiDB:YML099C.
SGDiS000004565. ARG81.

Phylogenomic databases

HOGENOMiHOG000247977.
InParanoidiP05085.
KOiK09246.
OMAiVQPLTRY.
OrthoDBiEOG092C0UHI.

Enzyme and pathway databases

BioCyciYEAST:G3O-32684-MONOMER.

Miscellaneous databases

PROiP05085.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR021858. Fun_TF.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF11951. Fungal_trans_2. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGR2_YEAST
AccessioniPrimary (citable) accession number: P05085
Secondary accession number(s): D6W0I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.