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P05063

- ALDOC_MOUSE

UniProt

P05063 - ALDOC_MOUSE

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Protein
Fructose-bisphosphate aldolase C
Gene
Aldoc, Aldo3, Scrg2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561Substrate
Binding sitei147 – 1471Substrate
Active sitei188 – 1881Proton acceptor By similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-P
Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. aging Source: Ensembl
  2. apoptotic process Source: Ensembl
  3. fructose 1,6-bisphosphate metabolic process Source: UniProtKB
  4. glycolytic process Source: UniProtKB-UniPathway
  5. organ regeneration Source: Ensembl
  6. protein heterotetramerization Source: Ensembl
  7. protein homotetramerization Source: Ensembl
  8. response to hypoxia Source: Ensembl
  9. response to organic cyclic compound Source: Ensembl
  10. response to organonitrogen compound Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

SABIO-RKP05063.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase C (EC:4.1.2.13)
Alternative name(s):
Aldolase 3
Brain-type aldolase
Scrapie-responsive protein 2
Zebrin II
Gene namesi
Name:Aldoc
Synonyms:Aldo3, Scrg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:101863. Aldoc.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 363362Fructose-bisphosphate aldolase C
PRO_0000216949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei111 – 1111N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP05063.
PaxDbiP05063.
PRIDEiP05063.

2D gel databases

REPRODUCTION-2DPAGEIPI00119458.
UCD-2DPAGEP05063.

PTM databases

PhosphoSiteiP05063.

Expressioni

Tissue specificityi

Expressed exclusively in Purkinje cells in bands running from anterior to posterior across most of the cerebellum. Expressed at higher levels in the brains of BSE-infected animals.2 Publications

Developmental stagei

Expression begins in the first week of postnatal life.1 Publication

Gene expression databases

BgeeiP05063.
CleanExiMM_ALDOC.
GenevestigatoriP05063.

Interactioni

Subunit structurei

Homotetramer. Interacts with ATP6V1E1 By similarity.

Protein-protein interaction databases

BioGridi198068. 1 interaction.
IntActiP05063. 6 interactions.
MINTiMINT-1864918.

Structurei

3D structure databases

ProteinModelPortaliP05063.
SMRiP05063. Positions 3-344.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiP05063.
KOiK01623.
OMAiRGQQDNA.
OrthoDBiEOG744T94.
PhylomeDBiP05063.
TreeFamiTF314203.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05063-1 [UniParc]FASTAAdd to Basket

« Hide

MPHSYPALSA EQKKELSDIA LRIVTPGKGI LAADESVGSM AKRLSQIGVE    50
NTEENRRLYR QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD 100
KGILVGIKVD KGVVPLAGTD GETTTQGLDG LLERCAQYKK DGADFAKWRC 150
VLKISDRTPS ALAILENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK 200
RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC PIKYSPEEIA 250
MATVTALRRT VPPAVPGVTF LSGGQSEEEA SLNLNAINRC PLPRPWALTF 300
SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEMNGLAAQ GRYEGSGDGG 350
AAAQSLYIAN HAY 363
Length:363
Mass (Da):39,395
Last modified:January 23, 2007 - v4
Checksum:i085C58AF163581C6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251T → A in AAH04802. 1 Publication
Sequence conflicti25 – 251T → A in AAH08184. 1 Publication
Sequence conflicti46 – 461Q → E in BAC30300. 1 Publication
Sequence conflicti62 – 621V → A in CAA27422. 1 Publication
Sequence conflicti113 – 1131V → L in CAA27422. 1 Publication
Sequence conflicti201 – 2011R → H in AAH04802. 1 Publication
Sequence conflicti201 – 2011R → H in AAH08184. 1 Publication
Sequence conflicti280 – 2801A → V in AAB32064. 1 Publication
Sequence conflicti358 – 3581I → V in AAH04802. 1 Publication
Sequence conflicti358 – 3581I → V in AAH08184. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S72537 mRNA. Translation: AAB32064.1.
AK005077 mRNA. Translation: BAB23801.1.
AK039267 mRNA. Translation: BAC30300.1.
BC004802 mRNA. Translation: AAH04802.1.
BC008184 mRNA. Translation: AAH08184.1.
X03796 mRNA. Translation: CAA27422.1.
AJ132391 mRNA. Translation: CAB77178.1.
CCDSiCCDS25099.1.
PIRiA25388. ADMSC.
I53145.
RefSeqiNP_033787.2. NM_009657.3.
XP_006532096.1. XM_006532033.1.
UniGeneiMm.7729.

Genome annotation databases

EnsembliENSMUST00000017534; ENSMUSP00000017534; ENSMUSG00000017390.
ENSMUST00000102478; ENSMUSP00000099536; ENSMUSG00000017390.
GeneIDi11676.
KEGGimmu:11676.
UCSCiuc007kiw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S72537 mRNA. Translation: AAB32064.1 .
AK005077 mRNA. Translation: BAB23801.1 .
AK039267 mRNA. Translation: BAC30300.1 .
BC004802 mRNA. Translation: AAH04802.1 .
BC008184 mRNA. Translation: AAH08184.1 .
X03796 mRNA. Translation: CAA27422.1 .
AJ132391 mRNA. Translation: CAB77178.1 .
CCDSi CCDS25099.1.
PIRi A25388. ADMSC.
I53145.
RefSeqi NP_033787.2. NM_009657.3.
XP_006532096.1. XM_006532033.1.
UniGenei Mm.7729.

3D structure databases

ProteinModelPortali P05063.
SMRi P05063. Positions 3-344.
ModBasei Search...

Protein-protein interaction databases

BioGridi 198068. 1 interaction.
IntActi P05063. 6 interactions.
MINTi MINT-1864918.

PTM databases

PhosphoSitei P05063.

2D gel databases

REPRODUCTION-2DPAGE IPI00119458.
UCD-2DPAGE P05063.

Proteomic databases

MaxQBi P05063.
PaxDbi P05063.
PRIDEi P05063.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000017534 ; ENSMUSP00000017534 ; ENSMUSG00000017390 .
ENSMUST00000102478 ; ENSMUSP00000099536 ; ENSMUSG00000017390 .
GeneIDi 11676.
KEGGi mmu:11676.
UCSCi uc007kiw.1. mouse.

Organism-specific databases

CTDi 230.
MGIi MGI:101863. Aldoc.

Phylogenomic databases

eggNOGi COG3588.
GeneTreei ENSGT00390000010235.
HOGENOMi HOG000220876.
HOVERGENi HBG002386.
InParanoidi P05063.
KOi K01623.
OMAi RGQQDNA.
OrthoDBi EOG744T94.
PhylomeDBi P05063.
TreeFami TF314203.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
SABIO-RK P05063.

Miscellaneous databases

ChiTaRSi ALDOC. mouse.
NextBioi 279307.
PROi P05063.
SOURCEi Search...

Gene expression databases

Bgeei P05063.
CleanExi MM_ALDOC.
Genevestigatori P05063.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning of zebrin II reveals its identity with aldolase C."
    Ahn A.H., Dziennis S., Hawkes R., Herrup K.
    Development 120:2081-2090(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Spinal cord.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. "Structure and expression of mouse aldolase genes. Brain-specific aldolase C amino acid sequence is closely related to aldolase A."
    Paolella G., Buono P., Mancini P., Izzo P., Salvatore F.
    Eur. J. Biochem. 156:229-235(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-227.
  5. Lubec G., Klug S., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-13; 29-57; 61-69; 73-96; 102-108; 112-134; 154-215; 244-258; 260-289; 305-315; 319-330 AND 332-363, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  6. "Enhanced levels of scrapie responsive gene mRNA in BSE-infected mouse brain."
    Dandoy-Dron F.C., Benboudjema L., Guillo F., Jaegly A., Jasmin C., Dormont D., Tovey M.G., Dron M.
    Brain Res. Mol. Brain Res. 76:173-179(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 281-363, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Brain.

Entry informationi

Entry nameiALDOC_MOUSE
AccessioniPrimary (citable) accession number: P05063
Secondary accession number(s): Q64011
, Q8CA91, Q99K96, Q9DBA4, Q9JK32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 146 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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