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Protein

Secretogranin-1

Gene

CHGB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

GO - Molecular functioni

  • hormone activity Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089199-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-1
Alternative name(s):
Chromogranin-B
Short name:
CgB
Secretogranin I
Short name:
SgI
Cleaved into the following 3 chains:
Gene namesi
Name:CHGB
Synonyms:SCG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:1930. CHGB.

Subcellular locationi

  • Secreted

  • Note: Neuroendocrine and endocrine secretory granules.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1114.
OpenTargetsiENSG00000089199.
PharmGKBiPA26462.

Polymorphism and mutation databases

BioMutaiCHGB.
DMDMi311033509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000000543821 – 677Secretogranin-1Add BLAST657
PeptideiPRO_0000005439440 – 513GAWK peptideAdd BLAST74
PeptideiPRO_0000432730575 – 585PE-11By similarityAdd BLAST11
PeptideiPRO_0000005440617 – 673CCB peptideAdd BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 57
Modified residuei79PhosphothreonineCurated1
Modified residuei93PhosphoserineBy similarity1
Modified residuei99PhosphoserineSequence analysis1
Modified residuei100PhosphoserineSequence analysis1
Modified residuei130Phosphoserine; by FAM20C1 Publication1
Modified residuei149PhosphoserineCombined sources1 Publication1
Modified residuei183PhosphoserineBy similarity1
Modified residuei225Phosphoserine; by FAM20C1 Publication1
Modified residuei259PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei293PhosphoserineSequence analysis1
Modified residuei294PhosphoserineSequence analysis1
Modified residuei311PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei341SulfotyrosineBy similarity1
Modified residuei367Phosphoserine; by FAM20C1 Publication1
Modified residuei377Phosphoserine; by FAM20CCombined sources1 Publication1
Modified residuei380Phosphoserine; by FAM20C1 Publication1
Modified residuei401Phosphotyrosine1 Publication1
Modified residuei405PhosphoserineCombined sources1 Publication1
Modified residuei471SulfotyrosineSequence analysis1
Modified residuei474SulfotyrosineCurated1
Modified residuei533PhosphoserineSequence analysis1
Modified residuei534PhosphoserineSequence analysis1
Modified residuei566SulfotyrosineCurated1
Modified residuei568SulfotyrosineSequence analysis1
Modified residuei617PhosphoserineCombined sources1
Modified residuei624SulfotyrosineBy similarity1
Modified residuei626PhosphoserineBy similarity1
Modified residuei631PhosphoserineBy similarity1

Post-translational modificationi

Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).By similarity
O-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP05060.
PeptideAtlasiP05060.
PRIDEiP05060.

PTM databases

iPTMnetiP05060.
PhosphoSitePlusiP05060.

Expressioni

Tissue specificityi

Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.1 Publication

Gene expression databases

BgeeiENSG00000089199.
CleanExiHS_CHGB.
ExpressionAtlasiP05060. baseline and differential.
GenevisibleiP05060. HS.

Organism-specific databases

HPAiCAB009403.
HPA008759.
HPA012602.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-712619,EBI-5323863
SMAD2Q157962EBI-712619,EBI-1040141

GO - Molecular functioni

  • hormone activity Source: ProtInc

Protein-protein interaction databases

BioGridi107539. 29 interactors.
IntActiP05060. 33 interactors.
MINTiMINT-1414600.
STRINGi9606.ENSP00000368244.

Structurei

3D structure databases

ProteinModelPortaliP05060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 120O-glycosylated at one site5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi163 – 171Poly-Glu9

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVJ3. Eukaryota.
ENOG410ZHMS. LUCA.
GeneTreeiENSGT00730000111312.
HOVERGENiHBG057317.
InParanoidiP05060.
KOiK19991.
OMAiNWGYEKR.
OrthoDBiEOG091G07VF.
PhylomeDBiP05060.
TreeFamiTF336596.

Family and domain databases

InterProiIPR001819. Chromogranin_AB.
IPR018054. Chromogranin_CS.
IPR001990. Granin.
[Graphical view]
PANTHERiPTHR10583. PTHR10583. 1 hit.
PfamiPF01271. Granin. 1 hit.
[Graphical view]
PRINTSiPR00659. CHROMOGRANIN.
PROSITEiPS00422. GRANINS_1. 1 hit.
PS00423. GRANINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPTLLLSLL GAVGLAAVNS MPVDNRNHNE GMVTRCIIEV LSNALSKSSA
60 70 80 90 100
PPITPECRQV LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS
110 120 130 140 150
RGEAGAPGEE DIQGPTKADT EKWAEGGGHS RERADEPQWS LYPSDSQVSE
160 170 180 190 200
EVKTRHSEKS QREDEEEEEG ENYQKGERGE DSSEEKHLEE PGETQNAFLN
210 220 230 240 250
ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG EETGSQENHP
260 270 280 290 300
QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP
310 320 330 340 350
SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG
360 370 380 390 400
VQAPEDLEWE RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG
410 420 430 440 450
YGEESEEERG LEPGKGRHHR GRGGEPRAYF MSDTREEKRF LGEGHHRVQE
460 470 480 490 500
NQMDKARRHP QGAWKELDRN YLNYGEEGAP GKWQQQGDLQ DTKENREEAR
510 520 530 540 550
FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD NMNDNFLEGE
560 570 580 590 600
EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ
610 620 630 640 650
YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE
660 670
DEKKELENLA AMDLELQKIA EKFSQRG
Length:677
Mass (Da):78,276
Last modified:November 2, 2010 - v2
Checksum:iBFDC97F7B21245B3
GO

Sequence cautioni

The sequence BAD92949 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24D → E in BAF82075 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04357893S → T.2 PublicationsCorresponds to variant rs6085324dbSNPEnsembl.1
Natural variantiVAR_024414117K → N.Corresponds to variant rs236150dbSNPEnsembl.1
Natural variantiVAR_028235145D → N.Corresponds to variant rs6133278dbSNPEnsembl.1
Natural variantiVAR_020287178R → Q.2 PublicationsCorresponds to variant rs910122dbSNPEnsembl.1
Natural variantiVAR_028236200N → H.Corresponds to variant rs881118dbSNPEnsembl.1
Natural variantiVAR_028237232R → Q.Corresponds to variant rs6139873dbSNPEnsembl.1
Natural variantiVAR_024415243T → A.6 PublicationsCorresponds to variant rs236151dbSNPEnsembl.1
Natural variantiVAR_024416353A → G.2 PublicationsCorresponds to variant rs236152dbSNPEnsembl.1
Natural variantiVAR_028238413P → L.Corresponds to variant rs742710dbSNPEnsembl.1
Natural variantiVAR_022012417R → H.2 PublicationsCorresponds to variant rs742711dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00064 mRNA. Translation: CAA68271.1.
AK289386 mRNA. Translation: BAF82075.1.
CR456726 mRNA. Translation: CAG33007.1.
AB209712 mRNA. Translation: BAD92949.1. Different initiation.
AL035461 Genomic DNA. Translation: CAB55272.1.
AL035461 Genomic DNA. Translation: CAC34360.1.
CH471133 Genomic DNA. Translation: EAX10410.1.
BC000375 mRNA. Translation: AAH00375.1.
CCDSiCCDS13092.1.
PIRiA29264. CNHUB.
RefSeqiNP_001810.2. NM_001819.2.
UniGeneiHs.516874.

Genome annotation databases

EnsembliENST00000378961; ENSP00000368244; ENSG00000089199.
GeneIDi1114.
KEGGihsa:1114.
UCSCiuc002wmg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00064 mRNA. Translation: CAA68271.1.
AK289386 mRNA. Translation: BAF82075.1.
CR456726 mRNA. Translation: CAG33007.1.
AB209712 mRNA. Translation: BAD92949.1. Different initiation.
AL035461 Genomic DNA. Translation: CAB55272.1.
AL035461 Genomic DNA. Translation: CAC34360.1.
CH471133 Genomic DNA. Translation: EAX10410.1.
BC000375 mRNA. Translation: AAH00375.1.
CCDSiCCDS13092.1.
PIRiA29264. CNHUB.
RefSeqiNP_001810.2. NM_001819.2.
UniGeneiHs.516874.

3D structure databases

ProteinModelPortaliP05060.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107539. 29 interactors.
IntActiP05060. 33 interactors.
MINTiMINT-1414600.
STRINGi9606.ENSP00000368244.

PTM databases

iPTMnetiP05060.
PhosphoSitePlusiP05060.

Polymorphism and mutation databases

BioMutaiCHGB.
DMDMi311033509.

Proteomic databases

PaxDbiP05060.
PeptideAtlasiP05060.
PRIDEiP05060.

Protocols and materials databases

DNASUi1114.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378961; ENSP00000368244; ENSG00000089199.
GeneIDi1114.
KEGGihsa:1114.
UCSCiuc002wmg.4. human.

Organism-specific databases

CTDi1114.
DisGeNETi1114.
GeneCardsiCHGB.
H-InvDBHIX0015625.
HGNCiHGNC:1930. CHGB.
HPAiCAB009403.
HPA008759.
HPA012602.
MIMi118920. gene.
neXtProtiNX_P05060.
OpenTargetsiENSG00000089199.
PharmGKBiPA26462.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJ3. Eukaryota.
ENOG410ZHMS. LUCA.
GeneTreeiENSGT00730000111312.
HOVERGENiHBG057317.
InParanoidiP05060.
KOiK19991.
OMAiNWGYEKR.
OrthoDBiEOG091G07VF.
PhylomeDBiP05060.
TreeFamiTF336596.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089199-MONOMER.

Miscellaneous databases

ChiTaRSiCHGB. human.
GeneWikiiSecretoneurin.
GenomeRNAii1114.
PROiP05060.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089199.
CleanExiHS_CHGB.
ExpressionAtlasiP05060. baseline and differential.
GenevisibleiP05060. HS.

Family and domain databases

InterProiIPR001819. Chromogranin_AB.
IPR018054. Chromogranin_CS.
IPR001990. Granin.
[Graphical view]
PANTHERiPTHR10583. PTHR10583. 1 hit.
PfamiPF01271. Granin. 1 hit.
[Graphical view]
PRINTSiPR00659. CHROMOGRANIN.
PROSITEiPS00422. GRANINS_1. 1 hit.
PS00423. GRANINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCG1_HUMAN
AccessioniPrimary (citable) accession number: P05060
Secondary accession number(s): A8K021
, Q59EU9, Q6IBS6, Q9BQV6, Q9UC25, Q9UJA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.