Reviewed,
UniProtKB/Swiss-Prot P05068 (CR1AC_BACTK)
Last modified
June 16, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Pesticidal crystal protein cry1Ac Alternative name(s): Insecticidal delta-endotoxin CryIA(c) Crystaline entomocidal protoxin 133 kDa crystal protein | ||||
| Gene names |
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| Encoded on | Plasmid 75 Kb | ||||
| Organism | Bacillus thuringiensis subsp. kurstaki | ||||
| Taxonomic identifier | 29339 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 1178 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Promotes colloidosmotic lysis by binding to the midgut epithelial cells of many lepidopteran larvae. |
| Developmental stage | The crystal protein is produced during sporulation and is accumulated both as an inclusion and as part of the spore coat. |
| Biotechnological use | Introduced by genetic manipulation and expressed in insect-resistant cotton and tomato by Calgene (Monsanto) and in maize by Dekalb Genetics. |
| Miscellaneous | Toxic segment of the protein is located in the N-terminus. |
| Sequence similarities | Belongs to the delta endotoxin family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Sporulation |
| Molecular function | Toxin |
| Technical term | Genetically modified food Plasmid |
| Gene Ontology (GO) | |
| Biological process | defense response Inferred from electronic annotation. Source: InterPro pathogenesisInferred from electronic annotation. Source: UniProtKB-KW sporulation resulting in formation of a cellular sporeInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | receptor binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 1178 | 1178 | Pesticidal crystal protein cry1Ac | PRO_0000174024 | |||
Sequences
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References
| [1] | "Characterized full-length and truncated plasmid clones of the crystal protein of Bacillus thuringiensis subsp. kurstaki HD-73 and their toxicity to Manduca sexta." Adang M.J., Staver M.J., Rocheleau T.A., Leighton J., Barker R.F., Thompson D.V. Gene 36:289-300(1985) [PubMed: 3000881] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: HD-73. |
| [2] | "Cloning and expression of a Bacillus thuringiensis (L1-2) gene encoding a crystal protein active against Glossina morsitans morsitans and Chilo partellus." Omolo E.O., James M.D., Osir E.O., Thomson J.A. Curr. Microbiol. 34:118-121(1997) [PubMed: 9003589] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: HD-73. |
| [3] | Herrera G., James M.D. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: HD-73. |
| [4] | "Cloning and nucleotide sequence of an insecticidal crystal protein gene from Bacillus thuringiensis DSIR732 active against 3 species of leafroller (Lepidoptera, Tortricidae)." Gleave A.P., Hedges R.J., Broadwell A.H., Wigley P.J. N. Z. J. Crop Hortic. Sci. 20:27-36(1992) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSIR732. |
| [5] | Sun M., Yu Z. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: YBT-1520. |
Cross-references
Sequence databases | |
|---|---|
| M11068 Genomic DNA. Translation: AAA22331.1. U87397 Genomic DNA. Translation: AAC44841.1. U87793 Genomic DNA. Translation: AAB46989.1. U89872 Genomic DNA. Translation: AAB49768.1. AJ002514 Genomic DNA. Translation: CAA05505.1. | |
| PIR | USBSXH. A23962. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1CIY based on UniProtKB P02965. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR005638. Endotoxin_C. IPR001178. Endotoxin_M. IPR015790. Endotoxin_m_sub_1. IPR005639. Endotoxin_N. [Graphical view] |
| Gene3D | G3DSA:2.100.10.10. Endotoxin_M. 1 hit. G3DSA:1.20.190.10. Endotoxin_N. 1 hit. |
| Pfam | PF03944. Endotoxin_C. 1 hit. PF00555. Endotoxin_M. 1 hit. PF03945. Endotoxin_N. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CR1AC_BACTK | ||||||||
| Accession | Primary (citable) accession number: P05068 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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