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Protein

Protein hunchback

Gene

hb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Gap class segmentation protein that controls development of head structures.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri240 – 26223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34925C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri733 – 75725C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBase
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • anterior/posterior axis specification, embryo Source: FlyBase
  • anterior region determination Source: FlyBase
  • epithelial cell migration, open tracheal system Source: FlyBase
  • ganglion mother cell fate determination Source: FlyBase
  • generation of neurons Source: FlyBase
  • morphogenesis of a branching structure Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • neuroblast fate determination Source: FlyBase
  • open tracheal system development Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • posterior head segmentation Source: FlyBase
  • regulation of development, heterochronic Source: FlyBase
  • regulation of transcription involved in anterior/posterior axis specification Source: FlyBase
  • salivary gland development Source: FlyBase
  • terminal region determination Source: FlyBase
  • torso signaling pathway Source: FlyBase
  • transcription, DNA-templated Source: InterPro
  • trunk segmentation Source: FlyBase
  • ventral cord development Source: FlyBase
  • zygotic determination of anterior/posterior axis, embryo Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Gap protein

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiP05084.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein hunchback
Gene namesi
Name:hb
ORF Names:CG9786
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0001180. hb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Protein hunchbackPRO_0000046948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781Phosphothreonine1 Publication
Modified residuei188 – 1881Phosphoserine1 Publication
Modified residuei207 – 2071Phosphoserine1 Publication
Modified residuei209 – 2091Phosphoserine1 Publication
Modified residuei210 – 2101Phosphoserine1 Publication
Modified residuei537 – 5371Phosphoserine1 Publication
Modified residuei540 – 5401Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP05084.

PTM databases

iPTMnetiP05084.

Expressioni

Tissue specificityi

In embryo, expression of maternal transcript is highest in anterior region. Zygotic transcript is expressed in anterior region until the beginning of gastrulation and in posterior region until early gastrulation. After this, it is expressed in developing nervous system.1 Publication

Developmental stagei

Expressed maternally and zygotically. Expression of the maternal transcript decreases until embryonic stage 14, zygotic transcript is first detected at stage 11.

Gene expression databases

BgeeiFBgn0001180.
ExpressionAtlasiP05084. differential.
GenevisibleiP05084. DM.

Interactioni

Protein-protein interaction databases

BioGridi66207. 10 interactions.
DIPiDIP-17417N.
IntActiP05084. 1 interaction.
MINTiMINT-293460.
STRINGi7227.FBpp0081431.

Structurei

3D structure databases

ProteinModelPortaliP05084.
SMRiP05084. Positions 233-351, 703-731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 699Poly-Gln
Compositional biasi102 – 1087Poly-Gln
Compositional biasi117 – 1226Poly-His
Compositional biasi404 – 4096Poly-Gln
Compositional biasi555 – 5617Poly-Gln

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri240 – 26223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri269 – 29123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34925C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri733 – 75725C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125424.
InParanoidiP05084.
KOiK09213.
OMAiHTRTHMK.
OrthoDBiEOG091G0DHN.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR027775. C2H2_Znf_fam.
IPR027742. Hunchback.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF201. PTHR10032:SF201. 2 hits.
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNWETTATT NYEQHNAWYN SMFAANIKQE PGHHLDGNSV ASSPRQSPIP
60 70 80 90 100
STNHLEQFLK QQQQQLQQQP MDTLCAMTPS PSQNDQNSLQ HYDANLQQQL
110 120 130 140 150
LQQQQYQQHF QAAQQQHHHH HHLMGGFNPL TPPGLPNPMQ HFYGGNLRPS
160 170 180 190 200
PQPTPTSAST IAPVAVATGS SEKLQALTPP MDVTPPKSPA KSSQSNIEPE
210 220 230 240 250
KEHDQMSNSS EDMKYMAESE DDDTNIRMPI YNSHGKMKNY KCKTCGVVAI
260 270 280 290 300
TKVDFWAHTR THMKPDKILQ CPKCPFVTEF KHHLEYHIRK HKNQKPFQCD
310 320 330 340 350
KCSYTCVNKS MLNSHRKSHS SVYQYRCADC DYATKYCHSF KLHLRKYGHK
360 370 380 390 400
PGMVLDEDGT PNPSLVIDVY GTRRGPKSKN GGPIASGGSG SGSRKSNVAA
410 420 430 440 450
VAPQQQQSQP AQPVATSQLS AALQGFPLVQ GNSAPPAASP VLPLPASPAK
460 470 480 490 500
SVASVEQTPS LPSPANLLPP LASLLQQNRN MAFFPYWNLN LQMLAAQQQA
510 520 530 540 550
AVLAQLSPRM REQLQQQNQQ QSDNEEEEQD DEYERKSVDS AMDLSQGTPV
560 570 580 590 600
KEDEQQQQPQ QPLAMNLKVE EEATPLMSSS NASRRKGRVL KLDTLLQLRS
610 620 630 640 650
EAMTSPEQLK VPSTPMPTAS SPIAGRKPMP EEHCSGTSSA DESMETAHVP
660 670 680 690 700
QANTSASSTA SSSGNSSNAS SNSNGNSSSN SSSNGTTSAV AAPPSGTPAA
710 720 730 740 750
AGAIYECKYC DIFFKDAVLY TIHMGYHSCD DVFKCNMCGE KCDGPVGLFV

HMARNAHS
Length:758
Mass (Da):83,114
Last modified:December 1, 2000 - v2
Checksum:iAD74802EB856ACD7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti437 – 4371A → P.
Natural varianti649 – 6491V → M.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00274 Genomic DNA. Translation: CAA68377.1.
U17742 Genomic DNA. Translation: AAB60232.1.
AE014297 Genomic DNA. Translation: AAN13395.1.
BT024234 mRNA. Translation: ABC86296.1.
AY051838 mRNA. Translation: AAK93262.1.
PIRiA93395. A29253.
RefSeqiNP_731267.1. NM_169233.2.
NP_731268.1. NM_169234.2.
UniGeneiDm.1105.

Genome annotation databases

EnsemblMetazoaiFBtr0081950; FBpp0081431; FBgn0001180.
FBtr0081951; FBpp0081432; FBgn0001180.
GeneIDi41032.
KEGGidme:Dmel_CG9786.
UCSCiCG9786-RA. d. melanogaster.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00274 Genomic DNA. Translation: CAA68377.1.
U17742 Genomic DNA. Translation: AAB60232.1.
AE014297 Genomic DNA. Translation: AAN13395.1.
BT024234 mRNA. Translation: ABC86296.1.
AY051838 mRNA. Translation: AAK93262.1.
PIRiA93395. A29253.
RefSeqiNP_731267.1. NM_169233.2.
NP_731268.1. NM_169234.2.
UniGeneiDm.1105.

3D structure databases

ProteinModelPortaliP05084.
SMRiP05084. Positions 233-351, 703-731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66207. 10 interactions.
DIPiDIP-17417N.
IntActiP05084. 1 interaction.
MINTiMINT-293460.
STRINGi7227.FBpp0081431.

PTM databases

iPTMnetiP05084.

Proteomic databases

PaxDbiP05084.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081950; FBpp0081431; FBgn0001180.
FBtr0081951; FBpp0081432; FBgn0001180.
GeneIDi41032.
KEGGidme:Dmel_CG9786.
UCSCiCG9786-RA. d. melanogaster.

Organism-specific databases

CTDi15120.
FlyBaseiFBgn0001180. hb.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125424.
InParanoidiP05084.
KOiK09213.
OMAiHTRTHMK.
OrthoDBiEOG091G0DHN.

Enzyme and pathway databases

SignaLinkiP05084.

Miscellaneous databases

GenomeRNAii41032.
PROiP05084.

Gene expression databases

BgeeiFBgn0001180.
ExpressionAtlasiP05084. differential.
GenevisibleiP05084. DM.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR027775. C2H2_Znf_fam.
IPR027742. Hunchback.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF201. PTHR10032:SF201. 2 hits.
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHUNB_DROME
AccessioniPrimary (citable) accession number: P05084
Secondary accession number(s): Q24018, Q29R06, Q960U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.